Sildenafil - Siv, Dosage, Cov Kev Mob Tshwm Sim thiab Ntau Ntxiv

Sildenafil yog ib yam tshuaj uas siv los kho kev ua haujlwm tsis zoo ntawm lub cev (ED) rau cov txiv neej thiab kev mob ntshav siab hauv lub ntsws (PAH) rau cov txiv neej thiab cov poj niam. Sildenafil (ua Revatio) tau txais kev pom zoo los ntawm FDA rau PAH rau cov neeg laus thiab cov menyuam yaus hnub nyoog 1 xyoos thiab laus dua. Nws yog ib hom tshuaj hu ua phosphodiesterase type 5 (PDE5) inhibitors. Sildenafil ua haujlwm los ntawm kev ua kom cov ntshav ntws mus rau qee qhov chaw ntawm lub cev, ua rau nws yooj yim dua los ua tiav thiab tswj kev ua haujlwm ntawm lub cev thaum muaj kev sib deev. Nws tau tsim thawj zaug los kho cov mob ntsig txog lub plawv tab sis txij li thaum ntawd los tau nrov npe rau nws txoj kev ua haujlwm zoo hauv kev kho ED.

Kev siv Sildenafil

• Erectile Dysfunction (ED): Feem ntau siv sildenafil yog los pab cov txiv neej uas muaj ED ua tiav thiab tswj tau erection thaum muaj kev sib deev.
• Pulmonary Arterial Hypertension (PAH): Sildenafil kuj tseem siv los kho PAH, ib yam mob uas muaj ntshav siab hauv cov hlab ntsha uas muab rau lub ntsws. Nws txhim kho lub peev xwm tawm dag zog, WHO kev ua haujlwm, thiab ncua qhov mob hnyav dua. Nws pab txhim kho lub peev xwm tawm dag zog thiab txo cov tsos mob uas cuam tshuam nrog tus mob no.

Nws Ua Haujlwm Li Cas?

Sildenafil ua haujlwm los ntawm kev txwv tsis pub enzyme phosphodiesterase hom 5 (PDE5). Hauv cov lus yooj yim, thaum ib tug txiv neej muaj kev sib deev, lub cev tso tawm cov tshuaj hu ua nitric oxide, uas pab kom cov hlab ntsha hauv qhov chaw mos so. Qhov kev so no ua rau cov ntshav ntws ntau ntxiv, ua rau erection. PDE5 rhuav tshem lwm yam tshuaj hu ua cyclic guanosine monophosphate (cGMP), uas yog lub luag haujlwm rau kev tswj hwm erection. Los ntawm kev thaiv PDE5, sildenafil pab kom cov qib cGMP siab, ua rau cov ntshav ntws zoo dua thiab erection muaj zog dua.

Dosage thiab Administration

Sildenafil feem ntau muaj nyob rau hauv cov ntsiav tshuaj daim ntawv thiab tau noj qhov ncauj. Tus txheej txheem neeg laus noj rau erectile kawg yog:

• Thawj koob tshuaj: 50 mg noj li ib teev ua ntej kev sib deev.
• Kev Kho Kom Zoo: Nyob ntawm seb qhov ua tau zoo thiab kev kam rau siab npaum li cas, qhov koob tshuaj yuav raug nce mus rau 100 mg lossis txo mus rau 25 mg. Qhov ntau zaus tshaj plaws uas pom zoo yog ib zaug ib hnub.

Rau kev mob ntshav siab hauv cov hlab ntsha hauv lub ntsws, cov tshuaj pib ib txwm yog 20 mg peb zaug hauv ib hnub (sib npaug li 5 mg ib zaug rau cov tshuaj haus hauv cov menyuam yaus), nrog rau kev hloov kho txog li 80 mg ib zaug raws li kev teb thiab kev kam rau siab.

Cov teebmeem ntawm Sildenafil

Zoo li txhua yam tshuaj, sildenafil tuaj yeem ua rau muaj kev phiv.

