Cov lus teb ncaj qha
Kev kuaj DHEAS yog kev kuaj ntshav uas ntsuas dehydroepiandrosterone sulfate, ib qho ua ntej androgen uas feem ntau yog tsim los ntawm cov qog adrenal. Cov kws kho mob siv kev kuaj DHEAS los pab tshawb xyuas cov plaub hau tsis xav tau kev loj hlob, pob txuv, lub caij tsis xwm yeem, hnub nyoog hluas ntxov thiab cov teeb meem adrenal uas xav tias muaj. Qhov tshwm sim ntawm DHEAS ib leeg tsis kuaj pom ib qho mob thiab xav tau kev txhais lus hauv kev kho mob.
Tus yuam sij takeaways
- DHEAS qhia txog cov zis ntawm adrenal androgen, tsis yog tag nrho cov tshuaj hormones kev noj qab haus huv lossis kev muaj menyuam.
- DHEAS feem ntau yog ib qho kev xeem hauv ib pawg, ua ke nrog rau tag nrho cov testosterone, 17-hydroxyprogesterone, prolactin thiab kev kuaj mob thyroid, nyob ntawm seb cov lus nug hauv kev kho mob yog dab tsi.
- Ib qho DHEAS ib txwm tsis suav nrog PCOS, kab mob adrenal lossis qog adrenal.
- Cov qib siv tau yog nyob ntawm hnub nyoog thiab poj niam txiv neej. thiab txawv ntawm cov chaw soj nstuam thiab cov platform assay, yog li piv koj tus nqi tsuas yog nrog qhov ntau yam luam tawm ntawm koj daim ntawv qhia.
- DHEAS nce me ntsis yog ib qho tshwm sim thiab feem ntau tsis yog vim muaj qog nqaij hlavcov nqi nce siab heev xav tau kev tshuaj xyuas sai sai ntawm cov kws tshwj xeeb.
Ib nrais muag
| feature | Nthuav dav |
|---|---|
| qauv | Cov ntshav tawm ntawm cov leeg, feem ntau yog los ntawm caj npab |
| Kev yoo mov | Feem ntau tsis tas yuav tsum tau ua; ua raws li koj lub chaw kuaj mob cov lus qhia, uas yog qhov tseem ceeb dua |
| Sij hawm | DHEAS ruaj khov heev thoob plaws hnub; qee cov chav tseem nyiam cov qauv thaum sawv ntxov thaum nws raug kos nrog cortisol lossis testosterone |
| Lub sijhawm tau txais | Kev kuaj ntshav nws tus kheej siv sijhawm li 2-5 feeb; tag nrho kev mus ntsib suav nrog kev sau npe thiab kev nias tom qab kuaj ntshav feem ntau yog 15-30 feeb. |
| Qhia txog | Txawv ntawm chav kuaj thiab txoj kev sim; nug koj lub chaw sau thaum twg koj daim ntawv qhia yuav muaj |
| Kev siv tseem ceeb | Androgen ntau dhau, xav tias muaj qog adrenal, adrenal hyperplasia txij thaum yug los, adrenarche ntxov ntxov, adrenal insufficiency assessment |
| Qhov nws ua tsis tau | Tsis tuaj yeem kuaj mob PCOS, tsis tuaj yeem lees paub lossis tshem tawm cov qog adrenal, tsis tuaj yeem ntsuas qhov txaus cortisol |
Kuj hu ua
- Kev kuaj DHEA-S, kev kuaj DHEA sulfate, dehydroepiandrosterone sulfate
- Cov tshuaj DHEAS hauv cov ntshav
- Feem ntau nug hauv Is Nrias teb tias yog "kev kuaj tshuaj hormones txiv neej" lossis "kev kuaj tshuaj hormones rau cov plaub hau ntawm lub ntsej muag", cov no yog cov lus piav qhia tsis raws cai, tsis yog lub npe tseeb ntawm kev kuaj.
- Feem ntau tsis meej pem nrog cov DHEA kev kuaj, uas ntsuas cov tshuaj hormones unsulfated thiab yog kev tshawb nrhiav sib txawv
Qhov kev xeem DHEAS yog dab tsi
Dehydroepiandrosterone sulfate yog ib qho androgen tsis muaj zog uas tsim los ntawm adrenal cortex, nrog rau kev koom tes me me los ntawm ovaries thiab noob qes. Lub cev hloov DHEAS mus rau hauv DHEA thiab tom qab ntawd, hauv cov ntaub so ntswg peripheral, mus rau hauv cov androgens thiab oestrogens muaj zog dua.
Vim tias DHEAS ncig mus los ntawm qhov concentration siab, muaj ib nrab-lub neej ntev thiab tsis viav vias sai sai thoob plaws hnub zoo li cortisol, qhov kev xeem DHEAS yog ib qho cim qhia yooj yim ntawm adrenal androgen ntau lawm. Cov theem DHEAS nce siab thaum yau (adrenarche), nce mus txog thaum kawg ntawm cov tub ntxhais hluas mus txog rau nees nkaum xyoo, thiab poob qis zuj zus raws li hnub nyoog. Qhov kev poob qis ntsig txog hnub nyoog yog ib qho qauv ntawm lub cev, tsis yog kab mob.
Vim li cas thiaj ua qhov kev xeem DHEAS
- Cov poj niam uas muaj androgen ntau dhau: mob hirsutism, pob txuv tas li, plaub hau nyias nyias ntawm lub taub hau, tsis tu ncua lossis tsis muaj hli. DHEAS pab cais cov androgen ntawm adrenal los ntawm cov zes qe menyuam.
