Mhinduro yakananga
Kuongororwa kweropa kweC3 complement kunoyera huwandu hwechikamu chechitatu chekuwedzera, protein yemuviri inorwisa zvirwere, muropa. Vanachiremba vanoshandisa C3 test zvakanyanya kubatsira kuongorora chirwere chinofungidzirwa kuti chine lupus, mamwe marudzi e glomerulonephritis uye mamwe matambudziko emuviri, uye kutevera mashandiro echirwere nekufamba kwenguva. Kuongororwa kweC3 chete hakugone kuona chero chirwere.
Key tora kutora
- Zvainoyera: huwandu hweprotein yeC3, chikamu chikuru chechikamu chekuwedzera.
- Nei yakarairwa: kazhinji kutsigira kuongororwa kwesystemic lupus erythematosus (SLE), lupus nephritis uye mamwe marudzi ekuzvimba kweitsvo.
- Zvaisingakwanise kuita: C3 yakajairika haibvisi chirwere che lupus, vasculitis kana chirwere cheitsvo, uye C3 yakaderera haibvumidzi chero chirwere chipi zvacho.
- Zvinoitwa sei: sampuli yeropa rimwe chete mutsinga, kazhinji kubva paruoko, zvichitora maminitsi mashoma.
- Kuiverenga sei: pamwe chete neC4, anti-dsDNA, bvunzo dzeweti, mashandiro eitsvo nezviratidzo zvako, zvinotsanangurwa nachiremba akakumbira bvunzo.
Pakuona
| mamiriro | umboo |
|---|---|
| chiratidza zvizhinji | Ropa remutsinga, rinowanzova chubhu imwe chete |
| Kutsanya | Kazhinji hazvidiwi paC3 chete; tevera mirairo yerabhoritari yako, kunyanya kana mimwe miedzo yakanyoreswa pakushanya kumwe chete. |
| Inguva yekutorwa kweropa | Kazhinji maminetsi mashanu kusvika gumi kubva pakugara kusvika pakubata bhandeji; tsono inenge iri mutsinga kwenguva isingasviki miniti |
| Nguva yese yekushanya | Kazhinji maminetsi makumi maviri kusvika makumi mana anosanganisira kunyoresa nekumirira, zvichienderana nekuti nzvimbo yekuunganidzira zvinhu yakabatikana zvakadii |
| Inowanzo rairwa ne | C4, CH50 (basa rose rekuwedzera), ANA, anti-dsDNA, maitiro eweti uye microscopy, chiyero cheprotein-creatinine yeweti, serum creatinine |
| Kushandiswa kwemhedzisiro | Inotsigira, kwete kuongorora chirwere chega |
| Reference range | Zvakanangana nerabhoritari uye nzira dzacho; gara uchiverenga huwandu hwezvinyorwa zvakadhindwa pamushumo wako wega |
Uyewo anozivikanwa se
- Kuongororwa kweC3, serum C3, kuwedzera kweC3
- Wedzera chikamu chechikamu chechitatu
- Chikamu che "profile yekuwedzera" kana "bvunzo yeC3 C4" mumarabhoritari mazhinji eIndia
- Dzimwe nguva zvakanyorwa pamishonga inonyorwa se "C3, C4"
Chii chinonzi bvunzo yeC3 complement test
Sisitimu yekuwedzera iboka remapuroteni eropa anoshanda muchikamu chekubatsira masoja emuviri kubvisa hutachiona, immune complexes uye masero akakuvara. C3 iri panzvimbo panosangana nzira dzese nhatu dzekushanda, saka ndeimwe yemapuroteni ekuwedzera ane ruzivo rwakanyanya kuyera.
Kana cascade yekuwedzera ikashanda nesimba, semuenzaniso ne immune complexes mu active lupus, C3 inodyiwa nekukurumidza kupfuura iyo inotsiva chiropa, uye huwandu hwakayerwa hunogona kudzikira. Mune mamwe mamiriro ezvinhu anogarwa nhaka, C3 ishoma nekuti muviri haudzore cascade zvakanaka. Kuongororwa kweC3 kunoyera kuti mapuroteni eC3 akawanda sei aripo; bvunzo dzakajairwa hadzikuudze kana C3 iyoyo inoshanda zvakanaka.
Nei bvunzo yeC3 complement yaitwa?
- Anofungidzirwa kana anozivikanwa SLE: sechikamu chekutanga chekuongorora mashandiro emuviri uye kubatsira kuronda mashandiro echirwere, kunyanya lupus nephritis.
- Kuzvimba kweitsvo: Muzvirwere zvakaita se glomerulonephritis mushure mekutapurirana, membranoproliferative glomerulonephritis uye C3 glomerulopathy, maitiro eC3 neC4 anobatsira kuderedza mikana yacho.
- Chirwere chekudzivirira muviri chisingatsanangurike: pamwe chete nedzimwe bvunzo apo mapundu, kurwadziwa kwemajoini, serositis uye kuwanikwa kweweti zvisina kujairika zvinoitika pamwe chete.
