I-Succimer - Ukusetyenziswa, Idosi, Iziphumo Ezingalindelekanga kunye nokunye

I-Succimer, ekwaziwa njenge-DMSA (i-dimercaptosuccinic acid), i-agent e-chelating esetyenziswa ikakhulu ukunyanga ityhefu yesinyithi esinzima, ngakumbi ityhefu yelothe ebantwaneni. Isebenza ngokubophelela kwiintsimbi ezinzima emzimbeni, ezivumela ukuba zikhutshwe ngomchamo. I-Succimer yonyango olubalulekileyo kwi-toxicology, inceda ukunciphisa imiphumo eyingozi yokuqokelela isinyithi emzimbeni.

Ukusetyenziswa kweSuccimer

I-Succimer ivunyiwe kusetyenziso oluninzi lwezonyango, kubandakanya:

• Ityhefu yelothe: Olona phawu luphambili lwe-succimer lunyango lwetyhefu yelothe, ngokukodwa kubantwana abanomlinganiselo welothe egazini ongaphezu kwama-45 eemicrogram ngedesilitha nganye.
• Ityhefu yeMercury: Ikwasetyenziswa ngaphandle kweleyibhile kwiimeko zetyhefu yemercury, nangona oku kungaqhelekanga.
• Ityhefu yeArsenic: I-Succimer inokuba luncedo kakhulu ekunyangeni ubuthi be-arsenic.
• Ezinye izinto ezinobungozi zeMetal: Ingasetyenziswa ngaphandle kweleyibhile kwezinye iintsimbi ezinzima, kuxhomekeke kwisigqibo seklinikhi.

Ingaba isebenza kanjani?

I-Succimer isebenza nge-chelation, inkqubo apho iyeza libopha kwiisinyithi ezinzima egazini. Nje ukuba zibotshelelwe, ezi metals azisebenzi kwaye zikhutshwa lula zizintso. Ngamazwi alula, cinga nge-succimer njengemagnethi etsala iisinyithi eziyingozi, inceda umzimba ukuba uzikhuphe ngomchamo, ngaloo ndlela inciphisa imiphumo yazo enobungozi.

Isisombululo kunye noLawulo

Idosi ye-succimer iyahluka ngokweminyaka yesigulana kunye nobukhulu betyhefu:

• Abadala: Idosi eqhelekileyo yi-10 mg/kg ngomlomo rhoqo emva kweeyure ezi-8 (kathathu ngemini) kangangeentsuku ezi-5, uze emva koko rhoqo emva kweeyure ezili-12 (kabini ngemini) kangangeentsuku ezili-14 zizonke, zingadluli kwi-500 mg ngedosi nganye okanye i-2.5 g/ngemini.
• Abantwana: Kubantwana, idosi iyafana: 10 mg/kg ngomlomo rhoqo emva kweeyure ezisi-8 (kathathu ngemini) kangangeentsuku ezi-5, uze emva koko rhoqo emva kweeyure ezili-12 (kabini ngemini) kangangeentsuku ezili-14 zizonke, zingadluli kwi-500 mg ngedosi nganye okanye i-2.5 g/ngemini.

I-Succimer ifumaneka kwifom ye-capsule kwaye kufuneka ithathwe ngamanzi. Kubalulekile ukulandela imiyalelo yomboneleli wezempilo malunga nedosi kunye nobude bonyango.

Iziphumo ezisecaleni zeSuccimer

Iziphumo ebezingalindelekanga eziqhelekileyo ze-succimer zinokubandakanya:

• I sizathu
• Ukuvutha
• Uhudo
• Intlungu zesisu
• Rash

Iziphumo ezibi kakhulu, nangona zinqabile, zinokubandakanya:

• Ukwalana (ukudumba, ubunzima bokuphefumla)
• Ukungasebenzi kakuhle kwesibindi
• Ukuphazamiseka kwegazi (okufana ne-thrombocytopenia)

Izigulane kufuneka zixele naziphi na iimpawu ezingaqhelekanga kumboneleli wabo wezempilo ngokukhawuleza.

Ukusebenzisana kweziyobisi

I-Succimer inokunxibelelana namayeza athile, kubandakanywa:

• Ii-antacids: Oku kunokunciphisa ukufunxwa kwe-succimer, kuyenze ingasebenzi kakuhle.
• Ezinye ii-Arhente eziChelating: Ukusebenzisa i-succimer kunye nezinye i-chelators kunokunyusa umngcipheko wemiphumo emibi.
• Amayeza achaphazela ukusebenza kwesibindi: Ekubeni i-succimer i-metabolized esibindini, iziyobisi ezichaphazela i-enzymes zesibindi zinokutshintsha ukusebenza kwazo.

Soloko wazisa umboneleli wakho wezempilo malunga nawo onke amayeza kunye nezongezo ozisebenzisayo ukuze uphephe ukudibana okunokwenzeka.

