Crisaborole - Uses, Dosage, Side Effects and More

Isingeniso: Kuyini iCrisaborole?

I-Crisaborole umuthi osetshenziswa kakhulu ekwelapheni i-atopic dermatitis emnene kuya kwephakathi, eyaziwa kakhulu ngokuthi i-eczema. Iwumuthi ongewona owe-steroidal wokulwa nokuvuvukala (NSAID) osebenza ngokuvimbela izindlela ezithile ohlelweni lokuzivikela komzimba, osiza ekunciphiseni ukuvuvukala nokunciphisa izimpawu ezihambisana ne-eczema. Ivunywe yi-FDA ngo-2016, i-Crisaborole itholakala ngesimo samafutha futhi yenzelwe ukusetshenziswa ngqo ezindaweni zesikhumba ezithintekile.

Ukusetshenziswa kweCrisaborole

I-Crisaborole isetshenziswa kakhulu ekwelapheni i-atopic dermatitis ezigulini ezineminyaka emibili nangaphezulu. Iwusizo kakhulu kubantu abangase bangasabeli kahle ekwelashweni kwendabuko, njenge-corticosteroids yasendaweni, noma kulabo abakhetha ukugwema ama-steroid ngenxa yemiphumela emibi engaba khona. I-Crisaborole isiza ekunciphiseni ukulunywa, ukubomvu, kanye nokuvuvukala okuhambisana ne-eczema, ithuthukise ikhwalithi yokuphila iyonke yeziguli.

Indlela Esebenza

I-Crisaborole isebenza ngokuvimbela i-enzyme i-phosphodiesterase 4 (PDE4), edlala indima ebalulekile enkambisweni yokuvuvukala. Ngokuvimba i-PDE4, i-Crisaborole ikhulisa amazinga e-cyclic adenosine monophosphate (cAMP) kumaseli omzimba. Amazinga aphezulu e-cAMP aholela ekunciphiseni ukukhishwa kwama-cytokines abangela ukuvuvukala, ngaleyo ndlela kunciphisa ukuvuvukala nokulunywa. Kalula nje, i-Crisaborole isiza ukuzola impendulo yomzimba yesikhumba, inciphise izimpawu ze-eczema.

Isilinganiso nokuphathwa

I-Crisaborole iyatholakala njengomuthi wokugcoba ongu-2%. Umthamo ojwayelekile wabantu abadala nezingane ezineminyaka emibili nangaphezulu ukufaka ungqimba oluncane lwamafutha ezindaweni ezithintekile zesikhumba kabili ngosuku. Kubalulekile ukuhlikihla kancane amafutha esikhumbeni kuze kube yilapho emuncwa ngokuphelele. Iziguli kufanele zigeze izandla zazo ngemva kokusebenzisa umuthi, ngaphandle uma izandla ziyindawo elashwe kuyo. Kubalulekile ukulandela imiyalelo kadokotela onikeza umuthi mayelana nobude besikhathi sokwelashwa.

Imiphumela Engemihle yeCrisaborole

Imiphumela emibi evamile ye-Crisaborole ingafaka:

• Ubuhlungu bendawo yohlelo lokusebenza
• Ukuzwa ukushisa noma ukuluma
• Itching
• ububomvu

Imiphumela emibi kakhulu ayivamile kodwa ingenzeka. Iziguli kufanele zithole usizo lwezokwelapha uma zizwa:

• Ukusabela okukhulu kwe-allergic (ukuqubuka, ukulunywa, ukuvuvukala)
• Izimpawu zokutheleleka (umkhuhlane, ukubanda, ukubomvu okuqhubekayo)

Ukusebenzisana kwezidakamizwa

I-Crisaborole inamandla aphansi okuxhumana kwemithi ngenxa yokusetshenziswa kwayo endaweni ethintekile kanye nokumuncwa okuncane emzimbeni. Kodwa-ke, iziguli kufanele zazise umhlinzeki wazo wezempilo ngayo yonke imithi eziyithathayo, okuhlanganisa nemithi kanye nezithasiselo ezithengiswa ngaphandle kwemithi kadokotela. Kubaluleke kakhulu ukuxoxa ngokusetshenziswa kweminye imithi ethintekile noma ukwelashwa kwe-eczema ukuze kugwenywe ukucasuka okungenzeka noma imiphumela emibi.

Izinzuzo zeCrisaborole

I-Crisaborole inikeza izinzuzo eziningana zezokwelapha nezisebenzayo:

• Okungeyona i-steroidal: Ngokungafani ne-corticosteroids yendabuko, i-Crisaborole ayinayo ingozi yokuncipha kwesikhumba noma eminye imiphumela emibi ehlobene ne-steroid.
• Kuphephile ukusetshenziswa isikhathi eside: Ingasetshenziswa njalo ngaphandle kokukhathazeka okufanayo okuhlobene nokusetshenziswa isikhathi eside kwe-steroid.
• Isicelo esilula: Ukwakheka kwamafutha kuvumela ukusetshenziswa okulula ezindaweni ezithintekile.
• Isebenza kahle esikhumbeni esibucayi: I-Crisaborole ifanele ukusetshenziswa ezindaweni ezibucayi zomzimba, njengobuso nentamo.

