Pediatric Non Hodgkins Lymphoma

Paediatrics Non-Hodgkin's Lymphoma

Diagnosis

  • PET CT accesses spread to regional nodes or distant metastases to other body parts. It provides functional and morphological details by utilising radiation derived from Isotope labelled Glucose molecules to detect cellular glucose uptake, in cancer.
  • Lymph node biopsy - The lymph node may be removed during an image-guided CT scan thoracoscopy, mediastinoscopy or laparoscopy. They may remove the lymph node and send it for further evaluation.
  • Bone marrow aspiration and biopsy – In this procedure, a sample of bone marrow and a small piece of bone is collected by inserting a hollow needle into the hipbone or breastbone.
    • Blood Test - Complete blood count (CBC), Liver and Renal function tests.
    • Pathology - The tissue and marrow samples collected are sent for further evaluation, such as Histopathological examination (HPE), cytology and Immunohistochemistry (IHC), to determine the type of disease and its grading.
    • Immunohistochemistry - It uses antibodies to identify cancer cells based on the types of antigens or markers on the surface of the cells. This test helps diagnose specific types of lymphoma
    • Flow cytometry - A laboratory test that measures the number of cells in a sample, the percentage of live cells in a sample, and specific characteristics of the cells, such as size, shape, and the presence of tumour (or other) markers on the cell surface.
    • Chromosomal Testing - Cytogenetic analysis, FISH - Fluorescence in situ hybridization
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