• Sex- Men are at a higher risk
• Age- More common in people over the age of 60
• Smoking increases the risk
• Alcohol Consumption
• Diet - Diets high in red meat and salted or smoked foods increases the risk of small intestine cancer
• Inherited syndromes - People with certain inherited conditions like
• Familial adenomatous polyposis (FAP)
• Peutz-Jeghers syndrome (PJS)
• Hereditary nonpolyposis colon cancer (HNPCC)
• Autoimmune Conditions - Autoimmune inflammatory bowel diseases like Crohn’s Disease and Celiac sprue increase the risk of small bowel cancers
• Immunosuppression - People who are immunosuppressed (post-organ transplant or in conditions like HIV) are at a higher risk of developing Jejunal cancers.