Deflazacort: Kev Siv, Kev Siv Tshuaj, Kev Mob Phem thiab Lwm Yam

Taw qhia: Deflazacort yog dab tsi?

Yog tias koj lossis ib tus neeg koj hlub tab tom tswj hwm tus kab mob autoimmune, kev mob o, lossis ib hom mob qog noj ntshav tshwj xeeb, koj tus kws kho mob yuav tau sau ntawv rau Deflazacort. Cov tshuaj corticosteroid no feem ntau yog siv los txo qhov o thiab tswj lub cev tiv thaiv kab mob.

Nws zoo ib yam li lwm cov corticosteroids tab sis paub txog qhov kev pheej hmoo qis dua ntawm qee qhov kev phiv, tshwj xeeb tshaj yog cov pob txha ceev thiab qhov hnyav nce, ua rau nws yog ib qho kev xaiv zoo rau ntau yam mob, suav nrog Duchenne muscular dystrophy.

Cov Cim Qhia thiab Kev Siv

Cov Lus Qhia Txog Kev Pom Zoo Los Ntawm FDA

Deflazacort (lub npe lag luam: Emflaza) tau txais kev pom zoo los ntawm FDA rau kev kho mob Duchenne muscular dystrophy (DMD) rau cov neeg mob hnub nyoog 2 xyoos thiab laus dua.

DMD yog ib qho kab mob nqaij ntshiv uas tsis tshua muaj, uas tau txais los ntawm noob caj ces uas ua rau cov leeg nqaij lwj thiab qaug zog zuj zus, uas yog los ntawm qhov tsis muaj protein dystrophin.

Deflazacort yog tib qho corticosteroid uas tau txais kev pom zoo los ntawm FDA rau DMD.

Siv Tsis Muaj Daim Ntawv Cim Hauv Is Nrias teb

Hauv kev kho mob hauv Is Nrias teb, deflazacort tau raug sau tseg dav dav ua corticosteroid rau ntau yam mob o thiab autoimmune. Cov kev siv no yog raws li kev paub dhau los hauv kev kho mob thiab cov qauv sau ntawv hauv cheeb tsam; lawv tsis yog cov cim qhia uas FDA pom zoo.

Cov kev siv tsis muaj daim ntawv lo feem ntau suav nrog:

• Cov kab mob autoimmune: Kab mob rheumatoid arthritis, systemic lupus erythematosus (SLE), kab mob autoimmune hepatitis
• Inflammatory tej yam kev mob: Mob hawb pob, mob plab hnyuv (IBD), mob nephrotic syndrome
• Allergic tej yam kev mob: Kev ua xua hnyav heev, mob ntswg ua xua (hauv cov mob nruab nrab mus rau mob hnyav xwb)
• Cov mob tawv nqaij: Mob eczema hnyav, pemphigus, thiab lwm yam kab mob ntawm daim tawv nqaij autoimmune
• Kev hloov pauv lub cev: Ua ib feem ntawm cov kev kho mob tiv thaiv kab mob kom tiv thaiv kev tsis lees txais cov noob caj noob ces
• Qee yam mob qog noj ntshav: Ua ib feem ntawm kev kho mob rau cov kab mob ntshav tshwj xeeb, suav nrog leukaemia thiab lymphoma

Tsis pom zoo kom siv Deflazacort rau cov mob ua xua me me lossis cov mob uas siv tau cov tshuaj tiv thaiv kev o uas tsis yog steroidal. Yuav tsum siv nws tsuas yog thaum qhov xwm txheej xav tau kev kho mob corticosteroid, raws li tus kws kho mob tau txiav txim siab.

Yuav ua li cas Nws Tej hauj lwm

Deflazacort ua haujlwm los ntawm kev ua raws li cov teebmeem ntawm cov tshuaj hormones uas tsim los ntawm cov qog adrenal, tshwj xeeb tshaj yog cortisol.

Nws txo qhov o los ntawm kev txwv tsis pub tso cov tshuaj hauv lub cev uas ua rau o thiab cov lus teb ntawm lub cev tiv thaiv kab mob.

