Thiothixene - Ngā Whakamahinga, Te Inenga, Ngā Pānga Taha me Ētahi Atu

He rongoā ārai mate hinengaro te Thiothixene e whakamahia ana hei rongoā i te schizophrenia me ētahi atu mate hinengaro. Nō roto i tētahi akomanga rongoā e mōhiotia ana ko ngā rongoā ārai mate hinengaro noa, e mahi ana mā te pā ki te taurite o ētahi matū i roto i te roro. E mōhiotia ana te Thiothixene mō tōna whai huatanga ki te whakahaere i ngā tohu pēnei i te moemoeā, te pohehe, me te whakaaro pōrearea, hei āwhina i ngā tāngata kia ora ake, kia ora ake hoki.

Ngā Whakamahinga o te Thiothixene

Ko te Thiothixene te mea matua kua whakaaetia mō te rongoā i te schizophrenia. Ka taea hoki te whakamahi i waho o te tapanga mō ētahi atu āhuatanga, pērā i te psychosis ū tonu. Ka āwhina te rongoā ki te whakamama i ngā tohu e pā ana ki ēnei mate, ka taea ai e ngā tūroro te wheako i te pai ake o te wairua, te whakaiti i te manukanuka, me te pai ake o te mahi whānui.

Kia pehea te E mahi te reira?

Ko te mahi matua a te Thiothixene mā te aukati i ngā kaiwhakawhiwhi dopamine i roto i te roro, inā koa te kaiwhakawhiwhi D2. Ko te Dopamine he neurotransmitter e whai wāhi nui ana ki te whakahaere i te wairua me te tirohanga. I roto i te hunga whai mate hinengaro schizophrenia, he maha tonu te dopamine hyperactivity i roto i ngā ara mesolimbic, ka puta ai ngā tohu pēnei i te moemoeā me te pohehe. Mā te aukati i te mahi dopamine, ka āwhina te thiothixene ki te whakahoki i te taurite i roto i te roro, ka whakaiti i ēnei tohu me te whakapai ake i te māramatanga hinengaro.

Te Inenga me te Whakahaerenga

Ka rerekē te horopeta paerewa o te thiothixene i runga i te tau o te tangata, tōna āhua, me tōna urupare ki te maimoatanga. Mō ngā pakeke, ko te horopeta tīmatanga noa ko te 5 mg e tangohia ana, e 2 ki te 3 ngā wā i te rā, ka taea te whakarerekē e te kaiwhakarato hauora i runga i te whai huatanga me te manawanui. Mō ngā tūroro tamariki, he iti ake te horopeta, ā, ka whakatauhia e te tohunga hauora. Kei te wātea te Thiothixene i roto i te ahua papa me te werohanga thiothixene HCl (IM) mō te whakaohooho ohorere i ētahi wā.

Ngā Pānga Taha o te Thiothixene

Ko ngā pānga taha noa o te thiothixene ko:

• Tuhinga o mua
• Tuhinga o mua
• mangai maroke
• Te kite matakite
• Te pauna moni
• Ko te mate whakaheke orthostatic
• Tuhinga

Ka puta nga paanga kino kino, ka uru pea ki:

• Nga tohu extrapyramidal (pērā i te wiri, te mārō rānei)
• Tardive dyskinesia (ngā nekehanga ā-ringa kore; ka piki ake te mōrearea me te whakamahinga roa)
• Neuroleptic malignant syndrome (he ahua onge engari he mate kino)
• Nga urupare mate kino

Me whakaatu wawe nga turoro i nga paanga kino rereke, kino ranei ki o raatau kaiwhakarato hauora.

Ngä Whakauru Iwi

Ka taea e te Thiothixene te taunekeneke me ētahi rongoā me ngā matū, ka nui ake pea te mōrearea o ngā pānga taha, ka whakaiti rānei i tōna whai huatanga. Ko ngā taunekeneke rongoā matua ko:

• Ētahi atu rongoā antipsychotic
• Tuhinga o mua
• Ngā aukati/whakaoho CYP1A2, CYP2D6 rānei (hei tauira, ētahi rongoā harore, paturopi macrolide)
• Ngā rongoā ārai-kōrini (tērā pea ka kino ake te EPS)
• Ngā rongoā whakaheke toto toto (e whakanui ana i te toto toto tiketike)
• Ngā rongoā e whakaroa ana i te QT (hei tauira, ētahi rongoā antiarrhythmic)
• Te waipiro me ngā raau taero whakangahau

He mea nui kia whakamohio atu ki to kaiwhakarato hauora mo nga rongoa me nga taapiri katoa e tangohia ana e koe hei karo i nga taunekeneke pea.

Ngā Hua o te Thiothixene

Ko ngā painga haumanu o te whakamahi i te thiothixene ko tōna whai huatanga ki te whakahaere i ngā tohu kino o te schizophrenia, tōna tere o te mahi, me tōna kaha ki te whakapai ake i te kounga whānui o te oranga mō ngā tūroro. Hei tāpiri, ko te thiothixene pea te mea pai mō ētahi tūroro nā te mea he rerekē ōna pānga taha ki te whakatauritea ki ētahi atu rongoā antipsychotic.

