Rolapitant - Mashandisirwo, Chipimo, Migumisiro Yemushonga uye Zvimwe

Nhanganyaya: Chii chinonzi Rolapitant?

Rolapitant mushonga unonyanya kushandiswa kudzivirira kuda kurutsa uye kurutsa kunokonzerwa nechemotherapy. Iri muboka remishonga inozivikanwa se neurokinin1 (NK1) receptor antagonists. Nekuvharira mamwe masaini muuropi, Rolapitant inobatsira kudzora mhedzisiro yekurapwa nekenza, zvichivandudza hupenyu hwevarwere vari kurapwa nechemotherapy.

Mashandisirwo eRolapitant

Rolapitant inotenderwa kushandiswa muvanhu vakuru kudzivirira kurutsa kwakanyanya uye kunonoka uye kurutsa kunokonzerwa nechemotherapy ine emetogenic yakanyanya. Inotenderwa kunyanya kune kurutsa/kurutsa kunonoka mushure me chemotherapy yekutanga/pakati nepakati (HEC/MEC), inoshandiswa pamwe chete nedzimwe mishonga inorwisa emetic (semuenzaniso, dexamethasone? 5-HT3 antagonist). Kuvharwa kwakanyanya kunowedzerwa, kwete kwekutanga. Mushonga uyu unobatsira zvikuru varwere vanowana cisplatin-based chemotherapy, inozivikanwa nekukwanisa kwayo kukuru kukonzera kurutsa nekurutsa.

Chinoshanda sei?

Rolapitant inoshanda nekudzivirira kushanda kwechinhu P, neuropeptide inoita basa guru mukurutsa. Nekudzivisa ma neurokinin1 receptors muuropi, Rolapitant inoderedza zviratidzo zvinokonzera kuda kurutsa nekurutsa. Iyi nzira inobatsira varwere kunzwa vakasununguka panguva uye mushure mekurapwa kwavo nechemotherapy.

Chipimo chemushonga uye Administration

Mushonga weRolapitant wevakuru unotorwa kamwe chete nemuromo we180 mg, unotorwa mukati memaawa maviri chemotherapy isati yatanga. Rolapitant inowanikwa muchimiro chepiritsi uye inofanira kumedzwa yese nemvura. Hazvikurudzirwi kutsenga kana kupwanya mapiritsi.

Migumisiro yeRolapitant

Migumisiro inowanzoonekwa yeRolapitant inogona kusanganisira:

• Kuneta
• Chizutu
• Diarrhea
• yadzikira Nzara

Migumisiro yakakomba, kunyange isingawanzoitiki, inogona kusanganisira:

• Allergic reactions (mapundu, itching, kuzvimba)
• Chidzungu chakanyanya kana kupera simba
• kuwedzera nguva yeQT
• Maitiro ane chekuita nekupinzwa kwemushonga (wemushonga wemutsinga)
• Matambudziko echiropa (asingawanzoitiki; anoratidzwa nekutsvuka kweganda kana maziso; mishumo yemashure ekushambadza)

Varwere vanofanirwa kuudza chero zvisingawanzo kana zvakakomba mhedzisiro kune avo vanovapa hutano nekukasira.

Kubatana Kwemishonga

Rolapitant inogona kushanda nemishonga yakasiyana-siyana, izvo zvinogona kukanganisa mashandiro ayo kana kuwedzera njodzi yemigumisiro yakaipa. Kushanda kwemishonga mikuru kunosanganisira:

• Mishonga yeCYP2D6 (semuenzaniso, thioridazine, pimozide) - haibvumidzwe nekuda kwengozi yekuwedzera nguva yeQT
• Mishonga yakasimba yeCYP3A4 inhibitors (semuenzaniso, ketoconazole, ritonavir) - inowedzera kuratidzwa kwerolapitant (monitor)
• Mishonga yakasimba yeCYP3A4 inducers (semuenzaniso, rifampin, St. John's Wort) - kuderedza kubatwa kwe rolapitant (dzivisa kana zvichibvira)
• Mimwe mishonga yekudzivirira kusvotwa (semuenzaniso, ondansetron, granisetron) - kazhinji haina kukosha asi inozivikanwa nekushandiswa pamwe chete.

Izvo zvakakosha kuti uzivise mutarisiri wako wehutano nezvese mishonga, ekuwedzera, uye mishonga yemakwenzi yauri kutora kuti udzivise kusangana kungangoita.

