Streptomycin - Uses, Dosage, Side Effects and More

Kev Taw Qhia: Streptomycin yog dab tsi?

Streptomycin yog ib hom tshuaj tua kab mob uas yog ib hom tshuaj aminoglycoside. Nws tau tshawb pom thawj zaug xyoo 1943 thiab feem ntau yog siv los kho ntau yam kab mob bacterial, tshwj xeeb tshaj yog cov uas tshwm sim los ntawm Mycobacterium tuberculosis, cov kab mob uas ua rau mob ntsws (TB). Streptomycin ua haujlwm los ntawm kev txwv tsis pub cov protein tsim los ntawm cov kab mob, ua rau nws muaj txiaj ntsig zoo rau ntau hom kab mob gram-negative thiab qee cov kab mob gram-positive.

Kev siv cov tshuaj Streptomycin

Streptomycin tau pom zoo rau ntau yam kev siv kho mob, suav nrog:

• Tuberculosis (TB): Feem ntau siv ua ke nrog lwm cov tshuaj tiv thaiv kab mob TB los kho cov kab mob TB uas tseem muaj sia nyob.
• Kab mob kab mob: Zoo tiv thaiv kab mob uas tshwm sim los ntawm Yersinia pestis (kab mob plague) thiab Francisella tularensis (tularemia).
• Endocarditis: Qee zaum siv ua ke nrog kev kho mob rau cov kab mob bacterial endocarditis.
• Kab mob Brucellosis: Siv ua ke nrog lwm cov tshuaj tua kab mob los kho tus kab mob brucellosis, uas yog ib qho kab mob uas tshwm sim los ntawm cov kab mob Brucella.

Nws Ua Haujlwm Li Cas?

Streptomycin ua haujlwm los ntawm kev khi rau cov kab mob ribosome, uas yog qhov tseem ceeb rau kev tsim cov protein. Los ntawm kev cuam tshuam rau ribosome ua haujlwm, nws tiv thaiv cov kab mob los ntawm kev tsim cov protein tsim nyog rau lawv txoj kev loj hlob thiab kev yug me nyuam. Qhov kev ua no thaum kawg ua rau cov kab mob tuag, pab tshem tawm cov kab mob ntawm lub cev.

Dosage thiab Administration

Cov tshuaj Streptomycin ntau npaum li cas sib txawv raws li tus mob uas tab tom kho thiab tus neeg mob lub hnub nyoog thiab qhov hnyav.

Cov Neeg Laus:

Tus nqi tshuaj rau tus kab mob ntsws yog 15 mg/kg (txog li ntawm 1 g) muab rau hauv cov leeg ib zaug ib hnub lossis faib ua ob koob tshuaj (piv txwv li, 25-30 mg/kg 2-3 zaug hauv ib lub lim tiam).

Pediatrics:

Rau cov menyuam yaus, feem ntau yog 20-40 mg/kg/hnub (tsis pub tshaj 1-2 g nyob ntawm hnub nyoog), faib yog tias txhua hnub, muab los ntawm kev txhaj tshuaj.

Cov tshuaj Streptomycin no yog siv los ntawm kev txhaj tshuaj rau hauv cov leeg nqaij, thiab qhov zaus siv yuav txawv raws li txoj kev kho mob tshwj xeeb. Nws yog ib qho tseem ceeb uas yuav tsum ua raws li cov lus qhia ntawm tus kws kho mob txog kev noj tshuaj thiab kev siv tshuaj.

Cov Kev Mob Tshwm Sim ntawm Streptomycin

Cov kev mob tshwm sim ntawm Streptomycin feem ntau muaj xws li:

• Xeev thiab ntuav
• Zawv plab
• Qhib
• npaws
• Mob ntawm qhov chaw txhaj tshuaj

Cov kev mob tshwm sim hnyav tuaj yeem suav nrog:

• Kev lom ntawm pob ntseg: (kev hnov ​​​​lus tsis zoo)
• Nephrotoxicity: (lub raum puas)
• Kev ua xua: (o, ua pa nyuaj)
• Kev thaiv cov hlab ntsha hauv lub hlwb: (cov leeg tsis muaj zog)

Cov neeg mob yuav tsum tshaj tawm cov tsos mob hnyav lossis txawv txav mus rau lawv tus kws kho mob tam sim ntawd.

Tshuaj Kev Sib Thoob

Cov tshuaj Streptomycin muaj peev xwm sib cuam tshuam nrog ntau yam tshuaj, uas yuav ua rau muaj kev pheej hmoo ntawm cov kev mob tshwm sim lossis txo qhov ua tau zoo. Cov kev sib cuam tshuam tseem ceeb ntawm cov tshuaj suav nrog:

• Lwm yam Aminoglycosides: Kev pheej hmoo ntawm nephrotoxicity nce ntxiv.
• Diuretics: Xws li furosemide, uas tuaj yeem ua rau muaj kev pheej hmoo ntawm ototoxicity.
• Neuromuscular Blockers: Tej zaum yuav ua rau muaj kev pheej hmoo ntawm kev thaiv cov hlab ntsha thiab cov leeg.

Nco ntsoov qhia koj tus kws kho mob txog txhua yam tshuaj, tshuaj, thiab tshuaj ntsuab uas koj noj kom tsis txhob muaj kev cuam tshuam.

