Ziprasidone - Uses, Dosage, Side Effects and More

Nhanganyaya: Chii chinonzi Ziprasidone?

Ziprasidone mushonga unoshandiswa kurapa chirwere chepfungwa chisingaperi unoshandiswa kurapa chirwere chepfungwa chinotapukira (schizophrenia) nechirwere chepfungwa chinotapukira. Unoshanda nekuchinja mashandiro emamwe ma neurotransmitters muuropi, kunyanya dopamine ne serotonin. Unowanikwa mumuromo nemujekiseni (mushonga uyu unobvumirwa kushandiswa pakurapa chirwere chinotapukira (acute agitation) muvanhu vane chirwere chinotapukira (schizophrenia) nechirwere chinotapukira (bipolar mania), ziprasidone inowanzo shandiswa kudzora acute agitation uye zviratidzo zvenguva refu zvepfungwa kana kuti mafungiro asina kunaka.

Mashandisirwo eZiprasidone

Ziprasidone inotenderwa kurapa zvirwere zvepfungwa zvakasiyana-siyana, zvinosanganisira:

• Schizophrenia: Inoshandiswa kuderedza zvisizvo, kufungidzira, uye kufunga kusina kurongeka.
• Bipolar Disorder: Yakapihwa kuti ibatsire kudzora manic episodes kana mixed episodes, yega kana pamwe chete ne mood stabilizers.
• Kushungurudzika kwakanyanya muSchizophrenia uye Bipolar Mania: Majekiseni ekubaiwa anoshandiswa munzvimbo dzehutano kuti adzore nekukurumidza kukanganiswa kwakanyanya.
• Mashandisirwo Asina Chiratidzo: Dzimwe nguva inoshandiswa (pasi pekutarisirwa nachiremba) kune zvimwe zvirwere zvakaita sekuwedzerwa kwedepression kana borderline personality disorder.

Chinoshanda sei?

Ziprasidone inoshanda nekuchinja huwandu hwe neurotransmitters dopamine uye serotonin muuropi. Inoshanda semupikisi paD2 dopamine receptors uye 5HT2A serotonin receptors, ichibatsira kuderedza zviratidzo zvepfungwa uye kudzikamisa mafungiro. Inewo zvimwe zvinoitwa ne agonist pa5HT1A receptors, izvo zvinogona kubatsira mumhedzisiro yayo yekuora mwoyo uye yekuzvidya mwoyo.

Chipimo chemushonga uye Administration

Ziprasidone inowanikwa semakapisiri uye jekiseni remutsinga (IM). Chipimo chinosiyana zvichienderana nechirwere chiri kurapwa:

• Schizophrenia (yemuromo): Muyero wekutanga unowanzo kuve 20 mg kaviri pazuva (40 mg pazuva) panguva yekudya; unogona kuwedzerwa kusvika pa80 mg kaviri pazuva (160 mg pazuva).
• Dambudziko reBipolar (Remuromo): Kazhinji inotanga ne40 mg kaviri pazuva, zvichigona kuwedzera kusvika 80 mg kaviri pazuva.
• Kutsamwa Kwakanyanya (Im Jekiseni): Kazhinji 10 mg IM maawa maviri ega ega kana 20 mg IM maawa mana ega ega kana zvichidikanwa, kusvika pa40 mg pazuva.

Nguva dzose tora ziprasidone pamwe chete nechikafu kuti uwedzere kupinza uye kushanda zvakanaka kwemushonga. Tevedzera mirairo yemupi wehutano wako nokungwarira.

Migumisiro yeZiprasidone

Nharaunda Dzakabatana

• Kurara kana kunyaradza
• Dizziness kana kupepuka musoro
• Nausea
• Kusagadzikana kana kushushikana
• Mapundu kana kutsamwa kweganda

Matambudziko Akakomba

• Kuwedzerwa kwenguva yeQT (chirwere chemwoyo)
• Neuroleptic Malignant Syndrome (chirwere chinotyisidzira hupenyu)
• Tardive dyskinesia (kufamba kusingatarisirwi)
• Kuwanda kwenjodzi yezvirwere zvetsinga dzeropa (semuenzaniso, sitiroko) kana kufa muvarwere vakwegura vane chirwere chepfungwa chine chekuita nedementia
• Pfungwa kana maitiro ekuzviuraya (kunyanya muvarwere vadiki)

Tsvaga rubatsiro rwechiremba nekukasika kana uchinzwa kurwadziwa muchipfuva, kupera simba, kuomarara kwetsandanyama, fivha yakanyanya, kana kurova kwemoyo kusina kurongeka.

Kubatana Kwemishonga

Ziprasidone inogona kushanda pamwe chete nemishonga yakasiyana-siyana:

• Mishonga inoderedza kusagadzikana kwepfungwa, mishonga inorwisa kuora mwoyo, uye mishonga inoderedza marwadzo epfungwa: Inogona kuwedzera njodzi yekuwedzera nguva yeQT.
• Mishonga inodzvinyirira CNS (semuenzaniso, doro, benzodiazepines): Inogona kuwedzera mhedzisiro yekunyaradza.
• Carbamazepine: Inogona kuderedza huwandu hweziprasidone uye kushanda kwayo.
• Mishonga yakasimba yeCYP3A4 inhibitors (semuenzaniso, ketoconazole, erythromycin): Inogona kuwedzera huwandu hweziprasidone muropa.