- Kurwara kwebhakitiriya kwakanyanya kana kusingawanzoitiki kunowanzoitika: kuongorora kushomeka kwekuwedzera kweropa, kazhinji neC4 neCH50.
- Kutarisa mhinduro yekurapwa: Mune zvimwe zvirwere zvinosanganiswa nekuwedzera, huwandu hweC3 hunoshandiswa pamwe chete nezviratidzo zvekiriniki uye weti.
Ndiani anofanira kuongororwa uku?
Bvunzo yeC3 haisi bvunzo yekuongorora hutano kana yekuongorora, uye hapana chikonzero chekuwedzera bvunzo yeC3 panel yenguva dzose yegore negore. Chiremba anogona kuraira bvunzo yeC3 zvine musoro kana uine:
- Kufungirwa kuti une lupus, semuenzaniso kurwadziwa kwemajoini kunogara kwenguva refu pamwe nemapundu, maronda emuromo, kurasikirwa nebvudzi, kupererwa neropa kusingatsananguriki kana kuti maplatelet mashoma, kana kurwadziwa pachipfuva.
- Ropa kana mapuroteni ari muweti, kuzvimba kwechiso, kudzikira kwehuwandu hweweti kana kuwedzera kwecreatinine zvichiratidza glomerulonephritis.
- Lupus inozivikanwa inogona kukonzera kuputika, kunyanya kana paine proteinuria itsva.
- Kuongororwa kweC3 glomerulopathy kana membranoproliferative glomerulonephritis kwaratidza kuti kwave nechirwere chinoda kuteverwa.
- Kurwara nemabhakitiriya anopinda mumuviri kakawanda, zvakadai sechirwere chemeningococcal kana pneumococcal kanopfuura kamwe chete, uko kushomeka kwekuwedzera kwemishonga kuri kutariswa.
- Kuongororwa kweAngioedema kusingatsanangurike kunoitika nguva nenguva, kunyangwe pano kuongororwa kweC4 neC1 inhibitor kuri bvunzo dzinopa ruzivo rwakawanda, kwete C3.
Kana usina zviratidzo kana mubvunzo chaiwo wekiriniki, mhedzisiro yeC3 haingango shandure hutano hwako uye inogona kukonzera kuzvidya mwoyo kusingadzivisiki pamusoro penhamba yemuganhu.
Izvo zvisingagoni kuonekwa kana kusabviswa neC3 complement test
Bvunzo yeC3 chiratidzo chinotsigira, kwete chekuongorora. Kujeka nezvemiganhu yayo kunodzivirira kuvimbiswa kwenhema uye kunetseka kusina basa.
- Kuongororwa kweC3 hakuongorori chirwere che lupus. Kuongororwa kwechirwere kunoenderana nezviratidzo zvekiriniki pamwe chete neautoantibodies uye, kana zvichidikanwa, biopsy. Vanhu vazhinji vane SLE vane C3 yakajairika, kunyanya kana chirwere chisiri kushanda kana kuti chiri paganda nemapfundo.
- C3 yakajairika haibatanidzi lupus, vasculitis kana glomerulonephritis. Hazvisi zvirwere zvese zvinokonzerwa nekudzivirira muviri zvinoshandisa mishonga inokwana. Vasculitis inokonzerwa neANCA uye IgA nephropathy, semuenzaniso, zvinowanzoratidza C3 yakajairika.
- C3 yakaderera haisi chaiyo. Kuderera kweC3 kunoitika mu active lupus, post-streptococcal glomerulonephritis, C3 glomerulopathy, cryoglobulinemia, sepsis yakanyanya, chirwere chechiropa chakakura chine kuderera kwekugadzirwa, uye zvimwe zvikanganiso zvakagarwa nhaka.
- Bvunzo yeC3 haiyere mashandiro. Kuongororwa kwemuviri kunoratidza huwandu hweprotein, kwete huwandu hwebasa rinoitwa. Kuongororwa kwebasa kunoda CH50 kana bvunzo dzenzira, uye kushomeka kunofungidzirwa kuti hakuna kukwana kunoda kududzirwa nenyanzvi.
- Kuongororwa kweC3 hakuratidzi kuti chirwere chacho chiri kupi. Haikwanise kukuudza kana itsvo, ganda kana majoini akanganiswa, uye haigone kutsiva kuongororwa kweweti, kufungidzira kana biopsy yeitsvo.
- Kuongororwa kweC3 hakugone kuratidza kukuvara kweitsvo. Haisi bvunzo yekushanda kweitsvo uye haitsivi creatinine, eGFR kana kuyerwa kwemapuroteni emuweti.
- Kuora kweropa kwemudumbu hakuonekwi neC3. Mu angioedema yekare yenhaka, C4 inowanzova yakaderera nepo C3 inowanzova yakajairika.
