Divalproex - Uses, Dosage, Side Effects and More

Intshayelelo: Yintoni iDivalproex?

I-Divalproex, edla ngokwenziwa njenge-divalproex sodium, liyeza elisetyenziswa kakhulu ekunyangeni izifo ezahlukeneyo zemithambo-luvo nezengqondo. Livela kwi-valproic acid kwaye lihlelwa njengeyeza lokulwa nokuxhuzula kunye nelizinzisa iimvakalelo. I-Divalproex iyasebenza ekulawuleni isifo sokuwa, isifo se-bipolar, kunye nokuthintela iintloko ezibuhlungu ze-migraine. Amandla ayo okuzinzisa iimvakalelo kunye nokulawula ukuxhuzula kwenza ukuba ibe lukhetho olubalulekileyo ekunyangeni ezi meko.

Ukusetyenziswa kweDivalproex

I-Divalproex ivunyiwe kusetyenziso oluninzi lwezonyango, kubandakanya:

• Ukuxhuzula: Isetyenziselwa ukulawula iintlobo ezahlukeneyo zokuxhuzula, kubandakanywa ukuxhuzula okuqhelekileyo kwe-tonic-clonic, ukungabikho kokuxhuzula, kunye nokuxhuzula inxalenye.
• Ukuxhuzula: I-Divalproex iyasebenza ekunyangeni i-manic episodes ezinxulumene ne-bipolar disorder, inceda ukuzinzisa ukuguquka kwemizwelo.
• Uthintelo lweMigraine: Imiselwe ukunciphisa ukuhlaselwa yi-migraine rhoqo kubantu abaphethwe ziintloko ezibuhlungu eziphindaphindayo.

Ingaba isebenza kanjani

I-Divalproex isebenza ngeendlela ezahlukeneyo, kuquka ukwandisa amanqanaba e-gamma-aminobutyric acid (GABA) kunye nokulawula ukuvuseleleka kwe-neuronal engqondweni. I-GABA yi-neurotransmitter ethintelayo, oko kuthetha ukuba inceda ukuzola umsebenzi wengqondo. Ngokuphucula iziphumo ze-GABA, i-Divalproex inceda ekunciphiseni umsebenzi wombane ogqithisileyo engqondweni onokubangela ukuxhuzula kunye nokuphazamiseka kweemvakalelo. Ngamazwi alula, inceda "ukuzola" ingqondo, okwenza kube nzima ukuba ihlaselwe kukuxhuzula okanye ukutshintsha kweemvakalelo.

Isisombululo kunye noLawulo

Idosi ye-Divalproex iyahluka ngokwemeko enyangwayo, iminyaka yesigulana, kunye nempendulo yabo kwiyeza.

Abadala:

Idosi yokuqala yesifo sokuxhuzula yi-10-15 mg/kg/ngosuku, enokunyuswa kancinci kancinci. Kwi-bipolar disorder, umthamo wokuqala uhlala ujikeleze i-750 mg / ngosuku, ulungelelaniswa njengoko kufuneka.

Iintsholongwane:

Kubantwana, i-dose yokuqala i-10-15 mg / kg / ngosuku, kunye nohlengahlengiso olwenziwe ngokusekelwe kwimpendulo yomntwana kunye nokunyamezela.

I-Divalproex ifumaneka ngeendlela ezahlukeneyo, kuquka:

• Amacwecwe: Ukukhutshwa okwandisiweyo kunye nokukhutshwa okulibaziseka imixube.
• IiCapsules zokufefa: Inokuvulwa kwaye itshizwe ekutyeni ukuze kube lula ukulawula.
• Inaliti: I-Valproate sodium (isetyenziswa xa kungenakwenzeka ukuba isetyenziswe ngomlomo).

