Succinylcholine - Uses, Dosage, Side Effects and More

Nhanganyaya: Chii chinonzi Succinylcholine?

Succinylcholine mushonga unonyanya kushandiswa semushonga unorerutsa tsandanyama panguva yekuvhiyiwa uye intubation. Unonzi neuromuscular blocker, zvinoreva kuti unoremadza tsandanyama kwenguva pfupi nekudzivirira kutapurirana kwetsinga dzinoenda kutsandanyama. Izvi zvinoita kuti nzira yekufema ive nyore uye zvinoita kuti tsandanyama dzisununguke panguva yekuvhiyiwa. Succinylcholine inozivikanwa nekutanga kwayo nekukurumidza uye kwenguva pfupi, zvichiita kuti ive sarudzo inofarirwa munguva dzenjodzi.

Mashandisirwo eSuccinylcholine

Succinylcholine inotenderwa kushandiswa kwakasiyana-siyana mukurapa, kusanganisira:

• Kukurumidza Kutevedzana Kwemukati (RSI): Inowanzoshandiswa kubatsira varwere vanoda rubatsiro rwekukurumidza pakufambisa mweya.
• Maitiro Ekuvhiya: Succinylcholine inoshandiswa panguva pfupi yekuvhiyiwa inoda kuzorora kwenguva pfupi kuti tsandanyama dzizorore, zvichibvumira vanachiremba vekuvhiya kuti vaite maoparesheni vasina kufamba-famba kwetsandanyama vasingazvidi.
• Electroconvulsive Therapy (ECT): Inogona kushandiswa kudzivirira marwadzo emhasuru panguva yeECT, zvichiita kuti murwere agare akachengeteka uye akasununguka.

Chinoshanda sei?

Succinylcholine inoshanda nekutevedzera mashandiro anoita acetylcholine, neurotransmitter inozivisa tsandanyama kuti dzimire. Kana ikashandiswa, inosunga kuma receptors ari pamasero etsandanyama, zvichikonzera kudzikira kwekutanga (kunozivikanwa sefasciculation) zvichiteverwa nekuoma mitezo. Kuoma mitezo uku kunoitika nekuti masero etsandanyama anova asina kunzwa kwekuwedzera kukurudzira, zvichidzivirira kudzikira kwemitezo. Mhedzisiro yacho inokurumidza, inowanzoitika mukati memasekonzi makumi matatu, uye inogara kwenguva pfupi, kazhinji kwemaminitsi mashanu kusvika gumi, sezvo ichinyanya kugadzirwa neplasma cholinesterase.

Chipimo chemushonga uye Administration

Chiyero che succinylcholine chinosiyana zvichienderana nezera remurwere uye mamiriro ehutano:

• Vakuru: Chipimo chinowanzo shandiswa pakupinza munhu mudumbu nekukurumidza i1-1.5 mg/kg IV yeRSI; mhedzisiro yacho inoonekwa mukati memasekonzi 30-60.
• Pediatrics: Kune vana, 1-2 mg/kg IV, nyatsoongorora huremu uye nhoroondo yekurapa.

Succinylcholine inopihwa nejekiseni, kazhinji nenyanzvi yehutano munzvimbo inodzorwa, senge kuchipatara kana nzvimbo yekuvhiya. Hazvifanirwe kushandiswa nguva dzose; zvinokurudzirwa kushandisa IV.

Migumisiro yeSuccinylcholine

Kunyange hazvo succinylcholine yakachengeteka kana ikashandiswa nemazvo, inogona kukonzera migumisiro yakaipa, kusanganisira:

Common Side Effects:

• Fasciculations
• Myalgia mushure mekuvhiyiwa (kurwadziwa kwetsandanyama kana kurwadziwa mushure mekuvhiyiwa)
• Kuwedzera kwenhamba yemwoyo
• Kuwedzerwa kweropa
• Allergic reactions (mapundu, itching, kuzvimba)

Serious Side Effects:

• Kupisa kwakanyanya kwemuviri (kuitika kwakanyanya kune mamwe mishonga inonyaradza marwadzo)
• Hyperkalemia (kunyanya kuvarwere vari panjodzi), zvinogona kukonzera kumisa kwemwoyo
• Kuora mwoyo kwekufema (kunetseka kufema)

Kubatana Kwemishonga

Succinylcholine inogona kushanda pamwe chete nemishonga yakasiyana-siyana nezvimwe zvinhu, kusanganisira:

• mishonga: Mimwe mishonga inorwisa mabhakitiriya, senge aminoglycosides (semuenzaniso, gentamicin), inogona kuwedzera simba re succinylcholine, zvichikonzera kuoma mitezo kwenguva refu.
• Anesthetics: Zvimwe zvinodzivirira tsandanyama dzemutsinga zvinogona kupindirana, zvichida kutariswa nekungwarira uye kugadziriswa kwemuyero.
• Cholinesterase inhibitors: Mishonga inodzivisa enzyme inoputsa succinylcholine inogona kuwedzera kushanda kwayo.
• Others: Cyclosporine, magnesium.

