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HLA-ABC & DR,DQ Typing

HLA typing remains relevant for donor selection for kidney transplantation. In bone marrow transplantations, the selection of HLA-compatible sibblings remains the best pre-conditions for clinical success.For platelet and granulocyte transfutions in bone marrow transplant patient’s, and in general oncology, HLA typed donors provide meterial of choice.

In the area of HLA and disease association , the number of diseases for which HLA typing can have a diagnostic role is increasing. In addition to the classical association of HLA-B27 with ankylosing spondylitis, the presence of DR2 has become a useful tool for the diagnosis of narcolepsy. HLA typing can be employed to assess genetic risks in juvenile diabetes mellitus and in prenatal diagnosis for 21-hydroxylase deficiency.

The extreme polymorphism of the HLA system offers a high probability in paternity testing both for excluding and for identifying candidates as the true father.

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