Piperacillin - Uses, Dosage, Side Effects and More

Isingeniso: Kuyini i-Piperacillin?

I-Piperacillin iyi-antibiotic ebanzi eyingxenye yemithi ye-penicillin. Isetshenziswa kakhulu ukwelapha izifo ezahlukahlukene zamagciwane ngokuvimbela ukukhula kwamagciwane. I-Piperacillin ivame ukuhlanganiswa ne-beta-lactamase inhibitor, njenge-tazobactam, ukuze ithuthukise ukusebenza kwayo ngokumelene namagciwane amelana namagciwane. Le nhlanganisela ivame ukubizwa ngokuthi i-piperacillin tazobactam futhi isetshenziswa kabanzi ezindaweni zezokwelapha ngoba isebenza kangcono ngokumelene nohlu olubanzi lwamagciwane.

Ukusetshenziswa kwe-Piperacillin

I-Piperacillin ivame ukusetshenziswa kanye ne-beta-lactamase inhibitor ebizwa ngokuthi i-tazobactam, ethengiswa ndawonye njenge-piperacillin-tazobactam. Le nhlanganisela ithuthukisa ukusebenza kahle ngokumelene namagciwane amelana namagciwane futhi iyisinqumo esikhethwayo ezindaweni eziningi zezokwelapha. I-Piperacillin iyodwa ayisetshenziswa njalo futhi igcinelwe izimo ezithile lapho ukumelana kungeyona inkinga.

I-Piperacillin ivunyelwe ukwelapha izifo ezahlukahlukene, okuhlanganisa:

• Ukutheleleka Ngepheshana Lokuphefumula: Isebenza kahle ekulweni ne-pneumonia kanye ne-bronchitis.
• Ukutheleleka kwe-Urinary Tract: Yelapha izifo eziyinkimbinkimbi zomchamo.
• Ukutheleleka Kwangaphakathi Kwesisu: Isetshenziselwa izifo ezifana ne-peritonitis.
• Izifo Zesikhumba Nezicubu Ezithambile: Njenge-cellulite kanye nama-abscesses.
• Ukutheleleka Kwamathambo Namalunga: Yelapha i-osteomyelitis kanye ne-septic arthritis.
• i-sepsis: Isetshenziswa ezifweni ezinzima ezisakazeka emzimbeni wonke.

Isebenza Kanjani?

I-Piperacillin isebenza ngokugxila odongeni lweseli lamagciwane. Iphazamisa ukwakheka kwe-peptidoglycan, ingxenye ebalulekile yodonga lweseli lamagciwane, okuholela ekuqhekekeni kweseli nokufa. Kalula nje, iphazamisa isakhiwo esivikela amagciwane, okwenza abe sengozini yokubhujiswa amasosha omzimba kanye namanye ama-antibiotic.

Isilinganiso nokuphathwa

I-Piperacillin kanye ne-piperacillin-tazobactam zinikezwa ngomjovo. I-Piperacillin-tazobactam isetshenziswa kakhulu futhi ilandela lezi ziqondiso zokulinganisa:

• Abantu abadala: Amagremu angu-3.375 kuya ku-4.5 njalo emahoreni angu-6 kuya kwangu-8 (umthamo kuye ngokuthi ukutheleleka kungakanani).
• Ukwelashwa Kwezingane: 80?00 mg/kg/ngosuku lwengxenye ye-piperacillin ehlukaniswe njalo emahoreni ayi-6 kuya kwayi-8.

Uma usebenzisa i-piperacillin yodwa, umthamo ungahluka futhi kufanele unqunywe uchwepheshe wezempilo. Landela njalo imiyalelo yomhlinzeki wakho.

Imiphumela Engemihle Ye-Piperacillin

Njengayo yonke imithi, i-piperacillin ingabangela imiphumela emibi. Lokhu kungaba nemiphumela emibi kusukela kwencane kuya kweyingozi.

Imiphumela emibi evamile ingafaka:

• I-nausea
• Uhudo
• Rash
• bekhanda

Imiphumela emibi kakhulu ingabandakanya:

• Ukusabela okweqile: amaqhubu, ubunzima bokuphefumula
• Uhudo olubi kakhulu: inkinga engenzeka kodwa engavamile ebangelwa ukutheleleka kweClostridium difficile
• Ukwanda kwama-enzyme esibindi: kungabangela ukuvuvukala kwesibindi, okungaholela emiphumeleni engavamile yelebhu noma ukukhathala
• Ukuphazamiseka kwegazi: kungabangela i-anemia kanye ne-thrombocytopenia

Funa usizo lwezokwelapha ngokushesha uma uhlangabezana nemiphumela emibi kakhulu.

Ukusebenzisana kwezidakamizwa

I-Piperacillin ingasebenzisana nemithi eminingana, okuhlanganisa:

• Aminoglycosides: ingozi ekhulayo yobuthi bezinso.
• I-Probenecid: kungakhuphula amazinga e-piperacillin egazini.
• Anticoagulants (isib. i-warfarin, i-heparin) ingathuthukisa imiphumela yokunciphisa igazi, yandise ingozi yokopha.
• I-Methotrexate: I-piperacillin inganciphisa ukuphuma kwayo, okwandisa ubuthi be-methotrexate.