Mabhenefiti eSuccinylcholine

Kushandiswa kwe succinylcholine kune zvakawanda zvakanakira zvekiriniki:

• Kurumidza kutanga: Kukurumidza kwayo kuita basa kwakakosha kana paine dambudziko guru apo nzira yekufema inodiwa nekukurumidza.
• Nguva Pfupi: Nguva pfupi yekuoma mitezo inobvumira kuti munhu akwanise kupora nekukurumidza, zvichiita kuti zvive zvakanaka kune vanovhiyiwa kwenguva pfupi.
• Kudzoreredza Kwekushandisa: Succinylcholine iri nyore kushandisa, inoda kugadzirira kushoma.

Zvimwe zvinopesana neSuccinylcholine

Vamwe vanhu vanofanira kudzivisa succinylcholine, kusanganisira:

• Nhoroondo yemunhu/yemhuri yechirwere che malignant hyperthermia (MH); njodzi dze hyperkalemia (kutsva kwemaawa anopfuura makumi maviri nemana, kukuvara kwemutsipa, denervation, zvirwere zvetsinga dzemutsinga zvakaita se muscular dystrophy); kushomeka kwe pseudocholinesterase.
• Kuberekwa: Chikamu C; dzivisa, kana zvichibvira, kunyanya trimester yekutanga (ruzivo rwekuchengetedza rushoma asi runoshandiswa kana zvichidikanwa).
• Kushomeka kwecholinesterase kana kusashanda zvakanaka kwechiropa zvakanyanya.

Chenjedzo uye Nyevero

Vasati vashandisa succinylcholine, vanachiremba vanogona kukurudzira matanho chaiwo ekudzivirira:

• Nhoroondo yezvokurapa Udza chiremba wako nezve chero nhoroondo yezvirwere zvetsinga dzemutsinga, matambudziko emwoyo, kana allergies.
• Lab Tests: Kuongororwa kweropa kunogona kudiwa kuti kuongororwe mashandiro echiropa neitsvo usati wapiwa mushonga.
• Kuongorora: Kugara uchitarisa kurova kwemoyo uye mashandiro ekufema kwakakosha panguva yekutora mushonga uye mushure mekushandisa.
• Dzivisai kudzokororwa kwemishonga nekuda kwenjodzi yekuwanda kwemishonga; iva ne "reversal" (neostigmine) yakagadzirira mushonga kunyange zvazvo isingashande zvakanaka.

FAQs

• Chii chinoshandiswa succinylcholine? Succinylcholine inonyanya kushandiswa kukurudzira kuzorora kwetsandanyama panguva yekuvhiyiwa uye kubatsira kupinza tambo mumitsetse yeropa panguva dzenjodzi.
• Succinylcholine inoshanda nekukurumidza zvakadii? Inowanzo shanda mukati memasekonzi makumi matatu kusvika makumi matanhatu mushure mekupiwa.
• Ndezvipi migumisiro ye succinylcholine? Migumisiro inowanzo sanganisira kurwadziwa kwetsandanyama uye kurova kwemoyo kwakanyanya, nepo migumisiro yakakomba inogona kusanganisira kurwara kwakanyanya uye kuora mwoyo kwekufema.
• Succinylcholine inogona kushandiswa here kuvana? Ehe, asi muyero wemushonga unofanira kugadziriswa nokungwarira zvichienderana nehuremu hwemwana uye nhoroondo yehutano hwake.
• Succinylcholine yakachengeteka here panguva yekuzvitakura? Chikamu C; dzivisa kana zvichibvira, kunyanya trimester yekutanga (ruzivo rwekuchengetedza rushoma asi runoshandiswa kana zvichidikanwa).
• Succinylcholine inopihwa sei? Inopihwa sejekiseni nenyanzvi yehutano.
• Chii chandinofanira kuudza chiremba wangu ndisati ndashandisa succinylcholine? Udza chiremba wako nezve chero allergies, zvirwere, kana mishonga yauri kutora.
• Ko succinylcholine inogona kukonzera allergic reaction here? Ehe, vamwe vanhu vanogona kusangana nezvirwere zvakaita seallergy, kusanganisira mapundu kana kuzvimba.
• Mhedzisiro ye succinylcholine inogara kwenguva yakareba sei? Mhedzisiro yacho inowanzogara kwemaminitsi mashanu kusvika gumi.
• Chii chandinofanira kuita kana ndikasangana nemigumisiro yakaipa? Bata chiremba wako nekukasika kana ukasangana nematambudziko akakomba.

Mazita eBrand

Succinylcholine inowanikwa pasi pemazita akasiyana-siyana, anosanganisira:

• Anectine
• Quelicin
• Scoline (yakajairika pasi rose)

Cherechedza: Mishonga yemhando dzegeneric inowanikwa zvakanyanya.

mhedziso

Succinylcholine mushonga unokosha zvikuru munyaya dzekurapa kwekukurumidzira uye mishonga yekukurumidzira. Kukurumidza kwayo kutanga uye kushanda kwayo kwenguva pfupi kunoita kuti ive chishandiso chakakosha chekubatsira kurapa nekuvhura chipfuva uye kuve nechokwadi chekuti murwere akachengeteka panguva yekuvhiyiwa. Kunyange zvazvo kazhinji yakachengeteka, kuziva nezvemigumisiro inogona kuitika, zvinopesana, uye kusangana kwemishonga kwakakosha kuti ushandiswe zvinobudirira. Gara uchibvunza nyanzvi yehutano usati washandisa succinylcholine kana chero imwe mishonga.