Impendulo ethe ngqo
Uvavanyo lwe-SGPT (i-serum glutamic pyruvic transaminase, ngoku edla ngokubizwa ngokuba yi-ALT okanye i-alanine aminotransferase) lulinganisa i-enzyme ekhutshwa kwiiseli zesibindi iye egazini xa ezo seli zonzakele. I-SGPT ephakanyisiweyo ibonisa ukurhawuzelelwa kweeseli zesibindi, hayi isifo esithile. I-SGPT eqhelekileyo ayikhuphi isifo sesibindi, kuquka ne-cirrhosis.
Ukuthatha okuphambili
- I-SGPT kunye ne-ALT ziluvavanyo olufanayo: I-SGPT ligama elidala lelabhoratri yaseIndiya le-alanine aminotransferase.
- I-SGPT ibonisa ukwenzakala kweseli yesibindi, hayi unobangela wayo: isibindi esinamafutha, i-hepatitis ebangelwa yintsholongwane, utywala, amayeza kunye nezongezo zonke ezinokubangela oku.
- I-SGPT eqhelekileyo iyaqinisekisa kodwa ayisosiqinisekiso: i-fibrosis ephucukileyo kunye ne-cirrhosis zihlala zihamba nee-enzymes eziqhelekileyo okanye eziphantse zibe zezoqhelekileyo.
- Inani lodwa alithethi nto ingako: I-SGPT itolikwa kunye ne-SGOT (AST), i-ALP, i-GGT, i-bilirubin, i-albumin, inani leeplatelet kunye nemifanekiso.
- Uluhlu lweereferensi luyahluka phakathi kweelabhoratri: funda ixabiso lakho rhoqo xa lithelekiswa noluhlu olushicilelwe kwingxelo yakho.
Ngokukrwaqula kanye
| umcimbi | inkcukacha |
|---|---|
| Igama lovavanyo | I-SGPT / ALT (i-alanine aminotransferase) |
| sample | Igazi, elihlala livela kumthambo wengalo |
| Oko kubonakalisayo | Ukulimala okanye ukuvuza okuvela kwiiseli zesibindi (ii-hepatocytes) |
| Idla ngoku-odolwa njenge | Inxalenye yephaneli yovavanyo lomsebenzi wesibindi (LFT), ayisoloko yodwa |
| Ukuzila | Akufuneki kwi-SGPT ngokwayo; ukuzila ukutya kunokufuneka kwezinye iimvavanyo ezihlanganiswe kwi-draw efanayo, landela imiyalelo yelabhoratri yakho |
| Ixesha lokutsalwa kwegazi | Malunga nemizuzu emi-5 ukuya kweli-10, kuquka ukubhaliswa kunye noxinzelelo phezu kwendawo yokubhoboza |
| Ukubika | Uninzi lweelabhoratri zixela ngosuku olufanayo okanye ngosuku olulandelayo; ixesha lixhomekeke kwiyunithi |
| Uluhlu lwezalathiso | Ngokwelabhoratri ethile nangendlela ethile; ishicilelwe kwingxelo yakho |
Kwaziwa njenge
- Uvavanyo lwe-ALT, i-alanine aminotransferase
- Uvavanyo lwegazi lwe-SGPT, amanqanaba e-SGPT
- Inxalenye ye-"LFT", "uvavanyo lwesibindi", "iprofayili yesibindi"
- EIndiya, idla ngokucelwa njenge "uvavanyo lwe-enzyme yesibindi" okanye "uvavanyo lwe-jaundice", i-SGPT yinxalenye enye yezi paneli, hayi ipaneli yonke.
Yintoni uvavanyo lwe-SGPT
I-Alanine aminotransferase yi-enzyme egxile ngaphakathi kwiiseli zesibindi, enenani elincinci kwizintso, intliziyo kunye nemisipha yamathambo. Le enzyme inceda ekudluliseni amaqela e-amino ngexesha lokuguqulwa kwe-amino acid. Xa iiseli zesibindi zivuvukala, zixinezelekile okanye zifa, i-alanine aminotransferase iyavuza kwaye amanqanaba egazi ayanyuka.
Ngenxa yokuba le enzyme ihambelana nesibindi, i-SGPT yenye yezona mpawu ziluncedo kakhulu zokwenzakala kwesibindi. Nangona kunjalo, i-SGPT ilinganisa ukwenzakala , hayi ukusebenza . Umsebenzi wokwenziwa kwesibindi ubonakaliswa ngcono yi-albumin, ixesha le-prothrombin/INR kunye ne-bilirubin.
Ngubani ofanele afumane olu vavanyo
- Abantu abaneempawu ezibonisa isifo sesibindi: inyongo, umchamo omnyama, ilindle elikhanyayo, isicaphucaphu esingapheliyo, ukungakhululeki esiswini sasekunene, ukudinwa okungachazekiyo okanye ukurhawuzelelwa.
- Abantu abasebenzisa amayeza aziwayo ukuba achaphazela isibindi: unyango oluchasene nesifo sephepha, i-methotrexate, amayeza athile okuxhuzula, amayeza okulwa neentsholongwane, amayeza athile okukhuhla iintsholongwane kunye namayeza okubulala iintsholongwane. Iishedyuli zokubeka esweni zimiselwa ngugqirha.
- Abantu abasebenzisa amayeza e-AYUSH, iimveliso zemifuno okanye izongezo zejimu/zokwakha umzimba: ezi zizizathu ezaziwayo zokwenzakala kwesibindi okubangelwa ngamayeza eIndiya.