Mhedzisiro inotsanangurwa sekuti "hapana chakaipa chakaonekwa" zvinoreva kuti hapana chisina kunaka chakaonekwa neongororo iyoyo pamuenzaniso iwoyo. Hazvirevi kuti chirwere hachina kubviswa. Kana zviratidzo zvako zvikaramba zvichienderera mberi pasinei neC3 yakajairika, dzokera kuna chiremba wako pane kufunga kuti dambudziko racho harina kunyatsojeka.
Bvunzo dzakabatana asi dzakasiyana
Bvunzo dzekuwedzera dzinopindura mibvunzo yakasiyana. Imwe haina kunaka pane imwe; sarudzo chaiyo inoenderana nedambudziko rekiriniki.
| bvunzo | Zvinopindura sei? | Musiyano mukuru kubva kuC3 |
|---|---|---|
| C3 | Mapuroteni epakati ekuwedzera ari kudyiwa here kana kuti haasi kugadzirwa zvakakwana? | Inoratidza nzira nhatu dzese dzekushanda dzinosangana; inonyanya kubatsira mu lupus nephritis uye C3 glomerulopathy |
| C4 | Nzira yekare kana kuti ye lectin iri kushandiswa here? | C4 yakaderera neC3 yakajairika inokonzera angioedema yenhaka uye mamwe ma cryoglobulinemia; maitiro eC3:C4 ane ruzivo rwakawanda kupfuura ese ari maviri. |
| CH50 (basa rose rekuwedzera) | Nzira yese yekare inoshanda zvakanaka here? | Inoshanda, kwete yehuwandu; inoshandiswa zvakanyanya kuongorora kushomeka kwehutachiona hunodzokororwa. Inonyanya kusimba kana ikashandiswa mukubata nemuenzaniso. |
| ANA uye anti-dsDNA | MaAutoantibodies anokonzerwa neLupus aripo here? | Kuongororwa kweAutoantibodies, kwete zviratidzo zvekushandiswa; zvinoshandiswa pamwe chete neC3 neC4, kwete panzvimbo pazvo |
| C3 nephritic factor, factor H, zvidzidzo zvefactor B | Sei nzira yekurapa isina kunaka? | Kuongororwa kwechiremba, kazhinji mushure mekuongororwa kweitsvo, kunoratidza C3 glomerulopathy |
| ESR uye CRP | Pane kuzvimba kwakajairika here? | Zviratidzo zvekuzvimba zvisiri zvega; hazviratidzi kushandiswa kwekuwedzera uye zvinowanzoita zvakasiyana neC3 mu lupus |
| Maitiro ekuita weti, microscopy uye chiyero cheprotein-creatinine | Itsvo iri kuzvimba here kana kuti iri kubuda mapuroteni? | Kazhinji inonyanya kubatwa nechirwere che nephritis chiri kukura kupfuura C3; haigone kutsiviwa nekuyedzwa kwekuwedzera |
Maitiro ekugadzirira
Kugadzirira kuri nyore, asi zvinodiwa pakuongororwa kwekuwedzera kwemishonga zvinoenderana nekubata kwayo uye zvinosiyana zvichienderana nema laboratories. Mirayiridzo yakanyorwa yerabhoritari yako ndiyo inonyanya kukosha pane chero gwara rekushandisa pano.
- Kutsanya: kazhinji hazvidikanwi paC3 chete. Kana kuongororwa kwemafuta, shuga kana kumwe kutsanya kwakaitwa panguva imwe chete, tevera mirairo yekutsanya yeizvozvo.
- Mishonga: Udza chiremba ari kukumbira rubatsiro nevashandi vekutora mishonga nezvemishonga yese yakanyorerwa nachiremba, mishonga inotengeswa kunze kwemutero, AYUSH kana mishonga yemishonga uye mishonga yekurovedza muviri. Usatange, kumisa kana kuchinja chero mushonga wakanyorerwa nachiremba, kusanganisira masteroids kana mishonga inodzvinyirira immune system, kuti ugadzirire bvunzo iyi. Tanga wataura nechiremba ari kunyorera mushonga.
- Kurwara kwazvino: taura nezvehutachiona, fivha kana kupinda muchipatara mumavhiki apfuura, sezvo chirwere chakanyanya chinogona kuchinja huwandu hwechirwere kubva kune chimwe kuenda kune chimwe.
- Hydration: Kunwa mvura nguva dzose kunoita kuti ropa ribude nyore. Kana wakaudzwa kuti udzikise mvura nekuda kwekushaya simba kwemoyo, chirwere cheitsvo chisingaperi kana dialysis, tevera mutemo iwoyo woudza vashandi vekutora ropa.
- Sample kubata: mapuroteni ekuwedzera anopera kana serum ikasiyiwa patembiricha yemumba. Mamwe marabhoritari anoda kupatsanurwa nekukasira uye kuomeswa nechando, ndosaka sampuro dzekunze kana dzekutorwa kumba dzichigona kurambwa dzimwe nguva kana kupa huremu hwakaderera.
