Rufinamide - Ntchito, Mlingo, Zotsatirapo ndi Zina

Chiyambi: Kodi Rufinamide ndi chiyani?

Rufinamide ndi mankhwala oletsa khunyu omwe amagwiritsidwa ntchito makamaka pochiza khunyu lokhudzana ndi matenda a Lennox-Gastaut, mtundu woopsa wa khunyu womwe nthawi zambiri umayamba ali mwana. Yovomerezedwa ndi FDA mu 2008, Rufinamide imathandiza kuthana ndi khunyu zomwe zimakhala zovuta kuzilamulira ndi mankhwala ena. Imapezeka mu mawonekedwe a mapiritsi komanso ngati chotsukira pakamwa, zomwe zimapangitsa kuti ikhale yogwiritsidwa ntchito ndi akuluakulu ndi ana.

Ntchito za Rufinamide

Rufinamide imagwiritsidwa ntchito makamaka pochiza khunyu lokhudzana ndi matenda a Lennox-Gastaut. Matendawa amadziwika ndi mitundu yosiyanasiyana ya khunyu, kuchedwa kukula, komanso kulephera kuzindikira. Rufinamide nthawi zambiri imagwiritsidwa ntchito limodzi ndi mankhwala ena oletsa khunyu kuti athandize kuchepetsa khunyu ndikukweza moyo wa odwala.

Kodi Ntchito?

Rufinamide imagwira ntchito pokhazikitsa mphamvu zamagetsi muubongo. Imachita izi mwa kuletsa njira zina za sodium, zomwe zimayambitsa kuphulika kwa ma neuron mwachangu zomwe zingayambitse khunyu. Mwa kusintha njirazi, Rufinamide imathandiza kuchepetsa kuchuluka ndi kuopsa kwa khunyu, kupereka mpumulo kwa omwe akukhudzidwa ndi khunyu.

Mlingo ndi Utsogoleri

Mlingo wa Rufinamide umasiyana malinga ndi zaka, kulemera, ndi momwe munthu amayankhira mankhwalawo.

Akuluakulu:

Mlingo woyambira wamba ndi 400 mg/tsiku, womwe ungawonjezedwe kufika pa 1,600 mg/tsiku, wogawidwa m'milingo iwiri.

Odwala Ana:

Kwa ana azaka 4 kapena kuposerapo, mlingo woyambira nthawi zambiri umadalira kulemera kwa thupi, kuyambira pa 10 mg/kg/tsiku, ndipo ukhoza kusinthidwa ngati pakufunika.

Rufinamide imatengedwa pakamwa, kaya ngati piritsi kapena mankhwala opangidwa pakamwa, ndipo iyenera kumwedwa pamodzi ndi chakudya kuti iwonjezere kuyamwa. Ndikofunikira kutsatira malangizo a dokotala okhudza mlingo ndi kuchuluka kwa mankhwalawa.

Zotsatirapo za Rufinamide

Monga mankhwala ena onse, Rufinamide ingayambitse zotsatirapo zoyipa. Zotsatirapo zoyipa zomwe zimachitika nthawi zambiri ndi izi:

• kugona
• kutopa
• nseru
• kusanza
• Kutaya njala

Zotsatira zoyipa zingaphatikizepo:

• Zotsatira zoyipa kwambiri (zidzolo, kuyabwa, kutupa)
• Kusintha kwa malingaliro kapena machitidwe
• Malingaliro kapena zochita zodzipha
• Mavuto a chiwindi (monga jaundice, omwe amawonetsedwa ndi kusintha kwa khungu kapena maso)

Odwala ayenera kuuza dokotala wawo za zizindikiro zilizonse zachilendo mwamsanga.

Kuyanjana kwa Mankhwala

Rufinamide imatha kuyanjana ndi mankhwala angapo, zomwe zingakhudze mphamvu yake kapena kuonjezera chiopsezo cha zotsatirapo zake. Kuyanjana kwakukulu kwa mankhwala ndi monga:

• Mankhwala ena oletsa khunyu (monga carbamazepine, phenytoin, phenobarbital)
• Mankhwala oletsa kubereka pogwiritsa ntchito mahomoni (angathandize kuchepetsa mphamvu ya mankhwala)
• Maantibayotiki ena (monga rifampin)

Ndikofunikira kudziwitsa dokotala wanu za mankhwala onse, zowonjezera, ndi mankhwala azitsamba omwe mukumwa kuti mupewe kuyanjana komwe kungachitike.

