Ziprasidone - Ntchito, Mlingo, Zotsatirapo ndi Zina

Chiyambi: Kodi Ziprasidone ndi chiyani?

Ziprasidone ndi mankhwala achilendo oletsa matenda amisala omwe amagwiritsidwa ntchito makamaka pochiza matenda amisala ndi matenda a bipolar. Amagwira ntchito pokhudza ntchito ya ma neurotransmitters ena muubongo, makamaka dopamine ndi serotonin. Amapezeka m'kamwa komanso m'njira zobayira jakisoni (yomwe imavomerezedwa kuti igwiritsidwe ntchito pochiza matenda amisala ndi bipolar mania), ziprasidone nthawi zambiri imaperekedwa kuti ichepetse kusokonezeka kwadzidzidzi komanso zizindikiro za nthawi yayitali za matenda amisala kapena amisala.

Kugwiritsa ntchito Ziprasidone

Ziprasidone imavomerezedwa kuti igwiritsidwe ntchito pochiza matenda osiyanasiyana amisala, kuphatikizapo:

• Schizophrenia: Amagwiritsidwa ntchito kuchepetsa malingaliro olakwika, kuganiza molakwika, komanso kuganiza molakwika.
• Matenda a Bipolar: Amalembedwa kuti azisamalira zochitika zamisala kapena zosakanikirana, kaya payekha kapena pamodzi ndi zinthu zolimbitsa maganizo.
• Kusokonezeka Kwambiri mu Schizophrenia ndi Bipolar Mania: Mitundu yobayira jakisoni imagwiritsidwa ntchito m'malo azachipatala kuti muchepetse kusokonezeka kwakukulu mwachangu.
• Ntchito Zopanda Chizindikiro: Nthawi zina amagwiritsidwa ntchito (motsogozedwa ndi dokotala) pa matenda ena monga kuvutika maganizo kapena matenda a borderline personality disorder.

Kodi Ntchito?

Ziprasidone imagwira ntchito posintha kuchuluka kwa ma neurotransmitters dopamine ndi serotonin muubongo. Imagwira ntchito ngati mdani pa ma D2 dopamine receptors ndi ma 5HT2A serotonin receptors, kuthandiza kuchepetsa zizindikiro za psychotic ndikukhazikitsa malingaliro. Imakhalanso ndi agonist ena pa ma 5HT1A receptors, zomwe zingathandize kuti ikhale ndi mphamvu zoletsa kupsinjika maganizo komanso nkhawa.

Mlingo ndi Utsogoleri

Ziprasidone imapezeka ngati makapisozi akumwa ndi jakisoni wa m'mitsempha (IM). Mlingo umasiyana malinga ndi vuto lomwe likuchiritsidwa:

• Schizophrenia (Kukamwa): Mlingo woyambirira nthawi zambiri umakhala 20 mg kawiri patsiku (40 mg patsiku) ndi chakudya; ukhoza kuwonjezeredwa mpaka 80 mg kawiri patsiku (160 mg patsiku).
• Matenda a Bipolar (Oral): Kawirikawiri amayamba ndi 40 mg kawiri patsiku, ndipo nthawi zina amatha kuwonjezeredwa mpaka 80 mg kawiri patsiku.
• Kukwiya Kwambiri (Im Injection): Kawirikawiri 10 mg IM maola awiri aliwonse kapena 20 mg IM maola anayi aliwonse ngati pakufunika, mpaka 40 mg patsiku.

Nthawi zonse imwani ziprasidone pamodzi ndi chakudya kuti muwonjezere kuyamwa ndi kugwira ntchito bwino. Tsatirani malangizo a dokotala wanu mosamala.

Zotsatirapo za Ziprasidone

Zotsatira Zogwirizana

• Kugona kapena kugona tulo
• Chizungulire kapena kuwala pang'ono
• nseru
• Kusakhazikika kapena kupindika
• Kutupa kapena kukwiya kwa khungu

Zovuta Kwambiri

• Kutalikitsa nthawi kwa QT (vuto la mtima)
• Matenda a Neuroleptic Malignant (vuto lomwe lingayambitse imfa)
• Tardive dyskinesia (kusuntha kosafunikira)
• Kuwonjezeka kwa chiopsezo cha matenda a mitsempha ya ubongo (monga sitiroko) kapena imfa mwa odwala okalamba omwe ali ndi matenda amisala okhudzana ndi dementia
• Maganizo kapena machitidwe odzipha (makamaka kwa odwala achichepere)

Funani thandizo lachipatala mwamsanga ngati mukumva kupweteka pachifuwa, kukomoka, kuuma kwa minofu kwambiri, kutentha thupi kwambiri, kapena kugunda kwa mtima kosakhazikika.

Kuyanjana kwa Mankhwala

Ziprasidone ikhoza kuyanjana ndi mankhwala angapo:

• Mankhwala oletsa kupweteka kwa mtima, oletsa kupsinjika maganizo, ndi oletsa matenda amisala: Angawonjezere chiopsezo cha kutalikitsa nthawi ya QT.
• Mankhwala oletsa kuvutika maganizo a CNS (monga mowa, benzodiazepines): Angawonjezere mphamvu zotonthoza.
• Carbamazepine: Ikhoza kuchepetsa kuchuluka kwa ziprasidone ndi mphamvu yake.
• Mankhwala amphamvu oletsa CYP3A4 (monga ketoconazole, erythromycin): Angawonjezere kuchuluka kwa ziprasidone m'magazi.

