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Overview
Dr. Seerapani Gopaluni is a UK-trained nephrologist and transplant specialist with over 18 years of experience. A PhD graduate from the University of Cambridge, he has extensive expertise in kidney transplantation, autoimmune kidney diseases, glomerulonephritis, and dialysis care.
He has led multiple international clinical trials and has over 25 publications in leading journals. Dr. Gopaluni is known for combining advanced research with compassionate, evidence-based patient care.
Hospital Details
Apollo Health City, Jubilee Hills
Apollo Health City, Road No 72, Opp. Bharatiya Vidya Bhavan School, Film Nagar, Jubilee Hills, Hyderabad, TS, 500033
Experience
- Consultant Nephrologist & Transplant Physician – Citizens Hospital Nov 2020 to Aug 2025
- PhD in Auto-immune diseases at University of Cambridge 2015 to 2020
- 2009 to 2014 – Specialty registrar at Churchill Hospitals, Oxford, UK
- 2008 to 2009 – Specialty registrar at St James Hospital, Leeds, UK
Memberships
- Indian Society of Transplantion
- Indian Society of Nephrology
- Federation of Royal College of Physician
Awards
- Dr APJ Abdul Kalam Health & Medical Excellence Award – 2024
- Received grant for £2 Million to conduct a clinical trial called BIOVAS by NIHR - 2019
- Received grant for £45,000 by Vasculitis UK Organization to conduct a clinical study - 2017
- Received scholarship of £250,000 through Experimental Medicine Training Initiative fellowship for PhD at University of Cambridge - 2016
- Received Distinction in the Anatomy / ENT/ Ophthalmology in the University Examination at NTR University of Health Sciences
Research and Publication
- M McClure, S Gopaluni et al, A randomised study of rituximab and belimumab
sequential therapy in PR3 ANCAassociated vasculitis (COMBIVAS): design of the
study protocol. DOI: 10.21203/rs.3.rs-2138639/v1, March 2023. - S Gopaluni, R Smith, D Jayne et al, Alemtuzumab for refractory primary systemic
vasculitis—a randomised controlled dose ranging clinical trial of efficacy and safety
(ALEVIATE), April 2022, Arthritis Research & Therapy 24(1), DOI:
10.1186/s13075-022-02761-6 - J Tieu, R Smith, S Gopaluni, et al. Rituximab Associated Hypogammaglobulinemia in
Autoimmune Disease, May 2021, Frontiers in Immunology 12, DOI:
10.3389/fimmu.2021.671503 - T Helper Cell Dysfunction in ANCA Associated Vasculitis, Dr S Gopaluni, PhD
Thesis – University of Cambridge, March 2021 - McClure, M. E., Zhu, Y., Smith, R. M., Gopaluni, S., Tieu, J., Pope, T., … Jones, R.
B. (2021). Long-term maintenance rituximab for ANCA-associated vasculitis: relapse
and infection prediction models. Rheumatology, 60(3), 1491–1501.
https://doi.org/10.1093/rheumatology/keaa541 - Rutherford, M. A., Scott, J., Karabayas, M., Antonelou, M., Gopaluni, S., Gray, D., …
Basu, N. (2021). Risk factors for severe outcomes in patients with systemic vasculitis
& COVID‐19: a bi‐national registry‐based cohort study. Arthritis &
Rheumatology, art.41728. https://doi.org/10.1002/art.41728 - Trivioli, G., Gopaluni, S., Urban, M. L., Gianfreda, D., Cassia, M. A., Vercelloni, P.
G., … Vaglio, A. (2021). Slowly progressive anti-neutrophil cytoplasmic antibodyassociated
renal vasculitis: clinico-pathological characterization and outcome. Clinical
Kidney Journal, 14(1), 332–340. https://doi.org/10.1093/ckj/sfaa139
Rutherford, M. A., Scott, J., Karabayas, M., Antonelou, M., Gopaluni, S., Gray, D., …
Basu, N. (2021). Risk factors for severe outcomes in patients with systemic vasculitis
& COVID‐19: a bi‐national registry‐based cohort study. Arthritis &
Rheumatology, art.41728. https://doi.org/10.1002/art.41728(Rutherford et al., 2021) - Wagner J, Harrison E. M, Martinez M, Pero D, Blane B, Mayer G, Leierer J,
Gopaluni S, Holmes M A, Parkhill J, Peacock S J, Jayne D R, Kronbichler A (2019).
The composition and functional protein subsystems of the human nasal microbiome in
granulomatosis with polyangiitis : a pilot study. Microbiome (2019) 7:137
https://doi.org/10.1186/s40168-019-0753-z - Evaluation of PR3-ANCA Status After Rituximab for ANCA-Associated Vasculitis.
McClure ME, Wason J, Gopaluni S, Tieu J, Smith RM, Jayne DR, Jones RB. J Clin
Rheumatol. 2019 Mar 20. doi: 10.1097/RHU.0000000000001030. - A novel glucocorticoid-free maintenance regimen for anti-neutrophil cytoplasm
antibody-associated vasculitis. Pepper RJ, McAdoo SP, Moran SM, Kelly D, Scott J,
Hamour S, Burns A, Griffith M, Galliford J, Levy JB, Cairns TD, Gopaluni S, Jones
RB, Jayne D, Little MA, Pusey CD, Salama AD. Rheumatology (Oxford). 2019 Feb
1;58(2):260-268. doi: 10.1093/rheumatology/key288. - Effect of Disease Activity at Three and Six Months After Diagnosis on Long-Term
Outcomes in Antineutrophil Cytoplasmic Antibody-Associated Vasculitis. Gopaluni S,
Flossmann O, Little MA, O'Hara P, Bekker P, Jayne D; European Vasculitis Society.
