• Sex - Duodenal tumors are slightly higher risk in men
• Age - Duodenal tumors tend to occur more often in older people. (average age at 60s and 70s)
• Smoking increases the risk of duodenal cancer
• Alcohol consumption increases the risk of duodenal cancer
• Diet - Diets high in red meat and salted or smoked foods increases the risk of duodenal cancer
• Inherited Syndromes- People with certain inherited conditions like
• Familial adenomatous polyposis (FAP)
• Peutz-Jeghers syndrome (PJS)
• Hereditary nonpolyposis colon cancer (HNPCC)
• Autoimmune Conditions - Autoimmune inflammatory bowel diseases like Crohn’s Disease, Celiac sprue increase the risk of small bowel cancers
• Immunosuppression - People who are immunosuppressed (post-organ transplant or in conditions like HIV) are at a higher risk of developing small bowel cancers like duodenal cancers.