Kana iwe uri nepamuviri
Kuongororwa kweC3 kunongosanganisira kutorwa kweropa chete uye kunoshandiswa panguva yekuzvitakura kana zvichidikanwa, semuenzaniso pakuongorora lupus. Huwandu hwemuviri hunowanzo kukwira panguva yekuzvitakura kwakajairika, saka kududzira kunofanira kuenderana nekuzvitakura uye kunofanira kuitwa nachiremba wezvekubereka kana chiremba wemapfupa ari kurapa.
Children
Bvunzo yeC3 inoshandiswa kuvana, kazhinji kana paine fungidziro yekuti glomerulonephritis mushure mekutapurirana kana kuti lupus yevana. Nguva dzekuongororwa kwevana dzinosiyana nedzevakuru uye dzinosiyana zvichienderana nezera, saka mhedzisiro inofanira kuverengwa zvichienderana nehuwandu hunopihwa nerabhoritari yezera iroro. Tsono diki, kubatwa nemusoro uye kuvapo kwemubereki kunobatsira.
Vakuru nevanhu vane mitsipa isina kusimba
Kuedza kakawanda kunogona kuitika. Udza chiremba wephlebotomist nezvekudhonzwa kwakaoma kwemusana, lymphoedema, dialysis fistula kana mastectomy kune rumwe rutivi kuitira kuti rumwe ruoko rushandiswe.
Vanhu vanonwa mishonga inobvisa ropa rakawanda
Ramba uchinwa mishonga inorwisa ropa rinobuda ropa uye mishonga inorwisa maplatelet kunze kwekunge chiremba wako akakuudza zvakasiyana. Tarisira kuti udzvanye panzvimbo yacho kwemaminitsi akati wandei, wobva wataura nezvemushonga wacho kuitira kuti kumanikidzwa kwakasimba kushandiswe.
Chirwere cheshuga chiri pakurapwa kuderedza shuga yeropa
Kana kushanya kumwe chete uku kuchisanganisira bvunzo yekutsanya, kurukurai nguva yekutora insulin kana mapiritsi nechiremba wenyu nguva isati yasvika, uye takurai kabhohaidhiretsi inoshanda nekukurumidza kana paine hypoglycemia panguva yekutsanya.
Chii chinoitika panguva yebvunzo
Chiremba wephlebotomist anosimbisa kuti ndiwe ani uye bvunzo dzinokumbirwa, anoisa tourniquet, anochenesa ganda uye anoburitsa ropa kubva mutsinga iri muruoko. Unganzwa kuruma kwenguva pfupi. Kumanikidzwa kunoiswa uye nzvimbo yacho inosungwa nebhandeji. Nguva yetsono inowanzova pasi peminiti imwe chete; nguva yese yekusangana inowanzova maminetsi makumi maviri kusvika makumi mana kusanganisira kunyoresa, zvichienderana nepakati. Unogona kudya, kutyaira uye kudzokera kubasa nekukasika kunze kwekunge wanzwa kupera simba.
Kunzwisisa mushumo wako weC3
Verenga zvawakawana uchienzanisa nenguva yekutarisa yakadhindwa pamushumo wako wega. C3 inoshumwa mu mg/dL kana g/L zvichienderana nerabhoritari, uye nguva dzekutarisa dzinosiyana zvichienderana neanalyzer uye nzira, saka nhamba kubva murabhoritari imwe haifanirwe kuenzaniswa zvakananga nehuwandu hwerabhoritari imwe.
- Mukati menzvimbo yekutarisa: Hapana humbowo hwekushandiswa kwakawanda kwemishonga yekuwedzera pamuenzaniso iwoyo. Izvi hazvibvisi chirwere che autoimmune kana chirwere cheitsvo.
- Pasi pehuwandu hwezvinotarisirwa: zvinogona kuratidza kushandiswa kwemishonga inokwana (active lupus, immune complex disease, post-infectious glomerulonephritis, cryoglobulinemia), kuderera kwekugadzirwa (chirwere chechiropa chakafambira mberi, kushaya chikafu chakakwana), kushomeka kweropa, kana dambudziko rekubata sample. Maitiro ane C4 anokosha: C3 yakaderera ine C4 yakaderera inoratidza kushandiswa kwenzira yekare, nepo C3 yakaderera ine C4 yakajairika inoratidza kusashanda zvakanaka kwenzira dzakasiyana dzakadai seC3 glomerulopathy.
- Pamusoro penzvimbo yekuverengera: C3 inoita seprotein inopinda muchikamu cheacute-phase uye inowanzokwira kana paine hutachiona, kukuvara, kuzvimba kana pamuviri. C3 yakakwira kazhinji haisi chaiyo uye haiwanzoonekwa pachayo. Chinonyanya kukosha ndechekuti, kuwedzera kusvika padanho rakajairika kunogona kuvharira kudya kwemunhu ane huwandu hwakakwira hweropa.
