procainamide

Nhanganyaya: Chii chinonzi Procainamide?

Procainamide mushonga unonyanya kushandiswa kurapa mamwe marudzi ekurova kwemoyo zvisina kurongeka, unozivikanwa se arrhythmias. Uri weboka remishonga inonzi antiarrhythmics, inoshanda kudzorera kurova kwemoyo kwakajairika. Inokurudzirwa mune zvimwe zviitiko zvinoenderana neAHA/ACC/HRS neESC nhungamiro, dzakadai se tachycardia yakagadzikana kana kana mamwe marapirwo akakundikana, mushure mekuongorora njodzi dzakadai sekuwedzera kweQT. Procainamide inowanzo kunyorerwa kana mamwe marapirwo asingashande, kana kana varwere vaine mamwe marudzi e arrhythmia anoda kupindira.

Mashandisirwo eProcainamide

Procainamide inotenderwa kushandiswa kwakasiyana-siyana mukurapa, kusanganisira:

• Ventricular Arrhythmias: Inowanzoshandiswa kurapa ventricular tachycardia, chirwere apo moyo unorova nekukurumidza nekuda kwemagetsi asina kunaka.
• Atrial Fibrillation: Procainamide inogona kubatsira kudzoreredza rhythm yakajairika muvarwere vane atrial fibrillation, rudzi rwakajairika rwe arrhythmia.
• Supraventricular tachycardia: Mushonga uyu unoshandawo mukurapa supraventricular tachycardia, uko makamuri epamusoro emoyo anorova nekukurumidza.

Procainamide Inoshanda Sei?

Procainamide inovhara nzira dzesodium mumoyo, ichideredza masaini emagetsi anodzora kurova kwemoyo. Nekuita izvi, inobatsira kudzikamisa rhythm yemoyo uye kudzivirira kurova kwayo nekukurumidza kana zvisina kurongeka. Izvi zvinoita kuti moyo ukwanise kupomba ropa zvinobudirira, zvichivandudza mashandiro emoyo.

Chipimo chemushonga uye Administration

Chipimo cheProcainamide chinosiyana zvichienderana nemamiriro emurwere, zera rake, mashandiro eitsvo, uye maitiro ake pakurapwa, zvichitevera nhungamiro dzakaita sedzinobva kuAHA/ACC/HRS.

Vakuru:

Muyero wekutanga wemushonga unowanzova 100 mg kusvika 150 mg maawa matanhatu kusvika masere ega ega, uchigadziriswa kusvika pa3 gramu pazuva. Kana paine dambudziko rekukurumidzira, mushonga unotanga ne10-15 mg/kg (kusvika 1 gramu) uchipiwa zvishoma nezvishoma pa20-50 mg/min, uchiteverwa ne2-6 mg/min yekuchengetedza uchishandisa ECG uye kuongororwa kweropa.

Pediatrics:

Chipimo chinotorwa zvichienderana nehuremu, kazhinji 15 mg/kg/zuva inokamurwa mumuromo maawa matanhatu kusvika masere ega ega, kana kuti kupiwa kwemushonga ne 10-15 mg/kg (1 gram pa 0.5 mg/kg/min) kunoteverwa nekuiswa kwe 30-80 mcg/kg/min. Procainamide inouya semapiritsi anonwiwa kana jekiseni remushonga ne intravenous, uye inoiswa ne intravenous inochengeterwa kuchipatara inoda kutariswa zvakanyanya. Gara uchitevera mirairo chaiyo yachiremba wako.

Migumisiro yeProcainamide

Kufanana nemishonga yese, Procainamide inogona kukonzera migumisiro yakaipa. Mimwe yacho inosanganisira kuda kurutsa, kurutsa, manyoka, dzungu, uye kuneta. Migumisiro yakaipa inogona kusanganisira heart block, lupus-like syndrome (kurwadziwa kwemajoini, kuneta), matambudziko eropa akadai seagranulocytosis (masero machena eropa mashoma anowedzera njodzi yehutachiona), uye kuwedzera kwenguva pfupi kweQT, izvo zvinowedzera njodzi ye rhythm ine njodzi inonzi torsades de pointes? kunyanya ne metabolite yayo N-acetylprocainamide mumatambudziko eitsvo. Unofanira kutsvaga rubatsiro rwechiremba nekukurumidza kana uine kurwadziwa kwechipfuva, kufema zvishoma, kupera simba, kana dzungu rakakomba.

Kubatana Kwemishonga

Procainamide inogona kushanda pamwe chete nemimwe mishonga, zvichiwedzera njodzi dzemigumisiro kana kuderedza kushanda kwayo. Kushanda pamwe chete kunosanganisira:

• Mimwe mishonga yekurwisa arrhythmia: Migumisiro yekuwedzera inogona kuwedzera arrhythmias.
• Mishonga inowedzera nguva yeQT: (semuenzaniso, mimwe mishonga inorwisa kuora mwoyo yakaita secitalopram, mishonga inorwisa mabhakitiriya yakaita seciprofloxacin, mishonga inorwisa pfungwa): Kuwedzera njodzi ye torsades de pointes risk.
• Zvinodzivisa kubuda kwetsvo: (semuenzaniso, cimetidine, trimethoprim): Wedzera huwandu hweProcainamide.