Hauv cov lus yooj yim dua, nws ua rau lub cev tiv thaiv kab mob so thiab txo qhov o, liab, thiab mob uas cuam tshuam nrog ntau yam mob.

Tom qab noj tshuaj, deflazacort hloov pauv sai sai mus rau nws cov metabolite nquag, 21-desacetyldeflazacort, uas yog lub luag haujlwm rau nws cov txiaj ntsig kho mob.

ntau npaum

Kev Siv Tshuaj DMD (FDA Pom Zoo)

• Cov neeg laus thiab cov menyuam yaus hnub nyoog 2 xyoos thiab laus dua: 0.9 mg / kg / hnub, muab ib zaug ib hnub
• Cov tshuaj muaj: Cov ntsiav tshuaj (6 mg, 18 mg, 30 mg, 36 mg) thiab cov tshuaj haus (22.75 mg/mL)
• Yog tias siv cov ntsiav tshuaj, suav kom ze li qhov ntau npaum li cas; txhua qhov sib xyaw ua ke ntawm lub zog ntawm cov ntsiav tshuaj yuav siv tau los ua kom tau raws li qhov ntau npaum li cas uas tau xam.
• Yog siv cov tshuaj haus, ces muab ib feem kaum ntawm ib milliliter (mL) puv nkaus.

Kev Siv Tshuaj Tsis Muaj Daim Ntawv Qhia (Is Nrias teb)

Rau cov tsos mob ntawm kev o thiab cov kab mob autoimmune uas tsis yog los ntawm daim ntawv lo, cov koob tshuaj rau cov neeg laus feem ntau yog txij li 6 txog 48 mg / hnub, nyob ntawm seb tus mob, qhov hnyav, thiab kev teb hauv kev kho mob.

Feem ntau cov tshuaj pib ntawm qib siab dua thiab maj mam txo mus rau qhov tshuaj tsawg tshaj plaws uas siv tau.

Kev noj tshuaj yuav tsum tau ua raws li tus kheej lub cev nyob rau hauv kev saib xyuas ntawm tus kws kho mob.

Rau cov menyuam yaus (tsis suav nrog daim ntawv lo), qhov ntau npaum li cas feem ntau yog raws li qhov hnyav ntawm lub cev, xws li 0.5 txog 1.5 mg / kg / hnub nyob ntawm tus mob thiab qhov hnyav.

Noj deflazacort nrog lossis tsis nrog zaub mov. Nqos tag nrho lub tshuaj.

Ua raws li koj tus kws kho mob cov lus qhia nruj me ntsis.

Yog koj tsis nco qab noj ib koob tshuaj, noj sai li sai tau thaum koj nco qab. Yog tias nws ze rau lub sijhawm rau koj cov koob tshuaj tom ntej, hla cov koob tshuaj uas koj tsis nco qab thiab rov qab noj koj cov sijhawm ib txwm. Tsis txhob noj ob npaug ntawm cov tshuaj kom them rau qhov uas koj tsis nco qab.

Cov Lus Qhia Tseem Ceeb Tshuam Tseem Ceeb

Cov teebmeem ntawm Deflazacort

Txawm hais tias Deflazacort tuaj yeem ua tau zoo, nws kuj tseem yuav ua rau muaj kev phiv.

Feem Xyuam Los Feem

• Qhov hnyav nce
• Qab qab los noj mov
• Kev xav hloov pauv (xws li kev ntxhov siab, kev nyuaj siab)
• insomnia
• Ntshav qab zib ntau ntau

Teebmeem Sab Loj

• Muaj kev pheej hmoo kis mob
• Osteoporosis (pob txha thinning)
• Cov teeb meem hauv plab (piv txwv li, ulcers)
• Teeb meem qhov muag (piv txwv li, cataracts, glaucoma)
• Adrenal suppression (lub cev tsis muaj peev xwm tsim cov tshuaj steroids)

Tshuaj Kev Sib Thoob

Deflazacort tuaj yeem cuam tshuam nrog ntau yam tshuaj thiab tshuaj, suav nrog:

• CYP3A4 inhibitors: Cov tshuaj CYP3A4 inhibitors muaj zog (xws li ketoconazole, itraconazole, clarithromycin, thiab ritonavir) tuaj yeem ua rau cov tshuaj deflazacort nce ntxiv. Yog tias tsis tuaj yeem zam kev siv ua ke, cov tshuaj deflazacort yuav tsum txo kom tsawg li ib feem peb ntawm cov tshuaj pom zoo.
• Cov tshuaj CYP3A4 inducers: Cov tshuaj xws li rifampicin, carbamazepine, phenytoin, thiab phenobarbital tuaj yeem txo cov tshuaj deflazacort, uas tej zaum yuav ua rau nws cov txiaj ntsig tsis zoo.
• Anti coagulants: Xws li warfarin, uas tej zaum yuav muaj kev hloov pauv.
• Cov tshuaj Antidiabetic: Tej zaum yuav xav tau kev hloov kho vim muaj ntshav qab zib ntau ntxiv.
• Nonsteroidal anti-inflammatory tshuaj (NSAIDs): Muaj kev pheej hmoo ntawm plab hnyuv los ntshav.
• Cov tshuaj tiv thaiv kab mob: Cov tshuaj tiv thaiv kab mob uas tseem muaj sia nyob tsis zoo siv. Cov tshuaj tiv thaiv kab mob uas tuag lawm lossis tsis ua haujlwm yuav ua rau lub cev tiv thaiv kab mob tsis zoo thaum siv tshuaj corticosteroid.

Nco ntsoov qhia rau koj tus kws kho mob txog txhua yam tshuaj thiab tshuaj uas koj noj kom tsis txhob muaj kev cuam tshuam.

Cov txiaj ntsig ntawm Deflazacort

Txawm hais tias muaj kev pheej hmoo cuam tshuam nrog kev siv corticosteroid mus sij hawm ntev, deflazacort muaj ntau yam txiaj ntsig thaum siv kom raug:

• DMD: Hauv Duchenne muscular dystrophy, deflazacort tau pom tias ua rau nws taug kev tau ntev dua (muaj peev xwm taug kev), ua rau cov leeg nqaij tsis muaj zog, txo qhov kev pheej hmoo ntawm scoliosis, thiab ncua qhov pib ntawm cardiomyopathy thiab kev ua pa tsis zoo.
• Piv rau qhov txuag pob txha: Piv nrog rau lwm cov tshuaj corticosteroids xws li prednisone, deflazacort tau cuam tshuam nrog qhov cuam tshuam qis dua rau qhov ceev ntawm cov pob txha, ua rau nws yog qhov kev xaiv zoo dua thaum xav tau kev kho mob corticosteroid mus sij hawm ntev.
• Kev ua haujlwm tiv thaiv kev o: Zoo rau kev txo qhov o thiab kev puas tsuaj ntawm cov nqaij mos tiv thaiv kab mob hauv ntau yam mob autoimmune thiab inflammatory.
• Immunosuppression: Pab tau rau kev tswj cov mob uas xav tau kev tiv thaiv kab mob, suav nrog cov neeg tau hloov cev.

Contraindications ntawm Deflazacort

Qee tus neeg yuav tsum tsis txhob siv Deflazacort, suav nrog:

• Cov poj niam cev xeeb tub: Nws tuaj yeem ua mob rau tus menyuam hauv plab. Kev siv nws yuav tsum tau ua tib zoo xav txog, thiab kev kuaj cev xeeb tub yuav tsum tau ua ua ntej pib kho yog tias ua tau.
• Cov neeg uas muaj kab mob active: Nws tuaj yeem cuam tshuam lub cev tiv thaiv kab mob, ua rau muaj kev pheej hmoo ntawm kev kis tus kab mob loj zuj zus tuaj.
• Cov neeg mob uas muaj qee yam mob: Xws li kab mob siab heev, kab mob peptic ulcers, lossis ntshav qab zib tsis tswj tau.

Nco ntsoov sab laj nrog kws kho mob los txiav txim seb Deflazacort puas tsim nyog rau koj qhov xwm txheej.

