Vancomycin - Uses, Dosage, Side Effects and More

Nhanganyaya: Chii chinonzi Vancomycin?

Vancomycin mushonga une simba unoshandiswa kurapa hutachiona hwakakomba hwebhakitiriya. Ndeweboka remishonga inorwisa mabhakitiriya inozivikanwa seglycopeptides uye inoshanda zvakanyanya pakurwisa mabhakitiriya ane Gram-positive, kusanganisira marudzi asingapindi mishonga inorwisa mabhakitiriya. Vancomycin inowanzo chengeterwa hutachiona hwakasimba, kunyanya hunokonzerwa nemethicillin-resistant Staphylococcus aureus (MRSA). Inogona kupiwa zvakanyanya netsinga kana nemuromo, zvichienderana nerudzi rwehutachiona huri kurapwa.

Mashandisirwo eVancomycin

Vancomycin inotenderwa kushandiswa kwakasiyana-siyana mukurapa, kusanganisira:

• Zvirwere Zvakanyanya: Inowanzoshandiswa kurapa zvirwere zvakakomba zvinokonzerwa nemabhakitiriya ane Gram-positive, kunyanya MRSA.
• Endocarditis: Vancomycin inowanzoshandiswa pakurapa endocarditis, chirwere chemwoyo.
• Bone Infections: Inogona kushanda zvakanaka pakurapa osteomyelitis, chirwere chemapfupa.
• Skin Infections: Vancomycin inoshandiswa pakurapa hutachiona hweganda nenyama dzakapfava.
• Clostridium difficile Infection: Vancomycin inonwiwa mushonga wekutanga wekurapa manyoka ane chekuita neC. difficile.
• Chirwere chemabayo: Inogona kushandiswa kana paine pneumonia inotorwa muchipatara kana kuti inokonzerwa nekufema inokonzerwa nemabhakitiriya eGram-positive asingakuvadzi.

Chinoshanda sei?

Vancomycin inoshanda nekudzivisa kugadzirwa kwemadziro emasero ebhakitiriya. Muchidimbu, inodzivirira mabhakitiriya kuvaka chikamu chavo chekunze chinodzivirira, icho chakakosha kuti ararame. Pasina madziro emasero akasimba, mabhakitiriya haagone kuchengetedza chimiro chawo kana kuti kusimba kwawo, zvichikonzera kufa kwawo. Iyi nzira inoita kuti vancomycin ishande zvakanyanya pakurwisa mabhakitiriya asingadyirwe nemamwe maantibiotic.

Chipimo chemushonga uye Administration

Chiyero chevancomycin chinosiyana zvichienderana nerudzi rwehutachiona, zera remurwere, huremu, uye mashandiro eitsvo.

Vakuru:

Muyero wemushonga weC. difficile unowanzo shandiswa ne intravenous 15-20 mg/kg maawa 8-12 ega ega, uye mushonga wacho unotungamirirwa neAUC/MIC chinangwa che400-600 mg?h/L kuderedza chepfu. Pakunwa, muyero wehutachiona hweC. difficile unowanzo kuve 125-500 mg kana kana pazuva kwemazuva gumi.

Pediatrics:

Kuvana, muyero unowanzo kuve 15 mg/kg maawa matanhatu ega ega (asingasviki 2 g/zuva); gadzirisai vacheche/vacheche.

Vancomycin inogona kupiwa nejekiseni mutsinga (IV) kana kunwiwa nemuromo mumakapisi kana mushonga unonwiwa. Nzira yekupa mushonga inoenderana nerudzi rwehutachiona huri kurapwa.

Migumisiro yeVancomycin

Migumisiro yakajairika yevancomycin inosanganisira:

• Nausea
• Kudzora
• Diarrhea
• Zvinorwadza mumimba
• Mapundu
• chimhepo

Serious side effects inogona kusanganisira:

• Kukuvara kweitsvo zvakanyanya (kukuvadza kweitsvo)
• Kunzwa kurasikirwa
• Kusawirirana kwakanyanya (anaphylaxis)
• Chirwere cheRed Man (kusviba, mapundu, uye kuvaviwa, kazhinji kunokonzerwa nekupinzwa nekukurumidza), chinogona kudzivirirwa nekupinzwa zvishoma nezvishoma kwemaminitsi makumi matanhatu uye kupiwa mishonga inorwisa mabhakitiriya.
• Neutropenia (isingawanzoitiki)

Varwere vanofanirwa kuudza chero zviratidzo zvakakomba kana zvisingawanzo kune avo vanovapa hutano nekukasira.

Kubatana Kwemishonga

Vancomycin inogona kushanda pamwe chete nemishonga yakasiyana-siyana, izvo zvinogona kuwedzera njodzi yemigumisiro kana kuderedza kushanda kwemishonga yese. Kushanda pamwe chete kukuru kwemishonga kunosanganisira:

• Aminoglycosides: Kuwedzerwa kwenjodzi yekukuvara kweitsvo.
• Mishonga inobvisa tsvina mumuviri (semuenzaniso, furosemide): Inogona kuwedzera njodzi yekukuvadzwa nekunzwa.
• Zvinozorodza tsandanyama: Zvinogona kukonzera kuwedzera kwekuvhara kwetsinga dzemutsinga.
• Mamwe maantibiotic: Anogona kuchinja kushanda kwekurapa.
• Piperacillin-tazobactam: kuwedzera kwengozi yekukuvadza nephrotoxicity.

