CAR-T Cell Therapy kwizibhedlele Apollo, Lucknow

Kutheni Izigulana Zikhetha Izibhedlele zaseApollo Ukuze Zifumane Unyango Lweeseli zeCAR-T

• Ilifa leminyaka engaphezu kwama-40: Iqela lee-Apollo Hospitals laqala ngo-1983 eChennai kwaye namhlanje lisebenza enye yezona nethiwekhi zinkulu zezempilo ezidibeneyo e-Asia, ezinezibhedlele ezingaphezu kwama-70 kunye namava eqela lonke okunyanga izigulana ezivela kumazwe angaphezu kwe-120.
• Isibhedlele i-Apollomedics Super Specialty, eLucknow: Isikhungo semfundo ephakamileyo esinobuchwephesha obuphezulu e-Uttar Pradesh esinamasebe azinikeleyo kwi-Medical Oncology, i-Haemato-Oncology, i-Bone Marrow Transplant, i-Radiation Oncology kunye ne-Surgical Oncology esebenza njengebhodi enye ye-tumor.
• Iqela le-CAR-T elinamacandelo amaninzi: Iingcali ze-Hemato-oncologists, oogqirha bokufakelwa izitho, iingcali zonyango lokufaka igazi kunye ne-apheresis, iingcali zokuqina kwentliziyo, iingcali ze-neurologists, abacebisi bezifo ezisulelayo, iingcali ze-pharmacologist zonyango, abahlengikazi bokufakelwa izitho kunye neengcali zokutya. Inani elichanekileyo labacebisi abanxulumene nenkqubo ye-CAR-T kunye neminyaka yabo yamava yabelwana ngalo ngumququzeleli we-oncology xa ubhukisha, kuba iphaneli iyatshintsha ngokuhamba kwexesha.
• I-Apheresis kunye nokukwazi ukucubungula iiseli: I-Leukapheresis yokuqokelelwa kweeseli ze-T, ukuphathwa okulungele ukugcinwa, kunye nokunxibelelana namaqabane anelayisenisi okuvelisa i-CAR-T eIndiya.
• Iibhedi ze-BMT ezihluziweyo ze-HEPA kunye neebhedi zokwahlukanisa kunye neyunithi yokhathalelo olubalulekileyo enamava ekulawuleni i-cytokine release syndrome (CRS) kunye ne-ICANS (i-immune effector cell-associated neurotoxicity syndrome), kunye ne-tocilizumab kunye ne-steroid protocols kunye ne-24x7 intensivist cover.
• Ubunzulu bokuxilongwa phantsi kophahla olunye: I-Flow cytometry, i-immunophenotyping, i-cytogenetics, uvavanyo lwe-molecular kunye ne-MRD, i-PET-CT, ibhanki yegazi engama-24x7 enezixhobo ezikhanyisiweyo kunye ne-leucodepleted.
• Iinkqubo ezenzelwe abantu abaneminyaka yobudala: Iindlela ze-hemato-oncology zabantwana kunye nabakwishumi elivisayo ze-B-cell ALL, iindlela ezahlulwe ngabantu abadala ze-lymphoma kunye ne-myeloma, kunye nendlela yokuvavanya abantu abadala abagulayo abaneengxaki ezifanayo.
• Ukufikelela kwi-CAR-T eyenziwe eIndiya: Iimveliso zaseIndiya ezivunyiweyo yi-CDSCO ezifana ne-NexCAR19 (actalycabtagene autoleucel, eyavunywa ngo-Okthobha 2023) kunye ne-Qartemi (eyavunywa ngo-2025) zizise olu nyango kufutshane neentsapho zaseIndiya; ukufaneleka kunye nokufumaneka kwemveliso kuqinisekiswa kwimeko nganye.
• Inkxaso yomjikelo opheleleyo: I-inshurensi kunye ne-TPA desk, uncedo lwezigulane ezingaphandle kwedolophu, iingcebiso, ukutya okunempilo kunye nokulandelela ixesha elide lokusinda.

isishwankathelo

Kwizibhedlele zase-Apollo eLucknow, sizingca ngokuba phambili ekuveliseni izinto ezintsha kwezonyango kunye nokhathalelo lwezigulane. Inkqubo yethu ye-CAR-T Cell Therapy ibonisa ukuzinikela kwethu ekugqweseni, sisebenzisa ubuchwepheshe obuphambili ukunyanga ii-malignancies ezintsonkothileyo ze-hematological. I-CAR-T Cell Therapy, okanye i-Chimeric Antigen Receptor T-cell Therapy, lunyango olutshintshayo olusebenzisa amandla enkqubo yomzimba yesigulana ukulwa nomhlaza. Ngeqela leengcali zomhlaza ezinobuchule kunye nezibonelelo zanamhlanje, izibhedlele zase-Apollo eLucknow ziyaziwa njengenye yeziko eliphambili le-CAR-T Cell Therapy kulo mmandla, zizuza ukuthenjwa zizigulana kunye neentsapho zazo.