Gara uchizivisa chiremba wako nezvemishonga yese uye zvimwe zvinovaka muviri zvauri kutora kuti usasanganise mishonga inokuvadza.

Mabhenefiti eZiprasidone

• Inoshanda pakurapa chirwere chepfungwa (schizophrenia) uye chirwere chepfungwa chinonzi bipolar mania
• Njodzi shoma yekuwedzera uremu zvichienzaniswa nedzimwe mishonga inorwisa psychotic
• Kukanganisa kushoma kweshuga yeropa necholesterol
• Inowanikwa mune zvese nemuromo uye nemajekiseni mafomu
• Zvinogona kuitika zvekuora mwoyo kuburikidza nebasa re serotonin receptor

Zvimwe zvinopesana neZiprasidone

Ziprasidone haifanirwe kushandiswa mune zvinotevera:

• Kuzivikanwa kwekunzwa kusawirirana ne ziprasidone
• Nhoroondo yekuwedzera kwenguva yeQT kana chirwere chenguva refu cheQT chekuzvarwa
• Kurwara kwemoyo kwazvino kana kutadza kwemoyo kusingabhadharwi
• Kushandisa mishonga inowedzera QT panguva imwe chete

Chenjedzo uye Nyevero

Usati washandisa ziprasidone, funga nezve zvinotevera:

• ECG Monitoring: Funga nezve ECG yekutanga muvarwere vane njodzi yemwoyo; tarisa panguva yekurapwa kana kuwedzera kwenguva yeQTc.
• Shandisa muvanhu vakwegura: Hazvibvumidzwe kurapwa nepfungwa dzine chekuita nedementia nekuda kwekuwedzera kwengozi yekufa.
• Pamuviri uye Kuyamwisa: Shandisa chete kana zvichidikanwa. Kurukurai nechiremba wenyu nezvengozi dzacho.
• Chiropa uye Kidney Basa: Zvingada kugadziriswa kwemushonga.

FAQs

• Ziprasidone yakachengeteka here kushandiswa kwenguva refu? Ehe, nekutarisa nguva dzose. Inowanzo shandiswa kwenguva refu kune chirwere chepfungwa (schizophrenia) nechirwere chebipolar.
• Ko ziprasidone inogona kukonzera kuwedzera uremu here? Ine njodzi shoma yekuwedzera uremu zvichienzaniswa nedzimwe mishonga yekurwisa pfungwa isingawanzoitiki.
• Ndinofanira kutora ziprasidone pamwe chete nechikafu here? Ehe. Chikafu chinowedzera zvakanyanya kupinza kwacho uye kushanda kwacho.
• Ko ziprasidone inokura here? Kwete, hazvionekwi sezvinhu zvinopindwa muropa.
• Ndinganwa doro here ndiri kutora ziprasidone? Zvakanakisisa kurega doro, sezvo rinogona kuwedzera hope nezvimwe zvinokanganisa.
• Ziprasidone inotanga kushanda kwenguva yakareba sei? Zvimwe zviratidzo zvinogona kudzikira mumazuva mashoma, asi kushanda kwacho zvizere kunogona kutora mavhiki.
• Ko ziprasidone inogona kushandiswa here pakurapa kushushikana? Hazvitenderwi, asi dzimwe nguva zvinoshandiswa zvisina kutaurwa senzira yekuwedzera kurapwa pasi pekutarisirwa.
• Chii chinoitika kana ndikapotsa dose? Inwa nekukurumidza paunenge uchiyeuka. Kana yave pedyo nekutora mushonga unotevera, siya mushonga wawakarasikirwa nawo. Usawedzera kaviri.
• Ndingarega kushandisa ziprasidone kamwe kamwe here? Kwete. Kumira kamwe kamwe kunogona kukonzera zviratidzo zvekurega kana kuti kudzokera shure kwezviratidzo. Nguva dzose deredza kunwa doro uchitungamirirwa nachiremba.
• Kuongororwa kweECG kunodiwa here? Hazvikurudzirwi, kunyanya pakutanga kune varwere vane njodzi dzemwoyo, kuti vaongorore njodzi dzemoyo.

Mazita eBrand

Mazita anozivikanwa emhando yeZiprasidone anosanganisira:

• Geodon (US)
• Zeldox (pasi rose)

Mishonga yemhando yepamusoro inowanikwawo zvakanyanya.

mhedziso

Ziprasidone mushonga wechizvarwa chechipiri wekurapa pfungwa unoshanda kurapa chirwere chepfungwa chinonzi schizophrenia nebipolar disorder, kunyanya kune vanhu vane hanya nekuwedzera uremu kana matambudziko ekugaya chikafu. Kunyange zvazvo kazhinji ichishivirira zvakanaka, inoda kutariswa kwakanyatsonaka kwemigumisiro ine chekuita nemoyo uye inofanira kushandiswa pasi pekutarisirwa kwachiremba. Kana ikatorwa sezvakarairwa, ziprasidone inogona kuvandudza hupenyu hwevanhu vane matambudziko epfungwa zvakanyanya.