Succimer - Uses, Dosage, Side Effects and More

I-Succimer, eyaziwa nangokuthi i-DMSA (i-dimercaptosuccinic acid), iyi-chelating agent esetshenziswa kakhulu ukwelapha ubuthi bensimbi esindayo, ikakhulukazi ubuthi be-lead ezinganeni. Isebenza ngokubopha izinsimbi ezisindayo emzimbeni, okuvumela ukuthi zikhishwe ngomchamo. I-Succimer iyimithi ebalulekile kwezokwelapha ubuthi, esiza ekunciphiseni imiphumela elimazayo yokuqongelela kwensimbi emzimbeni.

Ukusetshenziswa kwe-Succimer

I-Succimer ivunyelwe ukusetshenziswa kwezokwelapha okuningana, okuhlanganisa:

• Ubuthi bomthofu: Isibonakaliso esiyinhloko se-succimer ukwelashwa kobuthi be-lead, ikakhulukazi ezinganeni ezinamazinga e-lead egazini angaphezu kwama-microgram angu-45 nge-deciliter ngayinye.
• Ubuthi beMercury: Iphinde isetshenziswe ngaphandle kwelebula ezimweni zobuthi be-mercury, nakuba lokhu kungavamile.
• Ubuthi be-Arsenic: I-Succimer ingaba yimpumelelo ekwelapheni ubuthi be-arsenic.
• Ezinye Izinto Eziyingozi Ezisebenzisa Insimbi Eningi: Kungasetshenziswa ngaphandle kwelebula kwezinye izinsimbi ezisindayo, kuye ngokwahlulela kwezokwelapha.

Isebenza kanjani?

I-Succimer isebenza nge-chelation, inqubo lapho umuthi ubopha khona izinsimbi ezisindayo egazini. Uma seziboshiwe, lezi zinsimbi azisebenzi futhi zikhishwa kalula yizinso. Ngamagama alula, cabanga nge-succimer njengomagnet odonsela izinsimbi eziyingozi, okusiza umzimba ukuba uzikhiphe ngomchamo, ngaleyo ndlela unciphise imiphumela yazo enobuthi.

Isilinganiso nokuphathwa

Umthamo we-succimer uyahlukahluka kuye ngobudala besiguli kanye nobunzima bokushelwa:

• Abantu abadala: Umthamo ojwayelekile u-10 mg/kg ngomlomo njalo emahoreni angu-8 (kathathu ngosuku) izinsuku ezi-5, bese kuba njalo emahoreni angu-12 (kabili ngosuku) izinsuku eziyi-14 sezizonke, ungadluli ku-500 mg ngomthamo noma u-2.5 g ngosuku.
• Izingane: Ezinganeni, umthamo uyafana: 10 mg/kg ngomlomo njalo emahoreni angu-8 (kathathu ngosuku) izinsuku ezi-5, bese kuba njalo emahoreni angu-12 (kabili ngosuku) izinsuku eziyi-14 sezizonke, kungadluli ku-500 mg ngomthamo noma u-2.5 g ngosuku.

I-Succimer itholakala ngesimo se-capsule futhi kufanele iphuzwe ngamanzi. Kubalulekile ukulandela imiyalelo yomhlinzeki wezempilo mayelana nomthamo kanye nobude besikhathi sokwelashwa.

Imiphumela Engemihle ye-Succimer

Imiphumela emibi evamile ye-succimer ingafaka:

• I-nausea
• Ukuvota
• Uhudo
• Ubuhlungu besisu
• Rash

Imiphumela emibi kakhulu, nakuba ingavamile, ingabandakanya:

• Ukungezwani komzimba (ukuvuvukala, ukuphefumula kanzima)
• Ukungajwayelekile kokusebenza kwesibindi
• Izinkinga zegazi (njenge-thrombocytopenia)

Iziguli kufanele zibike noma yiziphi izimpawu ezingajwayelekile kumhlinzeki wazo wezempilo ngokushesha.

Ukusebenzisana kwezidakamizwa

I-Succimer ingasebenzisana nemithi ethile, okuhlanganisa:

• Ama-Antacids: Lokhu kunganciphisa ukumuncwa kwe-succimer, okwenza ingasebenzi kahle.
• Amanye ama-Chelating Agents: Ukusebenzisa i-succimer nezinye izidakamizwa kungandisa ingozi yemiphumela emibi.
• Imithi Ethinta Ukusebenza Kwesibindi: Njengoba i-succimer iguqulwa esibindini, izidakamizwa ezithinta ama-enzyme esibindi zingashintsha ukusebenza kwayo.

Njalo yazisa umhlinzeki wakho wezempilo ngayo yonke imithi kanye nezithasiselo ozithathayo ukuze ugweme ukusebenzisana okungenzeka.