Kutheni iCAR-T Cell Therapy iyimfuneko

Unyango lweCell ye-CAR-T lukhetho oluphambili lonyango kwizigulane ezineentlobo ezithile zomhlaza wegazi, kubandakanya i-acute lymphoblastic leukemia (ALL) kunye neentlobo ezithile ze-non-Hodgkin lymphoma. Unyango lwendabuko, olufana ne-chemotherapy kunye ne-radiation, lusenokungasebenzi kubo bonke abaguli, ingakumbi abo banesifo esibuyela umva okanye esingenakuphikiswa. Unyango lweCell ye-CAR-T lubonelela ngendlela eyenzelwe wena, apho ii-T-cells zikhutshwa egazini lesigulana, zitshintshwe ngokwemfuza ukuze zijolise kwiiseli zomhlaza, zize ziphinde zifakwe kwisigulana. Olu nyango lutsha lunokuphucula amathuba okukhululwa kwaye lubonelela ngokhetho kwizigulane eziye zasebenzisa ezinye iindlela zonyango.

Ukubaluleka kwezonyango ze-CAR-T Cell Therapy kuxhomekeke ekubeni ikwazi ukujolisa nokutshabalalisa iiseli zomhlaza eziveza i-antigen ekhethiweyo, njenge-CD19 okanye i-BCMA, endaweni yokwahlulahlula iiseli ngokubanzi. Le ndlela yonyango echanekileyo itshintshe indlela ebonwa ngayo isifo esibuyela umva nesinganyangekiyo, nto leyo eyenza ukuba kube lukhetho oluyimfuneko olufanele luqwalaselwe kwizigulane ezifanelekileyo. Nangona kunjalo, ayisiyongozi, kwaye iprofayili yesiphumo esibi yahlukile kweye-chemotherapy kunokuba ibe buthathaka nje.

Imingcipheko yokuLibazisa

Ukulibazisa unyango lweeseli ze-CAR-T kunokuba neziphumo ezibi kwizigulana ezilwa nomhlaza wegazi. Njengoko isifo siqhubela phambili, iiseli zomhlaza zinokuphindaphindeka kwaye zisasazeke, zenze unyango lube ngumngeni ngakumbi kwaye zinciphise ukubakho kwesiphumo esiyimpumelelo. Ukuhlehlisa unyango kunokukhokelela kwiingxaki ezinjengokonakala kwamalungu, ukwanda komthwalo wethumba, kunye nokuncipha kwempilo yonke, enokuthi ibe nefuthe elibi kakhulu ekusebenzeni konyango olulandelayo.

Kukho isizathu sesibini esisebenzayo sokungalibazisi. Ukwenziwa kwemveliso ye-CAR-T kuthatha iiveki, kwaye isigulana kufuneka sihlale sisempilweni ngokwaneleyo ukuze sifumane iiseli xa zilungile. Isigulana esinesifo esikhawulezayo ngelo xesha sisenokungafaneleki. Kwizibhedlele zase-Apollo eLucknow, iqela lethu elizinikeleyo lisebenzisana ngokusondeleyo nezigulana ukuqinisekisa ukuba zifumana uvavanyo olufunekayo kunye nonyango ngaphandle kokulibaziseka okungeyomfuneko. Ukubonisana kwangethuba kunokuba yinto ebalulekileyo ekumiseleni inyathelo elifanelekileyo kwimpilo yakho.

Izibonelelo CAR-T Cell Therapy

• Unyango ekujoliswe kulo: Unyango lweeCell zeCAR-T luyilelwe ukujolisa ngqo kwiiseli zomhlaza eziphethe uphawu oluthile, zisindisa izicubu ezininzi ezisempilweni ezichaphazeleka yichemotherapy eqhelekileyo.
• Ithuba lokufumana uxolelo oluhlala ixesha elide: Izigulane ezininzi zifumana iimpendulo ezihlala ixesha elide, kwaye ezinye zifumana ukuphumla okupheleleyo okuhlala ixesha elide, nto leyo enokuphucula kakhulu umgangatho wobomi. Iimpendulo zahlukile kakhulu kwaye azinakuqinisekiswa.
• Indlela eyenzelwe wena: Unyango ngalunye lwenziwa ngee-T-cells zesigulana ngasinye, ngoko ke unyango lolwahlukileyo kuloo mntu.
• Imodeli yokufunxa kanye: Kwizigulane ezininzi iiseli eziguquliweyo zinikwa njenge-infusion enye, endaweni yemijikelo ephindaphindwayo kwiinyanga ezininzi.
• Itekhnoloji entsha: Izibonelelo zethu eziphambili, amandla e-apheresis kunye neyunithi yokufakelwa ejongiweyo zixhasa umgangatho ophezulu wonyango kulo lonke uhambo lonyango.
• Inkxaso eBanzi: Ukhathalelo olupheleleyo oluquka inkxaso yengqondo, isikhokelo sesondlo, iingcebiso zokuthintela usulelo kunye nolandelelwano olucwangcisiweyo.