Maitiro ekuongorora chirwere anonyanya kukosha kupfuura mwero mumwe chete muvanhu vane chirwere chinozivikanwa kuti chinokonzerwa nekuwedzera kweprotein. Kuderera kweC3 neproteinuria itsva kunoreva zvakawanda kupfuura nhamba imwe chete. Mhedzisiro yacho inosiyana zvichienderana nemamiriro ezvinhu ekurapa, uye dudziro ndeyachiremba akakumbira bvunzo.
Kana mhedzisiro yeC3 inogona kutsausa
Zvikonzero zveC3 yakaderera zvisiri pamutemo
- Kunonoka kugadziriswa kwemuenzaniso kana kuchengetwa kunodziya: Kushanda kwemushonga we in-vitro uye kuora kwemasero kunoderedza C3 yakayerwa. Ichi ndicho chikonzero chinowanzoitika che artefactual.
- Mienzaniso yakabviswa ropa kana kuti yakachengetwa muchando kakawanda uye yakanyungudutswa.
- Nguva yakareba yekutamba kana kudhonzwa kwakaoma, kunorwadza.
- Kupindira kwenzira mune sampuli dzine mafuta akawanda, paraproteins kana rheumatoid factor, zvichienderana neassay.
Zvikonzero zvekusataura chokwadi kana kuti kutaura chokwadi zvisirizvo C3
- Kutapukirwa kana kuzvimba panguva imwe chete: Kukwira kwechikamu cheacute kunogona kudhonza C3 yakadyiwa kuti idzokere panzvimbo yakatarwa, zvichivhara chirwere chinoshanda.
- Kuberekwa: kuwedzera kwemapuroteni anowedzera muviri.
- Kurapa kwe corticosteroid kana immunosuppressive kwakaitwa munguva pfupi yapfuura: Kurapwa kunogona kuita kuti C3 ive yakajairika chirwere chacho chisati chadzorwa zvizere.
- Kusiyana kwekutanga: mumwe munhu ane C3 yakajairika anogara kumusoro anogona kunge achidya complement achiri kuverenga "zvakajairika".
Nekuda kweizvi, C3 inodudzirwa pamwe chete neC4, maautoantibodies, zvinowanikwa muweti uye kuongororwa kwekiriniki, kwete zvese zviri zvega.
Njodzi nekuchengetedzeka
Kuongororwa kweC3 kunoda chete kuongororwa kweropa remutsinga nguva dzose. Njodzi dzinoitika ndedzekubhoborwa kwetsinga uye kazhinji kacho idiki.
Zvakajairika uye zvinotarisirwa
Kurwadziwa kwenguva pfupi, kurwadziwa kudiki, uye kukuvara kudiki panzvimbo yakaboorwa kunozopera mukati memazuva.
Uncommon
Kureruka kana kufenda, kunyanya kune avo vakambofenda kare kana kuti vakauya vasina kudya; kukuvara kukuru kana kubuda ropa, kazhinji pamishonga inorwisa ropa; kudiwa kwekuyedza kechipiri.
rova
Utachiona hwepanzvimbo yacho, kutsamwa kwetsinga kunokonzera kukwenya, kana phlebitis. Udza vashandi nekukurumidza kana uchinzwa kupera simba kana kurwadziwa zvakanyanya panguva yekudhonza.
Mireza tsvuku
Dambudziko: tsvaga rubatsiro izvozvi
- Kuzvimba kwemiromo, rurimi kana pahuro, kuoma kufema kana kumedza.
- Fivha ine musoro wakanyanya, kuomarara kwemutsipa, hope, kuvhiringidzika kana mapundu anopararira nekukurumidza asinganyangarike kana munhu amanikidzwa.
- Kutadza kuita weti kwenguva yakareba kana kusaita weti kwenguva yakareba, kana kushaya mweya wakarara pasi.
- Kubatwa nepfari, kushaya simba kamwe kamwe kune rumwe rutivi, kana kurwadziwa kwakanyanya kwechipfuva kamwe kamwe.
- Kubuda ropa rakawanda, kuzvimba kunowedzera nekukurumidza kana kutsvuka kuchipararira pamwe nefivha panzvimbo inotorwa ropa.
Ongororo yezvekurapa yezuva rimwe chete
- Kuzvimba kutsva kwechiso kana gumbo, weti ine furo, kana weti ine mavara anooneka eropa kana kuti ine ruvara rwemhando ye cola.
- Fivha ine marwadzo emajoini uye mapundu matsva kumunhu ane chirwere chinonzi lupus.
- Kurutsa nguva dzose kana kudzikira kwakanyanya kwehuwandu hweweti.
- Lupus inozivikanwa ine kurwadziwa kutsva pachipfuva kana munhu achifema zvakadzama.
