Thalidomide

Kev Taw Qhia: Thalidomide yog dab tsi?

Thalidomide yog ib yam tshuaj uas tau tsim thawj zaug thaum xyoo 1950s ua tshuaj loog thiab tom qab ntawd tau muag ua kev kho mob rau cov poj niam cev xeeb tub mob plab thaum sawv ntxov. Txawm li cas los xij, nws tau raug rho tawm ntawm kev ua lag luam vim nws cuam tshuam nrog kev yug me nyuam tsis zoo. Txawm hais tias nws muaj keeb kwm tsis sib haum xeeb, thalidomide tau pom qhov chaw hauv kev kho mob niaj hnub no, tshwj xeeb tshaj yog hauv kev kho mob qee yam mob qog noj ntshav thiab mob o.

Kev siv ntawm Thalidomide

Thalidomide tau pom zoo rau ntau yam kev siv kho mob, suav nrog:

• Myeloma ntau yam: Thalidomide yog siv ua ib feem ntawm kev kho mob rau ntau yam myeloma, ib hom mob qog ntshav.
• Erythema Nodosum Leprosum (ENL): Nws zoo rau kev kho qhov mob ntawm daim tawv nqaij uas cuam tshuam nrog tus kab mob ruas no.
• Cov Mob Uas Muaj Feem Xyuam Nrog HIV: Thalidomide siv tau rau cov teeb meem ntsig txog HIV (piv txwv li, aphthous stomatitis).
• Kab Mob Sib Kis Los Ntawm Tus Neeg Mob Uas Muaj Tus Kab Mob Sib Kis: Nws siv tau rau GVHD tom qab hloov hlwb pob txha.

Nws Ua Haujlwm Li Cas?

Thalidomide ua haujlwm los ntawm ntau txoj hauv kev. Nws muaj cov khoom tiv thaiv kev o, uas pab txo qhov o thiab mob. Nws kuj tseem tiv thaiv kev loj hlob ntawm cov hlab ntsha tshiab (angiogenesis) uas cov qog nqaij hlav xav tau kom loj hlob. Tsis tas li ntawd, thalidomide hloov kho lub cev tiv thaiv kab mob, pab nws tawm tsam cov hlwb qog noj ntshav kom zoo dua.

Dosage thiab Administration

Cov tshuaj thalidomide ntau npaum li cas nyob ntawm seb tus mob twg kho:

• Myeloma ntau yam: Cov koob tshuaj pib feem ntau yog 100-200 mg noj ib zaug ib hnub (nrog rau dexamethasone raws li NCCN cov lus qhia); cov koob tshuaj yuav tsum tau ua raws li tus kheej.
• Erythema Nodosum Leprosum: Cov koob tshuaj ib txwm yog 100-300 mg txhua hnub; cov koob tshuaj yuav tsum tau kho raws li tus kheej.

Thalidomide muaj nyob rau hauv daim ntawv capsule thiab yuav tsum tau noj tib lub sijhawm txhua hnub, zoo dua thaum mus pw kom txo cov kev mob tshwm sim xws li qaug zog.

Cov Kev Mob Tshwm Sim ntawm Thalidomide

Cov teebmeem tshwm sim muaj xws li:

• Tsaus ntuj
• cem quav
• Qhuav ntawm daim tawv nqaij
• Qhib

Cov kev mob tshwm sim hnyav tuaj yeem suav nrog:

• Kev puas tsuaj rau cov hlab ntsha peripheral (kev puas tsuaj rau cov hlab ntsha)
• Neutropenia/ntshav tsawg tsawg
• Cov ntshav txhaws (qhov tob vein thrombosis lossis pulmonary embolism)
• Cov teeb meem yug los yog noj thaum cev xeeb tub

Tshuaj Kev Sib Thoob

Thalidomide tuaj yeem cuam tshuam nrog ntau yam tshuaj, suav nrog:

• Sedatives: Ua rau tsaug zog ntau ntxiv thaum noj nrog lwm cov tshuaj sedatives.
• Anti coagulants: Kev pheej hmoo ntawm kev los ntshav thaum ua ke nrog cov tshuaj ua kom cov ntshav nyias.
• Antiretrovirals (piv txwv li, didanosine): Tej zaum yuav cuam tshuam rau qhov ua tau zoo; kev sib cuam tshuam tseem ceeb kuj suav nrog cov tshuaj hormones tiv thaiv kev xeeb tub (kev ua tau zoo txo ​​qis), cov tshuaj proton twj tso kua mis inhibitors, thiab CYP1A2 inhibitors.

Qhia rau koj tus kws kho mob txog txhua yam tshuaj uas koj noj.

