Paromomycin - Uses, Dosage, Side Effects and More

Isingeniso: Iyini i-Paromomycin?

I-Paromomycin iyi-antibiotic ye-aminoglycoside esetshenziswa kakhulu ekwelapheni izifo ezithile ezibangelwa yi-parasite. Isebenza kahle kakhulu ekulweni nezifo ezibangelwa yi-protozoan parasite I-Entamoeba histolytica, okungaholela ekushayweni yisisu okubangelwa yi-amoebic. I-Paromomycin isetshenziswa futhi ekwelapheni i-leishmaniasis nezinye izifo. Lo muthi utholakala ngezindlela ezahlukene, kufaka phakathi amaphilisi omlomo kanye nezixazululo ezijovwayo, okwenza ube nokuguquguquka ezidingweni ezahlukene zokwelapha.

Ukusetshenziswa kwe-Paromomycin

I-Paromomycin ivunyelwe ukusetshenziswa kwezokwelapha eziningana, okuhlanganisa:

• Uhudo lwe-Amoebic: Ngokuvamile inqunyelwe ukwelapha izifo zamathumbu ezibangelwa yi- I-Entamoeba histolytica.
• I-Leishmaniasis: I-Paromomycin iyasebenza ekulweni nezinhlobo ezithile ze-leishmaniasis, isifo esibangelwa yizinambuzane ezidluliselwa ngokulunywa yizimpukane.
• Ukutheleleka Kwamagciwane: Ingasetshenziswa futhi kanye namanye ama-antibiotic ukwelapha izifo ezithile zamagciwane.
• Ezinye izifo ze-Parasitic: I-Paromomycin ingasetshenziswa kwezinye izifo ezibangelwa yizinambuzane njengoba kunqunywe umhlinzeki wezempilo.

Indlela Esebenza

I-Paromomycin isebenza ngokuvimbela ukwakheka kwamaprotheni kumabhaktheriya kanye nezinambuzane. Ibopha i-ribosomal RNA yezinto eziphilayo, iphazamise ukukhiqizwa kwamaprotheni abalulekile ekukhuleni nasekusindeni kwazo. Lesi senzo ekugcineni siholela ekufeni kwamagciwane noma amagciwane, okusiza ekususeni ukutheleleka emzimbeni.

Isilinganiso nokuphathwa

Umthamo we-Paromomycin uyahlukahluka kuye ngesimo eselashwayo kanye nobudala besiguli.

Abantu abadala:

Isilinganiso esijwayelekile se-amoebic dysentery singama-25-35 mg/kg/ngosuku, sihlukaniswe ngezilinganiso ezintathu, sithathwe izinsuku eziyi-7. Nge-leishmaniasis, isilinganiso singahluka ngokuya ngobukhulu bokutheleleka.

Izingane:

Ezinganeni, umthamo uvame ukubalwa ngokusekelwe esisindweni somzimba, ngokuvamile cishe u-15-25 mg/kg/ngosuku, uhlukaniswe ngemithamo emithathu.

I-Paromomycin itholakala ngesimo sethebhulethi ukuze isetshenziswe ngomlomo futhi njengesixazululo esijovwayo. Kubalulekile ukulandela imiyalelo yomhlinzeki wezempilo mayelana nendlela yokusetshenziswa kanye nobude besikhathi sokwelashwa.

Imiphumela Engemihle ye-Paromomycin

Njengayo yonke imithi, i-Paromomycin ingabangela imiphumela emibi. Imiphumela emibi evamile ihlanganisa:

• I-nausea
• Ukuvota
• Uhudo
• Ubuhlungu besisu
• Rash

Imiphumela emibi kakhulu, nakuba ingavamile, ingase ihlanganise:

• Ukuzwa ukulahlekelwa
• Ukulimala kwezinso
• Ukungezwani komzimba (ukuvuvukala, ukuphefumula kanzima)
• Ukuvinjelwa kwemisipha ye-neuromuscular

Iziguli kufanele zibike noma yimiphi imiphumela emibi enzima noma eqhubekayo kumhlinzeki wazo wezempilo ngokushesha.

Ukusebenzisana kwezidakamizwa

I-Paromomycin ingasebenzisana neminye imithi, okungathinta ukusebenza kwayo noma kwandise ingozi yemiphumela emibi. Ukusebenzisana okukhulu kwemithi kuhlanganisa:

• Amanye ama-Aminoglycosides: Ukusetshenziswa ngasikhathi sinye kungandisa ingozi yokuba nesifo sezinso (ukulimala kwezinso).
• Ama-diuretics: Amanye ama-diuretics angandisa ingozi yokuba yingozi yokuzwa (ukulimala kokuzwa).
• Ama-Neuromuscular Blockers: I-Paromomycin ingase ithuthukise imiphumela yezivimbeli ze-neuromuscular, okuholela ezinkingeni zokuphefumula.

Ngaso sonke isikhathi wazisa umhlinzeki wakho wezempilo mayelana nayo yonke imithi nezithako zokudla ozithathayo ukuze ugweme ukusebenzisana okungenzeka.