Kugadzwa kwenguva dzose
- Mhedzisiro yeC3 iri kunze kwehuwandu hwezviratidzo, pasina zviratidzo zvitsva.
- Marwadzo emumajoini anoenderera mberi, kurasikirwa nebvudzi, maronda mumuromo, mapundu anonzwa kupenya kwechiedza kana kuneta.
- Kurwara kudiki kunodzokororwa, kana nhoroondo yemhuri yechirwere che lupus kana cheitsvo.
- Zviratidzo zveC3 zvakajairika asi zvichiri kuramba zvichienderera mberi, dzosera mushumo kuti uongororwe zvakare.
Mamiriro ezvinhu anokosha
Kuberekwa
Mapuroteni ekuwedzera anowanzo kukwira mukuzvitakura kwakajairika, saka C3 "yakajairika" inogona kuva yakaderera pakuzvitakura. Mukuzvitakura kwakaoma ne lupus, maitiro ekuwedzera anoverengwa neropa, mapuroteni emuweti, huwandu hwemaplatelet uye ma enzymes echiropa, sezvo zviratidzo zve lupus flare ne pre-eclampsia zvichipindirana. Kungwarira kunofanira kugoverwa pakati pechiremba wezvekubereka nenyanzvi yezvemapfupa.
Children
Kuderera kweC3 neC4 yakajairika mumwana ane weti ine ruvara rwecola uye maziso akazvimba mavhiki maviri kusvika mana mushure mekurwara pahuro kana hutachiona hweganda zvinoratidza post-streptococcal glomerulonephritis. C3 inowanzo pora kwemavhiki; kuderera kweC3 nguva dzose mushure memwedzi mitatu kunoita kuti atumirwe kuna chiremba wepfungwa wevana kuti aongorore C3 glomerulopathy.
Chirwere cheitsvo chisingaperi uye dialysis
C3 haiyere mashandiro eitsvo uye haiteveri eGFR. Dialysis membranes inogona kumutsa complement, saka nguva yemuenzaniso kana tichienzanisa ne dialysis session inofanira kucherechedzwa. Tevedzera chero chipi zvacho chakarairwa chemvura paunenge uchigadzirira.
Chirwere chechiropa chakakura
C3 inogadzirwa muchiropa. Muchirwere checirrhosis, C3 yakaderera inogona kuratidza kudzikira kwekugadzirwa kwemasero panzvimbo pekushandiswa kwemasoja emuviri, uye inofanira kutsanangurwa nealbumin, INR uye kuongororwa kwekiriniki.
Vanhu vari kutora mishonga inodzvinyirira immune system kana steroid
Kurapwa kunogona kuita kuti C3 iite seyakajairika uku chirwere chichiri kushanda munyama. Usaverenge C3 yakajairwa semvumo yekuchinja mushonga. Chero shanduko inofanira kubva kuna chiremba.
Vakuru vakuru
Zvirwere zvakawanda zvinoitwa panguva imwe chete, hutachiona uye kenza zvese zvinoshandura mapuroteni echikamu cheacute, zvichiita kuti C3 yakaparadzana ive yakaoma kunzwisisa. Serial values inobatsira kupfuura kuverenga kamwe chete.
Bvunzo reC3 rekuwedzera muIndia
- Mashoko ari pakaunda: Bvunzo iyi inowanzo nyorwa se "C3, C4" kana "complement profile". Dzimwe nzvimbo dzinoinyora pasi pema "immunology" kana ma "rheumatology pane pane ma "routine biochemistry".
- Glomerulonephritis mushure mekutapurirana ichiri kukosha mukurapa muIndia, kunyanya kuvana mushure mehutachiona hwe streptococcal pahuro kana ganda. Nzira yeC3 yakaderera ine maitiro akajairika eC4, inoteverwa nekupora, inzira inozivikanwa mukurapa vana.
- Mutoro wehutachiona unokanganisa dudziro: Tibhii, fevha yemudumbu, dengue, leptospirosis, malaria, hepatitis E kana humwe hutachiona hunogona kutevedzera zviratidzo zve lupus uye kuchinja mapuroteni echikamu cheacute, saka mhinduro dzinoenderana dzinofanira kuverengwa uchifunga nezvenhoroondo yehutachiona.
- Muenzaniso wezvinhu zvinoitwa pakufambisa zvinhu: uko sampuro dzinounganidzwa panzvimbo diki dzoendeswa kurabhoritari iri kure munzvimbo inodziya, kukundikana kwechando ndicho chikonzero chaicho chekuderera kweC3. Kudzokorora bvunzo nekubata nemazvo kunowanzo batsira pane kuwedzera kuferefeta pane imwe chete.
- Kupinda uye ruzivo rwenyanzvi: Kuongororwa kweC3 neC4 kunowanikwa zvakanyanya mumaguta, nepo CH50, factor H neC3 nephritic factor assays zvichiwanzoendeswa kumahofisi mashoma ekuongorora, pamwe nekumirira kwenguva yakareba.