Cov txiaj ntsig ntawm Thalidomide

Thalidomide muaj ntau yam zoo rau kev kho mob:

• Kev kho mob zoo: Nws tau pom tias muaj txiaj ntsig zoo hauv kev kho mob ntau yam mob myeloma thiab ENL.
• Txhim Kho Lub Neej Zoo: Rau cov neeg mob uas muaj mob ntev, thalidomide tuaj yeem txo cov tsos mob thiab txhim kho kev noj qab haus huv tag nrho.
• Txoj Kev Ua Haujlwm Tshwj Xeeb: Nws lub peev xwm los hloov kho lub cev tiv thaiv kab mob muab txoj hauv kev sib txawv piv rau cov kev kho mob qog noj ntshav ib txwm muaj.

Cov kev tsis sib haum xeeb ntawm Thalidome

Yuav tsum tsis txhob siv Thalidomide rau qee cov pej xeem, xws li:

• Cov poj niam cev xeeb tub: Nws tuaj yeem ua rau muaj teeb meem loj heev rau menyuam yug los.
• Cov poj niam uas muaj peev xwm yug me nyuam: Yuav tsum siv kev tiv thaiv kom tsis txhob xeeb tub zoo thiab kuaj cev xeeb tub raws li iPLEDGE program (Tebchaws Meskas) thaum lub sijhawm kho mob.
• Cov neeg mob uas muaj kab mob siab heev: Tej zaum yuav ua rau cov teeb meem siab hnyav dua.

Ceev faj thiab Kev Ceeb Toom

Ua ntej pib siv thalidomide, cov neeg mob yuav tsum tau kuaj mob hauv chaw kuaj mob kom paub txog kev ua haujlwm ntawm daim siab thiab cov ntshav. Kev saib xyuas tas li yog qhov tseem ceeb rau kev tswj cov kev mob tshwm sim, tshwj xeeb tshaj yog cov kab mob peripheral neuropathy thiab cov ntshav txhaws. Cov neeg mob kuj yuav tsum tau kawm txog kev pheej hmoo ntawm kev cev xeeb tub thiab qhov tseem ceeb ntawm kev tiv thaiv kev xeeb tub.

FAQ

• Thalidomide siv rau dab tsi? Thalidomide tau txais kev pom zoo los ntawm FDA rau ntau yam mob myeloma thiab erythema nodosum leprosum (ENL), nrog rau kev siv tawm ntawm daim ntawv lo rau lwm yam mob.
• Thalidomide ua haujlwm li cas? Nws txo qhov o, tiv thaiv kev loj hlob ntawm qog, thiab hloov kho lub cev tiv thaiv kab mob.
• Cov kev phiv tshwm sim yog dab tsi? Cov kev mob tshwm sim feem ntau suav nrog qaug zog, raws plab, thiab tawv nqaij qhuav.
• Puas yog thalidomide ua rau muaj teeb meem yug me nyuam? Yog, thalidomide tuaj yeem ua rau muaj teeb meem loj heev rau menyuam yug los yog tias noj thaum cev xeeb tub.
• Kuv yuav tsum noj thalidomide li cas? Feem ntau nws noj hauv daim ntawv capsule, zoo dua thaum mus pw.
• Puas muaj kev sib tham nrog tshuaj? Yog, thalidomide tuaj yeem cuam tshuam nrog cov tshuaj sedatives thiab anticoagulants.
• Leej twg yuav tsum tsis txhob siv thalidomide? Cov poj niam cev xeeb tub, cov poj niam uas muaj peev xwm yug me nyuam tsis tau tiv thaiv kev xeeb tub, thiab cov neeg uas muaj kab mob siab hnyav yuav tsum tsis txhob noj.
• Kuv yuav tsum tau ceev faj dab tsi? Kev kuaj mob tsis tu ncua thiab kev tiv thaiv kom tsis txhob muaj menyuam yog qhov tseem ceeb thaum lub sijhawm kho mob.
• Puas yog thalidomide muaj kev nyab xeeb rau kev siv mus sij hawm ntev? Kev siv mus sij hawm ntev yuav tsum tau saib xyuas zoo vim muaj tej yam tshwm sim tsis zoo xws li mob neuropathy (txog li 50% ntawm kev pheej hmoo tag nrho).
• Kuv puas tuaj yeem tsum tsis txhob noj thalidomide tam sim ntawd? Ua ntej koj yuav tsum nres, nrog koj tus kws kho mob tham; maj mam txo qhov koob tshuaj kom tsis txhob rov qab zoo li qub hauv ENL.

Hom Lub Npe

Thalidomide muaj ntau hom lag luam, suav nrog:

• Thalomid
• Thalidomide (los ntawm Celgene/BMS); muaj cov tshuaj generic

xaus

Thalidomide muaj keeb kwm nyuaj tab sis tau tshwm sim los ua ib yam tshuaj muaj txiaj ntsig zoo rau kev kho cov mob tshwj xeeb xws li mob multiple myeloma thiab erythema nodosum leprosum. Txawm hais tias nws muaj txiaj ntsig zoo, nws kuj muaj kev pheej hmoo, tshwj xeeb tshaj yog rau cov poj niam cev xeeb tub. Cov neeg mob yuav tsum ua haujlwm nrog lawv cov kws kho mob kom ntseeg tau tias kev siv cov tshuaj no muaj kev nyab xeeb thiab zoo.