Progesterone

Progesterone ndi mahomoni achilengedwe opangidwa ndi mazira, ma adrenal glands, ndi placenta panthawi ya mimba. Imagwira ntchito yofunika kwambiri poyendetsa ntchito zosiyanasiyana m'thupi, makamaka m'njira yoberekera ya akazi. Progesterone ndi yofunika kwambiri pokonzekera chiberekero kuti chikhale ndi mimba, kusunga mimba, komanso kuwongolera nthawi ya msambo. Imapezekanso ngati mankhwala ochizira matenda osiyanasiyana okhudzana ndi kusalingana kwa mahomoni.

Mankhwala a progesterone amabwera m'mitundu iwiri ikuluikulu: progesterone yachilengedwe (yofanana ndi mahomoni amthupi, nthawi zambiri mkamwa kapena m'chikazi) ndi ma progestin opangidwa (mitundu yopangidwa ndi anthu yokhala ndi zotsatira zosiyanasiyana). Zotsatirapo ndi zochita zimatha kusiyana pakati pawo, kotero si mitundu yonse yomwe ingasinthidwe nthawi zonse? Nthawi zonse tsatirani malangizo enieni a mankhwala ochokera kwa dokotala wanu.

Ntchito za Progesterone

Progesterone ili ndi njira zingapo zovomerezeka zachipatala, kuphatikizapo:

• Chithandizo cha Ma Hormone Replacement (HRT): Amagwiritsidwa ntchito limodzi ndi estrogen kuti achepetse zizindikiro za kusamba komanso kuchepetsa chiopsezo cha khansa ya endometrial mwa amayi omwe ali ndi chiberekero chosawonongeka.
• Matenda a Msambo: Amachiza matenda osakhazikika a msambo komanso matenda monga kusakhalapo kwa msambo (kusakhalapo kwa msambo).
• Chithandizo cha Kusabereka: Zimathandizira gawo la luteal mwa akazi omwe akugwiritsa ntchito njira zothandizira kubereka, monga feteleza ya in-vitro (IVF).
• Kupewa Kubadwa Nthawi Isanakwane: Amaperekedwa kwa amayi omwe ali ndi mbiri yobereka nthawi isanakwane kuti athandize kukhala ndi pakati.
• Endometrial hyperplasia: Amagwiritsidwa ntchito popewa kapena kuchiza vutoli, lomwe limakhudza kukhuthala kwa chiberekero.

Kodi Progesterone Imagwira Ntchito Bwanji?

Progesterone imagwira ntchito polumikizana ndi ma receptors enaake m'thupi, makamaka m'chiberekero ndi minofu ya m'mawere. Pamene kuchuluka kwa progesterone kukukwera, imakonzekeretsa dzira lokhala ndi umuna, zomwe zimapangitsa kuti likhale lovomerezeka bwino kuti liyikidwe. Ngati mimba sichitika, kuchuluka kwa progesterone kumatsika. Izi zimayambitsa nthawi ya msambo. Kuphatikiza apo, progesterone imagwira ntchito ngati neurosteroid muubongo, kuthandiza kuwongolera mahomoni ena ndikuthandizira ntchito monga kukhazikika kwa malingaliro panthawi ya kusintha kwa mahomoni ndikukhala ndi mimba yathanzi.

Mlingo ndi Utsogoleri

Mlingo ndi kaperekedwe ka progesterone zimasiyana malinga ndi momwe zinthu zilili:

• Chithandizo cha Ma Hormone Replacement: Kawirikawiri, 200 mg ya progesterone imatengedwa pakamwa asanagone kwa masiku 12 pamwezi.
• Matenda a Msambo: Mlingo ukhoza kuyambira 5 mpaka 10 mg patsiku kwa masiku 10 mpaka 14, kutengera ndi vuto lenilenilo.
• Chithandizo cha Kusabereka: Kawirikawiri, 100 mpaka 200 mg imaperekedwa kudzera mu intramuscularly kapena ngati njira yolowetsera m'mimba tsiku lililonse, kuyambira ovulation itatha.
• Kupewa Kubereka Mwana Asanakwane Nthawi: Mlingo wofala kwambiri ndi jakisoni wa progesterone wa 250 mg mlungu uliwonse, kuyambira masabata 16 a mimba.