Ceev faj thiab Kev Ceeb Toom

Ua ntej pib Deflazacort, xav txog cov kev ceev faj hauv qab no:

• Kev saib xyuas tsis tu ncua: Cov neeg mob yuav tsum tau kuaj ntshav tsis tu ncua txhawm rau saib xyuas cov ntshav qab zib, lub siab ua haujlwm, thiab lwm yam.
• Gradual Discontinuation: Yog tias koj tau nyob rau Deflazacort rau lub sijhawm ntev, nws yog ib qho tseem ceeb kom txo qis cov tshuaj maj mam kom tsis txhob muaj cov tsos mob tawm.
• Txhaj tshuaj tiv thaiv: Sib tham txog cov phiaj xwm txhaj tshuaj tiv thaiv nrog koj tus kws kho mob, tshwj xeeb tshaj yog hais txog cov tshuaj tiv thaiv nyob.
• Kab mob Risk: Ua tib zoo saib xyuas cov tsos mob ntawm tus kab mob (ua npaws, mob caj pas, mob hnyav), thiab ceeb toom rau koj tus kws kho mob tam sim ntawd, vim tias koj lub cev tiv thaiv kab mob yuav raug txwv.

Cov Lus Nquag Nug (FAQ)

Deflazacort siv rau dab tsi?

Deflazacort tau txais kev pom zoo los ntawm FDA rau kev kho mob Duchenne muscular dystrophy (DMD) rau cov neeg mob hnub nyoog 2 xyoos thiab laus dua. Hauv Is Nrias teb, nws kuj siv dav dav rau cov kab mob autoimmune thiab inflammatory xws li rheumatoid arthritis, hawb pob, nephrotic syndrome, thiab cov kab mob hnyav.

Koob tshuaj kom raug rau DMD yog dab tsi?

Cov koob tshuaj uas FDA pom zoo rau DMD yog 0.9 mg/kg/hnub, muab ib zaug ib hnub. Cov koob tshuaj yog raws li qhov hnyav ntawm tus neeg mob thiab tus kws kho mob yuav tsum tau xam.

Kuv yuav tsum noj Deflazacort li cas?

Nws feem ntau yog noj hauv cov ntsiav tshuaj hauv daim ntawv los yog muab los ntawm kev txhaj tshuaj, raws li koj tus kws kho mob qhia.

Cov kev phiv tshwm sim yog dab tsi?

Cov kev mob tshwm sim feem ntau suav nrog qhov hnyav nce, nce qab los noj mov, hloov mus los, thiab insomnia.

Kuv puas tuaj yeem tsum tsis txhob siv deflazacort tam sim ntawd?

Tsis yog. Yuav tsum tsis txhob tsum tsis txhob siv Deflazacort tam sim ntawd tom qab siv ntev. Cov tshuaj yuav tsum tau txo qis maj mam nyob rau hauv kev saib xyuas ntawm tus kws kho mob kom tsis txhob muaj teeb meem adrenal.

Kuv puas tuaj yeem noj Deflazacort yog tias kuv cev xeeb tub?

Yuav tsum siv Deflazacort thaum cev xeeb tub tsuas yog tias qhov txiaj ntsig zoo ua rau muaj kev pheej hmoo rau tus menyuam hauv plab. Tsis muaj kev tshawb fawb txaus rau tib neeg. Tham nrog koj tus kws kho mob.

Kuv puas tuaj yeem txhaj tshuaj tiv thaiv kab mob thaum noj deflazacort?

Cov tshuaj tiv thaiv kab mob uas muaj sia nyob tsis zoo siv thaum lub sijhawm uas siv tshuaj tiv thaiv kab mob. Cov tshuaj tiv thaiv kab mob uas tuag lawm lossis tsis ua haujlwm yuav muab tau tab sis tej zaum yuav muaj kev teb tsawg dua. Txhua yam kev txhaj tshuaj tiv thaiv kab mob yuav tsum tau ua tiav ua ntej pib siv deflazacort.

Puas yog deflazacort zoo ib yam li prednisolone?

Tsis yog. Txawm hais tias ob qho tib si yog corticosteroids, deflazacort yog ib hom tshuaj sib txawv nrog cov ntaub ntawv tshuaj sib txawv.