Izimo ze-Crisaborole

I-Crisaborole kufanele igwenywe kubantu abanokuzwela okukhulu komuthi noma kunoma yiziphi izingxenye zawo. Abesifazane abakhulelwe noma abancelisayo kufanele baxhumane nomhlinzeki wabo wezempilo ngaphambi kokusebenzisa i-Crisaborole, njengoba imiphumela ekukhuleni komntwana noma ezinganeni ezincelisayo ayiqondakali ngokugcwele. Ngaphezu kwalokho, iziguli ezinesifo sesibindi esibi kufanele zisebenzise i-Crisaborole ngokuqapha.

Ukuqapha Nezexwayiso

Ngaphambi kokusebenzisa i-Crisaborole, iziguli kufanele zazise umhlinzeki wazo wezempilo nganoma yiziphi izimo zezokwelapha ezikhona, ikakhulukazi izifo zesikhumba noma ukungezwani komzimba. Kunconywa ukwenza ukuhlolwa kwe-patch endaweni encane yesikhumba ukuze kuhlolwe noma yimiphi imiphumela emibi ngaphambi kokuyisebenzisa ezindaweni ezinkulu. Kungadingeka ukuqokwa njalo ukuze kuqashwe ukusebenza kahle kokwelashwa kanye nanoma yimiphi imiphumela emibi engaba khona.

Imibuzo Evame Ukubuzwa

1. I-Crisaborole isetshenziselwani? I-Crisaborole isetshenziselwa ukwelapha i-atopic dermatitis (eczema) ezigulini ezineminyaka emibili nangaphezulu.
2. Ngingayisebenzisa kanjani iCrisaborole? Faka ungqimba oluncane lwamafutha ezindaweni zesikhumba ezithintekile kabili ngosuku, uluhlikihle kancane kuze kube yilapho umuncwa ngokuphelele.
3. Ngingayisebenzisa yini i-Crisaborole kanye neminye imithi yokwelapha i-eczema? Xhumana nomhlinzeki wakho wezempilo ngaphambi kokuhlanganisa i-Crisaborole nezinye izindlela zokwelapha ezisetshenziswa endaweni yokwelapha ukuze ugweme ukucasuka.
4. Yimiphi imiphumela emibi evamile? Imiphumela emibi evamile ihlanganisa ubuhlungu endaweni yokufaka, ukusha, ukuhlaba, ukulunywa, kanye nokubomvu.
5. Ingabe i-Crisaborole iphephile ezinganeni? Yebo, i-Crisaborole ivunyelwe ukusetshenziswa ezinganeni ezineminyaka emibili nangaphezulu.
6. Ngingayisebenzisa yini i-Crisaborole ngesikhathi sokukhulelwa? Abesifazane abakhulelwe kufanele baxhumane nomhlinzeki wabo wezempilo ngaphambi kokusebenzisa i-Crisaborole.
7. Ngingayisebenzisa isikhathi esingakanani iCrisaborole? I-Crisaborole ingasetshenziswa isikhathi eside, kodwa landela izincomo zomhlinzeki wakho wezempilo mayelana nobude besikhathi.
8. Yini okufanele ngiyenze uma ngiphuthelwa umthamo? Uma uphuthelwe umthamo, faka ngokushesha nje lapho ukhumbula. Uma sekuseduze nomthamo olandelayo, yeqa umthamo ophuthelwe bese uqhubeka nesimiso sakho esijwayelekile.
9. Ngingayisebenzisa yini i-Crisaborole ebusweni bami? Yebo, i-Crisaborole iphephile ukusetshenziswa ezindaweni ezibucayi, okuhlanganisa nobuso.
10. Yini okufanele ngiyenze uma ngiba nemiphumela emibi kakhulu? Funa usizo lwezokwelapha ngokushesha uma uhlangabezana nokusabela okukhulu kokungezwani komzimba noma izimpawu zokutheleleka.

Amagama Omkhiqizo

I-Crisaborole imakethwa ngaphansi kwegama lomkhiqizo i-Eucrisa. Itholakala emakhemisi futhi inganqunywa abahlinzeki bezempilo.

Isiphetho

I-Crisaborole imelela intuthuko ebalulekile ekwelapheni i-atopic dermatitis, inikeza inketho engeyona eye-steroidal ezigulini ezifuna impumuzo ezimpawini ze-eczema. Indlela yayo eyingqayizivele yokusebenza, kuhlanganiswe nephrofayili yayo yokuphepha, iyenza ithuluzi eliwusizo ekuphatheni lesi simo sesikhumba esingamahlalakhona. Njenganoma yimuphi umuthi, kubalulekile ukubonisana nomhlinzeki wezempilo ukuze uthole uhlelo lokwelapha olungcono kakhulu oluhambisana nezidingo zomuntu ngamunye.