Mlingo wonse umaperekedwa ngati mg/tsiku pokhapokha ngati tatchulapo mwanjira ina, ndipo kuchuluka kwenikweni kumatha kusiyana malinga ndi mankhwala. Chifukwa mitundu yosiyanasiyana ya progesterone, vaginal, kapena jakisoni imakhala ndi mayamwidwe osiyanasiyana ndi zotsatira zake; sizingasinthidwe. Gwiritsani ntchito fomu yokhayo yomwe mwapatsidwa ndipo nthawi zonse tsatirani malangizo a dokotala wanu a mlingo ndi kaperekedwe kake.

Zotsatirapo za Progesterone

Zotsatira zoyipa zomwe progesterone imabweretsa zingaphatikizepo:

• kutopa
• chizungulire
• litsipa
• nseru
• Chikondi cha m'mimba
• Maonekedwe amasintha

Zotsatira zoyipa zingaphatikizepo:

• Magazi amatha
• Matenda a chiwindi
• Matenda oopsa a ziwengo (monga kupuma movutikira, kutupa kwa nkhope/milomo/lilime, kapena ziphuphu)
• Kutuluka magazi kwachilendo kumaliseche

Ngati mukukumana ndi zovuta zilizonse, pitani kuchipatala mwamsanga.

Kuyanjana kwa Mankhwala

Progesterone imatha kuyanjana ndi mankhwala ndi zinthu zingapo, kuphatikizapo:

• Mankhwala oletsa magazi kuundana (akhoza kusokoneza magazi kuundana)
• Mankhwala oletsa kupweteka kwa m'mimba omwe amachititsa ma enzyme monga phenytoin (amachepetsa kuchuluka kwa progesterone)
• St. John? Wort (imayambitsa enzyme ya CYP3A4, kuchepetsa mphamvu ya progesterone)
• Corticosteroids (ingawonjezere mphamvu ya progesterone)

Nthawi zonse dziwitsani dokotala wanu za mankhwala ndi zowonjezera zomwe mumamwa.

Ubwino wa Progesterone

Ubwino wamankhwala komanso wothandiza wogwiritsa ntchito progesterone ndi monga:

• Kuwongolera Kayendedwe ka Msambo: Zimathandiza kubwezeretsa machitidwe abwinobwino a msambo mwa akazi omwe ali ndi nthawi zosakhazikika.
• Chithandizo cha mimba: Chofunika kwambiri kuti mimba ikhale yabwino komanso kuchepetsa chiopsezo cha kutaya mimba.
• Kuchepetsa Zizindikiro za Kusiya Msambo: Amachepetsa zizindikiro zokhudzana ndi kusamba, monga kutentha thupi komanso kusintha kwa maganizo.
• Chitetezo cha Endometrium: Amachepetsa chiopsezo cha endometrial hyperplasia ndi khansa mwa akazi omwe amatenga estrogen.

Zotsutsana za Progesterone

Progesterone siilimbikitsidwa kwa anthu ena, kuphatikizapo:

• Anthu omwe ali ndi mbiri ya magazi kuundana kapena sitiroko.
• Anthu omwe ali ndi matenda a chiwindi kapena zotupa za chiwindi.
• Azimayi omwe ali ndi magazi otuluka m'mimba omwe sanadziwike.
• Anthu omwe ali ndi vuto la progesterone kapena chilichonse mwa zigawo zake.

Nthawi zonse funsani dokotala wanu kuti mudziwe ngati progesterone ndi yotetezeka kwa inu.