Izinzuzo ze-Succimer

Izinzuzo zezokwelapha zokusebenzisa i-succimer zifaka:

• Ukwelashwa Okuphumelelayo: Kuyindlela yokwelapha eqinisekisiwe yokwelapha ubuthi be-lead kanye nezinye izinto eziyingozi zensimbi.
• Ukuphatha Oral: Ngokungafani nezinye izidakamizwa ze-chelating ezidinga imijovo, i-succimer ithathwa ngomlomo, okwenza kube lula ezigulini, ikakhulukazi ezinganeni.
• Iphrofayela Yokuphepha: Uma isetshenziswa njengoba kuqondiswe, i-succimer inephrofayili yokuphepha enhle uma iqhathaniswa nezinye izinto ezibangela ukubola.

Izimo zokuphikisana ne-Succimer

I-Succimer kufanele igwenywe kwezinye izinhlobo, okuhlanganisa:

• Abesifazane Abakhulelwe: Ukuphepha kwe-succimer ngesikhathi sokukhulelwa akukaqinisekiswa.
• Abantu Abanesifo Sesibindi Esibi: Njengoba i-succimer iguqulwa ibe yi-metabolism esibindini, labo abanenkinga yesibindi kufanele bayigweme.
• I-Alergic: Iziguli ezinesifo sokungezwani komzimba ne-succimer noma ezinye izakhi zayo akufanele zisebenzise lo muthi.

Ukuqapha Nezexwayiso

Ngaphambi kokuqala i-succimer, iziguli kufanele ziqaphele okulandelayo:

• Ukuhlolwa Kokusebenza Kwesibindi: Ukuqapha njalo ukusebenza kwesibindi kungadingeka ngesikhathi sokwelashwa.
• Ukuhambisa amanzi: Ukuhlala unamanzi anele kubalulekile ukusiza izinso ukuthi zikhiphe izinsimbi eziboshiwe.
• I-Alergic: Qaphela izimpawu zokusabela kokungezwani komzimba, ikakhulukazi ngesikhathi sokuthatha imithamo embalwa yokuqala.
• Akuvunyelwe ezinganeni ezingaphansi konyaka ngenxa yedatha elinganiselwe.

Imibuzo Evame Ukubuzwa

• Isetshenziswa ngani i-succimer? I-Succimer isetshenziswa kakhulu ekwelapheni ubuthi be-lead kanye nobunye ubuthi be-heavy metal.
• Ithathwa kanjani i-succimer? I-Succimer ithathwa ngomlomo ngesimo se-capsule, ngokuvamile ngamanzi.
• Yiziphi imiphumela emibi ye-succimer? Imiphumela emibi evamile ihlanganisa isicanucanu, ukuhlanza, kanye nobuhlungu besisu. Imiphumela emibi emibi ingavela kodwa ayivamile.
• Ingabe i-succimer ingasetshenziswa ezinganeni? Yebo, i-succimer ivunyelwe ukusetshenziswa ezinganeni, ikakhulukazi ekubuthisweni kwe-lead.
• Isebenza kanjani i-succimer? I-Succimer ibopha izinsimbi ezisindayo emzimbeni, okuvumela ukuthi zikhishwe ngomchamo.
• Ingabe kukhona ukusebenzisana kwezidakamizwa ne-succimer? Yebo, i-succimer ingasebenzisana nama-antacid kanye neminye imithi ethinta ukusebenza kwesibindi.
• Ingabe i-succimer iphephile ngesikhathi sokukhulelwa? I-Succimer ayinconywa ukusetshenziswa ngesikhathi sokukhulelwa ngenxa yokuntuleka kwedatha yokuphepha.
• Yini okufanele ngiyenze uma ngiphuthelwa umthamo? Uma uphuthelwe umthamo, thatha ngokushesha ngangokunokwenzeka ngaphandle kokuthi sekuyisikhathi somthamo olandelayo; ungaphindi kabili umthamo.
• Ukwelashwa nge-succimer kuthatha isikhathi esingakanani? Ngokuvamile, izinsuku ezingu-19 (izinsuku ezi-5 ku-TID, izinsuku ezingu-14 ku-BID), kanye nezifundo eziphindaphindwayo ezingaba khona ngemva kwamasonto ama-2 uma amazinga okuhola ehlala ephakeme.
• Ngingayisebenzisa yini i-succimer kanye neminye imithi? Njalo thintana nomhlinzeki wakho wezempilo ngaphambi kokuthatha i-succimer neminye imithi ukuze ugweme ukusebenzisana.

Amagama Omkhiqizo

I-Succimer ithengiswa ngaphansi kwe-Chemet.

Isiphetho

I-Succimer iyimithi ebalulekile ekwelapheni ubuthi bensimbi esindayo, ikakhulukazi i-lead. Ikhono layo lokususa ngempumelelo izinsimbi eziyingozi futhi lenze kube lula ukukhishwa kwazo kuyenza ithuluzi elibalulekile kwezokwelapha. Nakuba ngokuvamile kuphephile, kubalulekile ukusebenzisa i-succimer ngaphansi kokuqashwa kwezokwelapha ukuqapha imiphumela emibi kanye nokusebenzisana. Njalo xhumana nomhlinzeki wakho wezempilo ukuze uthole iseluleko esiqondene nawe kanye nezinketho zokwelapha.