- Abantu abanezinto ezinobungozi bokusetyenziswa kwe-metabolic: isifo seswekile sohlobo lwesibini, uxinzelelo lwegazi oluphezulu, i-dyslipidemia, i-central fat. Abantu baseMzantsi Asia bafumana isifo sesibindi esitshintshatshintshayo kwi-body mass index ephantsi kunabanye abantu abaninzi.
- Abantu abaziwayo okanye abarhanelwayo abane-hepatitis B okanye C, njengenxalenye yokubeka esweni okugqitywa yingcali yesibindi okanye ngugqirha.
- Abantu abasebenzisa utywala rhoqo okanye kakhulu.
- Abantu abanesifo sesibindi esinamafutha esingalindelekanga kwi-ultrasound.
Ukuhlolwa rhoqo kwe-SGPT kumntu ophilileyo ngokupheleleyo ongenazo izinto ezinobungozi akukhuthazwa ngokubanzi; kudla ngokufakwa kwiiphakheji zokuhlolwa kwempilo zaseIndiya, kwaye ingxaki encinci kuloo ndawo ifuna ukutolikwa okunengqiqo kunokuba ibe yinto exhalabisayo.
Kutheni uvavanyo lwe-SGPT lwenziwa
- Ukufumanisa ukwenzakala kweseli yesibindi xa kukho iimpawu okanye izinto ezinokubangela umngcipheko.
- Ukunceda ekuchazeni ingxaki yesibindi: indlela i-SGPT ethelekiswa ne-ALP kunye ne-GGT inceda ukwahlula ukwenzakala kwesibindi kwiingxaki ze-cholestatic (i-bile flow).
- Ukubeka iliso ngokuhamba kwexesha: iindlela ezisetyenziswa kwiimvavanyo eziphindaphindwayo zinika ulwazi oluthe kratya kunokufunda kube kanye.
- Ukubeka esweni ukhuseleko lweziyobisi ngexesha lonyango olunokuchaphazela isibindi.
- Ukulandelela impendulo kwiimeko ezifana ne-hepatitis engapheliyo okanye i-hepatitis ye-autoimmune, kunye nezinye iimvavanyo.
Oko uvavanyo lwe-SGPT lungenakukwazi ukukubona okanye ukungakukhupheli ngaphandle
Le yeyona nxalenye uninzi lweengxelo ezingayikhankanyiyo, kwaye ibaluleke ngaphezu kwenani ngokwalo.
- I-SGPT ayinakukuxelela unobangela. I-hepatitis ebangelwa yintsholongwane, isifo sesibindi esibangelwa yimetabolism, utywala, amayeza, izongezo, i-hepatitis ye-autoimmune, isifo se-celiac, isifo se-thyroid kunye nokwenzakala kwemisipha konke oku kunokunyusa i-SGPT.
- I-SGPT ayinakuyikhupha ngaphandle i-cirrhosis okanye i-fibrosis eqhubele phambili. Amanqanaba e-enzyme ahlala ehla aye kwisiqhelo njengoko iiseli zesibindi ezikhulayo nezisebenzayo zilahleka. I-SGPT eqhelekileyo ayibobungqina besibindi esisempilweni.
- I-SGPT ayikwazi ukulinganisa amafutha okanye i-fibrosis. Ayithethi nto malunga nokuba ingakanani i-steatosis, ukudumba okanye amanxeba akhoyo. Oko kufuna i-imaging, i-elastography, amanqaku angangenisi okanye ngamanye amaxesha i-biopsy.
- I-SGPT ayikwazi ukubona umhlaza wesibindi okanye ubunzima besibindi. I-carcinoma ye-hepatocellular inokwenzeka ngee-enzymes eziqhelekileyo. Kufuneka imifanekiso.
- I-SGPT ayinakulinganisa ukusebenza kwesibindi. Isibindi esingayihlanganisiyo iproteni okanye i-bilirubin ecacileyo sisenokubonisa ukwanda okuncinci kwee-enzymes.
- I-SGPT ayinakuyithintela ingxaki yokuvaleka kwe-bile duct okanye isifo se-gallstone. I-ALP, i-GGT, i-bilirubin kunye ne-ultrasound ziphendula loo mbuzo.
- I-SGPT ayisiyo yesibindi kuphela. Ukulimala kwemisipha yamathambo, ukuzilolonga okunzima kunye nezinye iingxaki zemisipha kunokuyinyusa ngaphandle kwesifo sesibindi.
Iziphumo ezichazwe njengesiqhelo zithetha ukuba i-enzyme ayizange inyuswe kuloo sampuli ngelo xesha. Oko akuthethi ukuba isifo sesibindi asisekho. Ukuba iimpawu zakho ziyaqhubeka nangona i-SGPT iqhelekile, buyela kugqirha wakho endaweni yokuba ucinge ukuba isibindi sicocekile.
