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Symptoms depend on the phase of the disease. For example,CML has three phases: chronic, accelerated, and blast.
- Chronic phase – It is the earliest stage and the easiest to treat. During this period, there may be no or few symptoms of leukaemia. This phase can last several months to several years.
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Accelerated phase - In this period, more blast cells are found in the blood and bone marrow. The presence of blast cells indicates the disease is becoming more aggressive or advanced. Symptoms may include:
- Night sweats Anaemia
- Fatigue
- Shortness of breath
- Infections and Fever
- Easy bruising and bleeding
- Frequent or severe nosebleeds
- Bleeding gums
- Bone or joint pain
- Abdominal pain or swelling on the left side (which could be a sign of an enlarged spleen
- Loss of appetite and weight loss
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Blast Phase -Leukaemia cells multiply and crowd healthy blood cells and platelets. During this phase, more than 30 percent of bone marrow cells are blast cells. This phase of CML can be complicated to differentiate from acute lymphoblastic leukaemia (ALL).
In this stage, symptoms may be more severe such as:
- Infections Bleeding
- Skin changes with small bumps
- Swollen glands
- Bone pain