Cov teebmeem tshwm sim muaj xws li:

• Mob taub hau
• Flushing (sov, liab, los yog tingly xav)
• Indigestion
• Lub qhov ntswg
• Kauj taub hau
• Kev cuam tshuam ntawm qhov muag (xws li kev hloov pauv ntawm kev pom xim, kev pom tsis zoo (xim xiav))
• Tom qab mob
• Myalgia

Cov kev mob tshwm sim loj heev, txawm tias tsis tshua muaj, tuaj yeem suav nrog:

• Priapism (lub sijhawm ntev thiab mob erection)
• Sudden tsis pom kev
• Tsis hnov ​​​​qab
• Cov tsos mob ntawm lub plawv nres (mob hauv siab, ua tsis taus pa)

Yog tias muaj kev phiv loj heev tshwm sim, nrhiav kev kho mob tam sim ntawd.

Tshuaj Kev Sib Thoob

Sildenafil tuaj yeem cuam tshuam nrog ntau yam tshuaj thiab tshuaj, suav nrog:

• Nitrates: Feem ntau siv rau mob hauv siab, nitrates tuaj yeem ua rau muaj kev poob siab txaus ntshai thaum noj nrog sildenafil.
• Alpha-blockers: Siv rau cov ntshav siab lossis teeb meem prostate, cov no kuj tuaj yeem ua rau cov ntshav qis thaum ua ke nrog sildenafil.
• Lwm yam tshuaj PDE5 inhibitors: Kev noj ntau yam tshuaj PDE5 inhibitors tuaj yeem ua rau muaj kev pheej hmoo ntawm cov kev mob tshwm sim.
• Muaj zog CYP3A4 inhibitors: (piv txwv li, ketoconazole, itraconazole, ritonavir): Cov no tuaj yeem ua rau cov sildenafil ntau ntxiv hauv cov ntshav.

Ib txwm qhia rau koj tus kws kho mob txog txhua yam tshuaj thiab cov tshuaj ntxiv uas koj noj.

Cov txiaj ntsig ntawm Sildenafil

Sildenafil muaj ntau yam kev kho mob thiab siv tau zoo, suav nrog:

• Kev Kho Mob Zoo rau ED: Muaj ntau tus txiv neej muaj kev ua haujlwm zoo dua thiab kev txaus siab.
• Quick pib ntawm Action: Feem ntau Sildenafil ua haujlwm hauv 30 txog 60 feeb, ua rau muaj kev sib deev sai.
• Txhim Kho Lub Neej Zoo: Los ntawm kev hais txog ED, sildenafil tuaj yeem txhim kho kev noj qab haus huv ntawm lub siab thiab kev txaus siab rau kev sib raug zoo.
• Kev kho mob rau PAH: Nws pab txhim kho lub peev xwm tawm dag zog thiab lub neej zoo rau cov neeg uas muaj ntshav siab hauv lub ntsws.

Contraindications ntawm Sildenafil

Qee tus neeg yuav tsum tsis txhob siv sildenafil, suav nrog:

• Tsis pom zoo kom siv thaum cev xeeb tub (Qeb B) lossis pub niam mis vim tias nws yuav tso tawm rau hauv mis.
• Cov neeg uas muaj kab mob siab lossis raum hnyav: Cov mob no tuaj yeem cuam tshuam rau txoj kev uas lub cev ua cov tshuaj.
• Cov neeg noj nitrates: Raws li tau hais lawm, qhov kev sib xyaw ua ke no tuaj yeem ua rau muaj kev mob ntshav qis heev.
• Cov tib neeg uas muaj keeb kwm muaj teeb meem plawv: Tshwj xeeb tshaj yog cov neeg uas nyuam qhuav muaj mob plawv nres lossis mob hlwb.
• Kev ua xua rau sildenafil.
• Cov tshuaj guanylate cyclase stimulators ua ke (piv txwv li, riociguat).