Mutengo neinishuwarenzi muIndia
C3 ibvunzo yekudzivirira muviri isingadhuri mumarabhoritari mazhinji ekuIndia, uye inowanzo kuve nemutengo wakakwira kupfuura bvunzo dze biochemistry dzenguva dzose asi dziri pasi peongororo dze specialized functional complement assays. Mitengo inosiyana zvakanyanya pakati pemaguta, pakati pehurumende, trust nema laboratory akazvimirira, uye pakati pemarabhoritari akabatana nechipatara, saka bvunza laboratory kuti ione mutengo wayo wepari zvino usati wabhuka pane kuvimba nenhamba ipi zvayo yakabudiswa.
Zvinhu zvinokanganisa mari yaunobhadhara:
- Kunyangwe C3 yakarairwa yoga kana kuti sechikamu chepaneru yekuwedzera kana yekudzivirira muviri, mapaneru anowanzo kuve akachipa pane huwandu hwebvunzo dzega dzega.
- Nzira yekuedza inoshandiswa uye kana muenzaniso wacho uchifanira kuendeswa kuchipatara chekunze.
- Kuunganidza zvinhu pamba, kugadzirisa zvinhu nekukurumidza kana mari yebasa mushure menguva yebasa.
- Guta, danho rerabhoritari uye chinzvimbo chekubvumidzwa.
- Kungave bvunzo yacho ichiitwa uri muchipatara, kana kuti inobhadharwa mukati mepakeji yekugamuchira varwere, kana kuti uri kunze kwechipatara.
Inishuwarenzi: bvunzo dzekuongorora varwere vasiri muchipatara hadziwanzo kuvharwa kunze kwekunge mutemo wako uine OPD kana rubatsiro rwekuongorora. Kana bvunzo yeC3 iri chikamu chechirongwa chekubvumidzwa kupinda muchipatara kana chekuchengeta varwere masikati nekuda kwechirwere chakatenderwa, inowanzo kudzoserwa mari. Chengeta mushonga nemushumo, uye bvunza neinishuwarenzi yako kana dhipatimendi reinishuwarenzi rechipatara pachine nguva.
Ngano nezvokwadi
| Nhema | chokwadi |
|---|---|
| Kuderera kweC3 zvinoreva kuti ndine lupus. | Kuderera kweC3 kune zvikonzero zvakawanda, zvinosanganisira hutachiona, nephritis mushure mekutapurirana, chirwere chechiropa, kushomeka kweropa kubva kuvabereki uye kusabatwa zvakanaka kwesampuli. Kuongororwa kwechirwere kunoda kuongororwa kwekiriniki uye kuongororwa kwakawedzerwa. |
| C3 yakajairika inobvisa chirwere che autoimmune. | Zvirwere zvakawanda zve autoimmune uye itsvo hazvidyi zvinovaka muviri. C3 yakajairika haibvisi lupus, vasculitis kana nephritis. |
| Kukwira kweC3 kunoreva kuti dziviriro yemuviri wangu yakasimba. | C3 inomuka sepuroteni inobuda muchikamu cheacute ine kuzvimba kana hutachiona. Haisi chiyero chesimba rekudzivirira muviri. |
| C3 inogona kutsiva bvunzo dzeitsvo. | C3 haitauri chinhu nezvekushanda kweitsvo. Kuongororwa kweCreatinine, eGFR uye mapuroteni emuweti zvinodiwa. |
| C3 inofanira kunge iri muongororo yehutano yegore negore. | Pasina mubvunzo wekiriniki, bvunzo yeC3 haiwanzo shandura maitiro uye inogona kukonzera kuzvidya mwoyo kusingakoshi. |
| Kana C3 ikaita seyakajairika, ndinogona kuderedza mishonga yangu. | Kuvandudzwa kwemurabhoritari hazvirevi kuti chirwere chinodzorwa kwese kwese. Murapi chete ndiye anofanira kuchinja marapirwo. |
| C3 neC4 zvinokuudza chinhu chimwe chete. | Zvinoratidza zvikamu zvakasiyana zve cascade. Mapatani ari pakati pazvo ndiwo anotungamira kuongororwa kwechirwere. |
Mibvunzo inowanzobvunzwa
Kuongororwa ropa reC3 kunotora nguva yakareba sei?
Kutorwa kweropa pachako kunotora maminetsi mashoma chete, tsono iri mutsinga kwenguva isingasviki miniti. Bvumira maminetsi angangoita 20-40 panguva yese yekushanyira kusanganisira kunyoresa, kumirira uye kumanikidzwa mushure mekutorwa kweropa panzvimbo yacho. Kazhinji unogona kutangazve kuita zvinhu zvakajairika ipapo ipapo.
Ndinofanira kutsanya ndisati ndaongororwa C3 here?