Ngā ārai mō te whakamahi i te Thiothixene

Me karohia te Thiothixene mō ngā tāngata whai mate pēnei i:

• Te mōhiotia he mate pāwera ki te thiothixene, ki tētahi atu rānei o ōna wāhanga
• Te mate ate tino
• Te mate a Parkinson
• Te koma, te pouri nui rānei o te pūnaha io matua
• Ngā ngoikoretanga toto
• Te whakaheke toto/te ohorere nui

Me kōrero hoki ngā wāhine hapū, ngā wāhine whāngai u rānei ki tā rātou kaiwhakarato hauora i mua i te whakamahi i te thiothixene (FDA Pregnancy Category C; whakamahia mēnā he nui ake te painga ki te pēpi, ki te kukune rānei).

Whakatupato me nga Whakatupato

I mua i te tīmatanga o te thiothixene, me whai aromatawai hauora hōhonu ngā tūroro. Tērā pea me aroturuki tonu, inā koa mō te hunga he hītori o ngā raruraru pūnaha toto, ngā haurangi, te mate huka, te mōrearea o te roa o te QT (kaua e aro ki ngā whānautanga roa o te QT), ngā toto toto rānei (aroturukihia te agranulocytosis/leukopenia); kia tūpato ki ngā kaumātua nā te mea he mōrearea ki te hinga. Tērā pea me whakamātautau toto hei tirotiro i ngā pānga taha pea, pērā i ngā huringa o te maha o ngā pūtau toto, te mahi ate rānei, me te aro nui ki te aroturuki i te NMS.

FAQs

1. He aha te whakamahinga o te thiothixene? Ko te Thiothixene te mea matua e whakamahia ana hei rongoā i te mate hinengaro schizophrenia, ā, ka taea hoki te whakamahi mō ētahi atu āhuatanga hauora hinengaro kino.
2. Me pēhea te tango i te thiothixene? Ko te Thiothixene ka horomia i te nuinga o te wā hei papa, e rua ki te toru ngā wā i te rā, e ai ki te whakahau a tō tākuta.
3. He aha nga paanga taha noa? Ko ngā pānga taha noa ko te hiamoe, te whanoke, te waha maroke, me te taumaha.
4. Ka pā mai pea ngā pānga kino kino i te thiothixene? Ae, ka puta pea ngā pānga taha kino, tae atu ki ngā tohu extrapyramidal me te neuroleptic malignant syndrome.
5. He taunekeneke rongoā kei waenganui i te thiothixene me ētahi atu? Ae, ka taea e te thiothixene te taunekeneke me ētahi atu rongoā, waipiro, me ētahi tāpiringa. Me whakamōhio atu ki tō tākuta mō ngā matū katoa e tangohia ana e koe.
6. He haumaru te thiothixene i te wā e hapu ana? Me kōrero ngā wāhine hapū ki tā rātou kaiwhakarato hauora i mua i te whakamahi i te thiothixene (FDA Pregnancy Category C; whakamahia mēnā he nui ake te painga i te mōrearea), nā te mea ka tūpono he mōrearea.
7. Kia pēhea te roa ka mahi te thiothixene? Ka pai ake ngā tohumate ohorere i roto i te 1-2 wiki; ka roa pea te pānga katoa o te rongoā ārai mate hinengaro ki te 4-6 wiki.
8. Ka taea e au te whakamutu ohorere i te tango i te thiothixene? Kāo, mā te whakamutu ohorere i te thiothixene ka puta pea ngā tohumate tango. Me kōrero tonu ki tō tākuta i mua i te whakarerekē i tō tikanga rongoā.
9. Me aha ahau ki te ngaro ahau i te horopeta? Ki te ngaro koe i tētahi horopeta, me tango tonu i te wā e mahara ana koe. Ki te tata te wā mō tō horopeta e whai ake nei, pekehia te horopeta i ngaro, ka haere tonu ki tō hōtaka noa.
10. Ka taea te whakamahi i te thiothixene mō ngā tamariki? He iti noa te whakamahinga mō ngā taiohi (?12 tau) mō te mate hinengaro; kāore i te tūtohutia kia whakamahia mō ngā tamariki nohinohi nā runga i ngā āwangawanga mō te haumaru, engari ka whakarerekētia te horopeta i runga i te tau me te taumaha mēnā ka tohua.

Nga Ingoa Tohu

E hokohokohia ana te Thiothixene i raro i ētahi ingoa waitohu, tae atu ki a Navane. Kei te wātea te thiothixene HCl whānui (kua mutu te hoko o Navane i te US); tirohia ki tō kaiwhakarato hauora, ki tō kaiwhakahaere rongoā rānei mō ngā taipitopito.

Opaniraa

He rongoā whai hua te Thiothixene mō te rongoā i te mate hinengaro schizophrenia me ētahi atu mate hinengaro kino. Mā tōna kaha ki te whakahaere i ngā tohumate ka pai ake te kounga o te oranga mō te tini o ngā tūroro. Heoi, he mea nui kia whakamahia te thiothixene i raro i te arataki a te tohunga hauora, me te whakaaro ki ngā pānga taha pea, ngā taunekeneke rongoā, me ngā āhuatanga hauora takitahi.