Uvavanyo oluhambelanayo kodwa olwahlukileyo
| uvavanyo | Yibuze iyaphendula | Indlela eyahluke ngayo kwi-SGPT |
|---|---|---|
| I-SGOT / AST | Ngaba kukho ukwenzakala kwesibindi, kwaye ngaba kukho indlela enxulumene nezihlunu okanye utywala? | Isibindi asixhomekekanga kangako kwi-SGPT; sikwakho nakwimisipha yentliziyo neyethambo. Umlinganiselo we-AST:ALT ongaphezulu kwe-2 uphakamisa ukurhanelwa kokwenzakala kwesibindi okubangelwa butywala; umlinganiselo okhulayo unokuhambisana nokukhula kwe-fibrosis. |
| I-ALP (i-alkaline phosphatase) | Ingaba kukho ingxaki yokuhamba kwenyongo okanye yethambo? | I-Cholestatic endaweni ye-hepatocellular marker. Iphezulu kakhulu emzimbeni kubantwana abasakhulayo naxa bekhulelwe. |
| I-GGT | Ingaba i-ALP ephakanyisiweyo ivela kwisibindi okanye kumthi wenyongo? | Ibuthathaka kodwa ayichazi ngqo; inyuka ngotywala namayeza aliqela. |
| Bilirubin | Kutheni umguli enesifo seswekile? | Ilinganisa ukuphathwa kwebala, hayi ukwenzakala kweeseli. Ingakhula kwi-Gilbert syndrome nakwi-hemolysis nge-SGPT eqhelekileyo. |
| I-Albumin, i-INR/ixesha le-prothrombin | Isibindi sisebenza kakuhle kangakanani ngokwenene? | Iimpawu zomsebenzi zokwenyani; i-SGPT ayinjalo. |
| Iphaneli ye-LFT | Umfanekiso wesibindi siphela | I-SGPT ngumgca omnye ngaphakathi kweli phaneli. I-SGPT enye eyodwa ayifane yanele. |
| Isisu se-USG (i-sonography) | Ingaba kukho amafutha, ubunzima, ukuvuleka kombhobho okanye amatye enyongo? | Ulwakhiwo, hayi iikhemikhali. Ukuhlolwa kwesibindi ngamanqatha nge-ultrasound kuyachaza kwaye kuxhomekeke kumsebenzisi. |
| I-Elastography (ehamba kancinci okanye eshear-wave) | Ngaba kukho ukuqina kwesibindi okubonisa ukuba i-fibrosis ibangelwa yi-fibrosis? | Ivavanya ukuqina, into i-SGPT engenakukwazi ukuyenza. I-elastography ye-Transient kunye ne-shear-wave ziindlela ezahlukeneyo ezinee-thresholds ezahlukeneyo kwaye azinakutshintshwa. |
| I-Hepatitis B kunye ne-C serology | Ingaba kukho intsholongwane ethile ekhoyo? | Uvavanyo lwe-etiological. I-SGPT ayikwazi ukuchonga intsholongwane. |
Akukho vavanyo lunye "luqala" kuyo yonke indawo. Ukuba ingxaki ekhoyo yi-jaundice, i-bilirubin kunye ne-ultrasound ye-biliary zihlala zikhokela. Ukuba ingxaki sisibindi esinamafutha esinobungozi kunye nomngcipheko we-metabolic, ii-enzymes kunye ne-fibrosis zikhokelela kuvavanyo lomngcipheko. Ukuba ingxaki ikwicala eliphezulu leentlungu ezibonisa amatye enyongo, ii-ultrasound zikhokelela.
Ukulungiselela
Imiyalelo yokulungiselela iyasebenza kwaye yahlukile kwiilabhoratri kunye nezibhedlele. Imiyalelo ebhaliweyo yelabhoratri yakho ibaluleke ngaphezu kwayo nayiphi na into ekweli phepha.
- Ukuzila ukudla: I-SGPT ayifuni kuzila ukutya ngokubanzi. Ukuzila ukutya kunokufuneka ukuba iprofayili ye-lipid okanye i-glucose yokuzila ukutya itsalwe kutyelelo olunye.
- Amayeza kunye nezongezo: Zisa uluhlu olupheleleyo, oluquka ukusetyenziswa kwe-paracetamol, unyango oluchasene nesifo sephepha, ii-statins, ii-antibiotics, iintlungu zentlungu, i-AYUSH kunye ne-herbal preparations, ii-protein powders kunye nezongezo ze-gym. Musa ukuyeka naluphi na unyango olunikiweyo ukuze "uphucule" isiphumo, thetha nogqirha kuqala.
- Utywala: Xelela ugqirha wakho malunga nokusela kwakho okusandul’ ukutyiwa endaweni yokukufihla; ukusela kwakho okusandul’ ukutyiwa kuchaphazela indlela otolikwa ngayo.
- Umthambo onzima: Iiseshoni ezininzi zejimu okanye ukubaleka ixesha elide ngosuku oludlulileyo okanye ezimbini kunokunyusa i-SGPT kunye ne-SGOT. Yikhankanye, kwaye ucinge ngokuphepha ukuzilolonga okungaqhelekanga kwangaphambili.
Ukuba unesifo seswekile kunyango lokunciphisa iswekile
Ukuba kucelwe ukuba uzile ukutya kwezinye iimvavanyo kwi-draw efanayo, buza ugqirha okunika imiyalelo ukuba ungalibala njani ixesha le-insulin okanye i-sulfonylureas, kwaye uphathe umthombo weglucose. Ukuzila ukutya ixesha elide ngaphandle kokulawulwa kwezi ziyobisi kunokubangela ukuba umntu angabi naswekile egazini.
Ukuba ukhulelwe
Akukho mfuneko yokuzila ukutya kwi-SGPT. Xelela ilabhoratri ukuba ukhulelwe, njengoko iziphumo ezininzi kwiphaneli zitolikwa ngokwahlukileyo xa ukhulelwe.