- Qhov xav tias muaj qog adrenal uas tsim cov androgen: Qhov pib sai, kev ua kom mob hnyav zuj zus nrog DHEAS nce siab ua rau muaj qhov teeb meem no thiab ua rau muaj kev tshuaj ntsuam xyuas.
- Kev loj hlob ntawm cov qog adrenal txij thaum yug los (CAH): DHEAS tej zaum yuav raug tsa, tab sis 17-hydroxyprogesterone yog qhov kev ntsuam xyuas tseem ceeb rau qhov tsis muaj zog 21-hydroxylase classic thiab non-classic.
- Cov menyuam yaus uas muaj kev loj hlob ntawm kev sib deev thaum ntxov: adrenarche ua ntej lub sijhawm (cov plaub hau ntawm qhov chaw mos lossis hauv qab caj npab thaum ntxov, ntxhiab tsw ntawm lub cev thaum laus) piv rau qhov tseeb ntawm lub sijhawm laus.
- Kev kho mob ntawm adrenal insufficiency: DHEAS qis heev tuaj yeem txhawb nqa daim duab, tab sis kev kuaj cortisol thiab ACTH, feem ntau nrog kev kuaj ACTH stimulation, yog qhov tseeb ntsuas adrenal insufficiency.
- xyuas tom qab kho mob qog adrenal lossis thaum lub sijhawm kho mob CAH glucocorticoid, thaum tus kws kho mob tshwj xeeb thov.
Leej twg yuav tsum tau txais qhov kev xeem no
DHEAS yog kev kuaj mob uas tsom mus rau ib qho xwb, tsis yog kev kuaj mob dav dav. Nws yog qhov tsim nyog thaum tus kws kho mob tau txheeb xyuas ib qho ntawm cov hauv qab no:
- Cov poj niam thiab cov ntxhais hluas uas muaj hirsutism, pob txuv uas tsis kho tau, plaub hau poob zoo li txiv neej, lossis cov hli uas tsis tshua muaj, tsis muaj lossis tsis paub tseeb.
- Cov neeg uas muaj tus kab mob virilisation uas zuj zus tuaj sai sai, lub suab tob zuj zus, clitoromegaly, cov leeg nqaij hloov pauv ntau heev, uas xav tau kev soj ntsuam sai.
- Cov menyuam yaus uas muaj cov plaub hau ntawm qhov chaw mos lossis qhov chaw mos ua ntej hnub nyoog li ntawm 8 xyoo rau cov ntxhais lossis 9 xyoo rau cov tub, lossis lawv loj hlob sai heev uas tsis paub meej.
- Cov neeg raug tshuaj xyuas seb puas muaj teeb meem adrenal insufficiency lossis muaj qog adrenal uas pom tsis tau los ntawm kev thaij duab.
- Cov poj niam raug mob vim muaj teeb meem xeeb tub uas xav tias muaj androgen ntau dhau.
Cov neeg uas tsis xav tau nws: cov neeg uas tsis muaj tsos mob uas tsuas yog xav "kuaj xyuas cov tshuaj hormones", lossis cov neeg uas xav ntsuam xyuas qhov xwm txheej "tiv thaiv kev laus". Tus nqi DHEAS tsis ntsuas lub zog, lub zog lossis lub hnub nyoog ntawm lub cev.
Qhov kev kuaj DHEAS tsis tuaj yeem ntes lossis tsis suav nrog
- Nws tsis tuaj yeem kuaj mob PCOS. PCOS raug kuaj pom los ntawm kev kuaj mob, biochemical thiab ultrasound tom qab tsis suav nrog lwm yam ua rau. Ntau tus poj niam uas muaj PCOS muaj DHEAS zoo li qub. PCOD tsis yog ib yam kab mob sib cais los ntawm PCOS, ob lub npe no hais txog tib yam mob.
- Nws tsis tuaj yeem lees paub lossis tsis suav nrog qog adrenal lossis ovarian. Tsuas yog kev thaij duab xwb thiaj li paub qhov ntawd. Qee cov qog nqaij hlav uas tsim cov androgen tsim cov testosterone ntau dua li DHEAS, yog li DHEAS tuaj yeem zoo li qub thaum lawv nyob ntawd.
- Nws tsis tuaj yeem ntsuas qhov xwm txheej cortisol. DHEAS tsis hais dab tsi txhim khu kev qha txog seb koj puas tsim cortisol txaus, thiab nws tsis tuaj yeem kuaj mob Cushing's syndrome.
- Nws tsis ntsuas qhov muaj menyuam, qe menyuam, qhov chaw cia qe menyuam lossis qhov zoo ntawm cov phev.
- Nws tsis tuaj yeem txheeb xyuas qhov chaw ntawm androgen ntawm nws tus kheej. Cov kev ua haujlwm ntawm cov qog adrenal thiab ovarian sib tshooj.
- Ib qho txiaj ntsig ib txwm yog ib qho kev piav qhia ntawm cov qauv ntawd, tsis yog pov thawj tias tsis muaj dab tsi tsis ncaj ncees lawm. Yog tias koj cov tsos mob tseem muaj lossis nce qib txawm tias muaj DHEAS ib txwm muaj, rov qab mus ntsib koj tus kws kho mob es tsis txhob xav tias qhov teeb meem tau daws lawm.