Cherechedza: Procainamide hainyanyi kugayiwa nema enzymes eCYP450 asi kuburikidza ne acetylation; metabolite yayo inoshanda yeNAPA inoumbwa nenzira iyi, ine shanduko mu "acetylators dzinokurumidza/dzinononoka." Zivisa chiremba wako nezvemishonga yese, zvinovaka muviri, uye mishonga yemishonga.

Mabhenefiti eProcainamide

Procainamide ine zvakawanda zvakanakira pakurapa:

• Inoshanda kune Specific Arrhythmias: Inonyanya kushanda pakurapa ventricular arrhythmias, uye inopa sarudzo yakavimbika kana mamwe marapirwo akatadza.
• Kukurumidza Kutanga Kwekuita: Kana ikapinzwa netsinga, Procainamide inogona kudzikamisa kumhanya kwemoyo nekukurumidza mumamiriro ezvinhu akaoma.
• Nhoroondo Yakareba Yekushandisa: Nekushandiswa kwemishonga iyi kwemakumi emakore, Procainamide yagara ichizivikanwa kuti yakachengeteka uye inoshanda zvakanaka.

Zvinopesana neProcainamide

Vamwe vanhu vanofanira kudzivisa kushandisa Procainamide, kusanganisira:

• Varwere vane mwoyo wakavharika zvachose kunze kwekunge vaine pacemaker, nekuda kwenjodzi ye asystole.
• Vakadzi vane pamuviri, sezvo zvingakuvadza mwana ari mudumbu (Chikamu C).
• Vanhu vane myasthenia gravis, systemic lupus erythematosus, kana kuti vane hypersensitivity kune mushonga.

Ngwarira kune avo vane nguva yakareba yeQT, AV block yedhigirii rechipiri/rechitatu, chirwere chakakomba chechiropa/itsvo, kana kusawirirana kwema electrolyte, sezvo zvichiwedzera njodzi ye arrhythmia.

Chenjedzo uye Nyevero

Vasati vatanga kushandisa Procainamide, varwere vanofanira kuongororwa murabhoritari kuti vaone mashandiro emwoyo uye mazinga eropa. Kugara uchiongororwa kwakakosha kuti uve nechokwadi chekuti mushonga uri kushanda zvakanaka uye kugadzirisa huwandu hwemushonga sezvinodiwa. Varwere vanofanirawo kungwarira nezvekuita zvinhu zvinoda kungwarira, sezvo Procainamide inogona kukonzera dzungu.

FAQs

• Chii chinoshandiswa neProcainamide? Procainamide inoshandiswa kurapa kurova kwemoyo kusina kurongeka, kunyanya ventricular tachycardia uye atrial fibrillation.
• Procainamide inopihwa sei? Inogona kutorwa nemuromo iri muchimiro chepiritsi kana kubaiwa jekiseni muchipatara.
• Ndezvipi zvinowanzoitika? Migumisiro inowanzo sanganisira kuda kurutsa, dzungu, uye kuneta.
• Procainamide inogona kutorwa pamwe chete nemimwe mishonga here? Mimwe mishonga inogona kushanda pamwe chete neProcainamide, saka zvakakosha kuzivisa chiremba wako nezvemishonga yese yauri kutora.
• Procainamide yakachengeteka here panguva yekuzvitakura? Vakadzi vane pamuviri vanofanira kusashandisa Procainamide kunze kwekunge yapihwa nachiremba, sezvo inogona kuisa njodzi kumwana ari mudumbu.
• Procainamide inoshanda sei? Inoshanda nekuvhara nzira dzesodium mumoyo, zvichibatsira kudzikamisa rhythm yemoyo.
• Chii chandinofanira kuita kana ndikapotsa dose? Kana ukarasikirwa nedosi, tora pakarepo paunoyeuka. Kana yave pedyo nedosi rinotevera, svetuka dosi rakapotsa uye enderera nehurongwa hwako hwenguva dzose.
• Procainamide inogona kukonzera migumisiro yakaipa here? Ehe, migumisiro yakaipa inogona kuitika, kusanganisira kuvhara kwemoyo uye matambudziko eropa. Tsvaga rubatsiro rwechiremba kana ukaona zviratidzo zvakakomba.
• Zvinotora nguva yakareba sei kuti Procainamide ishande? Kutanga kwekushanda kunogona kusiyana; kupiwa kwemushonga netsinga kunogona kupa mhedzisiro inokurumidza, nepo nzira dzemuromo dzingatora nguva yakareba.
• Kuongororwa nguva dzose kunodiwa here kana uri kutora Procainamide? Ehe, kugara uchitarisa mashandiro emwoyo uye huwandu hweropa kwakakosha kuti uve nechokwadi chekuti kuchengetedzeka uye kushanda zvakanaka.

Mazita eBrand

Procainamide inowanikwa pasi pemazita akasiyana-siyana, anosanganisira:

• Pronestyl
• Procanbid

mhedziso

Procainamide mushonga unokosha pakurapa mhando dzakasiyana dze arrhythmias, uchipa nzira dzekurapa dzinoshanda kune varwere vane kurova kwemoyo kusina kurongeka. Kunzwisisa mashandisirwo ayo, migumisiro yayo, uye kushanda kwayo kwakakosha pakurapa kwakachengeteka uye kunobudirira. Gara uchibvunza chiremba usati watanga kana kurega chero mushonga.