Ubwino wa Rufinamide

Rufinamide ili ndi ubwino wambiri:

• Kulamulira bwino khunyu: Zawonetsedwa kuti zimachepetsa kwambiri kuchuluka kwa khunyu mwa odwala omwe ali ndi matenda a Lennox-Gastaut.
• Kulekerera bwino: Odwala ambiri amalekerera bwino Rufinamide, ndipo zotsatira zake zimakhala zovuta.
• Mlingo wosinthasintha: Imapezeka m'mapiritsi ndi m'madzimadzi, imatha kupangidwa kuti ikwaniritse zosowa za odwala osiyanasiyana, kuphatikizapo ana.

Zotsutsana za Rufinamide

Anthu ena ayenera kupewa kugwiritsa ntchito Rufinamide, kuphatikizapo:

• Anthu omwe amadziwika kuti ali ndi vuto la kusagwirizana ndi Rufinamide kapena chilichonse mwa zigawo zake.
• Odwala omwe ali ndi matenda aakulu a chiwindi, chifukwa cha deta yochepa komanso kuthekera koyipa kwa ntchito ya chiwindi.
• Amayi oyembekezera kapena oyamwitsa ayenera kufunsa dokotala wawo, chifukwa zotsatira zake pa mwana wosabadwayo kapena khanda sizikumveka bwino.

Kusamala ndi machenjezo

Odwala asanayambe kugwiritsa ntchito Rufinamide ayenera kuyesedwa bwino ndi dokotala. Zofunikira zodzitetezera ndi izi:

• Kuyang'anira ntchito ya chiwindi nthawi zonse, makamaka kwa odwala omwe ali ndi matenda a chiwindi.
• Kuwunika mbiri iliyonse ya matenda a maganizo kapena maganizo ofuna kudzipha.
• Chenjezo kwa odwala omwe ali ndi mbiri ya ziwengo ku mankhwala.

Ibibazo

• Kodi Rufinamide imagwiritsidwa ntchito pa chiyani? Rufinamide imagwiritsidwa ntchito pochiza khunyu lokhudzana ndi matenda a Lennox-Gastaut, mtundu woopsa wa khunyu.
• Kodi Rufinamide imagwira ntchito bwanji? Zimakhazikitsa mphamvu zamagetsi muubongo mwa kuletsa njira za sodium, kuchepetsa kuchuluka kwa khunyu.
• Zotsatira zoyipa zomwe zimachitika nthawi zambiri ndi zotani? Zotsatirapo zoyipa zomwe zimachitika nthawi zambiri ndi kugona, kutopa, nseru, komanso kusowa chilakolako cha chakudya.
• Kodi Rufinamide ingagwiritsidwe ntchito limodzi ndi mankhwala ena? Inde, koma ndikofunikira kudziwitsa dokotala wanu za mankhwala onse omwe mukumwa kuti mupewe kuyanjana ndi mankhwala ena.
• Kodi ndingatani ndikaphonya mlingo? Imwani mlingo womwe mwaphonya mwamsanga mukangokumbukira koma musaugwiritse ntchito ngati nthawi yatsala pang'ono kuyamba mlingo wotsatira. Musawonjezere kawiri.
• Kodi Rufinamide ndi yotetezeka panthawi ya mimba? Funsani dokotala wanu, chifukwa zotsatira zake pa mimba sizikumveka bwino.
• Kodi Rufinamide iyenera kumwedwa bwanji? Iyenera kumwedwa pakamwa pamodzi ndi chakudya, kaya ngati piritsi kapena chotsukira pakamwa.
• Bwanji ngati ndikumana ndi zotsatira zoyipa? Lumikizanani ndi dokotala wanu nthawi yomweyo ngati mukukumana ndi vuto lalikulu la ziwengo kapena kusintha kwa maganizo.
• Kodi Rufinamide ingakhudze momwe ndimamvera mumtima mwanga? Inde, odwala ena angasinthe momwe akumvera kapena khalidwe lawo. Uzani dokotala wanu nkhawa zilizonse.
• Kodi Rufinamide imagwira ntchito nthawi yayitali bwanji? Zingatenge milungu ingapo kuti muwone ubwino wonse wa Rufinamide pochepetsa khunyu.

Mayina A Brand

Rufinamide imagulitsidwa pansi pa mayina angapo a makampani, kuphatikizapo:

• Banzel
• Inovelon (m'madera ena)

Kutsiliza

Rufinamide ndi mankhwala othandiza kwambiri pochiza khunyu chifukwa cha matenda a Lennox-Gastaut. Kagwiridwe kake ka ntchito, njira zogwiritsira ntchito bwino, komanso zotsatira zake zabwino zimapangitsa kuti ikhale njira yofunika kwambiri kwa odwala ndi opereka chithandizo chamankhwala. Komabe, monga mankhwala ena aliwonse, ndikofunikira kugwiritsa ntchito Rufinamide motsogozedwa ndi katswiri wa zaumoyo kuti muwonetsetse kuti ndi yotetezeka komanso yogwira ntchito.