Ukuba une-CKD, ukusilela kwentliziyo okanye ukunqongophala kolwelo
Musa ukwandisa ulwelo olusetyenziswayo ngaphaya komda omiselweyo njengengcebiso eqhelekileyo "yokumanzisa". Landela umda obekwe liqela lakho lonyango.
abantwana
Ukutsalwa kwegazi ebantwaneni kusebenzisa imiqulu emincinci kunye noluhlu lwezalathiso zabantwana. Ukuzila ukutya ixesha elide akufanelekanga kubantwana abancinci ngaphandle kokuba ugqirha wabantwana ebanike imiyalelo ethile.
Kwenzeka ntoni ngexesha lovavanyo kwaye kuthatha ixesha elingakanani
Ingcali ye-phlebotomist ihlambulula ulusu, ifake i-tourniquet ize itsale isampuli yegazi encinci, ngokuqhelekileyo emthanjeni osesandleni. Ukutsalwa ngokwako kuthatha ngaphantsi komzuzu. Kubandakanya ubhaliso, utyelelo ludla ngokuba yimizuzu emi-5 ukuya kweli-15. Uxinzelelo lubanjwa phezu kwendawo kwaye kufakwa ibhandeji elincinci.
Uninzi lweelabhoratri ezikhupha i-SGPT ziphuma ngosuku olufanayo okanye olulandelayo lomsebenzi, njengoko uvavanyo luqhutywa ngokuzenzekelayo rhoqo. Utshintsho oluchanekileyo luxhomekeke kwiyunithi, amaxesha okuphela kokuqokelela kunye nokuba isampulu ithathwe kwiziko lokuqokelelwa okanye kwilabhoratri ephambili.
Ukuqonda ingxelo yakho ye-SGPT
I-SGPT ixelwa ngokweeyunithi ngelitha (U/L) okanye iiyunithi zamazwe ngamazwe ngelitha (IU/L). Uluhlu lweereferensi luyahluka ngokwendlela yovavanyo, ilebhu, isini kunye nobudala, kwaye ezinye iilebhu zisebenzisa imida ephezulu ephantsi kunezinye. Sebenzisa uluhlu oluprintiweyo kwingxelo yakho. Musa ukuthelekisa ixabiso lakho noluhlu oluvela kwilebhu eyahlukileyo okanye kwiwebhusayithi.
Imigaqo ebanzi esetyenziswa ngugqirha wakho:
- Ukuphakama okuphantsi: isifo sesibindi esidla ngokuba sisifo se-metabolic (amafutha), utywala, amayeza okanye izongezo. Idla ngokulawulwa ngokuchongwa kwesizathu, ukuvavanywa okuphindaphindiweyo kunye novavanyo lomngcipheko we-fibrosis.
- Ukuphakama okuphawulweyo: iphakamisa amathuba okuba ne-hepatitis ebangelwa yintsholongwane ebukhali (kuquka i-hepatitis A kunye ne-hepatitis E, zombini ezixhaphakileyo eIndiya), ukwenzakala kwesibindi okubangelwa ngamayeza, ukwenzakala kwe-ischemic okanye i-hepatitis ye-autoimmune. Ezi zifuna uvavanyo lweklinikhi olukhawulezileyo.
- Ipateni ibaluleke ngaphezu komfanekiso omnye: I-SGPT dominant ibonisa ukwenzakala kwesibindi; i-ALP kunye ne-GGT dominant zibonisa inkqubo ye-cholestatic.
- Ibalulekile intsingiselo: Ukuwa kwe-SGPT kwisigulana esiwohlokayo ngokwezonyango akuyonto ilungileyo.
- I-SGPT ephantsi Ngokuqhelekileyo ayinangxaki yezonyango ngokwayo.
Amanani athile afana ne-75, 90, 110 okanye 200 U/L awanakubonwa njengo "obuthathaka" okanye "obunzima" ngokwahlukileyo. Eli xabiso linye linentsingiselo eyahlukileyo kakhulu kumntu onesifo somkhuhlane seentsuku ezimbini kunye ne-jaundice, kumntu osebenzisa unyango lwe-anti-tubercular, nakumntu ongenazimpawu onesibindi esinamafutha kwi-sonography. Ngugqirha kuphela ocele uvavanyo, kunye nembali yakho, uhlolo kunye nabanye abaphandi, onokulutolika. Iziphumo ziyahluka ngokuxhomekeke kwiimeko zeklinikhi nganye.
Inqaku lokuqanjwa kwamagama: into eyayibizwa ngokuba yi-NAFLD ngoku ibizwa ngokuba yi-MASLD (isifo sesibindi esinxulumene nokungasebenzi kakuhle kwe-metabolic), i-NASH ngoku yi -MASH , igama elisisiseko liyi -steatotic liver disease , kwaye i-MetALD ichaza igalelo elifanayo le-metabolic kunye ne-alcohol-related (i-multi-society Delphi consensus, 2023). Iingxelo ezindala zisenokusebenzisa amagama angaphambili.
Xa iziphumo ze-SGPT zinokulahlekisa
Izizathu ze-SGPT ephakanyisiweyo ngobuxoki okanye ngokulahlekisayo
- Ukuzilolonga okunzima okanye ukwenzakala kwemisipha: izihlunu zamathambo ziqulethe i-alanine aminotransferase; uqeqesho olunzulu, ukuwa okanye inaliti ye-intramuscular inokuyiphakamisa ngaphandle kwesifo sesibindi.
- I-Haemolysis yesampuli ngexesha lokuqokelelwa okanye ukuthuthwa kunokuphazamisana neengcali ezininzi zohlalutyo.
- Utywala obusandul' ukuselwa okanye isongezelelo esitsha kunokubangela ukunyuka okwethutyana okuya kusombulula xa kuvavanywa ngokuphindaphindiweyo.