Kev ntsuam xyuas sib txuas tab sis sib txawv
Cov kev xeem no teb cov lus nug sib txawv. Ib qho tsis zoo dua lwm qhov; qhov kev xeem thawj zaug zoo nyob ntawm seb koj ua tau zoo li cas.
| xeem | Lo lus nug nws teb | Qhov txawv tseem ceeb ntawm DHEAS |
|---|---|---|
| DHEAS | Puas yog adrenal androgen ntau lawm ntau dua lossis qis heev? | Ruaj khov thoob plaws hnub; feem ntau yog adrenal hauv keeb kwm |
| DHEA (tsis muaj sulfated) | Kev tsim DHEA luv luv | Hloov pauv txhua teev; tsis tshua muaj txiaj ntsig rau kev ua haujlwm androgen niaj hnub |
| Tag nrho thiab dawb testosterone | Puas yog cov androgen uas tseem ceeb hauv lub cev tsim tawm, thiab los ntawm qhov twg? | Feem ntau qhov kev xeem muaj cov ntaub ntawv ntau dua hauv hirsutism; rhiab heev rau qhov zoo ntawm kev ntsuam xyuas hauv cov poj niam |
| 17-hydroxyprogesterone | Qhov no puas yog hyperplasia ntawm adrenal uas yug los? | Yuav tsum tau kuaj thaum sawv ntxov, theem follicular kom ntseeg tau |
| Kev kuaj mob cortisol / ACTH / ACTH hauv cov ntshav | Puas yog adrenal cortisol ua haujlwm txaus, lossis ntau dhau? | DHEAS tsis tuaj yeem hloov pauv rau cov no |
| Kev kuaj mob dexamethasone thaum hmo ntuj | Puas muaj cortisol ntau dhau thiab nws puas tuaj yeem tshem tawm tau? | Ib qho kev xeem dynamic, tsis yog ib qib static |
| TSH, LH, FSH, prolactin | Puas muaj teeb meem ntawm lub qog pituitary, thyroid lossis ovarian ua rau muaj teeb meem ntawm lub cev ntas? | Kev daws teeb meem uas tsis yog androgen ua rau DHEAS tsis nco qab |
| CT los yog MRI ntawm cov qog adrenal | Puas muaj qhov teeb meem ntawm cov qog adrenal? | Tsuas yog kev thaij duab xwb thiaj teb tau qhov no; kev kuaj ntshav tsis tuaj yeem teb tau |
Yuav npaj li cas
Cov lus qhia txog kev npaj yuav siv tau thiab sib txawv ntawm cov chaw kuaj mob thiab cov tsev kho mob. Cov lus qhia sau ntawm koj lub chaw khaws khoom muaj qhov tseem ceeb dua li cov lus qhia dav dav, suav nrog nplooj ntawv no.
- Kev yoo mov: feem ntau tsis tas yuav siv rau DHEAS xwb. Yog tias siv cov qauv no rau cov piam thaj, cov roj lipid lossis cov tshuaj insulin, tej zaum yuav xav tau kev yoo mov.
- sij hawm: DHEAS tsis muaj lub zog txhua hnub, tab sis ntau lub chaw tseem teem sijhawm kos duab thaum sawv ntxov thaum cortisol, testosterone lossis 17-hydroxyprogesterone raug thov ua ke.
- Tshuaj thiab tshuaj ntxiv: qhia rau tus kws kho mob uas thov txog cov tshuaj tiv thaiv kev xeeb tub, kev kho mob hormone, corticosteroids (suav nrog kev nqus pa, txhaj tshuaj lossis tshuaj steroids ntev), metformin, insulin, anti-androgens, thiab txhua yam DHEA, "testosterone booster", gym lossis AYUSH tshuaj ntxiv. Tsis txhob tsum lossis hloov cov tshuaj uas tau muab rau koj tus kheej, nug tus kws kho mob seb puas xav tau kev hloov pauv ua ntej kuaj.
- Lub voj voog ntawm lub hli: DHEAS txawv me ntsis thoob plaws lub voj voog, tab sis yog tias 17-hydroxyprogesterone lossis lwm yam tshuaj hormones raug rub nrog nws, koj tus kws kho mob yuav thov kom muaj ib hnub tshwj xeeb ntawm lub voj voog.
- Biotin: Cov tshuaj biotin ntau ntau tuaj yeem cuam tshuam rau qee qhov kev ntsuam xyuas immunoassays. Hais txog kev siv biotin; koj lub chaw kuaj mob yuav qhia txog qhov sib txawv uas xav tau.
Yog koj xeeb tub
Kev cev xeeb tub hloov pauv cov androgen thiab cov protein khi, thiab kev txhais lus txawv. Qhia rau lub chaw kuaj mob thiab tus kws kho mob uas thov koj tias koj cev xeeb tub kom cov txiaj ntsig tau nyeem hauv cov ntsiab lus ntawd.
Cov me nyuam
Yuav tsum muab DHEAS rau cov menyuam yaus piv rau cov hnub nyoog thiab theem hnub nyoog hluas, tsis yog cov neeg laus piv rau. Nug tus kws kho mob ntshav uas tau kawm txog kev kho mob rau cov menyuam yaus yog tias muaj, thiab coj niam txiv lossis tus saib xyuas tuaj rau koj kom lawv pom zoo thiab nplij koj.
Cov laus
DHEAS poob qis raws li lub hnub nyoog. Tus nqi qis hauv ib tus neeg laus feem ntau yog qhov ua rau lub cev tsis ua haujlwm thiab tsis qhia tias muaj kab mob adrenal lossis xav tau cov tshuaj ntxiv.
Kev kho mob ntshav qab zib kom txo qis glucose
Yog tias koj lub chaw kho mob hais kom koj yoo mov rau kev kuaj mob uas muaj DHEAS, tham txog lub sijhawm siv insulin lossis sulfonylurea nrog koj tus kws kho mob ua ntej, yog li koj thiaj li tsis muaj kev pheej hmoo ntawm hypoglycemia thaum tos.
