Milrinone - Uses, Dosage, Side Effects and More

Nhanganyaya: Chii chinonzi Milrinone?

Milrinone mushonga unonyanya kushandiswa kurapa kutadza kwemoyo. Iri muboka remishonga inozivikanwa se phosphodiesterase inhibitors, iyo inobatsira kuvandudza mashandiro emoyo uye kuwedzera kuyerera kweropa. Nekuwedzera kugona kwemoyo kupomba ropa, Milrinone inowanzo shandiswa munzvimbo dzakakomba, kunyanya kune varwere vari kusangana nekutadza kwemoyo kwakanyanya kana avo vakamirira kuisirwa moyo.

Mashandisirwo eMilrinone

Milrinone inotenderwa kushandiswa kwakasiyana-siyana mukurapa, kusanganisira:

• Kurapwa kwenguva pfupi kwevarwere vane chirwere chemwoyo chakabviswa mari.
• Rutsigiro rwevarwere vari kuvhiyiwa mwoyo.
• Kutarisirwa kwevarwere vane chirwere chemwoyo chisingaperi vasiri kupindura zvakakwana kune mamwe marapirwo.

Ainoita

Milrinone inoshanda nekudzivisa enzyme inonzi phosphodiesterase type 3 (PDE3), izvo zvinoita kuti huwandu hwe cyclic AMP (cAMP) huwedzere mumasero emwoyo netsinga dzeropa. Kuwedzera uku kunoguma nemigumisiro miviri mikuru: kuwedzera kwekugumburwa kwetsandanyama dzemwoyo (positive inotropic effect) uye kugadzikana kwetsinga dzeropa (vasodilation). Muchidimbu, Milrinone inobatsira moyo kupomba zvinobudirira ukuwo ichikudza tsinga dzeropa, zvichiita kuti zvive nyore kuti ropa rifambe.

Chipimo chemushonga uye Administration

Chipimo cheMilrinone chinosiyana zvichienderana nemamiriro emurwere uye maitiro ake pakurapwa. Kune vakuru, kupiwa kwakajairika ndekwekuti:

• Yekutanga Dose: 50 mcg/kg semushonga unoiswa mutsinga kwemaminitsi gumi.
• Maintenance Dose: 0.375 kusvika 0.75 mcg/kg/min semushonga unopinzwa nguva dzose, uchigadziriswa zvichienderana nemhinduro yekiriniki.

Kune varwere vevana, mishonga inotorwa zvichienderana nehuremu uye mamiriro chaiwo ekurapa. Milrinone inopihwa nejekiseni, kazhinji muchipatara, nekuda kwekudikanwa kwekutarisirwa kwakaringana.

Migumisiro yeMilrinone

Misungo yakajairika inogona kusanganisira:

• kurwadziwa nemusoro
• Nausea
• Kudzora
• Kuderera kweropa (hypotension)
• Arrhythmias (kurova kwemoyo kusingaite)

Serious side effects zvinogona kusanganisira:

• Kushaya simba kwakanyanya kweropa
• Thrombocytopenia (yakaderera platelet count)
• Kuwedzerwa kwengozi ye arrhythmias

Varwere vanofanirwa kuudza chero zviratidzo zvisingawanzo kune avo vanovapa hutano nekukasira.

Kubatana Kwemishonga

Milrinone inogona kushanda pamwe chete nemishonga yakasiyana-siyana, kusanganisira:

• Mishonga inobvisa ropa: Inogona kuwedzera njodzi yekuderera kweropa.
• Mimwe mishonga yemwoyo: Yakadai se beta-blockers, iyo inogona kukanganisa kurova kwemoyo uye rhythm.
• Mimwe mishonga inorwisa mabhakitiriya: Semaaminoglycosides, ayo anogona kuwedzera njodzi yematambudziko eitsvo.

Gara uchizivisa mutarisiri wako wehutano nezvese mishonga yauri kutora kuti udzivise kusangana kungangoita.