Kusamala ndi machenjezo

Musanagwiritse ntchito progesterone, ganizirani njira zotsatirazi zodzitetezera:

• Mbiri Yachipatala: Uzani dokotala wanu za mbiri yanu kapena ya banja lanu ya magazi oundana, matenda a chiwindi, kapena khansa yomwe imakhudzidwa ndi mahomoni.
• Kuyang'anira Nthawi Zonse: Dokotala wanu angakulangizeni kuti muyezedwe nthawi zonse komanso muyesedwe la labu kuti muwone kuchuluka kwa mahomoni anu komanso thanzi lanu lonse.
• Mimba: Progesterone nthawi zambiri imakhala yotetezeka panthawi ya mimba koma nthawi zonse kambiranani za kugwiritsa ntchito kwake ndi dokotala wanu.

Ibibazo

• Kodi Progesterone imagwiritsidwa ntchito bwanji? Progesterone imagwiritsidwa ntchito pokonza nthawi ya msambo, kuthandizira mimba, komanso kuchepetsa zizindikiro za kusamba.
• Kodi Progesterone imaperekedwa bwanji? Ikhoza kumwedwa pakamwa, kubayidwa jekeseni, kapena kugwiritsidwa ntchito ngati cholowetsa m'mimba, kutengera vuto lomwe likuchiritsidwa.
• Kodi zotsatirapo zoyipa za Progesterone ndi ziti? Zotsatirapo zoyipa zomwe zimapezeka kawirikawiri ndi kutopa, chizungulire, mutu, nseru, kupweteka kwa mabere, komanso kusintha kwa malingaliro. Zotsatirapo zoyipa kwambiri zitha kuphatikizapo magazi kuundana.
• Kodi ndingatenge Progesterone ngati ndili ndi pakati? Progesterone nthawi zambiri imaperekedwa panthawi ya mimba kuti ithandizire mkati mwa chiberekero koma funsani dokotala kaye.
• Kodi Progesterone imagwira ntchito bwanji? Zimakonzekeretsa chiberekero kuti chikhale ndi pakati ndipo zimawongolera nthawi ya msambo pokhudza kuchuluka kwa mahomoni.
• Kodi pali kuyanjana kulikonse pakati pa mankhwala ndi Progesterone? Inde, imatha kuyanjana ndi mankhwala oletsa magazi kuundana, mankhwala oletsa kupweteka mutu, ndi mankhwala owonjezera azitsamba monga St. John? Wort.
• Ndani ayenera kupewa Progesterone? Anthu omwe ali ndi mbiri ya magazi kuundana, matenda a chiwindi, kapena khansa zina ayenera kupewa izi.
• Kodi Progesterone imatenga nthawi yayitali bwanji kuti igwire ntchito? Zotsatira zake zimatha kusiyana, koma akazi ambiri amaona kusintha kwa nthawi yawo ya msambo mkati mwa miyezi ingapo.
• Kodi Progesterone ingathandize ndi kusabereka? Inde, nthawi zambiri imagwiritsidwa ntchito pothandizira gawo la luteal mwa akazi omwe akulandira chithandizo cha chonde.
• Kodi Progesterone ndi yotetezeka kugwiritsidwa ntchito kwa nthawi yayitali? Kugwiritsa ntchito mankhwalawa kwa nthawi yayitali kuyenera kuyang'aniridwa ndi dokotala kuti athetse zoopsa zomwe zingachitike.

Mayina A Brand

Mayina ena akuluakulu a Progesterone ndi awa:

• Prometrium
• Crinone
• Endometrin
• Prochieve

Kutsiliza

Progesterone ndi mahomoni ofunikira kwambiri omwe ali ndi ntchito yofunika kwambiri pa kubereka kwa akazi komanso thanzi lawo lonse. Amagwiritsidwa ntchito pochiza matenda osiyanasiyana, kuphatikizapo matenda a msambo, kusabereka, ndi zizindikiro za kusamba. Kumvetsetsa momwe amagwiritsidwira ntchito, ubwino wake, ndi zotsatirapo zake kungathandize odwala kupanga zisankho zolondola zokhudza thanzi lawo. Nthawi zonse funsani dokotala musanayambe mankhwala aliwonse kuti muwonetsetse kuti ndi oyenera zosowa zanu.