- Isifo se-Coeliac, iingxaki ze-thyroid kunye nesifo semisipha inokuvelisa ukuphakama okuncinci okungapheliyo okuphambanisiweyo nesifo sesibindi esiyintloko.
Izizathu ze-SGPT eqinisekisayo ngokungeyonyani okanye ephantsi ngokungeyonyani
- Isifo sesibindi esiqinisekisiweyo: ii-enzyme zihlala ziqheleka njengoko ubunzima be-hepatocyte busehla, ngoko ke i-SGPT eqhelekileyo inokuhambisana nesifo esiqhubekileyo.
- I-hepatitis B okanye C engapheliyo kwisigaba esingasebenziyo: ii-enzymes eziqhelekileyo nangona usulelo luqhubeka kwaye kunokwenzeka ukuba i-fibrosis.
- Isifo esitshintshatshintshayo: ii-enzymes kwi-hepatitis engapheliyo kunye ne-MASLD ziyanyuka kwaye ziyancipha, ngoko ke ixabiso elinye eliqhelekileyo linokuwa kwifestile ethuleyo.
- Ukunqongophala kweVitamin B6 (pyridoxine) kunye ne-chronic dialysis zinokunciphisa umsebenzi olinganiswayo.
- Imida ephezulu yovavanyo eyahlukeneyo: ezinye iilabhoratri zisebenzisa iindlela ezisezantsi, ngoko ke ixabiso eliphawulwe njengeliqhelekileyo kwelinye ilabhoratri linokubekwa njengeliphezulu kwelinye.
Iingozi kunye nokhuseleko
Ukuthathwa kwesampulu yegazi lemithambo yegazi
Ukubhoboza igazi rhoqo kuneengozi eziphantsi kodwa zokwenyani: iintlungu ezimfutshane, ukukrweleka, ukuba nentloko ekhaphukhaphu okanye ukuquleka, kwaye akusoloko kukho i-hematoma encinci okanye usulelo lwasekuhlaleni. Abantu abasebenzisa amayeza okunciphisa ukugabha kwegazi okanye abaneengxaki zokopha basenokukrweleka ngakumbi kwaye kufuneka baxelele i-phlebotomist.
Isampuli ye-capillary okanye yabantwana
Ukuthathwa kwesampulu ngesithende okanye ngeminwe kwiintsana nabantwana abancinci kubangela ukungakhululeki okwethutyana kunye nokugruzuka okuncinci; umthamo wesampulu uncinci, kwaye ngamanye amaxesha kufuneka ukuphinda kuthathwe ukuba isampulu ayonelanga okanye ayinayo i-hemolysis.
Akukho mahluko, imitha okanye ukuthomalalisa okubandakanyekileyo kuvavanyo lwe-SGPT.
Iiflegi ezibomvu
Funa ukhathalelo olungxamisekileyo ngoku
- Ukudideka, ukudideka, ukozela, intetho engacacanga okanye ukuziphatha okungaqhelekanga kumntu onesifo sesibindi esaziwayo okanye ocingelwayo
- Ukuhlanza igazi, okanye indle emnyama engapheliyo
- I-jaundice enzulu ngokukhawuleza kunye nokuhlanza kunye nokungakwazi ukugcina ulwelo luphantsi
- Ukusela kakhulu i-paracetamol okanye ukurhanelwa ukuba utyhefwe, nokuba umntu uzive ephilile
- Intlungu ebuhlungu yesisu enomkhuhlane kunye ne-jaundice
Lungiselela uphononongo lwaloo mini
- I-jaundice entsha, umchamo omnyama okanye indle ekhanyayo
- Ingxelo ye-SGPT iphakamise kakhulu, ingakumbi xa kukho isicaphucaphu, ukuhlanza okanye iintlungu zesisu esingaphezulu.
- Ukudumba kwesisu okutsha okanye ukudumba kwemilenze okuya kusiba mandundu ngokukhawuleza
- Iienzymes zesibindi eziphakamileyo ngelixa usebenzisa unyango lwe-anti-tubercular, i-methotrexate okanye iyeza elitsha okanye isongezelelo, nxibelelana nogqirha ngaloo mini inye.
- I-jaundice, ukurhawuzelelwa, iintlungu zesisu esingentla okanye ukuhlanza okungapheliyo ngexesha lokukhulelwa
Bhukisha idinga lesiqhelo
- I-SGPT ekhuliswe kancinci kumntu oziva ephilile
- Isibindi esinamafutha sixelwe kwi-sonography ngee-enzymes eziqhelekileyo okanye eziphakanyisiwe kancinci
- Iziphumo zomda ezihlala ixesha elide ezifuna uvavanyo oluphindaphindwayo kunye novavanyo lomngcipheko we-fibrosis
- Iimpawu eziqhubekayo nangona i-SGPT iqhelekile
Iimeko ezikhethekileyo
Ukukhulelwa
Utshintsho oluncinci lunokwenzeka xa ukhulelwe, kodwa ii-transaminases eziphakanyisiweyo azifanele zithathwe njengeziqhelekileyo xa ukhulelwe. I-Intrahepatic cholestasis yokukhulelwa, i-pre-eclampsia ebandakanyeka kwisibindi, i-HELLP syndrome, i-hyperemesis gravidarum kunye ne-acute viral hepatitis (kuquka i-hepatitis E, enokuba nzima xa ukhulelwe eIndiya) zonke ezi zinto zifuna uvavanyo lokubeleka.
abantwana
Uluhlu lweereferensi zabantwana luyahluka kolwabantu abadala. Ukuphakama okuqhubekayo emntwaneni kukhuthaza ukuqwalaselwa kweengxaki zemetabolism, zemfuza, ze-autoimmune kunye nezemisipha kunye nesifo sesibindi esibizwa ngokuba yi-steatotic, kwaye kufuneka kuhlolwe ngugqirha wabantwana okanye ngugqirha wezifo zesisu zabantwana.