Ukulungiselela kunye noBuyiselo

1. Ukubonisana: Ukubonisana ngokucokisekileyo neqela lethu le-hemato-oncology ukuze sihlolisise imbali yakho yezonyango, iindlela zonyango zangaphambili, iingxelo ze-biopsy kunye ne-flow cytometry, kunye neendlela zonyango.
2. Uvavanyo lwangaphambi konyango: Ubalo lwegazi, uvavanyo lokusebenza kwamalungu omzimba, i-viral serology, uvavanyo lwe-PET-CT okanye lwe-bone marrow, uvavanyo lwentliziyo kunye nemiphunga, kunye nesiseko se-neurological ukuqinisekisa ukufaneleka.
3. Inkxaso yoMvakalelo: Ukunika iingcebiso kunye nenkxaso yoontanga ukunceda ukulawula ixhala malunga nendlela ende nengaqhelekanga yonyango.
4. Ukhathalelo lwasemva konyango: Ukulandela ngokusondeleyo, ukujonga i-CRS, ubuthi be-neurotoxicity, ukubala okuphantsi kunye nosulelo, kunye nokubuyela kubomi obuqhelekileyo ngokwemigangatho.
5. Ukutya: Ukutya okunesondlo nokulungiselelwe kakuhle ukuxhasa ukuchacha. Iingcali zethu zokutya zibonelela ngezicwangciso ezizodwa, kuquka ukutya kwemifuno kunye nokutya kweJain.

Ukuchacha kuyahluka kwisigulana ngasinye. Abanye bafumana umkhuhlane omncinci kunye nokudinwa; abanye bafuna ukubekwa esweni okunzulu kunyango olubalulekileyo. Iqela lethu kwi-Apollo Hospitals Lucknow libonelela ngonyango olulungiselelwe wena kunye nenkxaso kulo lonke uhambo lokuchacha.

Izikhokelo kunye neMigangatho yangoku elandelwayo

Indlela yethu ye-CAR-T yakhelwe kwimigangatho yesizwe neyehlabathi, kwaye ihlaziywa njengoko loo maxwebhu ehlaziywa:

• Izikhokelo zeSizwe zeBhunga laseIndiya loPhando lwezoNyango (i-ICMR) zoPhuhliso lweeMveliso zoNyango lweZizakhi zofuzo kunye novavanyo lwezonyango, ngo-2019, ekhutshwe ngokubambisana neSebe leBiotechnology, elilawula indlela eziphuhliswa kwaye zilawulwa ngayo iimveliso zeeseli eziguqulwe ngokwemfuza eIndiya.
• Umbutho oLawula iMigangatho yeZiyobisi oPhakathi (i-CDSCO) imvume yokuthengisa. I-NexCAR19 (actalycabtagene autoleucel), eyaphuhliswa yi-ImmunoACT kunye ne-IIT Bombay kunye neTata Memorial Centre, yafumana imvume ye-CDSCO ngo-Okthobha ka-2023 kwi-relapse/refractory B-cell lymphoblastic leukaemia kunye ne-B-cell non-Hodgkin lymphoma kwizigulana ezineminyaka eli-15 nangaphezulu. Imveliso yokulwa ne-BCMA, i-Qartemi, yafumana imvume ngo-2025 kwi-relapse/refractory multiple myeloma. Ukufumaneka kwayo nayiphi na imveliso ethile kwimeko yakho kuqinisekiswa liqela elinyangayo.
• I-Indian Society of Hematology and Blood Transfusion (ISHBT) kwaye i Umbutho wamaIndiya woTshintsho lweGazi kunye nomongo (ISBMT) iingxelo zesikhundla kunye noqheliselo lobhaliso malunga nonyango lweseli, uthintelo losulelo kunye nemigangatho yeyunithi yokufakelwa.
• Uvavanyo lwe-ASTCT (American Society for Transplantation and Cellular Therapy) lwe-CRS kunye ne-ICANS, ngo-2019, eyinkqubo yokubeka amanqaku esetyenziswa kwihlabathi liphela nakwiindawo zaseIndiya ekufumaneni amanqaku nokunyanga ezi tyhefu.
• Izikhokelo ze-NCCN Clinical Practice kwi-Oncology kwi-B-cell lymphomas, ALL kunye ne-multiple myeloma, kunye I-EBMT/JACIE imigaqo yomgangatho weeyunithi zonyango lweseli.