Gara uchizivisa chiremba wako nezvemishonga yese yauri kutora kuti usasanganise mishonga yacho.

Mabhenefiti eVancomycin

Zvakanakira zvekushandisa vancomycin zvinosanganisira:

• Kubudirira Kurwisa Utachiona Hwunodzivirira: Ndiyo imwe yemishonga mishoma inoshanda kurwisa MRSA nedzimwe mhando dzemishonga inodzivirira hutachiona.
• Inoshanda pakurwisa mabhakitiriya akawanda ane Gram-positive.
• Multile Administration: Inogona kupiwa netsinga kana nemuromo, zvichiita kuti ikwanise kurapa marudzi akasiyana-siyana ezvirwere.
• Yakasimbiswa Yekuchengetedza Profile: Vancomycin yave ichishandiswa kwemakumi emakore, zvichipa gwaro rakanyorwa zvakanaka rekuchengetedza uye kushanda kwayo.

Zvimwe zvinopesana neVancomycin

Vamwe vanhu vanofanira kudzivisa kushandisa vancomycin, kusanganisira:

• Vakadzi Vakazvitakura: Chikamu C; shandisa chete kana rubatsiro rwuchipfuura njodzi (data shoma rinoratidza njodzi shoma yemwana ari mudumbu).
• Varwere vane Kidney Disease: Avo vane dambudziko rekushanda kweitsvo vanogona kunge vari panjodzi huru yemigumisiro yakaipa.
• Allergic Reactions: Vanhu vane chirwere chinozivikanwa chekusawirirana nevancomycin kana chimwe chezvinhu zviri mairi havafanirwe kushandisa mushonga uyu.

Chenjedzo uye Nyevero

Vasati vatanga vancomycin, varwere vanofanira kuongororwa murabhoritari, kusanganisira:

• Kidney Function Tests: Kuongorora mashandiro eitsvo, sezvo vancomycin inonyanya kubviswa neitsvo.
• Kunzwa Miedzo: Kana paine nhoroondo yezvinetso zvekunzwa, vancomycin inogona kukonzera toxicity ye ototoxicity.
• Kuongororwa kwemishonga yekurapa (TDM) kwakakosha: Kusvika 10-20 mg/L yezvirwere zvakakomba (kana zvichidikanwa usati waenda kuAUC/MIC).

Varwere vanofanirawo kutariswa kuti vaone kana paine zviratidzo zvekusawirirana uye kushanda kweitsvo panguva yekurapwa.

FAQs

• Chii chinoshandiswa nevancomycin? Vancomycin inoshandiswa kurapa hutachiona hwakakomba hwemabhakitiriya, kunyanya hunokonzerwa neMRSA neC. difficile.
• Vancomycin inopihwa sei? Inogona kupiwa nemutsinga kana nemuromo, zvichienderana nerudzi rwechirwere.
• Ndezvipi zvinowanzoitika? Zvinowanzoitika zvinosanganisira kuda kurutsa, kurutsa, manyoka, uye mapundu.
• Ndingatora vancomycin here kana ndine pamuviri? Inofanira kushandiswa panguva yekuzvitakura chete kana zvichidikanwa, sezvo ruzivo rwemhuka runoratidza njodzi inogona kuitika mumwana ari mudumbu asi ruzivo rwevanhu haruna kukwana.
• Vancomycin inoshanda sei? Inodzivisa kugadzirwa kwemadziro emasero ebhakitiriya, zvichikonzera kufa kwebhakitiriya.
• Chii chandinofanira kuita kana ndikapotsa dose? Itore nekukurumidza paunenge uchiyeuka asi usaitore kana yava nguva yekutora mushonga unotevera. Usapeta mushonga kaviri. Bvunza chiremba kana paine hutachiona hwakakosha.
• Vancomycin inogona kukonzera kukuvara kweitsvo here? Ehe, zvinogona kukonzera kukuvara kweitsvo, kunyanya kune varwere vane matambudziko eitsvo.
• Ko vancomycin inoshanda here pakurwisa mabhakitiriya ese? Kwete, inonyanya kushanda pakurwisa mabhakitiriya ane Gram-positive.
• Chii chandinofanira kudzivisa pandinenge ndichitora vancomycin? Dzivisa mimwe mishonga inogona kukuvadza itsvo kunze kwekunge chiremba wako akuudza.
• Ndichatora vancomycin kwenguva yakareba sei? Nguva yekurapwa inoenderana nerudzi uye kuoma kwechirwere, kazhinji kubva pamazuva manomwe kusvika makumi maviri nerimwe kana kupfuura kune hutachiona hwakadzika midzi se osteomyelitis/endocarditis.

Mazita eBrand

Vancomycin inowanikwa pasi pemazita akasiyana-siyana, anosanganisira:

• Vancocin
• Vancoled
• Firvanq (mushonga wemuromo)

mhedziso

Vancomycin mushonga unoshanda zvikuru mukurwisa hutachiona hwakakomba hwemabhakitiriya, kunyanya hunokonzerwa nehutachiona husingapindi mishonga. Kushanda kwayo zvakanaka, kushandiswa kwayo kwakasiyana-siyana, uye kuchengetedzeka kwayo kunoita kuti ive chinhu chakakosha mukurapa kwemazuva ano. Zvisinei, semishonga yese, ine migumisiro inogona kuitika uye kusangana kwayo kunofanira kutarisirwa nokungwarira. Nguva dzose bvunza chiremba wako kuti uwane mazano akakodzera uye nzira dzekurapa.