Colistin - Mashandisirwo, Chipimo, Migumisiro Yemushonga uye Zvimwe

Nhanganyaya: Chii chinonzi Colistin?

Colistin, inozivikanwawo sepolymyxin E, mushonga unorwisa mabhakitiriya uri muboka repolymyxin remishonga inorwisa mabhakitiriya. Unonyanya kushandiswa kurapa hutachiona hunokonzerwa nebhakitiriya reGram-negative risingarapike nemishonga yakawanda. Colistin yave kuzivikanwa mumakore achangopfuura nekuda kwekuwedzera kwehutachiona husingarapike nemishonga inorwisa mabhakitiriya, zvichiita kuti ive sarudzo yakakosha mukurapa hutachiona hwakasimba.

Mashandisirwo eColistin

Colistin inotenderwa kurapa hutachiona hwakasiyana-siyana, kunyanya hunokonzerwa nemabhakitiriya akadai sePseudomonas aeruginosa, Acinetobacter baumannii, uye Klebsiella pneumoniae. Inowanzo shandiswa kana mamwe maantibiotics asingashande nekuda kwekusagona kurapwa. Kushandiswa kwakajairika mukurapa kunosanganisira:

• Mabayo akanyanya
• Urinary tract infections
• Utachiona hweropa
• Utachiona muvarwere vane cystic fibrosis

Ainoita

Colistin inoshanda nekukanganisa membrane yemasero ebhakitiriya. Inobatana ne lipopolysaccharides uye phospholipids mumembrane yekunze yebhakitiriya reGram-negative, zvichikonzera kufa kwemasero. Nemamwe mashoko, unogona kufunga nezve colistin se "disruptor" inoputsa dziviriro yebhakitiriya inokuvadza, zvichibvumira masoja emuviri kubvisa hutachiona.

Chipimo chemushonga uye Administration

Colistin inogona kupiwa nenzira dzakasiyana, kunyanya sejekiseni kana kufemerwa. Mishonga yakajairika ndeiyi inotevera:

• Vakuru: Muyero wemushonga unowanzo shandiswa mutsinga ndewe 2.5 kusvika 5 mg/kg pazuva, uchikamurwa kuita madosi maviri kana matatu.
• Pediatrics: Kune vana, chiyero chinowanzo verengerwa zvichienderana nehuremu hwemuviri, kazhinji kacho chiri pamusoro pe2.5 mg/kg pazuva.

Kuwanda uye nzira yekupa mushonga zvinogona kusiyana zvichienderana nekuoma kwehutachiona uye hutano hwemurwere. Gara uchitevera mirairo yemupi wehutano kuti uwane mushonga wakakodzera uye nzira yekupa mushonga.

Migumisiro yeColistin

Kufanana nemishonga yese, colistin inogona kukonzera migumisiro yakaipa. Migumisiro yakaipa inosanganisira:

• Nausea
• Diarrhea
• Chizutu
• kurwadziwa nemusoro

Serious side effects inogona kusanganisira:

• Nephrotoxicity (kukuvara kweitsvo)
• Neurotoxicity (kukuvara kwetsinga)
• Allergic reactions

Varwere vanofanirwa kuudza chero zviratidzo zvisingawanzo kune avo vanovapa hutano nekukasira.

Kubatana Kwemishonga

Colistin inogona kupindirana nemishonga yakasiyana-siyana, izvo zvinogona kuwedzera njodzi yemigumisiro kana kuderedza kushanda kwemishonga. Kupindirana kukuru kwemishonga kunosanganisira:

• Mimwe mishonga ine chepfu (semuenzaniso, aminoglycosides, vancomycin)
• Neuromuscular blocking agents

Gara uchizivisa mutarisiri wako wehutano nezvese mishonga uye zvinowedzera zvauri kutora kuti udzivise kusangana kungangoita.

Mabhenefiti eColistin

Colistin ine mabhenefiti akawanda ekurapa, kunyanya kana tichitarisa kusakwanisa kushandisa mishonga inorwisa mabhakitiriya:

• Inoshanda pakurwisa mabhakitiriya asingapindi mishonga yakawanda
• Inogona kushandiswa pamwe chete nemamwe maantibiotic kuti iwedzere kushanda zvakanaka
• Inowanikwa mumhando dzakasiyana dzezvirwere zvakasiyana-siyana

Mabhenefiti aya anoita kuti colistin ive sarudzo inokosha mukurapa hutachiona hwakakomba husingapindure nemishonga inorwisa mabhakitiriya yakajairika.

