I-Cycloserine - Ukusetshenziswa, Isilinganiso, Imiphumela Engemihle Nokunye

Isingeniso: Kuyini i-Cycloserine?

I-Cycloserine umuthi wama-antibiotic osetshenziswa kakhulu ukwelapha isifo sofuba (i-TB), ikakhulukazi ezimweni lapho amabhaktheriya engamelani nezinye izindlela zokwelapha. Ihlukaniswa njenge-ejenti yomugqa wesibili, okusho ukuthi ivame ukusetshenziswa lapho ukwelashwa komugqa wokuqala kungasebenzi kahle noma kungabekezeleleki. I-Cycloserine isebenza ngokuvimbela ukwakheka kodonga lwamaseli ebhaktheriya, okubalulekile ekusindeni nasekuphindaphindeni kwamabhaktheriya.

Ukusetshenziswa kwe-Cycloserine

I-Cycloserine isetshenziswa kakhulu ekwelapheni:

• Isifo sofuba: Isetshenziswa kanye neminye imithi yokulwa nesifo sofuba ezigulini ezine-TB engazweli emithini eminingi.
• Ukutheleleka kwe-Urinary Tract: Ngezinye izikhathi, ingasetshenziswa ezinhlotsheni ezithile zokutheleleka komgudu womchamo okubangelwa amagciwane asengozini.
• Ezinye izifo: Kwezinye izimo, ingasetshenziswa ngaphandle kwelebula lokutheleleka okubangelwa amagciwane athile amelana namanye ama-antibiotic.

Indlela Esebenza

I-Cycloserine isebenza ngokuphazamisa ukwakheka kodonga lweseli lamagciwane. Amabhaktheriya adinga udonga lweseli oluqinile ukuze alondoloze isimo sawo futhi azivikele endaweni ahlala kuyo. I-Cycloserine ivimbela ama-enzyme abalulekile ekwakheni lolu donga, okuholela ekubeni buthaka nasekufeni kwamabhaktheriya ekugcineni. Kalula nje, ivimba amabhaktheriya ekwakheni isithiyo sawo sokuvikela, okwenza abe sengozini yokubhujiswa.

Isilinganiso nokuphathwa

Umthamo we-cycloserine ungahluka ngokuya ngesimo eselashwayo kanye nezidingo zomuntu ngamunye zesiguli.

Isilinganiso Esijwayelekile Sabantu Abadala:

Ngesifo sofuba, umthamo ojwayelekile wokuqala u-250 mg uthathwa kabili ngosuku. Umthamo ungalungiswa ngokusekelwe empendulweni yesiguli kanye nokubekezelela kwaso, ngomthamo omkhulu wansuku zonke ongu-1,000 mg.

Umthamo Wezingane:

Ezinganeni, umthamo uvame ukusekelwe esisindweni somzimba, ngokuvamile cishe u-10-20 mg/kg ngosuku, uhlukaniswe ngemithamo emibili.

Ukuphatha:

I-Cycloserine itholakala ngesimo sethebhulethi futhi ithathwa ngomlomo. Kubalulekile ukuyithatha nokudla ukuze unciphise imiphumela emibi yesisu.

Imiphumela Engemihle Ye-Cycloserine

Njengayo yonke imithi, i-cycloserine ingabangela imiphumela emibi. Imiphumela emibi evamile ihlanganisa:

• I-nausea
• Ukuvota
• Ukulahlekelwa kwesifiso
• isiyezi
• bekhanda

Imiphumela emibi kakhulu ingase ihlanganise:

• Imiphumela yesistimu yezinzwa emaphakathi: (isib., ukuxhuzula, ukudideka, ukucindezeleka)
• Ukusabela okweqile: (isib., ukuqubuka, ukulunywa, ukuvuvukala)
• Ubuthi besibindi: (ama-enzyme aphakeme esibindi)

Iziguli kufanele zibike noma yiziphi izimpawu ezinzima noma ezingajwayelekile kumhlinzeki wazo wezempilo ngokushesha.

Ukusebenzisana kwezidakamizwa

I-Cycloserine ingasebenzisana nemithi eminingana, okungase kwandise ingozi yemiphumela emibi noma kunciphise ukusebenza kahle kokwelashwa. Ukusebenzisana okukhulu kufaka phakathi:

• Ama-Anticonvulsants: Imithi efana ne-phenytoin ingaba nemiphumela eshintshile uma ithathwa ne-cycloserine.
• Utshwala: Ukuphuza utshwala kungandisa ingozi yemiphumela emibi yesistimu yezinzwa ephakathi.
• Amanye ama-antibiotics: Amanye ama-antibiotic angaba nemiphumela eyengeziwe, okwandisa ingozi yemiphumela emibi.

Ngaso sonke isikhathi wazisa umhlinzeki wakho wokunakekelwa kwezempilo ngayo yonke imithi nezithako zokudla ozithathayo.