Izinzuzo zeParomomycin

I-Paromomycin inezinzuzo eziningana zezokwelapha nezisebenzayo:

• Isenzo Esihlosiwe: Ihlasela ngqo izifo ze-protozoan, okwenza isebenze kahle ezimweni ezifana ne-amoebic dysentery.
• Amafomu Omlomo Najovwa: Ukutholakala kwezinhlobo zomuthi womlomo kanye nowemijovo kuvumela ukuguquguquka kokwelashwa.
• Amanani Okumelana Aphansi: Uma kuqhathaniswa namanye ama-antibiotic, ukumelana ne-Paromomycin kuphansi kakhulu, okwenza kube ukukhetha okuthembekile kokwelapha izifo ezithile.
• Ukumuncwa Okuncane Kwesistimu: Uma ithathwa ngomlomo, ayinawo umuthi wokumunca umzimba, okunciphisa ingozi yemiphumela emibi emzimbeni.

Izimo zokuphikisana ne-Paromomycin

Abantu abathile kufanele bagweme ukusebenzisa i-Paromomycin, okuhlanganisa:

• Abesifazane Abakhulelwe: Ngokuvamile akukhuthazwa ngesikhathi sokukhulelwa ngaphandle kokuthi izinzuzo zidlula izingozi.
• Iziguli ezinesifo sezinso: Labo abanenkinga yezinso esezivele zikhona kufanele bagweme lo muthi ngenxa yengozi yokulimala kwezinso okwengeziwe.
• I-Alergic: Abantu abanokungezwani komzimba okwaziwayo neParomomycin noma amanye ama-aminoglycoside akufanele basebenzise lo muthi.

Ukuqapha Nezexwayiso

Ngaphambi kokuqala i-Paromomycin, iziguli kufanele zicabangele izinyathelo zokuphepha ezilandelayo:

• Umsebenzi Wezinso: Ukuqapha njalo ukusebenza kwezinso kungase kudingeke, ikakhulukazi ezigulini ezinezimo esezivele zikhona.
• Ukuhlolwa kokuzwa: Iziguli ezithola ukwelashwa kwesikhathi eside zingadinga ukuhlolwa kokuzwa ukuze kuqashwe ukuthi azinawo yini ushevu.
• Ukukhulelwa Nokuncelisa: Xoxa ngezingozi ezingaba khona nomhlinzeki wezempilo uma ukhulelwe noma uncelisa.

Imibuzo Evame Ukubuzwa

• Isetshenziswa ngani iParomomycin? I-Paromomycin isetshenziswa kakhulu ukwelapha izifo ezibangelwa yi-parasite I-Entamoeba histolytica kanye nezinhlobo ezithile ze-leishmaniasis.
• Ithathwa kanjani i-Paromomycin? Ingathathwa ngomlomo ngesimo sethebhulethi noma inikezwe ngomjovo, kuye ngesimo eselashwayo.
• Yimiphi imiphumela emibi evamile? Imiphumela emibi evamile ihlanganisa isicanucanu, ukuhlanza, isifo sohudo, nobuhlungu besisu.
• Ngingayithatha yini i-Paromomycin uma ngikhulelwe? Ngokuvamile akukhuthazwa ngesikhathi sokukhulelwa ngaphandle uma kudingeka. Xhumana nodokotela wakho ukuze uthole iseluleko.
• Isebenza kanjani i-Paromomycin? Ivimbela ukwakheka kwamaprotheni kuma-bacteria kanye nama-parasite, okuholela ekufeni kwawo.
• Ingabe ikhona imiphumela emibi kakhulu? Yebo, imiphumela emibi kakhulu ingafaka ukulahlekelwa ukuzwa kanye nokulimala kwezinso. Bika noma yiziphi izimpawu ezinzima kudokotela wakho.
• Ngingakwazi yini ukuphuza eminye imithi nge-Paromomycin? Eminye imithi ingasebenzisana ne-Paromomycin. Yazisa njalo umhlinzeki wakho wezempilo ngayo yonke imithi oyiphuzayo.
• Kufanele ngithathe i-Paromomycin isikhathi esingakanani? Isikhathi sokwelashwa siyahlukahluka kuye ngokutheleleka. Landela imiyalelo yomhlinzeki wakho wezempilo.
• Ingabe i-Paromomycin iyasebenza kuzo zonke izifo? Cha, isebenza kahle kakhulu ekulweni nezifo ezithile ezibangelwa amagciwane, hhayi zonke izifo ezibangelwa amagciwane.
• Yini okufanele ngiyenze uma ngiphuthelwa umthamo? Thatha umthamo ogejiwe ngokushesha nje lapho ukhumbula, kodwa weqe uma sekusondele isikhathi somthamo olandelayo. Ungaphindi.

Amagama Omkhiqizo

I-Paromomycin ikhangiswa ngaphansi kwamagama emikhiqizo eminingana, okuhlanganisa:

• I-Humatin
• I-Paromycin Sulfate

Isiphetho

I-Paromomycin iyimithi ewusizo ekwelapheni izifo ezithile ezibangelwa amagciwane, ikakhulukazi i-amoebic dysentery kanye ne-leishmaniasis. Isenzo sayo esiqondisiwe, ukutholakala ngezindlela eziningi, kanye namazinga aphansi okumelana kwenza kube ukukhetha okuthembekile kwabahlinzeki bezempilo. Kodwa-ke, kubalulekile ukusebenzisa lo muthi ngaphansi kokuqondiswa kochwepheshe bezempilo, ucabangela imiphumela emibi engaba khona kanye nokusebenzisana kwezidakamizwa.