Kab mob raum ntev, lub plawv tsis ua haujlwm lossis kev txwv dej
Tsis tas yuav tsum tau ntxiv dej tshwj xeeb rau kev kuaj ntshav DHEAS. Tsis txhob haus dej ntau dhau qhov koj tau teem tseg yog tias koj tsis haus dej ntau.
Yuav muaj dab tsi tshwm sim thaum lub sijhawm kuaj DHEAS
- Kev sau npe thiab kev kuaj xyuas tus kheej tawm tsam daim ntawv thov.
- Cov qauv sau: muab ib daim ntaub qhwv caj dab, ntxuav daim tawv nqaij, thiab rho ib qho ntshav me me los ntawm cov leeg ntawm caj npab. Feem ntau qhov no siv sijhawm 2-5 feeb.
- Tom qab kos duab: Muaj kev nias rau ntawm qhov chaw mob thiab muab ib daim ntaub qhwv rau. Cov neeg feem coob tawm hauv ob peb feeb xwb.
- Ntsuas: DHEAS raug ntsuas los ntawm kev ntsuam xyuas immunoassay lossis, hauv qee lub chaw soj nstuam, los ntawm kev ntsuas qhov hnyav. Cov txiaj ntsig los ntawm ntau txoj kev sib txawv tsis tuaj yeem hloov pauv tau ncaj qha.
Tag nrho lub sijhawm nyob ntawm qhov chaw feem ntau yog 15-30 feeb, ntev dua yog tias qhov chaw muaj neeg coob lossis yog tias muaj lwm yam kev kuaj lossis cov qauv kuaj raws sijhawm. Lub sijhawm tshaj tawm nyob ntawm lub chaw kuaj mob thiab seb qhov kev kuaj puas khiav hauv tsev lossis xa mus, nug thaum lub sijhawm sau.
Nkag siab txog koj daim ntawv qhia txog DHEAS
DHEAS raug tshaj tawm hauv 礸/dL lossis hauv 祄ol/L, nyob ntawm lub chaw kuaj mob. Cov sijhawm siv tau muab faib los ntawm poj niam txiv neej thiab los ntawm cov hnub nyoog nqaim, thiab lawv txawv ntawm cov platforms assay.
Vim li no, tsis muaj daim ntawv teev cov ntaub ntawv siv los ua piv txwv ntawm no. Siv tsuas yog qhov sib txawv ntawm hnub nyoog thiab poj niam txiv neej uas luam tawm ua ke nrog koj tus nqi ntawm koj daim ntawv qhia. Tus nqi uas "siab" ntawm ib lub chaw kuaj mob tej zaum yuav nyob hauv qhov sib txawv ntawm lwm lub.
Yog tias DHEAS nyob hauv qhov ntau uas tau tshaj tawm
Qhov no qhia tau tias cov qog adrenal androgen tsis yog tus tsav tsheb ntawm koj cov tsos mob. Nws tsis suav nrog PCOS, kab mob thyroid, prolactin ntau dhau, CAH tsis yog classic lossis qog nqaij hlav tso androgen. Cov tsos mob uas tseem muaj lossis hnyav zuj zus yuav tsum tau rov xyuas dua.
Yog tias DHEAS nce me ntsis mus rau nruab nrab
Qhov siab me ntsis yog ib qho uas pom ntau thiab pom hauv PCOS, uas tsis yog CAH ib txwm muaj, thiab qee zaum tsis muaj qhov ua rau pom tseeb. Feem ntau yuav kuaj ntshav ntxiv dua li siv duab thaij tam sim ntawd. Cov txiaj ntsig sib txawv nyob ntawm tus neeg mob tus mob.
Yog tias DHEAS nce siab heev
Ib qho DHEAS siab heev, tshwj xeeb tshaj yog nrog kev pib ua virilisation sai, ua rau muaj kev txhawj xeeb txog qog adrenal androgen-secreting lossis CAH thiab xav tau kev tshuaj xyuas endocrinology sai thiab feem ntau yog adrenal imaging.
Yog tias DHEAS qis
Feem ntau DHEAS qis tsuas yog muaj feem cuam tshuam nrog hnub nyoog xwb. Nws kuj tseem tuaj yeem tshwm sim nrog adrenal insufficiency, hypopituitarism, lossis kev siv glucocorticoid sab nraud. DHEAS qis ib leeg tsis kuaj pom tus kab mob Addison, cortisol, ACTH thiab kev kuaj mob dynamic yog qhov tsim nyog.
Tus kws kho mob uas tau thov kom kuaj DHEAS yog tus neeg uas yuav tsum txhais nws, nrog rau koj cov tsos mob, kev kuaj mob thiab lwm yam txiaj ntsig. Tsis txhob pib DHEA lossis lwm yam tshuaj hormones ntxiv rau ntawm tus lej.
Thaum cov txiaj ntsig DHEAS tuaj yeem ua rau neeg tsis meej pem
Ua rau muaj kev nyeem ntawv siab dhau los yog siab dhau lawm
- DHEA los yog "pro-hormone" cov tshuaj ntxiv, suav nrog ntau yam khoom siv hauv chaw dhia ua si thiab cov khoom siv tiv thaiv kev laus, tuaj yeem ua rau DHEAS nce siab heev. Qee cov tshuaj ntsuab thiab AYUSH uas tsis muaj daim ntawv lo muaj cov tshuaj steroids.
