• Age: Most cases of anal cancer occur in people over the age of 50 years
• Human papillomavirus (HPV): Infection with the Human Papillomavirus (HPV).
• Patients with a weakened immune system caused by HIV or an organ transplant.
• History of cancer: Those who have had cervical, vulvar or vaginal cancer have an increased risk of anal cancer.
• Promiscuity - People who have many sexual partners over their lifetime have a greater risk of anal cancer.
• Anal Sex: People who engage in receptive anal sex have an increased risk of anal cancer.
• Smoking: Smoking cigarettes may increase your risk of anal cancer.