Abantu abadala abadala
I-Polypharmacy yenza ukuba ukwenzakala kwesibindi okubangelwa ngamayeza kube lula. Ukunyuka kwee-enzyme kunokuba kuncinci nakwisifo esibalulekileyo, ngoko ke iimpawu zomfanekiso kunye nemisebenzi zithwala ubunzima obungaphezulu.
Abantu abanesifo seswekile
Isifo sesibindi esibizwa ngokuba yi-steatotic sixhaphakile kunye nesifo seswekile sohlobo lwesibini, kwaye umngcipheko we-fibrosis uphezulu. Amanqanaba e-enzyme awahambelani kakuhle ne-fibrosis, ngoko ke uvavanyo lwe-fibrosis lukhokelwa ngugqirha onyangayo endaweni ye-SGPT yodwa.
Abantu abane-CKD okanye abakwi-dialysis
Amanqanaba e-transaminase adla ngokuba phantsi kumaqela e-dialysis, ngoko ke i-SGPT "eqhelekileyo" ayikhuthazi kangako, kwaye kusetyenziswa imida ephantsi yovavanyo olongezelelweyo.
Abantu abanesifo sentliziyo
Ukuxinana kwesibindi kunye neemeko zokukhupha okuncinci zinokunyusa i-SGPT kunye ne-SGOT ngaphandle kwesifo sesibindi esiphambili. Isimo sentliziyo kufuneka siqwalaselwe xa sitolikwa.
Uvavanyo lwe-SGPT kumxholo waseIndiya
- Isigama: Iilabhoratri zaseIndiya zinika ingxelo ngokubanzi I-SGPT kwaye I-SGOT endaweni ye-ALT kunye ne-AST. Uvavanyo luyafana; yindlela yokubiza amagama kuphela eyahlukileyo. Zombini zihlala zivela kwiprinta ye-LFT efanayo.
- IHepatitis A kunye neHepatitis E Zisengunobangela obalulekileyo we-hepatitis ebukhali kunye ne-transaminases ephezulu eIndiya, ingakumbi kubantu abadala abancinci, kwaye i-hepatitis E inomngcipheko owongezelelekileyo xa ukhulelwe.
- Unyango oluchasene nesifo sephepha yimbangela eqhelekileyo yokwenzakala kwesibindi okubangelwa ngamayeza ngenxa yomthwalo wesifo sephepha. Ukubeka iliso kunye nesigqibo somthamo sixhomekeke kugqirha onyangayo, ungaze uyeke i-ATT wedwa.
- I-AYUSH, izongezo zemifuno kunye nejimu Ziyimbangela eyaziwayo nengaxelwanga ngokwaneleyo yokwenzakala kwesibindi kuluntu lwaseIndiya. Chaza yonke into oyithathayo, kuquka iimveliso ezithengiswa "njengezendalo" okanye "ukususwa kwesibindi". Amabango okuba imveliso iyaphilisa okanye ibuyisela umva isifo sesibindi nawo awekho phantsi koMthetho weDrugs and Magic Remedies (Iintengiso ezingachaswanga) ka-1954.
- Isifo sesibindi esibangelwa kukusetyenziswa kwe-metabolism kwi-BMI ephantsi: Abantu baseMzantsi Asia bahlakulela ukungasebenzi kakuhle kwe-metabolic kunye nesifo sesibindi esibizwa ngokuba yi-steatotic kwi-body mass index esezantsi kunye ne-waist thresholds kunabantu abamhlophe baseYurophu, ngoko ke ukwakheka "okuqhelekileyo" akuyikhuphi i-MASLD.
- I-Haemoglobinopathy kunye ne-anemia yokunqongophala kwesinyithi zixhaphakile eIndiya. Ezi azichaphazeli ngqo i-SGPT kodwa zichaphazela ezinye iimvavanyo ezidla ngokucwangciswa kutyelelo olunye, njenge-HbA1c, ekuthembeka kwayo kuncitshisiwe kwi-thalassemia trait kunye nezinye iintlobo ze-hemoglobin.
- Ukukhusela idatha: Ukuba ubhukisha okanye ufumana iingxelo nge-portal okanye i-app ekwi-intanethi, idatha yakho yezempilo yidatha yobuqu phantsi koMthetho woKhuseleko lweDatha yoBuqu yeDijithali, ka-2023.
Ixabiso kunye ne-inshurensi eIndiya
Uvavanyo lwegazi oluzimeleyo lwe-SGPT/ALT lolunye lolona vavanyo lwegazi lungabizi kakhulu olufumaneka eIndiya, kwaye ludla ngokuba nexabiso eliphantsi xa lu-odolwe kwiphaneli ye-LFT kunanjengovavanyo olunye olongezelelweyo. Amaxabiso ahluka kakhulu phakathi kwezixeko, phakathi kweelabhoratri zesibhedlele kunye namaziko okuqokelelwa azimeleyo, kunye naphakathi kwamaxabiso omntu ngamnye kunye namaxabiso ephakheji. Naliphi na inani elicatshulwe kwi-intanethi libonisa kuphela, qinisekisa intlawulo yangoku ngqo kwilabhoratri ngaphambi kokubhukisha.