Okutshintshileyo kutshanje: Kude kube ngu-2023, unyango lwe-CAR-T lwezigulane zaseIndiya lwaluthetha ukuhamba phesheya ngexabiso uninzi lweentsapho ezazingenakuliqwalasela. Iimveliso ze-CAR-T zemveli, ezivunyiweyo yi-CDSCO ezenziwe eIndiya zitshintshile oko, kwaye unyango ngoku lunikezelwa kumaziko avunyiweyo aseIndiya. Isikhokelo sokujonga izigulane ezingalaliswanga okanye zokuhlala ixesha elifutshane, ukusetyenziswa kwangaphambili kwe-tocilizumab, kunye nokusetyenziswa kwe-CAR-T kumgca wesibini endaweni ye-B-cell lymphoma enkulu yomgca wesithathu nako kuye kwavela kwiinguqulelo zamva nje zesikhokelo.

Ngubani Ofanelekileyo, Nongafanelekiyo

Iqhele ukuqwalaselwa kwi-CAR-T

• I-B-cell acute lymphoblastic leukemia ebuyela umva okanye enganyangekiyo
• I-lymphoma enkulu ye-B-cell ebuyela umva okanye enganyangekiyo kunye nezinye ii-lymphomas ezihlaselayo ze-B-cell ezingezizo ze-Hodgkin
• I-myeloma ephindaphindayo okanye enganyangekiyo emva kweendlela zonyango zangaphambili, apho imveliso eqondiswe yi-BCMA ifumaneka khona
• Ukusebenza kakuhle kwentliziyo, imiphunga, isibindi kunye nezintso, kunye nokusebenza okufanelekileyo

Ngokwesiqhelo ayifanelekanga, okanye ifuna ukulungiswa kuqala

• Usulelo olusebenzayo olungalawulekiyo, kuquka nesifo sephepha esisebenzayo, nto leyo ibalulekileyo eIndiya
• I-hepatitis B okanye i-C esebenzayo okanye i-HIV efuna ukuzinza ngaphambi kokuba kuqokelelwe iiseli
• Isifo senkqubo ye-nervous system esebenzayo kwezinye iinkqubo
• Ukungasebenzi kakuhle kwamalungu omzimba, okanye imeko yokusebenza kakubi kakhulu
• Ii-T-cells ezinganeleyo zokuqokelela emva kwe-chemotherapy enzima yangaphambili

Ukufaneleka sisigqibo seqela esenziwa kwibhodi yesifo se-tumor, kungekhona isigqibo sikagqirha omnye.

Ixesha leNkqubo kunye neSigaba soLungiselelo

Ixesha elibekiweyo libonisa ixesha lokwenziwa kwemveliso, ukufumaneka kwayo kunye nendlela oziphatha ngayo xa unesifo ingalufinyeza okanye ilundise uhambo.

Iindlela Ezizezinye kunye Neendlela Zobuchule Ezithelekiswayo

Iinkqubo ezidla ngokwenziwa kunye nonyango lwe-CAR-T

• Ukufakwa kwe-catheter yemithambo ephakathi okanye umgca we-apheresis yokuqokelelwa kweeseli kunye nokufakwa
• Umnqweno womongo wethambo kunye ne-biopsy ngovavanyo lwe-MRD ngaphambi nasemva konyango
• I-PET-CT okanye i-CT yokuvavanya izigaba kunye nempendulo
• Ukubhobozwa kwe-lumbar nge-chemotherapy yangaphakathi apho ukubandakanyeka kwe-CNS kuyinkxalabo
• Ingcebiso ngokugcinwa kokuchuma (i-semen banking, i-oocyte okanye i-embryo frozen) ngaphambi kokuba i-lymphodepletion ivele, ingakumbi kwizigulane ezincinci
• Ukuhlolwa kwamazinyo kunye nosulelo, kuquka ukuvavanywa kwesifo sephepha kunye ne-hepatitis
• Uvavanyo lwe-Echocardiography kunye nomsebenzi wemiphunga
• Inkxaso yemveliso yegazi enezixhobo ezikhanyisiweyo, ezine-leucodepleted

Ukubuyiselwa Kwenqanaba Ngenqanaba

Ukubuyela kwimisebenzi eqhelekileyo, emsebenzini nakwiindlela zemihla ngemihla zaseIndiya