- Cov tshuaj biotin ntau tuaj yeem cuam tshuam qee yam kev tiv thaiv kab mob hauv ob qho kev taw qhia nyob ntawm seb qhov kev tsim qauv ntsuas.
- Kev ntsuam xyuas hla kev ua haujlwm nrog cov tshuaj steroids zoo sib xws hauv qee lub platform immunoassay.
- Cov tshuaj tiv thaiv heterophile lossis cov tshuaj tiv thaiv reagent, ib qho tsis tshua muaj tab sis lees paub ua rau muaj cov txiaj ntsig tsis txaus ntseeg.
Ua rau cov nyeem ntawv qis qis lossis tsis tseeb
- Glucocorticoids: noj, txhaj tshuaj, lossis ua pa ntau, txo cov adrenal androgen tso zis, yog li DHEAS yuav zoo li qis rau cov laj thawj tsis muaj feem cuam tshuam nrog kab mob.
- Combined qhov ncauj contraceptives tej zaum yuav txo qis cov androgens uas ntsuas tau.
- Mob hnyav heev hloov cov adrenal steroid tso zis.
- Kev laus li qub, uas yog qhov laj thawj feem ntau rau tus nqi qis.
Lwm qhov chaw ntawm kev tsis meej pem
- Kev sib piv cov txiaj ntsig ntawm cov chaw kuaj mob lossis cov txheej txheem. Kev kuaj dua zoo tshaj plaws ua hauv tib lub chaw kuaj mob.
- Siv lub tshuab ua si rau menyuam yaus, lossis qhov ntau yam tsis tau teev tseg rau tus poj niam tom qab menopausal.
- Cov qauv kuaj uas tau ua qeeb lossis ua tsis tau zoo, txawm hais tias DHEAS muaj zog heev.
Yog tias qhov tshwm sim tsis haum rau daim duab kho mob, cov kauj ruam tsim nyog yog kev sib tham nrog tus kws kho mob uas thov thiab, feem ntau, rov ua cov qauv kuaj dua, tsis yog kev txiav txim siab kho mob.
Kev Pheej Hmoo thiab Kev Nyab Xeeb
Kev kuaj ntshav venous niaj hnub
Kev pheej hmoo me me thiab feem ntau yog nyob ib puag ncig: mob ib ntus, mob nqaij, qaug zog lossis tsaus muag, thiab tsis tshua muaj ntshav me me hauv qab daim tawv nqaij. Kev kis kab mob ntawm qhov chaw txhaj tshuaj tsis tshua muaj. Qhia rau tus kws kho mob ntshav yog tias koj tau tsaus muag thaum kuaj ntshav ua ntej, noj cov tshuaj ua kom ntshav nyias, lossis muaj teeb meem los ntshav, tej zaum yuav tsum tau tuav lub siab ntev dua.
Kev kuaj ntshav capillary lossis lwm txoj hauv kev
Qee cov kev pabcuam sau cov tshuaj hormones hauv tsev siv ntau txoj kev sib txawv. Qhov tseeb ntawm cov tshuaj hormones steroid nyob ntawm txoj kev uas lub chaw kuaj mob ntawd tau lees paub; paub meej nrog lawv ua ntej siv cov txiaj ntsig ntawd los kuaj mob.
Cov kev pheej hmoo uas tuaj tom qab kev kuaj mob
Qhov kev pheej hmoo loj dua nrog DHEAS yog kev txhais lus ntau dhau: kev soj ntsuam tsis tsim nyog, kev ntxhov siab, lossis kev noj tshuaj hormones rau tus kheej raws li tus nqi ciam teb. Cov txiaj ntsig sib txawv nyob ntawm tus kheej qhov xwm txheej thiab yuav tsum coj, tsis yog hloov, kev ntsuam xyuas kev kho mob.
Liab chij
Xwm txheej ceev tam sim no
- Yog tias koj lub cev qaug zog, ntuav heev nrog rau mob plab, tsis meej pem, ntshav qis heev lossis qaug zog heev rau ib tus neeg uas paub lossis xav tias muaj teeb meem adrenal insufficiency lossis noj tshuaj steroids ntev, qhov no yuav yog teeb meem adrenal. Mus rau chav kho mob ceev tam sim ntawd.
- Qhov chaw mos tsis meej, cov tsos mob poob ntsev, tsis noj mov zoo lossis poob siab rau tus menyuam mos.
Tib hnub ntawd los yog kev tshuaj xyuas sai
- Kev mob virilisation sai sai dhau lub lis piam mus rau lub hlis, lub suab tob zuj zus, cov plaub hau loj hlob, clitoral enlargement.
- Ib qho DHEAS siab heev tau tshaj tawm ntawm koj lub chaw kuaj mob.
- Cov cim qhia tias muaj cov qog hauv plab loj hlob tuaj, poob phaus yam tsis paub meej, lossis muaj ntshav siab heev nrog rau cov androgen ntau dhau.
Kev teem caij tsis tu ncua
- Maj mam li muaj plaub hau hirsutism, pob txuv, plaub hau nyias lossis lub hlis tsis xwm yeem.
- DHEAS tsis zoo li qub me ntsis yam tsis muaj lwm yam ntxwv txhawj xeeb.
- Qaug zog tas li nrog DHEAS qis tab sis tsis muaj cov yam ntxwv kub ntxhov.
Cov xwm txheej tshwj xeeb
Cev xeeb tub
Cov theem Androgen thiab cov protein khi hloov pauv thaum cev xeeb tub, thiab cov qib siv rau cov neeg laus uas tsis cev xeeb tub tsis siv tau. Kev tshawb nrhiav txog androgen ntau dhau feem ntau raug ncua lossis ua los ntawm tus kws tshwj xeeb thaum cev xeeb tub.