Izinto ezichaphazela iindleko:
- Nokuba i-SGPT iodolwe yodwa okanye ngaphakathi kwephakheji ye-LFT okanye yokujonga impilo
- Ilabhoratri esesibhedlele xa ithelekiswa nekhonkco lokuxilonga elizimeleyo xa ithelekiswa neziko lokuqokelela
- Isixeko kunye nendawo
- Iindleko zokuqokelela indlu
- Ukucutshungulwa ngokukhawuleza okanye emva kweeyure zomsebenzi
- Imeko yokuvunywa kwelebhu
- Nokuba uvavanyo luyinxalenye yesicwangciso sikarhulumente okanye somqeshi
I-inshurensi: uvavanyo lokuxilonga lwezigulane ezingalaliswanga ekhaya alusoloko lugutyungelwa yi-inshurensi yezempilo eqhelekileyo ngaphandle kokuba inxulunyaniswa nokwamkelwa okanye igutyungelwe yi-OPD okanye umkhweli ojonga impilo. Xa uvavanyo lwenziwa ngexesha lokungeniswa esibhedlele esigutyungelweyo, ludla ngokubandakanywa kwicandelo lophando. Jonga imiqathango yepolisi yakho kunye neemfuno zemvume yangaphambi kwexesha.
Iintsomi nezibakala
| Inkolelo | inyaniso |
|---|---|
| I-SGPT eqhelekileyo ithetha ukuba isibindi siphilile. | Isifo sofuba, i-hepatitis B engapheliyo engasebenziyo kunye ne-fibrosis ebalulekileyo zonke zinokwenzeka nge-SGPT eqhelekileyo. |
| I-SGPT ephezulu ithetha ukuba umonakalo wesibindi uhlala uhleli. | Izizathu ezininzi, kuquka ukusabela kwiziyobisi, i-acute viral hepatitis kunye nesifo sesibindi esibizwa ngokuba yi-steatotic liver disease, ziyatshintsha okanye ziyaphucuka xa imbangela ijongwa. Iziphumo ziyahluka ngokweemeko zomntu ngamnye. |
| I-SGPT inyuka kuphela ngotywala. | Utywala ngomnye wemiba emininzi. Isifo sesibindi esibangelwa kukusetyenziswa kwe-metabolism, iintsholongwane, amayeza, izongezo zokutya, isifo sokuzikhusela komzimba kwanokwenzakala kwemisipha kunokusibangela. |
| Isiselo okanye ijusi "yokususa ityhefu kwisibindi" iya kuyinciphisa i-SGPT. | Akukho mveliso yokususa ubuthi ebonakalisiweyo ukuba iyanyanga izifo zesibindi, kwaye ezinye iimveliso zezityalo nezongezelelo ngokwazo zibangela ukwenzakala kwesibindi. Unyango lujongana nonobangela oyintloko. |
| I-SGPT yama-200 isoloko ithetha isifo esinzulu. | Ukubaluleka kuxhomekeke kumfanekiso weklinikhi, umkhwa kunye nalo lonke iqela. Ifuna uvavanyo lwezonyango olukhawulezileyo, kungekhona ukuzitolika. |
| I-SGPT kunye ne-SGOT zizinto ezifanayo. | Zii-enzymes ezahlukeneyo. I-SGPT ihambelana nesibindi ngakumbi; i-SGOT ikwabonakalisa intliziyo kunye nezihlunu. |
| Kufuneka uzile ukutya iiyure ezili-12 ukuze wenze uvavanyo lwe-SGPT. | I-SGPT ngokwayo ayifuni kuzila ukutya. Imiyalelo yokuzila ukutya idla ngokunxulumana nezinye iimvavanyo ezikumzobo ofanayo kwaye iyahluka ngokwelabhoratri. |
Imibuzo ebuzwa qho
Ngaba i-SGPT iyafana ne-ALT?
Ewe. I-SGPT (serum glutamic pyruvic transaminase) ligama elidala le-alanine aminotransferase. Iilabhoratri zaseIndiya zihlala ziprinta i-SGPT, ngelixa iingxelo zamazwe ngamazwe zisebenzisa i-ALT. I-enzyme, uvavanyo kunye nentsingiselo yeklinikhi ziyafana, ngoko akukho mfuneko yokuphinda uvavanyo ukuba ingxelo yakho isebenzisa ilebheli eyahlukileyo.
Kuthetha ukuthini ukuba ne-SGPT ephezulu?
I-SGPT ephezulu ithetha ukuba iiseli zesibindi zivuza i-enzyme, nto leyo ebonisa ukurhawuzelelwa okanye ukwenzakala. Ayichazi unobangela. Isifo sesibindi seSteatotic, utywala, amayeza, izongezo, i-hepatitis yentsholongwane, i-hepatitis ye-autoimmune kunye nokwenzakala kwemisipha zonke ezi zinto zinokwenzeka. Ugqirha wakho udibanisa ixabiso nembali yakho, uhlolo, ezinye iimvavanyo zesibindi kwaye ngamanye amaxesha imifanekiso.
Ngaba kufuneka ndizile ukutya ngaphambi kovavanyo lwe-SGPT?
I-SGPT ayifuni ukuzila ukutya ngokubanzi. Ukuzila ukutya kudla ngokucelwa kuba iprofayili ye-lipid okanye i-glucose yokuzila ukutya iqokelelwa kutyelelo olunye. Landela imiyalelo ebhaliweyo evela kwilebhu yakho. Ukuba unesifo seswekile kumayeza okwehlisa i-glucose, buza ugqirha wakho ukuba angalibeka njani ixesha lomthamo ngaphambi kokuzila ukutya.