Izinzuzo ze-Cycloserine

Izinzuzo eziyinhloko ze-cycloserine zifaka:

• Ukusebenza Kahle Kokulwa Ne-TB Engazweli: Kuyindlela ebalulekile yokwelapha isifo sofuba esingamelana nemithi eminingi, okunikeza ithemba ezigulini ezingasabeli ekwelashweni okujwayelekile.
• Ukuphatha Oral: Ukutholakala ngesimo samaphilisi kwenza kube lula ngeziguli ukuthatha uma kuqhathaniswa nezinye izindlela zokujova.
• Ukwelapha Okuxubile: Ingasetshenziswa kanye neminye imithi ukuthuthukisa ukusebenza kahle kokwelashwa.

Ukuphikisana kwe-Cycloserine

Abantu abathile kufanele bagweme ukusebenzisa i-cycloserine, okuhlanganisa:

• Abesifazane Abakhulelwe: Ukuphepha kwe-cycloserine ngesikhathi sokukhulelwa akukaqinisekiswa.
• Abantu Abanesifo Sesibindi: Labo abanokukhubazeka okukhulu kwesibindi bangase babe sengozini enkulu yemiphumela emibi.
• Umlando Wokuquleka: Iziguli ezinomlando wokuxhuzula kufanele zisebenzise i-cycloserine ngokuqapha ngenxa yengozi yokwandisa ukuxhuzula.

Ukuqapha Nezexwayiso

Ngaphambi kokuqala i-cycloserine, iziguli kufanele zihlolwe ngendlela ethile:

• Ukuhlolwa Kokusebenza Kwesibindi: Kunconywa ukuqapha njalo ukusebenza kwesibindi, ikakhulukazi ezigulini ezinezinkinga zesibindi ezikhona kakade.
• Ukuhlolwa Kwempilo Yengqondo: Njengoba i-cycloserine ingathinta uhlelo lwezinzwa oluphakathi, iziguli ezinomlando wezinkinga zempilo yengqondo kufanele ziqashwe ngokucophelela.
• Umsebenzi Wezinso: Ukulungiswa komthamo kungadingeka ezigulini ezinenkinga yokusebenza kwezinso.

Imibuzo Evame Ukubuzwa

• I-cycloserine isetshenziselwani? I-Cycloserine isetshenziswa kakhulu ekwelapheni isifo sofuba esingamelani nemithi eminingi kanye nezifo ezithile zomgudu womchamo.
• Ngingayisebenzisa kanjani i-cycloserine? Phuza i-cycloserine ngomlomo kanye nokudla ukuze unciphise ukucasuka kwesisu, njengoba kuyalelwe umhlinzeki wakho wezempilo.
• Yimiphi imiphumela emibi evamile? Imiphumela emibi evamile ihlanganisa isicanucanu, isiyezi, kanye nokulahlekelwa yisifiso sokudla.
• Ngingaphuza utshwala ngenkathi ngithatha i-cycloserine? Kunconywa ukugwema utshwala, njengoba bungandisa ingozi yemiphumela emibi.
• Ingabe i-cycloserine iphephile ngesikhathi sokukhulelwa? Ukuphepha kwe-cycloserine ngesikhathi sokukhulelwa akukaqinisekiswa; xhumana nodokotela wakho uma ukhulelwe noma uhlela ukukhulelwa.
• Isebenza kanjani i-cycloserine? Ivimbela ukwakheka kodonga lweseli lebhaktheriya, okuholela ekufeni kwamagciwane.
• Yini okufanele ngiyenze uma ngiphuthelwa umthamo? Thatha umthamo ogejiwe ngokushesha nje lapho ukhumbula, kodwa weqe uma sekusondele isikhathi somthamo wakho olandelayo. Ungaphindi.
• Ingabe i-cycloserine ingabangela ukuquleka? Yebo, i-cycloserine ingandisa ingozi yokuxhuzula, ikakhulukazi kulabo abanomlando wokuxhuzula.
• Kuyoze kube nini ngidinga ukuthatha i-cycloserine? Isikhathi sokwelashwa siyahlukahluka kuye ngokutheleleka okwelashwayo; landela imiyalelo yomhlinzeki wakho wezempilo.
• Yini okufanele ngiyenze uma ngiba nemiphumela emibi kakhulu? Xhumana nomhlinzeki wakho wezempilo ngokushesha uma uhlangabezana nemiphumela emibi efana nokudideka, ukuqubuka, noma ubunzima bokuphefumula.

Amagama Omkhiqizo

I-Cycloserine itholakala ngaphansi kwamagama ahlukahlukene emikhiqizo, okuhlanganisa:

• I-Seromycin
• I-Cycloserine (ejwayelekile)

Isiphetho

I-Cycloserine idlala indima ebalulekile ekwelapheni isifo sofuba esingamelana nemithi eminingi kanye nezinye izifo ezithile. Nakuba inikeza izinzuzo ezibalulekile, kubalulekile ukuqaphela imiphumela emibi engaba khona, ukusebenzisana kwemithi, kanye ne-contraindications. Njalo xhumana nomhlinzeki wezempilo ukuze uthole iseluleko esiqondene nawe kanye nezinhlelo zokwelapha.