Iziphumo ezisecaleni zeDivalproex

Njengawo onke amayeza, i-Divalproex inokubangela iziphumo ebezingalindelekanga. Iziphumo ebezingalindelekanga eziqhelekileyo ziquka:

• I sizathu
• Ukulala
• Utywala
• Ukutyeba kwakho
• Ukugubha
• Ukulahleka kweenwele (alopecia)

Iziphumo ezibi kakhulu zinokubandakanya:

• Umonakalo wesibindi
• Pancreatitis
• Ukwaliwa kakhulu
• Ukuphazamiseka kwegazi (okufana ne-thrombocytopenia)
• I-Hyperammonemia, kunye okanye ngaphandle kwe-encephalopathy

Izigulana kufuneka ziqhagamshelane nomboneleli wazo wezempilo ukuba zifumana naziphi na iimpawu ezinzima okanye ezingaqhelekanga.

Ukusebenzisana kweziyobisi

I-Divalproex inokunxibelelana namayeza amaninzi kunye nezinto, ezinokuchaphazela ukusebenza kwayo okanye ukwandisa umngcipheko wemiphumo emibi. Unxibelelwano olukhulu lubandakanya:

• Ezinye ii-Anticonvulsants: Njenge-phenytoin kunye ne-carbamazepine, enokuguqula amanqanaba e-Divalproex.
• I-Aspirin: Inganyusa amanqanaba e-valproate kunye nomngcipheko wokopha.
• Ukuxhatshazwa: Ezinye ii-antidepressants zinokusebenzisana kwaye zifuna uhlengahlengiso lwedosi.
• Utywala: Ukusetyenziswa kotywala kunokuphucula iziphumo ze-Divalproex.

Ngalo lonke ixesha wazisa umboneleli wakho wezempilo malunga nawo onke amayeza kunye nezongezo ozithathayo.

Iinzuzo zeDivalproex

I-Divalproex ibonelela ngeengenelo ezininzi zeklinikhi kunye nezisebenzayo:

• Ukusebenza kakuhle: Isebenza kakuhle ekulawuleni ukuxhuzula kunye nokuzinzisa isimo sengqondo kwi-bipolar disorder.
• Iimpawu ezininzi: Ingasetyenziselwa iimeko ezahlukeneyo, iyenza ibe lukhetho oluguquguqukayo lonyango.
• Iziphumo ezihlala ixesha elide: Amalungiselelo okukhululwa okwandisiweyo avumela ukuba kube kanye okanye kabini i-dosing yonke imihla, ukuphucula ukuthotyelwa kwesigulane.
• Isekiwe iProfayile yoKhuseleko: I-Divalproex isetyenziswe iminyaka emininzi, inika ubutyebi bedatha yeklinikhi malunga nokhuseleko kunye nokusebenza kwayo.

Contraindications of Divalproex

Abantu abathile kufuneka bakuphephe ukusebenzisa iDivalproex, kubandakanya:

• Abasetyhini abakhulelweyo: I-Divalproex ayivumelekanga ngexesha lokukhulelwa ngaphandle kokuba akukho ndlela ifanelekileyo ekhoyo, ngenxa yomngcipheko ophezulu weziphene zetyhubhu ye-neural kunye neengxaki zophuhliso lwe-neurodevelopmental.
• Abantu abaneSifo Sesibindi: Inokunyusa iingxaki zesibindi kwaye ikhokelela kwiingxaki ezinzima.
• Iintshukumo Zokwalana Nezinto: Abo bane-allergies eyaziwayo kwi-Divalproex okanye amacandelo ayo akufanele basebenzise eli yeza.
• Iingxaki zoMjikelezo we-Urea: Izigulane ezineengxaki zomjikelezo we-urea ezaziwayo.

Izilumkiso kunye nezilumkiso

Ngaphambi kokuqala i-Divalproex, izigulana kufuneka zixoxe ngembali yazo yezonyango kunye nomboneleli wabo wezempilo. Izilumkiso ezibalulekileyo ziquka:

• Ukubeka iliso rhoqo: Iimvavanyo zesibindi kunye nokubalwa kwegazi kunokufuneka ukubeka iliso kwimiphumo enokubakho.
• Umngcipheko weengcinga zokuzibulala: Njengamayeza amaninzi okulwa nokuxhuzula, iDivalproex inokunyusa umngcipheko weengcinga okanye iindlela zokuziphatha zokuzibulala, ingakumbi ngexesha lonyango lwasekuqaleni.
• Ukurhoxa: Sukuyeka ukuthatha i-Divalproex ngequbuliso, njengoko oku kunokukhokelela ekwandeni komsebenzi wokubamba.
• Ukuncancisa: I-Divalproex ikhutshwa kubisi lwebele; ukuncancisa kufuneka kuxoxwe ngako nomboneleli wezempilo.