Cov menyuam yaus thiab tub ntxhais hluas
DHEAS nce nrog adrenarche, yog li lub sijhawm tseem ceeb. Tus kws kho mob endocrinologist rau menyuam yaus uas muaj DHEAS nce siab yuav tsum tau soj ntsuam nrog lub hnub nyoog pob txha, cov ntaub ntawv kev loj hlob thiab theem pubertal es tsis txhob nyob ib leeg.
Cov laus
Yuav muaj DHEAS tsawg zuj zus thaum muaj hnub nyoog. Tsis muaj ib qho cim qhia tias yuav kho tau DHEAS qis rau cov neeg laus uas laus dua; cov tshuaj ntxiv tsis yog ib qho tshuaj kho tau zoo rau cov tsos mob ntawm kev laus.
Cov neeg uas noj tshuaj steroids ntev
Cov tshuaj Glucocorticoids ua rau DHEAS tsis ua haujlwm. Kev txhais lus yuav tsum xav txog qhov koob tshuaj thiab lub sijhawm siv cov tshuaj steroid. Tsis txhob tsum cov tshuaj steroids kom "tau txais kev kuaj mob huv si", kev tshem tawm sai sai tuaj yeem ua rau muaj kev phom sij. Tham nrog tus kws kho mob kom paub meej.
Kab mob raum ntev thiab lub plawv tsis ua haujlwm
Cov pab pawg no tsis tas yuav npaj tshwj xeeb rau qhov kev kuaj mob no. Kev mob ntev ntev tuaj yeem hloov pauv cov tshuaj steroid hauv adrenal, yog li cov txiaj ntsig yuav tsum nyeem nrog qhov ntawd hauv siab.
Cov poj niam uas muaj PCOS tau txais kev kho mob
Cov tshuaj hormones tiv thaiv kev xeeb tub thiab cov tshuaj tiv thaiv androgens hloov cov kev ntsuas androgen. Koj tus kws kho mob yuav txiav txim siab seb qhov kev kuaj mob thaum kho mob puas muaj txiaj ntsig.
Kev xeem DHEAS hauv Is Nrias teb
- Terminology: cov neeg mob feem ntau nug txog "kev kuaj tshuaj hormones txiv neej", "kev kuaj tshuaj hormones rau cov plaub hau ntawm lub ntsej muag" lossis "kev kuaj PCOD". DHEAS tsuas yog ib feem ntawm kev ntsuam xyuas zoo li no. PCOD thiab PCOS yog tib yam mob.
- PCOS yog ib qho laj thawj uas yuav tsum tau xa mus rau ib tus kws kho mob hauv kev kho mob sab nraud ntawm Is Nrias teb, thiab cov neeg Esxias Qab Teb tuaj yeem qhia cov yam ntxwv ntawm PCOS ntawm qhov hnyav ntawm lub cev qis dua li cov pej xeem European. Qhov no txhais tau tias kev ntsuam xyuas kev kho mob tseem ceeb dua, tsis yog tsawg dua, dua li tus nqi hormone ib leeg.
- Kev cuam tshuam ntsig txog kev ntxiv yog qhov teeb meem tiag tiag. Cov khoom uas muaj DHEA "tiv thaiv kev laus", cov tshuaj hormones hauv chaw dhia ua si, thiab cov tshuaj ntsuab lossis AYUSH uas tsis muaj daim ntawv lo muaj ntau thiab tuaj yeem ua rau DHEAS nce ntxiv. Qhia txhua yam koj noj.
- Kev tshaj tawm ntawm cov tshuaj hormones "boosters" kev thov kho kab mob raug txwv raws li Txoj Cai Tshuaj thiab Kev Kho Mob Khawv Koob (Kev Tshaj Tawm Tsis Pom Zoo), 1954. Kho cov lus thov no nrog kev tsis ntseeg.
- Kev hloov pauv ntawm txoj kev ntawm cov chaw kuaj mob muaj ntau heev hauv Is Nrias teb, zoo li lwm qhov. Rau kev saib xyuas, nyob nrog tib lub chaw kuaj mob thiab txoj kev.
- Cov ntaub ntawv ntiag tug: Cov ntaub ntawv kev noj qab haus huv uas tau sau los ntawm tsev kho mob lossis chaw kuaj mob thiab cov ntawv foos yog cov ntaub ntawv tus kheej raws li Txoj Cai Tiv Thaiv Cov Ntaub Ntawv Tus Kheej Digital, 2023. Nug seb koj daim ntawv tshaj tawm thiab cov cim qhia tau khaws cia thiab sib qhia li cas.
- Kev nthuav qhia qeeb ntawm hirsutism thiab kev coj khaub ncaws tsis tu ncua yog qhov tshwm sim vim tias cov tsos mob feem ntau zoo li qub. Kev ntsuam xyuas ua ntej tso cai rau lwm yam ua rau pom.
Tus nqi thiab kev pov hwm hauv Is Nrias teb
DHEAS yog ib qho kev ntsuam xyuas tshwj xeeb txog cov tshuaj hormones, yog li nws feem ntau raug nqi ntau dua li kev kuaj biochemistry niaj hnub tab sis tsawg dua li kev kuaj mob endocrine dynamic. Cov nqi sib txawv ntawm cov nroog, ntawm cov chaw kuaj mob pej xeem thiab ntiag tug, thiab ntawm cov kev kuaj mob thiab cov chaw kuaj mob. Nug tus nqi tam sim no ua ntawv sau ua ntej sau.