Iinzuzo zeSuccimer

Izibonelelo zeklinikhi zokusebenzisa i-succimer ziquka:

• Unyango olusebenzayo: Lunyango olungqiniweyo lwelothe kunye nezinye iityhefu zentsimbi enzima.
• Ulawulo lomlomo: Ngokungafaniyo nezinye ii-chelating agents ezifuna iinaliti, i-succimer ithathwa ngomlomo, okwenza kube lula kwizigulane, ngakumbi abantwana.
• Iprofayile yoKhuseleko: Xa isetyenziswe njengoko kuyalelwe, i-succimer ineprofayili yokhuseleko efanelekileyo xa kuthelekiswa nezinye i-chelating agents.

Contraindications of Succimer

I-Succimer kufuneka ithintelwe kubantu abathile, kubandakanywa:

• Abasetyhini abakhulelweyo: Ukhuseleko lwe-succimer ngexesha lokukhulelwa aluzange lusekwe.
• Abantu abanesifo sesibindi esinzima: Ekubeni i-succimer i-metabolized esibindini, abo banokukhubazeka kwesibindi kufuneka bakuphephe.
• Iintshukumo Zokwalana Nezinto: Izigulane ezine-allergies eyaziwayo kwi-succimer okanye nayiphi na inxalenye yayo akufanele isebenzise eli yeza.

Izilumkiso kunye nezilumkiso

Ngaphambi kokuqala i-succimer, izigulane kufuneka ziqaphele oku kulandelayo:

• Iimvavanyo zokuSebenza kwesibindi: Ukubeka iliso rhoqo ekusebenzeni kwesibindi kunokufuneka ngexesha lonyango.
• Hydration: Ukuhlala kakuhle-hydrated kubalulekile ukunceda iintso zikhuphe iintsimbi eziboshiweyo.
• Iintshukumo Zokwalana Nezinto: Zilumkele iimpawu zokwaliwa, ngakumbi ngexesha leedosi ezimbalwa zokuqala.
• Ayivunywanga kubantwana abangaphantsi konyaka ngenxa yedatha encinci.

FAQs

• Isetyenziselwa ntoni i-succimer? I-Succimer isetyenziselwa ikakhulu ukunyanga ityhefu yelothe kunye nezinye iityhefu ezinzima.
• Ithathwa njani i-succimer? I-Succimer ithathwa ngomlomo kwifom ye-capsule, ngokuqhelekileyo ngamanzi.
• Ziziphi iziphumo ebezingalindelekanga ze-succimer? Iziphumo ebezingalindelekanga eziqhelekileyo ziquka isicaphucaphu, ukuhlanza, kunye neentlungu zesisu. Iziphumo ezibi kakhulu zingenzeka kodwa zinqabile.
• Ngaba i-succimer ingasetyenziswa ebantwaneni? Ewe, i-succimer ivunyiwe ukuba isetyenziswe ebantwaneni, ngakumbi kwityhefu yelothe.
• Isebenza njani i-succimer? I-Succimer ibophelela kwiintsimbi ezinzima emzimbeni, ezivumela ukuba zikhutshwe ngomchamo.
• Ngaba kukho nakuphi na ukusebenzisana kweziyobisi kunye ne-succimer? Ewe, i-succimer inokunxibelelana ne-antacids kunye namanye amayeza achaphazela ukusebenza kwesibindi.
• Ngaba i-succimer ikhuselekile ngexesha lokukhulelwa? I-Succimer ayikhuthazwa ukuba isetyenziswe ngexesha lokukhulelwa ngenxa yedatha enganeleyo yokhuseleko.
• Ndingenza ntoni xa ndiphosa ithamo? Ukuba uphoswe yidosi, yithathe ngokukhawuleza xa ukhumbula ngaphandle kokuba sele kusondele ixesha lokusebenzisa idosi elandelayo; musa ukuyiphinda kabini.
• Lude kangakanani unyango lwe-succimer? Ngokwesiqhelo, iintsuku ezili-19 (iintsuku ezi-5 kwi-TID, iintsuku ezili-14 kwi-BID), kunye nezifundo ezinokuthi ziphindwe emva kweeveki ezi-2 ukuba amanqanaba e-lead ahlala ephakanyisiwe.
• Ndingayithatha i-succimer namanye amayeza? Soloko udibana nomboneleli wakho wezempilo ngaphambi kokuba uthathe i-succimer namanye amayeza ukunqanda ukusebenzisana.

Amagama eBrand

I-Succimer ithengiswa phantsi kweChemet.

isiphelo

I-Succimer liyeza elibalulekileyo kunyango lwetyhefu yesinyithi esinzima, ingakumbi i-lead. Ukukwazi kwayo ukususa iintsimbi eziyingozi ngempumelelo nokwenza kube lula ukukhupha kwazo kwenza ukuba ibe sisixhobo esibalulekileyo kwi-toxicology. Nangona ikhuselekile ngokubanzi, kubalulekile ukusebenzisa i-succimer phantsi kweliso lezonyango ukujonga iziphumo ebezingalindelekanga kunye nokusebenzisana. Soloko unxibelelana nomboneleli wakho wezempilo ukuze ufumane iingcebiso ezenzelwe wena kunye neendlela zonyango.