• Ukuqhuba: Akuvumelekanga ubuncinane iiveki ezi-8 emva kokufakwa kwi-infusion kwiindlela ezininzi zokulungiselela, ngenxa yomngcipheko wemiphumo ye-neurological ebambezelekileyo. Qinisekisa umhla kunye nomcebisi wakho.
• Umsebenzi: Imisebenzi yasentsimini, efektri, ezolimo kunye nemisebenzi enzima yokuhamba idla ngokuthatha ixesha elide.
• Izihlwele kunye neendibano: Imitshato, imigca yeetempile, iimela kunye nezithuthi zikawonke-wonke ezixineneyo kungcono ukuba zingabandakanywa kwiinyanga ezintathu zokuqala.
• Imisebenzi yasekhaya: Ukulala phantsi kuyamkeleka ukuba umgangatho ucocekile kwaye awunathuli, kodwa kungcono ibhedi ngelixa inani liphantsi. Ukuhlala phantsi kunye nokuhlala unqamleze imilenze akuthintelwanga lunyango ngokwalo, nangona ubuthathaka kunye nokudinwa kunokwenza kube nzima ukuvuka kwiiveki zokuqala.
• Izindlu zangasese zesitayile samaNdiya: Sebenzisa i-western commode okanye isitulo se-commode ngexesha lokubala okuncinci, kuba ukuquleka okanye ukungazinzi kwigumbi lokuhlambela elitshixiweyo kuyingozi enkulu. Gcina ucango lungatshixwanga kwaye umntu akufutshane nawe.
• Ukuzivocavoca: Ukuhamba kancinci ngaphakathi endlwini ukususela kwiiveki zokuqala; ukuhamba ngokukhawuleza kunye neyoga ngokuqhelekileyo ukususela kwiiveki ezi-6 ukuya kwezi-8; ijimu, iintsimbi kunye nemidlalo yokudibanisa umzimba kuphela emva kokuba uvunyelwe.
• Ukutya namanzi: Ukutya okusandul’ ukuphekwa ekhaya, amanzi abilisiwe okanye ahluziweyo, akukho chutneys ziluhlaza, iisaladi, iziqhamo ezisikiweyo ezivela kubathengisi, okanye ubisi olungafakwanga iintsholongwane ngexesha lokungabikho komzimba oqinileyo.
• Izilwanyana zasekhaya kunye nokulima: Kuphephe ukuphatha umhlaba, iinkomo, iinkukhu kunye nezilwanyana zasekhaya ubuncinane iinyanga ezi-3.

Ukunciphisa Umngcipheko Wokubuyela Umva Neengxaki

• Yiya kuzo zonke iireviews ezicwangcisiweyo kunye neskeni, nokuba uzive uphilile ngokupheleleyo
• Thatha uthintelo lweentsholongwane, i-antifungal kunye ne-anti-pneumocystis njengoko kuchazwe ngumyalelo.
• Xela umkhuhlane ongaphezulu kwe-100.4°F (38°C) ngoko nangoko endaweni yokuqala amayeza okubulala iintsholongwane ekhaya
• Yamkela ukutshintshwa kwe-immunoglobulin ukuba kucetyiswa ukuba amanqanaba aphantsi e-immunoglobulin athathwe
• Gqibezela ukugonywa kwakhona kuphela ngokweshedyuli ebekwe liqela lakho, ngokuqhelekileyo iqala kwiinyanga ezimbalwa emva kokufakwa
• Yeka icuba, i-gutkha kunye notywala ngokupheleleyo; zombini ezi zinto ziyenza mandundu imiphumo kunye nomngcipheko wokosuleleka.
• Gcina ucoceko lomlomo nolwamazinyo, kwaye unyange naluphi na usulelo lwamazinyo ngokukhawuleza ngokwengcebiso
• Gcina isifo seswekile, uxinzelelo lwegazi kunye neengxaki ze-thyroid zilawulwa kakuhle

Izinto Eziqwalaselwayo Kubantwana, Abakwishumi Elivisayo Nabadala

Abantwana kunye nentsha

I-CAR-T ekhokelwa yi-CD19 inobungqina obuqinileyo kwi-B-cell ALL yabantwana kunye nabantu abadala abancinci. Ukuvunywa kwemithetho yaseIndiya ye-NexCAR19 ngoku kuqala xa beneminyaka eli-15 ubudala, ngoko ke ukhetho lwabantwana abancinci luxoxwa ngabanye kwaye lunokubandakanya amanye amaziko okanye iimvavanyo. Abantwana bafuna imvume yokudlala, unxibelelwano lwesikolo, ukukhula kunye nokulandelwa kwe-endocrine, kunye nomzali ohlala kuyo ngexesha lokwamkelwa.

Abantu abadala abadala

Ubudala bodwa abumenzi umntu angafaneleki. Ukufaneleka komzimba kubaluleke ngaphezu kwenani elikwisatifikethi sokuzalwa. Uvavanyo lwabantu abadala olubandakanya ukugcinwa kwentliziyo, ukusebenza kwezintso, ukuqonda, ukutya okunempilo, umngcipheko wokuwa kunye ne-polypharmacy lwenziwa ngaphambi kokuba kugqitywe. Izigulane ezindala zinomngcipheko ophezulu wokuba ne-neurotoxicity kunye nosulelo, ngoko ke ukubeka esweni imiqathango kuphantsi kwaye ukuphuma kwegazi kudla ngokuhamba kancinci.