Ceev faj thiab Kev Ceeb Toom

Ua ntej siv sildenafil, xav txog cov kev ceev faj hauv qab no:

• Nrog koj tus kws kho mob tham: Tham txog koj keeb kwm kev kho mob, tshwj xeeb yog tias koj muaj teeb meem plawv, ntshav siab lossis qis, mob qhov muag (piv txwv li, retinitis pigmentosa), lossis anatomical penile deformation, thiab kev pheej hmoo ntawm non-arteritic anterior ischemic optic neuropathy (NAION). Nco ntsoov kev sib cuam tshuam ntawm kua txiv qaub ntsuab.
• Kev kuaj xyuas tsis tu ncua: Yog tias koj muaj teeb meem kev noj qab haus huv, yuav tsum tau saib xyuas tsis tu ncua.
• Zam kev haus dej cawv: Cawv ntau dhau tuaj yeem ua rau muaj kev pheej hmoo ntawm cov kev mob tshwm sim thiab txo qhov ua tau zoo ntawm sildenafil.

FAQ

• Dab tsi yog sildenafil siv rau? Sildenafil feem ntau yog siv los kho erectile kawg thiab pulmonary arterial hypertension.
• Sildenafil siv sijhawm ntev npaum li cas los ua haujlwm? Sildenafil feem ntau yuav siv li 30 mus rau 60 feeb los pib ua haujlwm.
• Kuv puas tuaj yeem noj sildenafil nrog zaub mov? Yog lawm, tab sis cov zaub mov muaj roj ntau yuav ncua nws cov teebmeem.
• Kuv tuaj yeem noj sildenafil ntau npaum li cas? Qhov siab tshaj plaws tau pom zoo yog ib zaug hauv ib hnub.
• Kuv yuav ua li cas yog tias kuv tsis noj tshuaj? Sildenafil tau noj raws li qhov xav tau, yog li tsis muaj lub sijhawm noj tshuaj kom ua raws li.
• Puas yog sildenafil muaj kev nyab xeeb rau txhua tus? Tsis yog, cov tib neeg uas muaj qee yam mob lossis cov uas noj tshuaj tshwj xeeb yuav tsum zam.
• Cov poj niam puas tuaj yeem noj sildenafil? Sildenafil tsis tau txais kev pom zoo rau kev siv rau cov poj niam, txawm hais tias nws yuav raug sau tseg rau qee yam mob xws li PAH. Kev siv tshuaj tsis raws li daim ntawv lo rau kev ua tsis taus poj niam tsis muaj pov thawj zoo.
• Cov kev phiv tshwm sim yog dab tsi? Cov kev mob tshwm sim feem ntau muaj xws li mob taub hau, yaug, thiab plab zom mov.
• Kuv puas tuaj yeem noj sildenafil nrog lwm cov tshuaj ED? Tsis yog, kev sib txuas nrog sildenafil nrog lwm cov tshuaj ED tuaj yeem ua rau muaj kev phom sij ntau ntxiv.
• Kuv yuav ua li cas yog tias kuv muaj kev phiv loj heev? Nrhiav kev kho mob tam sim ntawd yog tias koj ntsib cov kev mob tshwm sim hnyav xws li tsis pom kev lossis hnov ​​​​lus tsis pom.

Hom Lub Npe

Sildenafil muaj nyob rau hauv ntau lub npe, suav nrog:

• Viagra (25/50/100 mg ntsiav tshuaj, rau kev ua haujlwm tsis zoo ntawm erectile)
• Revatio (20 mg ntsiav tshuaj los yog tshuaj suspension, rau kev mob ntshav siab hauv lub ntsws)
• Kuj muaj cov khoom siv dav dav.

xaus

Sildenafil yog cov tshuaj siv dav siv los kho erectile kawg thiab pulmonary arterial hypertension. Los ntawm kev nkag siab nws ua haujlwm li cas, nws siv, muaj peev xwm tshwm sim, thiab kev ceev faj, cov neeg mob tuaj yeem txiav txim siab paub txog lawv txoj kev kho mob. Nco ntsoov sab laj nrog tus kws kho mob ua ntej pib cov tshuaj tshiab kom ntseeg tau tias nws muaj kev nyab xeeb thiab tsim nyog rau koj tus kheej cov kev xav tau kev noj qab haus huv.