Ndiza kuyifumana nini iziphumo zam ze-SGPT?
I-SGPT luvavanyo oluzenzekelayo oluqhelekileyo, kwaye uninzi lweelabhoratri luyixela ngosuku olufanayo okanye olulandelayo lomsebenzi. Ixesha lokwenyani lixhomekeke ekunqunyanyisweni kweyunithi yakho, nokuba isampuli isetyenzwa kwindawo okanye ithuthwa iye kwilabhoratri ephakathi, kwaye nokuba kuceliwe na ukucubungula okungxamisekileyo.
Ngaba i-SGPT inganceda ekutyeni nasekuzilolongeni kuphela?
Kuxhomekeke ngokupheleleyo kwisizathu. Kwisifo sesibindi esinamafutha, utshintsho oluqhubekayo kwindlela yokutya kunye nomsebenzi womzimba ludla ngokunciphisa ii-enzymes ngokuhamba kweenyanga. Kwi-hepatitis ebangelwa yintsholongwane, i-hepatitis ye-autoimmune okanye ukwenzakala okubangelwa ngamayeza, utshintsho lwendlela yokuphila lodwa alwanelanga. Naluphi na utshintsho lweyeza kufuneka lugqitywe ngugqirha wakho.
Ngaba i-SGPT ingaba phezulu ngaphandle kweempawu?
Ewe, kwaye oku kuqhelekile. I-SGPT ephakanyisiwe kancinci idla ngokufumaneka ngengozi kwiphaneli yokujonga impilo kumntu oziva ephilile ngokupheleleyo. Ukungabikho kweempawu akuthethi ukuba iziphumo azibalulekanga; kudla ngokuthetha ukuba kufuneka uvavanyo oluphindaphindwayo, uphendlo lwesizathu kunye novavanyo lomngcipheko we-fibrosis.
Loluphi uvavanyo olundixelela ukuba ndinamanxeba esibindi?
I-SGPT ayinakuvavanya i-fibrosis. Ukulinganiswa kokuqina kwesibindi nge-elastography, amanqaku e-fibrosis angangenisi gazi kusetyenziswa iiparameter zegazi, kwaye ngamanye amaxesha kusetyenziswa i-biopsy yesibindi. I-elastography yesikhashana kunye ne-shear-wave ziindlela ezahlukeneyo ezinemilinganiselo eyahlukileyo, kwaye ukhetho lwenziwa ngugqirha wakho onyangayo.
Kutheni i-SGPT yam iphezulu emva kokuzilolonga ejimini?
Izihlunu zamathambo ziqulethe i-alanine aminotransferase, ngoko ke uqeqesho olunzima lokumelana nomzimba, iiseshoni zokunyamezela ixesha elide okanye ukwenzakala kwezihlunu kunokunyusa i-SGPT kunye ne-SGOT ngaphandle kwesifo sesibindi. Iipowuda zeproteni kunye nezongezo zangaphambi kokuzilolonga nazo zinokuba negalelo. Xelela ugqirha wakho ngoqeqesho lwakho kunye nezongezo ngaphambi kokuba kulungiselelwe uvavanyo lwesibindi olongezelelweyo.
Ngaba i-SGPT kufuneka ihlolwe ngexesha lokukhulelwa?
I-SGPT ijongwa xa ukhulelwe xa kukho i-jaundice, ukurhawuzelelwa, iintlungu zesisu esingaphezulu, ukuhlanza okungapheliyo, uxinzelelo lwegazi oluphezulu okanye i-pre-eclampsia erhanelwayo. Ii-transaminases eziphakanyisiweyo xa ukhulelwe azijongwa njengotshintsho oluqhelekileyo lomzimba kwaye zifuna uvavanyo lokubeleka, kuba iimeko ezifana ne-cholestasis yokukhulelwa kunye ne-HELLP syndrome zifuna ukuphathwa ngexesha elifanelekileyo.
imithombo
- Rinella ME et al. Ingxelo yesivumelwano se-Multi-society Delphi malunga nomenclature entsha yesifo sesibindi esinamafutha (ukwazisa i-SLD, i-MASLD, i-MASH kunye ne-MetALD), 2023.
- Isikhokelo seklinikhi seKholeji yaseMelika yeGastroenterology: uvavanyo lweekhemikhali zesibindi ezingaqhelekanga.
- Izikhokelo zonyango ze-European Association for the Study of the Liver malunga nokwenzakala kwesibindi okubangelwa ngamayeza kunye novavanyo olungangenisi gazi ukuze kuvavanywe ubukhali besifo sesibindi.
- Amaphepha eenkcukacha ze-World Health Organisation malunga ne-hepatitis A, B, C kunye no-E.
- Iingxelo ze-Indian National Association for Study of the Liver (INASL) malunga nokwenzakala kwesibindi okubangelwa ngamayeza kunye nesifo sesibindi esibangelwa yi-metabolic/steatotic kwizigulane zaseIndiya.
- ICandelo le-TB eliPhakathi, uMphathiswa wezeMpilo kunye neNtlalontle yoSapho, isikhokelo sokujonga ubuthi besibindi ngexesha lonyango lokulwa nesifo sephepha.
- UMthetho weZiyobisi kunye noNyango lweMilingo (iiNtengiso ezingachasekiyo), ka-1954; UMthetho woKhuseleko lweDatha yoBuqu yeDijithali, ka-2023.