Nthawi zonse dziwitsani dokotala wanu za mankhwala onse ndi zowonjezera zomwe mukumwa kuti mupewe kuwononga thanzi lanu.

Ubwino wa Ziprasidone

• Zothandiza pa matenda a schizophrenia ndi bipolar mania
• Chiwopsezo chochepa cha kunenepa poyerekeza ndi mankhwala ena oletsa matenda amisala
• Kuchepetsa kuchuluka kwa shuga m'magazi ndi cholesterol
• Amapezeka m'njira zonse zapakamwa komanso zobaya
• Zotsatira zomwe zingatheke chifukwa cha kupsinjika maganizo kudzera mu ntchito ya serotonin receptor

Zotsutsana za Ziprasidone

Ziprasidone sayenera kugwiritsidwa ntchito pazochitika zotsatirazi:

• Kudziwa bwino za hypersensitivity ku ziprasidone
• Mbiri ya QT prolongation kapena congenital long QT syndrome
• Matenda a mtima aposachedwa kapena kulephera kwa mtima kosalipidwa
• Kugwiritsa ntchito nthawi imodzi mankhwala owonjezera nthawi ya QT

Kusamala ndi machenjezo

Musanagwiritse ntchito ziprasidone, ganizirani izi:

• Kuwunika kwa ECG: Ganizirani za ECG yoyambira mwa odwala omwe ali ndi chiopsezo cha mtima; yang'anirani panthawi ya chithandizo ngati nthawi ya QTc yawonjezeka.
• Gwiritsani ntchito kwa Okalamba: Sizivomerezedwa pa matenda amisala okhudzana ndi matenda amisala chifukwa cha chiopsezo chowonjezeka cha imfa.
• Mimba ndi Kuyamwitsa: Gwiritsani ntchito pokhapokha ngati pakufunika kutero. Kambiranani ndi dokotala za zoopsa zake.
• Chiwindi ndi Impso Ntchito: Zingafunike kusintha mlingo.

Ibibazo

• Kodi ziprasidone ndi yotetezeka kugwiritsidwa ntchito kwa nthawi yayitali? Inde, ndi kuyang'aniridwa nthawi zonse. Nthawi zambiri imagwiritsidwa ntchito nthawi zonse pa matenda a schizophrenia ndi bipolar disorder.
• Kodi ziprasidone ingayambitse kunenepa kwambiri? Ali ndi chiopsezo chochepa cha kunenepa poyerekeza ndi mankhwala ena achilendo a antipsychotic.
• Kodi ndiyenera kumwa ziprasidone pamodzi ndi chakudya? Inde. Chakudya chimathandiza kwambiri kuyamwa kwake ndi kugwira ntchito bwino.
• Kodi mankhwala a ziprasidone amayambitsa chizolowezi? Ayi, sizimaonedwa kuti ndi zoledzeretsa.
• Kodi ndingathe kumwa mowa ndili ndi ziprasidone? Ndi bwino kupewa kumwa mowa, chifukwa kungapangitse kuti munthu agone komanso adwale matenda ena.
• Kodi ziprasidone imayamba kugwira ntchito nthawi yayitali bwanji? Zizindikiro zina zimatha kuchira pakatha masiku ochepa, koma zotsatira zake zonse zimatha kutenga milungu ingapo.
• Kodi ziprasidone ingagwiritsidwe ntchito pochiza matenda a maganizo? Sichivomerezedwa, koma nthawi zina chimagwiritsidwa ntchito ngati chithandizo chowonjezera pansi pa kuyang'aniridwa.
• Kodi chimachitika ndi chiyani ndikaphonya mlingo? Imwani nthawi yomweyo mukakumbukira. Ngati mlingo wanu wotsatira uli pafupi, siyani womwe munaphonya. Musawonjezere kawiri.
• Kodi ndingasiye kugwiritsa ntchito ziprasidone mwadzidzidzi? Ayi. Kusiya mwadzidzidzi kungayambitse zizindikiro zosiya kumwa kapena kubwereranso kwa zizindikirozo. Nthawi zonse chepetsani motsogozedwa ndi dokotala.
• Kodi mayeso a ECG ndi ofunikira? Sikoyenera, makamaka poyamba kwa odwala omwe ali ndi vuto la mtima, kuti aone zoopsa za kugunda kwa mtima.

Mayina A Brand

Mayina odziwika bwino a ziprasidone ndi awa:

• Geodon (US)
• Zeldox (padziko lonse lapansi)

Mankhwala opangidwa ndi anthu wamba amapezekanso kwambiri.

Kutsiliza

Ziprasidone ndi mankhwala a m'badwo wachiwiri oletsa matenda amisala omwe amachiza bwino matenda a schizophrenia ndi bipolar, makamaka kwa anthu omwe akuda nkhawa ndi kunenepa kwambiri kapena mavuto a kagayidwe kachakudya m'thupi. Ngakhale kuti nthawi zambiri amaloledwa, amafunika kuyang'aniridwa mosamala kuti aone zotsatirapo zoyipa zokhudzana ndi mtima ndipo ayenera kugwiritsidwa ntchito moyang'aniridwa ndi dokotala. Ziprasidone ikamwedwa monga momwe adalangizidwira, imatha kusintha kwambiri moyo wa anthu omwe ali ndi matenda amisala.