Njalo yazisa umhlinzeki wakho wezempilo ngayo yonke imithi oyiphuzayo.

Izinzuzo ze-Piperacillin

I-Piperacillin inezinzuzo eziningana zezokwelapha:

• Umsebenzi we-Broad-Spectrum: Isebenza kahle ngokumelene namagciwane ahlukahlukene, okuhlanganisa kokubili izinto eziphilayo ezinegremu kanye negremu.
• Ukwelapha Okuxubile: Uma isetshenziswa ne-tazobactam, inqoba izindlela zokumelana namagciwane.
• Isebenza Kahle Ezifweni Ezinzima: Iwusizo kakhulu ezindaweni zesibhedlela ekwelapheni izifo ezingathi sína.

Ukuphikisana kwe-Piperacillin

I-Piperacillin kufanele igwenywe kubantu abanokungezwani komzimba ne-penicillin noma i-cephalosporins kanye nasezigulini ezinesifo sesibindi esibi kakhulu. Abesifazane abakhulelwe noma abancelisayo kufanele basebenzise i-piperacillin ngokuqapha futhi baxoxe ngezingozi nezinzuzo ezingaba khona nomhlinzeki wabo wezempilo ngaphambi kokuqala ukwelashwa.

Ukuqapha Nezexwayiso

Ngaphambi kokuqala i-piperacillin, cabanga ngalokhu okulandelayo:

• Umlando Wokungezwani Nomzimba: Yazisa udokotela wakho nganoma yikuphi ukusabela kokungezwani komzimba okudlule kuma-antibiotic.
• Umsebenzi Wezinso: Ukusebenza kwezinso kufanele kuqashwe, ikakhulukazi ezigulini ezinezimo ezikhona kakade.
• Ukuhlolwa Kwelebhu: Ukuhlolwa kwegazi njalo kungadingeka ukuze kuqashwe ukusebenza kwesibindi nezinso ngesikhathi sokwelashwa.

Imibuzo Evame Ukubuzwa

• I-piperacillin isetshenziselwani? I-Piperacillin isetshenziselwa ukwelapha izifo ezahlukahlukene zamagciwane, okuhlanganisa izifo zokuphefumula, zomchamo, kanye nezesikhumba.
• Isetshenziswa kanjani i-piperacillin? Ngokuvamile inikezwa ngomjovo, kungaba ngemithambo noma nge-intramuscularly.
• Yimiphi imiphumela emibi evamile? Imiphumela emibi evamile ihlanganisa isicanucanu, isifo sohudo, kanye nokuqubuka.
• Ngingayisebenzisa yini i-piperacillin uma ngingezwani ne-penicillin? Cha, uma une-allergy ye-penicillin, kufanele ugweme i-piperacillin.
• Isebenza kanjani i-piperacillin? Kuphazamisa udonga lwamaseli ebhaktheriya, okuholela ekufeni kwamagciwane.
• Yini okufanele ngiyenze uma ngiphuthelwa umthamo? Njengoba i-piperacillin ivame ukunikezwa esibhedlela ochwepheshe bezempilo, ukuphuthelwa kwemithamo akuvamile. Uma wena noma umhlinzeki wezempilo weqa umthamo, ungaphindi kabili. Sicela wazise ithimba lakho lezokwelapha ukuze bakwazi ukulungisa ukwelashwa kwakho ngokuphephile.
• Ingabe i-piperacillin ingasetshenziswa ngesikhathi sokukhulelwa? Xhumana nodokotela wakho; i-Piperacillin kufanele inikezwe kuphela uma kudingeka.
• Ingabe ikhona imiphumela emibi kakhulu? Yebo, imiphumela emibi kakhulu ingafaka phakathi ukusabela kokungezwani komzimba kanye nesifo sohudo esibi.
• Ngingaphuza utshwala ngenkathi ngithatha i-piperacillin? Kungcono ukugwema utshwala, njengoba bungandisa imiphumela emibi.
• Kuyoze kube nini ngidinga ukuthatha i-piperacillin? Isikhathi sokwelashwa sincike ohlotsheni kanye nobukhali bokutheleleka.

Amagama Omkhiqizo

I-Piperacillin itholakala ngaphansi kwamagama emikhiqizo eminingana, okuhlanganisa:

• UZosyn: uhlobo oluvame kakhulu lwe-piperacillin-tazobactam, olusetshenziswa kabanzi ikakhulukazi e-US.
• I-Pipracil: igama lomkhiqizo le-piperacillin kuphela, elingasetshenziswa kakhulu.
• Eminye imikhiqizo ingatholakala kuye ngesifunda kanye nomkhiqizi.

Isiphetho

I-Piperacillin iyi-antibiotic ebalulekile ekwelapheni izifo ezahlukahlukene zamagciwane, ikakhulukazi ezibhedlela. Umsebenzi wayo obanzi kanye nokusebenza kwayo ngokumelene namagciwane amelana nayo kuyenza ibe ithuluzi eliwusizo kwezokwelapha zanamuhla. Kodwa-ke, kubalulekile ukuyisebenzisa ngaphansi kokuqashwa kwezokwelapha ukuze ugweme imiphumela emibi engaba khona kanye nokusebenzisana.