Mabhenefiti eRolapitant

Chinhu chikuru chinobatsira Rolapitant ndechekuti inoshanda mukudzivirira kuda kurutsa nekurutsa zvinokonzerwa nechemotherapy, kunyanya kuvarwere vanowana mishonga inokonzeresa matambudziko emudumbu. Nekuvandudza kudzora migumisiro iyi, Rolapitant inogona kuwedzera ruzivo rwekurapwa kwemurwere, zvichimubvumira kuchengetedza kudya kunovaka muviri uye kunyorova, uye pakupedzisira kuvandudza hupenyu hwake panguva yekurapwa kwegomarara.

Zvinopesana neRolapitant

Rolapitant inofanira kudzivirirwa mune mamwe mapoka evanhu, kusanganisira:

• Vakadzi vane pamuviri kana kuti vanoyamwisa (vasina kupihwa chikamu chepamuviri; ruzivo rwemhuka runoratidza njodzi) - zvinokurudzirwa kudzivirira.
• Kuzivikanwa kwekunzwa kusawirirana nemishonga inorwisa rolapitant kana zvimwe zvinokuvadza.
• Varwere vane chirwere chehepatic chakakomba (Child-Pugh C): Deredza dose kusvika 90 mg.

Gara uchibvunza chiremba kuti uone kana Rolapitant yakakodzera mamiriro ako ehutano.

Chenjedzo uye Nyevero

Varwere vanofanira kuongororwa zvakakwana nachiremba vasati vatanga kushandisa Rolapitant. Nzira dzakakosha dzekudzivirira dzinosanganisira:

• Kutarisa mashandiro echiropa, kunyanya kune varwere vane matambudziko echiropa aripo kare.
• Ongorora mafambiro emishonga nemishonga iripo.
• Kurukurai nezvenhoroondo yezviratidzo zvekusawirirana nemishonga.
• Kugara uchiongororwa nachiremba kunogona kudiwa kuti utarise maitiro emurwere pakurapwa uye kugadzirisa huwandu hwemushonga sezvinodiwa.

FAQs

1. Chii chinoshandiswa neRolapitant? Rolapitant inoshandiswa kudzivirira kuda kurutsa nekurutsa kunokonzerwa ne chemotherapy, kunyanya kune varwere vanorapwa nemishonga inokonzeresa matambudziko emudumbu.
2. Rolapitant inotorwa sei? Inotorwa sepiritsi rimwe chete rinonwiwa, kazhinji awa imwe chete chemotherapy isati yasvika.
3. Ndezvipi zvinowanzoitika? Migumisiro inowanzo sanganisira kuneta, dzungu, manyoka, uye kusada kudya.
4. Ndingatora Rolapitant pamwe chete nemimwe mishonga here? Unofanira kuzivisa chiremba wako nezvemishonga yese yauri kutora, sezvo Rolapitant inogona kukanganisa mishonga yakasiyana-siyana.
5. Rolapitant yakachengeteka here panguva yekuzvitakura? Kuchengeteka kwayo panguva yekuzvitakura hakuna kusimbiswa, saka inofanira kudziviswa kunze kwekunge yakanyorwa nachiremba.
6. Rolapitant inoshanda sei? Inovhara ma neurokinin1 receptors muuropi, ichideredza zviratidzo zvinokonzera kuda kurutsa nekurutsa.
7. Chii chandinofanira kuita kana ndikapotsa dose? Usatore mushonga we chemotherapy kana wava pedyo nekutanga; bvunza chiremba wako kuti mushonga uyu unotorwa kamwe chete, kwete zuva nezuva.
8. Vana vanogona kutora Rolapitant here? Kuyera kwevana kunosiyana, saka bvunza chiremba kuti uwane mushonga wakakodzera vana.
9. Chii chandinofanira kuita kana ndikasangana nemigumisiro yakakomba? Bata mutarisiri wako wehutano nekukurumidza kana iwe ukasangana neakanyanya mhedzisiro kana allergic reaction.
10. Rolapitant inogara kwenguva yakareba sei? Mhedzisiro yeRolapitant inogona kugara kwemazuva akati wandei (hafu yehupenyu ~ maawa 169-183), ichinyanya kunangana nechikamu chekunonoka (kusvika maawa 72 mushure mekemo).

Mazita eBrand

Rolapitant inotengeswa pasi pezita rekuti Varubi. Inowanikwa muchimiro chemapiritsi ekunwa.

mhedziso

Rolapitant mushonga unobatsira varwere vari kurapwa nechemotherapy, unodzivirira kurutsa nekurutsa zvine chekuita nekurapwa. Maitiro ayo akasiyana uye kugona kwayo kuvandudza hupenyu hwevarwere vegomarara zvinoita kuti ive chikamu chakakosha cherubatsiro rwekurapa mukenza. Gara uchibvunza chiremba kuti uone kana Rolapitant iriyo sarudzo yakakodzera yekurapa kwako.