Contraindications yeColistin

Vamwe vanhu vanofanira kudzivisa kushandisa colistin, kusanganisira:

• Vakadzi vane pamuviri kana kuti vanoyamwisa (kunze kwekunge zvichidikanwa zvachose)
• Varwere vane nhoroondo yeallergy yakanyanya kune polymyxins
• Vanhu vane chirwere cheitsvo chagara chiripo

Bvunza chiremba wako kuti uone kana colistin yakakodzera kwauri.

Chenjedzo uye Nyevero

Vasati vatanga colistin, varwere vanofanira kuongororwa murabhoritari kuti vaone mashandiro anoita itsvo, sezvo colistin inogona kukonzera chepfu. Zvakakosha kutarisa mashandiro anoita itsvo panguva yekurapwa. Pamusoro pezvo, varwere vanofanira kuzivisa mupi wehutano hwavo nezve chero matambudziko aripo kana mishonga yavari kutora.

FAQs

• Chii chinoshandiswa ne colistin? Colistin inoshandiswa kurapa hutachiona hunokonzerwa nemabhakitiriya eGram-negative asingapindi mishonga yakawanda, akadai sepneumonia uye hutachiona hweropa.
• Ko colistin inopihwa sei? Colistin inogona kupiwa sejekiseni kana kufemerwa, zvichienderana nerudzi rwehutachiona huri kurapwa.
• Ndezvipi migumisiro inowanzo konzerwa ne colistin? Migumisiro inowanzo sanganisira kuda kurutsa, manyoka, dzungu, uye musoro.
• Ko colistin inogona kukonzera kukuvara kweitsvo here? Ehe, colistin inogona kukonzera kenza, saka mashandiro eitsvo anofanira kutariswa panguva yekurapwa.
• Ko colistin yakachengeteka here panguva yekuzvitakura? Colistin inofanira kudzivirirwa panguva yekuzvitakura kunze kwekunge zvichidikanwa zvachose, sezvo kuchengetedzeka kwayo kusati kwazivikanwa.
• Ko colistin inoshanda sei? Colistin inovhiringidza membrane yemasero ebhakitiriya, zvichikonzera kufa kwemasero uye zvichibatsira masoja emuviri kurwisa hutachiona.
• Chii chandinofanira kuita kana ndikarasikirwa nedosi ye colistin? Kana ukarasikirwa nedosi, tora pakarepo paunoyeuka. Kana yave kuda nguva yedosi yako inotevera, svetuka iyo dosi yakapotsa uye enderera nehurongwa hwako hwenguva dzose.
• Ndinganwa doro here ndichitora colistin? Zvinokurudzirwa kurega doro paunenge uchitora colistin, sezvo inogona kuwedzera njodzi yemigumisiro yakaipa.
• Pane here kusangana kwekudya necolistin? Hapana hukama chaihwo pakati pekudya, asi zvakanaka kutevedzera zano remupi wehutano wako maererano nekudya paunenge uchitora mishonga.
• Ndichatora colistin kwenguva yakareba sei? Nguva yekurapwa necolistin inoenderana nerudzi uye kuoma kwehutachiona. Tevedzera mirairo yemupi wehutano wako.

Mazita eBrand

Colistin inowanikwa pasi pemazita akasiyana-siyana emhando, anosanganisira:

• ColyMycin M
• Polymyxin E
• Colistin sulfate

mhedziso

Colistin mushonga unoshanda zvikuru mukurwisa hutachiona husingapindi mishonga yakawanda. Maitiro ayo akasiyana ekushanda uye kushanda kwayo pakurwisa mabhakitiriya asingapindi mishonga zvinoita kuti ive chinhu chakakosha mukurapa kwemazuva ano. Zvisinei, nekuda kwemigumisiro inogona kuitika uye kusangana kwayo, zvakakosha kushandisa colistin uchitungamirirwa nenyanzvi yehutano.