Cov yam uas cuam tshuam rau tus nqi:
- Txoj kev ntsuas siv, immunoassay piv rau mass spectrometry, qhov tom kawg feem ntau kim dua.
- Txawm tias qhov kev xeem ntawd khiav hauv tsev lossis xa mus rau chav kuaj mob.
- Txawm hais tias DHEAS raug xaj ib leeg lossis ua ib feem ntawm hirsutism, PCOS lossis adrenal panel, qhov twg cov nqi bundled yuav siv tau.
- Lub nroog thiab theem ntawm qhov chaw; Cov chaw kuaj mob uas tau txais kev pom zoo los ntawm NABL yuav muaj tus nqi sib txawv.
- Cov nqi sau tsev, kev ua tiav sai lossis tib hnub, thiab kev kuaj rov ua dua lossis kuaj kom paub tseeb.
- Txawm qhov kev kuaj mob yog ib feem ntawm kev pw hauv tsev kho mob lossis kev mus ntsib kws kho mob sab nraud.
Kev Pov Hwm: feem ntau cov kev kuaj mob sab nraud tsis them nqi tshwj tsis yog tias daim ntawv pov hwm suav nrog cov txiaj ntsig OPD. Cov kev tshawb nrhiav ua thaum lub sijhawm nkag mus, lossis nyob rau hauv kev pov hwm ua ntej thiab tom qab pw hauv tsev kho mob uas cuam tshuam nrog tus mob nkag mus, yuav muaj feem ntau yuav tau txais nyiaj rov qab. Paub meej nrog koj tus neeg pov hwm lossis lub rooj pov hwm ntawm tsev kho mob ua ntej kuaj.
Cov lus dab neeg thiab qhov tseeb
| tswvyim hais ua dabneeg | fact |
|---|---|
| DHEAS siab txhais tau tias kuv muaj PCOS. | DHEAS tsis tas yuav tsum muaj thiab tsis txaus los kuaj mob PCOS. Kev kuaj mob yog kev kho mob, nrog rau lwm yam kev kuaj mob siv los tshem tawm lwm yam ua rau. |
| Ib qho DHEAS ib txwm tsis lees paub qhov mob qog adrenal. | Tus nqi ib txwm tsis suav nrog ib qho. Qee cov qog nqaij hlav tso tawm lwm cov androgens, thiab kev thaij duab yog qhov ntsuas qhov qauv. |
| DHEAS qis txhais tau tias kuv xav tau DHEA ntxiv. | Feem ntau DHEAS qis yog vim muaj hnub nyoog. Kev noj DHEA rau koj tus kheej tuaj yeem ua rau pob txuv thiab plaub hau loj hlob ntxiv thiab ua rau kev kuaj mob yav tom ntej tsis zoo. Tham nrog kws kho mob endocrinologist. |
| High DHEAS txhais tau hais tias kuv tsis muaj menyuam. | DHEAS tsis ntsuas qhov muaj menyuam. Cov Androgen ntau dhau yuav cuam tshuam rau kev tso qe rau qee tus neeg, tab sis qhov ntawd yuav tsum tau soj ntsuam cais. |
| Kuv yuav tsum yoo mov kom nruj me ntsis rau kev kuaj DHEAS. | Feem ntau tsis tas yuav tsum yoo mov rau DHEAS xwb. Ua raws li koj lub chaw kuaj mob cov lus qhia, tshwj xeeb yog tias muaj lwm yam kev kuaj mob sib xyaw ua ke. |
| PCOD yog ib qho teeb meem tsis hnyav dua li PCOS. | PCOD thiab PCOS yog ob lub npe rau tib yam mob. |
| DHEAS yog ib qho cim qhia txog lub hnub nyoog lossis lub zog ntawm lub cev. | Tsis muaj kev siv DHEAS raws li kev laus lossis kev noj qab haus huv. |
Lus nug cov lus nug
Qhov kev xeem DHEAS ntsuas dab tsi tiag tiag?
Qhov kev xeem DHEAS ntsuas dehydroepiandrosterone sulfate hauv cov ntshav, uas yog ib qho androgen tsis muaj zog uas yuav luag tag nrho los ntawm adrenal cortex. Vim tias DHEAS ruaj khov thiab muaj ntau, qhov kev xeem no ua haujlwm ua lub cim qhia txog kev tsim cov androgen hauv adrenal. Qhov kev xeem DHEAS tsis ntsuas cortisol, estrogen, kev ua haujlwm ntawm zes qe menyuam lossis kev sib npaug ntawm cov tshuaj hormones.
Qhov kev xeem DHEAS siv sijhawm ntev npaum li cas?
Qhov kev rho ntshav nws tus kheej yuav siv sijhawm li ob txog tsib feeb. Xws li kev sau npe, kev sau daim ntawv lo rau cov qauv thiab ob peb feeb ntawm kev nias rau ntawm qhov chaw tho, feem ntau cov neeg nyob ntawm qhov chaw sau ntshav li 15 txog 30 feeb. Lub sijhawm tshaj tawm nyob ntawm chav kuaj thiab seb qhov kev ntsuam xyuas puas tau ua hauv tsev.
Kuv puas yuav tsum tau yoo mov ua ntej kuaj DHEAS?
Feem ntau tsis tas yuav tsum yoo mov rau DHEAS xwb. Txawm li cas los xij, yog tias glucose, lipids lossis insulin raug sau rau tib lub sijhawm, koj lub chaw kuaj mob yuav xav kom yoo mov. Ua raws li cov lus qhia sau los ntawm koj lub chaw sau, thiab tham txog lub sijhawm tshuaj nrog koj tus kws kho mob yog tias koj noj insulin lossis sulfonylureas.