Cov txiaj ntsig ntawm Streptomycin

Streptomycin muaj ntau yam zoo rau kev kho mob:

• Kev Ua Tau Zoo Tiv Thaiv Cov Hom Kab Mob Uas Tiv Thaiv Tau: Nws tuaj yeem siv tau zoo rau qee hom kab mob uas tiv taus lwm yam tshuaj tua kab mob.
• Combination Therapy: Nws feem ntau siv ua ke nrog lwm cov tshuaj tua kab mob, txhim kho kev kho mob rau cov mob xws li mob ntsws.
• Kev ua nrawm nrawm: Streptomycin tuaj yeem txo cov kab mob sai sai, ua rau qee qhov kev kis kab mob rov zoo sai dua.

Cov kev tsis sib haum xeeb ntawm Streptomycin

Ib txhia neeg yuav tsum tsis txhob siv Streptomycin, xws li:

• Cov poj niam cev xeeb tub: FDA Qib D Thaum Cev Xeeb Tub; zam kom tsis txhob siv thaum cev xeeb tub, muaj kev pheej hmoo siab tshaj plaws hauv 2nd/3rd trimesters (8th cranial nerve puas tsuaj).
• Cov neeg muaj mob raum: Kev pheej hmoo ntawm nephrotoxicity nce ntxiv.
• Cov neeg uas muaj keeb kwm ntawm Ototoxicity: Cov teeb meem kev hnov ​​​​lus lossis kev sib npaug yav dhau los yuav hnyav zuj zus nrog Streptomycin.

Ceev faj thiab Kev Ceeb Toom

Ua ntej pib siv tshuaj Streptomycin, cov neeg mob yuav tsum tau kuaj qee yam hauv chaw kuaj mob, suav nrog kev kuaj lub raum ua haujlwm, kom paub txog cov kev mob tshwm sim. Nws yog ib qho tseem ceeb uas yuav tsum qhia rau cov kws kho mob txog tej yam mob uas twb muaj lawm, kev ua xua, lossis cov tshuaj uas lawv noj.

FAQ

• Tshuaj Streptomycin siv rau dab tsi? Tshuaj Streptomycin feem ntau yog siv los kho tus kab mob ntsws thiab qee yam kab mob xws li kab mob plague thiab brucellosis.
• Yuav siv tshuaj Streptomycin li cas? Nws yog muab los ntawm kev txhaj tshuaj intramuscular, feem ntau ib zaug ib hnub.
• Cov kev phiv tshwm sim yog dab tsi? Cov kev mob tshwm sim feem ntau muaj xws li xeev siab, ntuav, thiab pob khaus.
• Tshuaj Streptomycin puas ua rau pob ntseg tsis hnov ​​lus? Yog, nws tuaj yeem ua rau ototoxicity, ua rau qee tus neeg mob hnov ​​​​lus tsis zoo.
• Puas muaj kev nyab xeeb siv tshuaj Streptomycin thaum cev xeeb tub? Tsis yog, nws yog contraindicated thaum cev xeeb tub vim muaj peev xwm ua rau tus menyuam hauv plab.
• Tshuaj Streptomycin ua haujlwm li cas? Nws inhibits cov kab mob protein synthesis los ntawm kev khi rau ribosome, ua rau cov kab mob tuag.
• Kuv yuav ua li cas yog tias kuv tsis noj tshuaj? Tiv tauj koj tus kws kho mob; tsis txhob noj ob zaug.
• Kuv puas haus tau cawv thaum noj tshuaj Streptomycin? Tsis muaj kev sib cuam tshuam ncaj qha tab sis tsis txhob haus dej cawv kom tiv thaiv kev qhuav dej thiab ua rau mob nephrotoxic ntxiv.
• Kuv yuav tsum noj tshuaj Streptomycin ntev npaum li cas? Lub sijhawm ntawm kev kho mob txawv raws li tus kab mob tau kho; ua raws li koj tus kws kho mob cov lus qhia.
• Puas muaj kev txwv tsis pub noj tshuaj Streptomycin? Tsis muaj kev txwv tshwj xeeb rau kev noj zaub mov, tab sis kev noj zaub mov kom sib npaug yog qhov pom zoo. Tsis txhob noj cov khoom noj uas muaj ntsev ntau yog tias muaj teeb meem raum.

Hom Lub Npe

Streptomycin muaj nyob rau hauv daim ntawv ntawm Streptomycin Sulfate Injection (generic; tsis muaj cov npe loj hauv feem ntau ntawm cov khw).

xaus

Streptomycin tseem yog ib yam tshuaj tua kab mob tseem ceeb heev rau kev kho cov kab mob me me, tshwj xeeb yog mob ntsws. Nws lub peev xwm ua haujlwm tau zoo tiv thaiv cov kab mob uas tiv taus thiab nws lub luag haujlwm hauv kev kho mob ua ke ua rau nws yog ib qho cuab yeej tseem ceeb hauv kev kho mob niaj hnub no. Txawm li cas los xij, nws yog ib qho tseem ceeb uas yuav tsum siv cov tshuaj no raws li kev qhia ntawm tus kws kho mob kom txo qis kev pheej hmoo thiab xyuas kom meej tias muaj kev kho mob zoo.