FAQs

Kufuneka ndenze ntoni ukuba ndiphosa ithamo le-Divalproex?

Ukuba uphose ithamo, yithathe ngokukhawuleza xa ukhumbula. Ukuba kusondele ixesha ledosi yakho elandelayo, tsiba idosi oyiphosileyo kwaye uqalise kwakhona ishedyuli yakho yesiqhelo. Musa ukuphinda kabini.

Ngaba ndingasela utywala ngelixa ndithatha i-Divalproex?

Kucetyiswa ukuba ugweme utywala, njengoko kunokunyusa imiphumo ye-Divalproex kwaye kunokukhokelela kwimiphumo emibi.

Ithatha ixesha elingakanani ukuba iDivalproex isebenze?

Kungathatha iintsuku ezininzi ukuya kwiiveki ukuqaphela iziphumo ezipheleleyo ze-Divalproex, ngakumbi ukuzinzisa imo kunye nolawulo lokuxhuzula.

Ngaba i-Divalproex ikhuselekile kubantwana?

Ewe, i-Divalproex inokumiselwa kubantwana, kodwa idosi iya kulungelelaniswa ngokusekelwe kubunzima babo kunye nemeko.

Kufuneka ndenze ntoni xa ndifumana iziphumo ebezingalindelekanga?

Qhagamshelana nomboneleli wakho wezempilo ngokukhawuleza ukuba ufumana iziphumo ezibi kakhulu okanye naziphi na iimpawu ezingaqhelekanga.

Ndingayithatha i-Divalproex ngexesha lokukhulelwa?

I-Divalproex ngokuqhelekileyo ayikhuthazwa ngexesha lokukhulelwa ngenxa yengozi yokuzalwa kweziphene. Dibana nogqirha wakho ngezinye iindlela.

Ngaba i-Divalproex inokuchaphazela ubunzima bam?

Ukuzuza ubunzima yimpembelelo eqhelekileyo ye-Divalproex. Xoxa ngazo naziphi na izinto ezikuxhalabisayo nomboneleli wakho wezempilo.

Ndingayeka ukuthatha i-Divalproex ngequbuliso?

Hayi, akufanele uyeke ukuthatha i-Divalproex ngokukhawuleza, njengoko oku kunokukhokelela ekubanjweni kokurhoxisa. Hlala udibana nogqirha wakho ngaphambi kokuba wenze utshintsho.

Ndingayigcina njani i-Divalproex?

Gcina i-Divalproex kwiqondo lokushisa, kude nomswakama kunye nobushushu. Yigcine kude nabantwana.

Ngaba i-Divalproex iyakhobokisa?

I-Divalproex ayithathwa njengomlutha, kodwa kufuneka isetyenziswe njengoko kuchaziwe ukuphepha iimpawu ezinokubakho zokurhoxisa.

Amagama eBrand

I-Divalproex ithengiswa phantsi kwamagama amaninzi, kuquka:

• Depakote
• Depakote ER
• Depakote Ukufefa

isiphelo

I-Divalproex liyeza elibalulekileyo lokulawula ukuxhuzula, i-bipolar disorder, kunye nothintelo lwe-migraine. Ukukwazi kwayo ukuzinzisa imo kunye nokulawula ukuxhuzula kwenza ukuba ibe lukhetho oluxabisekileyo lonyango. Ngelixa ngokubanzi ikhuselekile kwaye isebenza, izigulane kufuneka ziqaphele iziphumo ebezingalindelekanga, ukusebenzisana kweziyobisi, kunye nokuchasana. Soloko udibana nomboneleli wezempilo ngengcebiso ezenzelwe wena kunye nezicwangciso zonyango.