Puas yog DHEAS zoo dua li kev kuaj testosterone rau hirsutism?
Tsis muaj ib qho twg zoo dua thoob ntiaj teb; lawv teb cov lus nug sib txawv. Tag nrho cov testosterone feem ntau qhia txog kev ua haujlwm androgen tag nrho, thaum DHEAS taw qhia meej dua rau qhov chaw adrenal. Qhov kev kuaj twg los ua ntej nyob ntawm qhov kev nthuav qhia, thiab cov kws kho mob feem ntau thov ob qho tib si ntxiv rau 17-hydroxyprogesterone los txheeb xyuas qhov ua rau muaj qhov teeb meem.
Cov tshuaj puas hloov tau kuv cov txiaj ntsig DHEAS?
Yog. Cov tshuaj Corticosteroids thiab cov tshuaj tiv thaiv kev xeeb tub ua ke tuaj yeem txo qis DHEAS, thaum cov tshuaj ntxiv uas muaj DHEA, cov tshuaj hormones hauv chaw ua si thiab qee cov tshuaj ntsuab uas tsis muaj daim ntawv lo tuaj yeem ua rau nws nce siab heev. Cov tshuaj biotin ntau dhau yuav cuam tshuam rau qee qhov kev kuaj mob. Qhia rau koj tus kws kho mob txhua yam koj noj, thiab tsis txhob tsum cov tshuaj uas tau sau tseg yam tsis tau nrog tus kws sau ntawv sau tshuaj tham.
Kuv tus DHEAS siab me ntsis. Kuv puas yuav tsum tau kuaj CT?
Tsis tas li ntawd xwb. Qhov nce me ntsis yog ib qho uas pom ntau thiab feem ntau kho tau los ntawm kev kuaj ntshav ntxiv thiab kev tshuaj xyuas hauv chaw kho mob es tsis yog kev thaij duab tam sim ntawd. Kev thaij duab ntawm adrenal feem ntau yog rau cov nqi nce siab heev, kev loj hlob sai ntawm cov qe menyuam, lossis lwm yam ntxwv uas koj tus kws kho mob pom.
Puas yog DHEAS ib txwm txhais tau tias kuv cov tshuaj hormones zoo?
Tsis yog. Ib qho DHEAS ib txwm piav qhia txog cov zis ntawm adrenal androgen hauv ib qho qauv ntawd. Kab mob thyroid, prolactin siab, adrenal hyperplasia tsis yog classic congenital, ovarian androgen ntau dhau thiab PCOS tuaj yeem nyob ua ke nrog DHEAS ib txwm. Yog tias cov tsos mob tseem muaj lossis hnyav dua tom qab qhov tshwm sim ib txwm, rov qab mus rau koj tus kws kho mob.
Cov menyuam yaus puas yuav tsum tau kuaj DHEAS?
Tsuas yog thaum muaj cov tsos mob qhia tias muaj mob xwb, xws li cov plaub hau ntawm qhov chaw mos lossis hauv qab caj npab tshwm sim thaum ntxov, kev loj hlob sai uas tsis paub meej, lossis xav tias muaj teeb meem adrenal hyperplasia txij thaum yug los. Cov txiaj ntsig ntawm kev kuaj mob rau menyuam yaus yuav tsum tau muab piv rau cov hnub nyoog thiab theem pubertal thiab txhais los ntawm tus kws kho mob endocrinologist rau menyuam yaus nrog rau cov duab qhia kev loj hlob thiab hnub nyoog pob txha.
Kuv puas rov ua qhov kev xeem DHEAS dua ntawm lwm lub chaw kuaj mob?
Koj ua tau, tab sis kev sib piv tsis txhim khu kev qha. DHEAS kev ntsuam xyuas sib txawv ntawm cov platforms thiab cov qib siv sib txawv raws li, yog li qhov kev hloov pauv ntawm tus nqi yuav cuam tshuam txog txoj kev es tsis yog koj lub cev. Rau kev soj ntsuam, siv tib lub chaw kuaj mob thiab tib txoj kev ntsuam xyuas txhua qhov chaw uas ua tau.
Qhov chaw
- Cov Lus Qhia Txog Kev Kho Mob Endocrine Society txog kev ntsuam xyuas thiab kev kho mob ntawm hirsutism hauv cov poj niam premenopausal.
- Cov lus qhia thoob ntiaj teb raws li pov thawj rau kev ntsuam xyuas thiab kev tswj hwm ntawm polycystic ovary syndrome (monash-led international consortium).
- Endocrine Society thiab European Society of Endocrinology cov lus qhia txog kev mob adrenal hyperplasia txij thaum yug los vim yog 21-hydroxylase deficiency.
- European Society of Endocrinology / European Network for the Study of Adrenal Tumours kev taw qhia txog kev tswj hwm cov adrenal incidentalomas.
- Cov Lus Qhia Txog Kev Kho Mob Endocrine Society rau Kev Tsis Txaus adrenal Thawj Zaug.
- Kev sib txuas lus txog kev nyab xeeb ntawm FDA hauv Tebchaws Meskas txog kev cuam tshuam ntawm biotin nrog kev kuaj mob immunoassay.
- Txoj Cai Lij Choj Txog Tshuaj thiab Kev Kho Mob Khawv Koob (Kev Tshaj Tawm Tsis Zoo), 1954; Txoj Cai Tiv Thaiv Cov Ntaub Ntawv Tus Kheej Digital, 2023.