Arthritis Rheumatol. 2019 May;71(5):784-791. doi: 10.1002/art.40776. Epub 2019 Mar
28. - B cell therapy in ANCA-associated vasculitis: current and emerging treatment options.
McClure M, Gopaluni S, Jayne D, Jones R. Nat Rev Rheumatol. 2018 Oct;14(10):580-
591. doi: 10.1038/s41584-018-0065-x. Epub 2018 Aug 14. Review. - A retrospective study comparing the phenotype and outcomes of patients with
polyarteritis nodosa between UK and Turkish cohorts. Karadag O, Erden A, Bilginer
Y, Gopaluni S, Sari A, Armagan B, Ertenli I, Ozen S, Jayne D. Rheumatol Int. 2018
Oct;38(10):1833-1840. doi: 10.1007/s00296-018-4122-1. Epub 2018 Aug 11. - Trimethoprim-sulfamethoxazole prophylaxis prevents severe/life-threatening infections
following rituximab in antineutrophil cytoplasm antibody-associated vasculitis.
Kronbichler A, Kerschbaum J, Gopaluni S, Tieu J, Alberici F, Jones RB, Smith RM,
Jayne DRW. Ann Rheum Dis. 2018 Oct;77(10):1440-1447. doi: 10.1136/annrheumdis-
2017-212861. Epub 2018 Jun 27. - McAdoo, S. P., Medjeral-Thomas, N., Gopaluni, S., Tanna, A., Mansfield, N.,
Galliford, J., Griffith, M., et al. (2018). Long-term follow-up of a combined rituximab
and cyclophosphamide regimen in renal anti-neutrophil cytoplasm antibody-associated
vasculitis.. Nephrology, dialysis, transplantation : official publication of the European
Dialysis and Transplant Association - European Renal Association, 2018, 33 (5), 899.
https://doi.org/10.1093/ndt/gfy075 - Gopaluni, S., Smith, R. M., Lewin, M., McAlear, C. A., Mynard, K., Jones, R. B.,
Jayne, D. R. W. (2017). Rituximab versus azathioprine as therapy for maintenance of
remission for anti-neutrophil cytoplasm antibody-associated vasculitis (RITAZAREM):
study protocol for a randomized controlled trial. Trials, 18(1), 112.
http://doi.org/10.1186/s13063-017-1857-z
Gopaluni, S., Sherif, M., & Ahmadouk, N. A. 2016. Cochrane systematic review:
Interventions for chronic kidney disease-associated restless legs syndrome. Cochrane
Database of Systematic Reviews. doi: 10.1002/ 14651858. CD010690.pub2 - Gopaluni, S., & Jayne, D. (2016). Clinical Trials in Vasculitis. Current Treatment
Options in Rheumatology, 2(2), 161–177. doi:10.1007/s40674-016-0045-8 - Gopaluni, S. and Jayne, D. 2015. Immune Vasculitis. eLS. 1–8. DOI:
10.1002/9780470015902.a0002150.pub3 - Hindocha, S., Gopaluni, S., Collins, G. P., & Shenbagaraman, P. (2015). Focal
segmental glomerulosclerosis in a patient with mantle cell lymphoma. BMJ Case
Reports, 2015. doi:10.1136/bcr-2015-211765 - Gopaluni, S., Gibson, M., & Mohteshamzadeh, M. (2014). An unusual case of familial
cystic kidney disease. Clinical Kidney Journal, 7(5), 484–485. doi:10.1093/ckj/sfu075 - Gopaluni, S., Sherif, M., & Ahmadouk, N. A. (2013). Protocol- Interventions for
chronic kidney disease-associated restless legs syndrome. Cochrane Database of
Systematic Reviews. doi:10.1002/14651858.CD010690. - Ball MJ, Gopaluni S, Mathavakkannan S, Brian M, and Farrington K. An
immunocompromised dialysis patient with skin and bone lesions. NDT Plus 2010 0:
sfq010v1-sfq010; doi:10.1093/ndtplus/sfq010 - S Gopaluni, S Lines, AJP Lewington, Acute kidney injury in the critically ill patient,
Current Anaesthesia & Critical Care 21 (2), 60-64, April 2010 - Seerapani Gopaluni, Aadil Shaukat, Martin Gray, Roshni Gokhale and M Al-Bustami
Premature myocardial infarction presenting with acuacutete pulmonary embolism: a
case report. Journal of Medical Case Reports 2009, 3:8786
Special Interests
- Kidney transplantation
- ABO and HLA-incompatible kidney transplantation
- Paired exchange transplantation
- IgA Nephropathy
- Complement-mediated glomerulopathies - aHUS
- Lupus & Vasculitis
- Glomerulonephritis
- Diabetic kidney disease
- Chronic kidney disease
- Acute kidney injury
- Haemodialysis
- Peritoneal dialysis
- Renal biopsies
- Dialysis line insertion
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