Ukuba Ukhetha Ukungafumani Unyango lwe-CAR-T

Ukwala lukhetho olufanelekileyo, kwaye kufuneka kube lolwazi oluchanekileyo. Ngokuxhomekeke kwisifo sakho, ezinye iindlela zokwenyani zi-chemotherapy eyongezelelweyo okanye unyango olujolise kuko, unyango lwe-bispecific antibody, ukufakelwa i-stem cell ukuba uyafaneleka, uvavanyo lweklinikhi, okanye unyango olungcono oluxhasayo olujolise kwintuthuzelo. Kwimihlaza yegazi ebuyela umva nengalawulekiyo, ukukhululwa kwi-chemotherapy eqhelekileyo kudla ngokuba kufutshane, kwaye ukuqhubela phambili kwesifo kunokuzisa i-anemia, usulelo, iintlungu zamathambo, ukopha kunye nokubandakanyeka kwamalungu omzimba. Iqela lethu liza kuchaza into omawuyilindele nangayiphi na indlela, aliyi kukunyanzela, kwaye liza kuqhubeka nokubonelela ngolawulo lweempawu kunye nenkxaso yokudambisa ukuba ugqiba ekubeni ungalufuni unyango lweseli. Ungacela noluvo lwesibini; siza kwabelana ngeerekhodi zakho ukuze sikuncede ufumane olunye.

Izinto Ezichaphazela Iindleko Zonyango lwe-CAR-T

I-CAR-T iphakathi kwezona ndlela zonyango zibiza kakhulu kwi-oncology, nangona iimveliso ezenziwe eIndiya zizise ixabiso eliphantsi kakhulu kwamaxabiso aphesheya. I-Apollo Hospitals Lucknow ayipapashi inani elimiselweyo lephakheji, kuba iyonke ixhomekeke kwiinguqu ezingezantsi. Nceda ubuze umququzeleli we-oncology okanye idesika yokuhlawula ukuba akunike uqikelelo olubhaliweyo lwetyala lakho.

I-inshurensi, Unyango olungenamali kunye noCwangciso lwezeMali eIndiya

• Jonga ukhuseleko olubhaliweyo kuqala. Iipolisi ezininzi ze-inshorensi yezempilo zaseIndiya zisaphatha i-CAR-T kunye nonyango lwe-gene njengendlela entsha okanye ekhethekileyo; ezinye ziyigubungela ngokupheleleyo, ezinye ziyigubungele, ezinye ziyikhuphela ngaphandle. Cela isiqinisekiso esibhaliweyo kwi-inshorensi yakho ngaphambi kwe-leukapheresis, kungekhona emva koko.
• Amaxesha okulinda abalulekile. Iipolisi zokhuseleko ezisemgangathweni zinexesha lokulinda lokuqala elimalunga neentsuku ezingama-30, kwaye ixesha lokulinda isifo esele sikhona lidla ngokuba yiminyaka emi-2 ukuya kwemine kuxhomekeke kwipolisi. Umhlaza ofunyaniswe ngaphambi kokuba ipolisi iqale uhlala uphantsi kwesigaba esikhoyo.
• I-inshorensi ecwangcisiweyo xa ithelekiswa neyengozi. I-CAR-T isoloko iyindlela yokungena ecwangcisiweyo, ngoko ke imigaqo-nkqubo yengozi okanye yengozi yomntu ayisebenzi. Abakhweli abanesifo esibuhlungu banokuhlawula isixa-mali xa bexilongiwe ukuba banomhlaza, nto leyo esetyenziswa ziintsapho ezininzi kwiindleko zemveliso.
• Inkqubo yokuhlawula ngaphandle kwemali kunye ne-TPA. Ngenisa ifomu yokugunyaziswa kwangaphambili, inqaku likagqirha, ukuxilongwa kunye noqikelelo ngedesika yeinshorensi yesibhedlele. Imvume yonyango lweseli olunexabiso eliphezulu idla ngokuthatha ixesha elide kunotyando oluqhelekileyo, ngoko ke qala kwangethuba. Ukuba akuvunyelwanga ukuba ufumane imali, unyango lunokuqhubeka ngesiseko sembuyekezo kwaye zonke iindleko zokuqala kunye nesishwankathelo sokukhululwa zigcinwe.
• Imida engaphantsi ekufuneka ijongwe: umda werenti yegumbi, umda we-ICU, ipesenti yentlawulo kunye, umda wezifo, kunye nokuba izinto ezisetyenziswayo kunye nekhemesti ziyahlawulwa na.
• Izikimu zikarhulumente kunye nabaqeshi: I-CGHS, i-ECHS, izikimu zabasebenzi bakarhulumente, iiphaneli ze-ESIC kunye ne-PSU zineendlela zazo zokuvunywa kunye noluhlu lwamaxabiso; idesika yeinshorensi iya kukuxelela ukuba ilungelo lakho liyasebenza na kweli ziko.
• Enye inkxaso: Ingxowa-mali yoNcedo lweSizwe yeNkulumbuso, iNgxowa-mali yeSigulana soMhlaza yoMphathiswa wezeMpilo, iNgxowa-mali yoNcedo yoMphathiswa oyiNtloko e-Uttar Pradesh, iingxowa-mali zentlalo-ntle yabaqeshi kunye neetrasti ezidumileyo zokunceda abantu. Amaxwebhu athatha iiveki, ngoko ke asebenza ngaxeshanye novavanyo lwezonyango.