Cov kev tshawb fawb qhia tias deflazacort tej zaum yuav muaj qhov cuam tshuam qis dua rau qhov ceev ntawm cov pob txha thiab qhov hnyav nce dua li prednisone / prednisolone, uas yog ib qho laj thawj uas nws nyiam siv ntev hauv DMD.

Deflazacort ua haujlwm li cas?

Nws ua cov tshuaj hormones ntuj los txo qhov mob thiab ua rau lub cev tsis muaj zog.

Puas muaj kev phiv loj heev?

Yog lawm, cov kev mob tshwm sim loj tuaj yeem suav nrog kev pheej hmoo ntawm kev kis kab mob, osteoporosis, thiab teeb meem plab hnyuv.

Kuv tuaj yeem tso tseg tsis noj Deflazacort tam sim ntawd?

Tsis yog, nws yog ib qho tseem ceeb kom txo qis cov tshuaj maj mam nyob rau hauv kev saib xyuas kev kho mob kom tsis txhob muaj cov tsos mob tshem tawm.

Kuv yuav ua li cas yog tias kuv tsis noj tshuaj?

Noj cov tshuaj uas tsis tau noj sai li sai tau thaum koj nco qab, tab sis hla nws yog tias nws yuav luag sij hawm rau koj cov koob tshuaj ntxiv. Tsis txhob muab ob npaug rau.

Deflazacort puas tuaj yeem cuam tshuam nrog lwm cov tshuaj?

Yog lawm, nws tuaj yeem cuam tshuam nrog cov tshuaj tiv thaiv coagulants, tshuaj tiv thaiv kab mob ntshav qab zib, thiab NSAIDs, thiab lwm yam.

Kuv tuaj yeem noj Deflazacort ntev npaum li cas?

Lub sij hawm ntawm kev kho mob txawv raws li tus mob tau kho. Ua raws li koj tus kws kho mob cov lus qhia kom tau txais txiaj ntsig zoo tshaj plaws.

Puas yog deflazacort cuam tshuam rau cov ntshav qab zib?

Yog. Deflazacort tuaj yeem ua rau hyperglycaemia (ntshav qab zib nce siab) thiab tej zaum yuav qhib qhov muag ntshav qab zib latent lossis ntshav qab zib uas twb muaj lawm hnyav dua.

Yuav tsum tau saib xyuas cov ntshav qab zib tsis tu ncua, tshwj xeeb tshaj yog thaum siv ntev.

Puas yuav tsum tau saib xyuas cov menyuam yaus uas noj deflazacort rau DMD txawv?

Yog. Cov menyuam yaus uas noj tshuaj deflazacort ntev rau DMD yuav tsum tau saib xyuas kev loj hlob, qhov ceev ntawm cov pob txha, cov piam thaj hauv cov ntshav, kev kuaj qhov muag, thiab kev ua haujlwm ntawm adrenal tsis tu ncua.

Koj tus menyuam tus kws kho mob yuav teem sijhawm rau cov kev ntsuam xyuas no.

Hom Lub Npe

Deflazacort tau ua lag luam hauv ntau lub npe, suav nrog:

• Emflaza
• Deflazacort
• Deflazacort Sandoz

xaus

Deflazacort yog ib hom tshuaj corticosteroid uas siv tau ntau yam thiab ua lub luag haujlwm tseem ceeb hauv kev tswj ntau yam mob o thiab autoimmune.

Txawm hais tias nws muaj cov txiaj ntsig zoo, suav nrog kev pheej hmoo qis dua ntawm qee qhov kev phiv piv rau lwm cov corticosteroids, nws yog ib qho tseem ceeb kom paub txog txhua qhov kev phiv thiab kev sib cuam tshuam tshuaj.

Nco ntsoov sab laj nrog koj tus kws kho mob kom txiav txim siab seb txoj kev kho mob zoo tshaj plaws uas haum rau koj cov kev xav tau, thiab sib txuas lus qhib siab txog cov tsos mob tshiab lossis cov tsos mob hnyav zuj zus, tshwj xeeb tshaj yog thaum siv ntev lossis thaum hloov kho qhov ntau npaum li cas.