Mabhenefiti eMilrinone

Zvakanakira zvekushandisa Milrinone zvinosanganisira:

• Kukurumidza kuvandudza mashandiro emwoyo kune varwere vane chirwere chemwoyo chakanyanya.
• Kukwanisa kupa rutsigiro panguva yekuvhiyiwa kwemwoyo.
• Inoshanda kune varwere vasingapindure kurapwa kwakajairika kwekushaya simba kwemoyo.

Zvinopesana neMilrinone

Milrinone inofanira kudzivirirwa mune mamwe mapoka evanhu, kusanganisira:

• Varwere vane chirwere chakakomba che aorta kana pulmonary valve.
• Avo vane kusawirirana neMilrinone kana chimwe chezvinhu zvayo.
• Vakadzi vane pamuviri kana kuti vanoyamwisa, kunze kwekunge mabhenefiti acho achipfuura njodzi.

Chenjedzo uye Nyevero

Varwere vasati vatanga kushandisa Milrinone, vanofanira kuongororwa zvakadzama, kusanganisira:

• Kuongororwa kwebasa reitsvo, sezvo Milrinone ichinyanya kubviswa kuburikidza neitsvo.
• Kuongororwa kweBP uye kurova kwemoyo panguva yekurapwa.
• Kuongororwa nguva dzose murabhoritari kuti vaone kana paine migumisiro yakaipa, kunyanya kana ikashandiswa kwenguva refu.

FAQs

1. Milrinone inoshandiswa pai? Milrinone inoshandiswa kurapa kutadza kushanda kwemoyo kwakanyanya uye kuvandudza mashandiro emoyo, kunyanya munzvimbo dzine chirwere chemwoyo.
2. Milrinone inopihwa sei? Inopihwa sejekiseni remutsinga, kazhinji muchipatara.
3. Ndezvipi zvinowanzoitika? Migumisiro inowanzo sanganisira musoro, kuda kurutsa, uye kuderera kweropa.
4. Milrinone inogona kushandiswa here kuvana? Ehe, asi chiyero chemushonga chinogadziriswa zvichienderana nehuremu hwemwana uye mamiriro ake ezvinhu.
5. Chii chandinofanira kuita kana ndikapotsa dose? Sezvo Milrinone ichiwanzopihwa muchipatara, kushaikwa kwemushonga hakuwanzoitiki. Bvunza chiremba wako kuti akupe mazano.
6. Milrinone yakachengeteka here panguva yekuzvitakura? Zvinofanira kudzivirirwa kunze kwekunge zvichidikanwa zvachose, sezvo zvingakonzera njodzi kumwana ari mudumbu.
7. Milrinone inoshanda sei? Inowedzera kusimba kwemoyo uye inozorodza mitsipa yeropa, ichivandudza kuyerera kweropa.
8. Ndingatora mimwe mishonga here neMilrinone? Gara uchiudza chiremba wako nezvemimwe mishonga kuti usasanganise mishonga yacho.
9. Ndingatora Milrinone kwenguva yakareba sei? Nguva yekurapwa inosiyana; chiremba wako ndiye achasarudza urefu hwakakodzera zvichienderana nemamiriro ako ezvinhu.
10. Chii chandinofanira kutarisa pandinenge ndichitora Milrinone? Kugara uchitarisa BP, kurova kwemoyo, uye mashandiro eitsvo kwakakosha.

Mazita eBrand

Milrinone inowanikwa pasi pemazita akasiyana-siyana, anosanganisira:

• Primacor
• Milrinone Lactate

mhedziso

Milrinone ine basa guru mukurapa kutadza kwemoyo, kunyanya mumamiriro ezvinhu akaoma. Kugona kwayo kusimudzira mashandiro emwoyo nekuvandudza kuyerera kweropa kunoita kuti ive sarudzo inokosha kune varwere vanorwara zvakanyanya. Zvisinei, semishonga yese, ine migumisiro inogona kuitika uye kusangana kwayo kunofanira kutarisirwa nokungwarira. Nguva dzose bvunza chiremba kuti uwane mazano akakodzera uye nzira dzekurapa.