Iimvume ezihambelana nomgaqo-nkqubo, intlawulo kunye neenkcukacha zephakheji kufuneka ziqinisekiswe kwi-inshurensi ye-Apollo Hospitals Lucknow kunye nedesika ye-TPA ngexesha lokubhukisha.

Ukucwangcisa ukwamkelwa kunye noko uza kuzisa

amaxwebhu

• Zonke iiresiphi zangaphambili, izishwankathelo zokukhululwa emzimbeni, iingxelo ze-biopsy kunye ne-bone marrow, i-flow cytometry kunye ne-cytogenetics, kunye neefilimu okanye ii-CD zangaphambili zokuskena.
• I-Aadhaar okanye i-ID enefoto yesigulana kunye nomguli oyintloko
• Ikhadi le-inshurensi, uxwebhu lomgaqo-nkqubo, ikhadi le-TPA kunye neleta yomqeshi okanye yesicwangciso
• Ikhadi leqela legazi kunye nazo naziphi na iirekhodi zotofelo-gazi zangaphambili

Izinto zobuqu

• Impahla yekotoni ekhululekileyo evuleka ngaphambili, kunye nezihlangu zangaphakathi ezicocekileyo ezahlukileyo
• Ibhrashi yamazinyo ethambileyo, isepha ethambileyo, itawuli yakho, i-lip balm
• Ifowuni, intambo yokutshaja ende, ii-headphones; iincwadi okanye ithebhulethi yokuhlala iiveki ezimbini
• Uluhlu olubhaliweyo lwamayeza onke akhoyo aneedosi, kuquka amalungiselelo e-ayurvedic okanye e-homeopathic, ekufuneka atyhilwe kwaye aqhele ukuyekiswa

Ucwangciso olusebenzayo

• Chonga umntu omnye oza kuncedisa umntwana kunye nomnye oza kuncedisa. Kwiintsapho ezidibeneyo, vumelanani kwangaphambili ukuba ngubani oza kuhlala ubusuku bonke, ngubani olawula amayeza kwaye ngubani olawula iindleko, ukuze imiyalelo ingalahleki phakathi kwezalamane.
• Lungiselela indawo yokuhlala kufutshane nesibhedlele kangangeeveki ezine emva kokukhululwa esibhedlele.
• Ceba umntu onokuqhuba ngexesha elifutshane, emini okanye ebusuku.
• Musa ukuzisa iintyatyambo, izityalo okanye ukutya okuphekiweyo ekhaya kwindawo yokuzigcina wedwa ngaphandle kokuba iqela labahlengikazi likuvumela oko.

Iimpawu Zesilumkiso Ezifuna Uphononongo Lwezonyango Ngokukhawuleza

Nxibelelana nesibhedlele ngoko nangoko, nangaliphi na ixesha, ukuba isigulana siphuhliswa:

• Umkhuhlane ongama-100.4°F (38°C) nangaphezulu, okanye ukungcangcazela
• Ukudideka, intetho engacacanga, ubunzima bokufumana amagama, ukungcangcazela, ukutshintsha umbhalo okanye ukuxhuzula
• Ukozela kakhulu okanye ubunzima bokuvuka
• Ukungakwazi ukuphefumla, iintlungu zesifuba, ukubetha kwentliziyo ngokukhawuleza okanye isiyezi xa umile
• Ukunciphisa ukukhutshwa komchamo
• Ukopha ngeentsini okanye empumlweni, igazi kumchamo okanye kwindle, okanye ukudumba okutsha okuxhaphakileyo
• Ukuhlanza okungapheliyo, urhudo oluqatha okanye ukungakwazi ukugcina ulwelo luphantsi
• Intloko ebuhlungu kakhulu, ukuqina kwentamo okanye ukuphazamiseka okutsha kokubona

Phatha ikhadi lakho lesigulana le-CAR-T ngamaxesha onke uze ulibonise ugqirha odibana naye kwenye indawo, kuquka nekliniki yasekuhlaleni.