Kutsanya hakudiwi paC3 chete. Zvisinei, kana chiremba wako akasanganisa bvunzo yeC3 neglucose yekutsanya, insulin kana lipid profile panguva imwe chete yekushanya, tevera mirairo yekutsanya yebvunzo idzodzo. Mirayiridzo yakanyorwa yerabhoritari yako ndiyo inofanira kutanga.
Zvinorevei kuti C3 yakaderera neC4 yakajairika?
Maitiro iwayo anoratidza kuti nzira imwe chete yekuwedzera huwandu hweropa iri kushandiswa kwete nzira yekare. Izvi zvinoonekwa muC3 glomerulopathy, post-infectious glomerulonephritis uye zvimwe zvirwere zvinogara nhaka. Ndiyo nzira yekuferefeta kwakawanda, kazhinji kusanganisira kuongororwa kweweti uye kutumira kune nyanzvi, kwete kuongororwa pachako.
Kuongororwa kweC3 kwakakwana here kuti uzive chirwere che lupus?
Kwete. Kuongororwa kweLupus kunoenderana nezviratidzo zvekiriniki pamwe chete nekuongororwa kweautoantibodies senge ANA uye anti-dsDNA, huwandu hweropa, kuwanikwa kweweti uye dzimwe nguva biopsy yeitsvo. C3 neC4 zvinotsigira kuongororwa kwebasa mune vamwe varwere asi hazvigone kusimbisa kana kubvisa kuongororwa kwega.
Mishonga inogona kuchinja huwandu hwangu hweC3 here?
Corticosteroids uye mishonga inodzvinyirira muviri inogona kuwedzera C3 yawakambonwa kare kuti iite sezvayakajairika sezvo chirwere chinenge chapera. Mimwe mishonga yemishonga, AYUSH kana mishonga yekuwedzera inogona kukanganisa chiropa uye kukanganisa mazinga emapuroteni zvisina kunanga. Taura zvese zvaunotora, uye usambofa wakagadzirisa mushonga wakanyorerwa kuti ugadzirire kuongororwa.
Sei marabhoritari angu maviri akataura nezvenhamba dzeC3 dzakasiyana?
Ma analyzer akasiyana, nzira dzakasiyana uye mwero we calibration zvinopa hunhu hwakasiyana uye nguva dzakasiyana dzekutarisa. Kutakurwa kwemuenzaniso uye kuchengetwa kunokanganisawo mapuroteni ekuwedzera. Kuti utarise, shandisa rabhoritari imwechete nguva imwe neimwe uye enzanisa mhedzisiro yako nehuwandu hwakadhindwa pamushumo iwoyo.
Kuongororwa kweC3 kunoitirwa vana here?
Ehe. Bvunzo yeC3 inowanzo shandiswa kana paine fungidziro yekuti glomerulonephritis kana kuti lupus yevana inopararira. Nguva dzekuongororwa dzinosiyana zvichienderana nezera, saka mhedzisiro yevana inofanira kuverengwa zvichienderana nezera ravo. Kutarisirwa kwakanyanya panguva yekutora, senge tsono diki nemubereki ari pedyo, zvinoita kuti chiitiko ichi chive nyore.
Bvunzo yeC3 inofanira kudzokororwa kangani?
Kuwanda kwechirwere kunoenderana nemamiriro acho ezvinhu. Muchirwere che lupus nephritis, kuongororwa kunogona kudzokororwa mavhiki mashoma kusvika kumwedzi wega wega pamwe chete neprotein yemuweti necreatinine; muchirwere chakagadzikana, kashoma. Mu glomerulonephritis mushure mekutapurirana, kupora kweC3 kunowanzo ongororwa kwemwedzi mishoma. Chiremba wako anokurapa ndiye anosarudza nguva yacho.
Chii chinoitika kana mhinduro yangu yeC3 isina kunaka?
Chiremba wako achatsanangura zviratidzo zvako, kuongororwa kwako nezvimwe zvabuda. Matanho anotevera anogona kusanganisira kudzokorora muenzaniso uyu nekubata kwako nokungwarira, kutarisa C4, autoantibodies, weti uye protein quantification, bvunzo dzekushanda kweitsvo, uye mune dzimwe nguva kutumira kuna rheumatologist kana nephrologist kuti awane biopsy kana zvidzidzo zvekuwedzera.
Sources
- American College of Rheumatology / EULAR classification criteria ye systemic lupus erythematosus.
- Gwaro reKDIGO Clinical Practice reKutarisira Zvirwere zveGlomerular.
- Chirwere cheItsvo: Kuvandudza nhungamiro yeGlobal Outcomes pakutarisira lupus nephritis.
- Mishumo yekubvumirana pamusoro pekuongororwa kweC3 glomerulopathy uye kuongororwa kwakawedzerwa kubva kumapoka anoshanda eitsvo neimmunology epasi rose.
- Mareferensi emishonga yemurabhoritari akajairika pamusoro pekuyedzwa kwekuwedzera uye kubata sampuro dzisati dzaongororwa.