Kwabaguli Abahambayo Abavela Kwizithili Nezixeko Ezikufutshane

Izibhedlele ze-Apollo uLucknow ufumana izigulana ezisuka kulo lonke elase-Uttar Pradesh nakumazwe angabamelwane, kubandakanya iKanpur, iBarabanki, iSitapur, iHardoi, i-Unnao, iRaebareli, iSultanpur, iFaizabad kunye neAyodhya, iGonda, iBahraich, iBasti, iGorakhpur, iVaranasi, iPrayagraj, i-Jhansi, i-Jhansi, kunye neenxalenye ze-Mehardaut, kunye ne-Barei. I-Uttarakhand, iMadhya Pradesh kunye neNepal.

• Ngaphambi kokuba uhambe: Thumela nge-imeyile okanye wabelane ngeengxelo eziskeniweyo ukuze iqela likwazi ukucebisa ukuba utyelelo lufanelekile na kwaye uza kuphatha ntoni.
• Hlanganisa utyelelo lwakho: Cela umququzeleli ukuba acwangcise iingxoxo kunye nophando kwiintsuku ezilandelelanayo.
• Musa ukucwangcisa ukuhamba ngexesha lokubeka esweni. Kangangeeveki ezine emva kokufakwa utyando kufuneka uhlale eLucknow, kumgama omfutshane ukusuka esibhedlele. Yiba nebhajethi yokuhlala kunye neendleko zokuphila zomguli.
• Ukufika apha: ILucknow inikwa inkonzo yiChaudhary Charan Singh International Airport, iLucknow Charbagh kunye nezikhululo zikaloliwe zaseGomti Nagar, kunye neendlela ezintle ezikufutshane neAgra?Lucknow kunye nePurvanchal Expressways.
• Ugcino lwezonyango lwasekuhlaleni: Chonga isibhedlele esinecandelo lezonyango ezingxamisekileyo elisebenzayo kufutshane nedolophu yakowabo kwixesha emva kokuba ubuyile, kwaye ugcine isishwankathelo sakho sokukhululwa esibhedlele kunye nekhadi le-CAR-T kuwe.
• INepal kunye nezinye izigulana zamazwe ngamazwe: Nxibelelana nedesika yezigulane zamazwe ngamazwe kwangaphambili ukuze ufumane amaxwebhu e-visa, imali kunye nenkxaso yomtoliki.

Unxibelelwano kunye neeNdibano zokuQeqesha

Imibuzo ebuzwa qho

Yeyiphi imingcipheko eyayanyaniswa neCAR-T Cell Therapy?

Nangona i-CAR-T Cell Therapy inikezelwa phantsi kweliso elibukhali, inokubangela i-cytokine release syndrome (CRS), iziphumo ze-neurological ezaziwa ngokuba yi-ICANS, ukubalwa kwegazi okuphantsi ixesha elide, ii-immunoglobulins ezisezantsi kunye nosulelo. Iqela lethu kwi-Apollo Hospitals Lucknow lijonga izigulana ngokuqhubekayo zisebenzisa inkqubo yokulinganisa i-ASTCT kwaye linyanga ezi ziphumo ngokukhawuleza nge-tocilizumab, ii-steroids kunye nonyango oluxhasayo.

Ndilucwangcisa njani uthethwano lwe-CAR-T Cell Therapy?

Ungabhukisha kwiwebhusayithi ye-Apollo Hospitals Lucknow, i-app ye-Apollo 24|7, umnxeba woncedo ophakathi ku-1860-500-1066, okanye ngokwakho kwidesika yokubhalisa. Zisa okanye wabelane ngazo zonke iingxelo zangaphambili ukuze iqela le-haemato-oncology likwazi ukuvavanya ukufaneleka ukususela kutyelelo lokuqala.

Lithini izinga lempumelelo yeCAR-T Cell Therapy?

Amanqanaba okuphendula ahluka kakhulu ngokwesifo, unyango lwangaphambili kunye nomthwalo wesimila. Idatha yovavanyo olupapashiweyo ixela amazinga aphezulu okuphendula kokuqala kwi-B-cell ALL ephinde yabuyela kwisifo kunye ne-B-cell lymphoma enkulu, kunye nenani lezigulana ezigcina ukuxolelwa kwexesha elide, kodwa akukho ziko linokuthembisa unyango. Ugqirha wakho we-oncologist uza kuchaza ulindelo oluyinyani kwimeko yakho ethile.

Ithatha ixesha elingakanani inkqubo yoNyango lweCell yeCAR-T?

Ukususela kwingxoxo yokuqala ukuya kwi-di