procainamide

Kupu Whakataki: He aha te Procainamide?

Ko te Procainamide he rongoā e whakamahia ana hei rongoā i ētahi momo ngakau koretake, e mōhiotia ana ko te arrhythmias. Nō roto i tētahi akomanga rongoā e kiia nei ko te antiarrhythmics, e mahi ana ki te whakahoki mai i te manawataki o te ngakau kia noa. E taunakihia ana i roto i ngā āhuatanga motuhake e ai ki ngā aratohu AHA/ACC/HRS me ESC, pērā i te tachycardia whānui-uaua pumau, i te wā rānei e kore ai e angitu ētahi atu maimoatanga, i muri i te aromatawai i ngā mōrearea pērā i te roa o te QT. He maha ngā wā ka tohua te Procainamide ina kore e whai hua ētahi atu maimoatanga, ina rānei he momo arrhythmias motuhake ā ngā tūroro e hiahia ana ki te wawaotanga.

Ngā Whakamahinga o te Procainamide

Kua whakaaetia te Procainamide mō ētahi whakamahinga hauora, tae atu ki:

• Arrhythmias ventricular: He mea noa te whakamahi hei rongoā i te tachycardia ventricular, he āhuatanga e tere rawa ai te pā o te ngakau nā te kore e tika o ngā tohu hiko.
• Whakawhanaunga Atrial: Ka taea e te Procainamide te āwhina ki te whakahoki mai i te manawataki noa o ngā tūroro e pāngia ana e te atrial fibrillation, he momo arrhythmia noa.
• Supraventricular Tachycardia: He whai hua anō hoki tēnei rongoā mō te whakahaere i te supraventricular tachycardia, te wāhi e tere ai te pā o ngā ruma o runga o te ngākau.

Me pehea te mahi a Procainamide?

Ka ārai te Procainamide i ngā awa konutai i roto i te ngākau, ka whakaroa i ngā tohu hiko e whakahaere ana i te ngakau. Mā te mahi i tēnei, ka āwhina i te whakaū i te manawataki o te ngākau, ā, ka ārai i te tere rawa o te patu, i te kore rānei e tika te patu. Mā tēnei mahi ka taea e te ngākau te pupuhi toto kia pai ake te mahi, ka whakapai ake i te mahi katoa o te ngākau.

Te Inenga me te Whakahaerenga

Ka rerekē te horopeta o te Procainamide i runga i te āhua o te mate, te tau o te tūroro, te mahi a te whatukuhu, me te urupare ki te maimoatanga, me te whai i ngā aratohu pēnei i ngā aratohu a te AHA/ACC/HRS.

Ngā pakeke:

Ko te horopeta tīmatanga ā-waha he 100 mg ki te 150 mg ia 6 ki te 8 hāora, ka taea te whakarerekē ki te horopeta mōrahi o ia rā o te 3 karamu. Mō ngā take ohorere, ka tīmata te tukunga ā-iwi me te horopeta uta o te 10-15 mg/kg (tae atu ki te 1 karamu) ka hoatu mārire i te 20-50 mg/min, ā, whai muri ko te werohanga pupuri o te 2-6 mg/min me te aroturukitanga ECG me te taumata toto.

Tamariki:

Ko te horopeta e whakawhirinaki ana ki te taumaha, he maha ngā wā 15 mg/kg/rā ka wehea kia 6-8 hāora, ka werohia rānei kia 10-15 mg/kg (1 karamu te mōrahi i te 0.5 mg/kg/min) ā, muri iho ka werohia kia 30-80 mcg/kg/min. Ka tukuna te Procainamide hei papa, hei werohanga rānei, ā, ko te IV e rahuitia ana mō ngā wāhi hōhipera e hiahia ana kia aro turukihia. Me whai tonu i ngā tohutohu a tō tākuta.

Ngā Pānga Taha o te Procainamide

Pērā i ngā rongoā katoa, ka pāngia pea koe e te Procainamide e ngā pānga taha. Ko ngā mea noa ko te whakapairuaki, te ruaki, te korere, te whanoke, me te ngenge. Ko ngā pānga taha kino ko te aukati i te ngākau, te mate lupus-like (mamae hononga, ngenge), ngā mate toto pērā i te agranulocytosis (he iti ngā toto toto mā e whakanui ana i te mōrearea o te mate), me te roa o te wā QT, e whakapiki ake ana i te mōrearea o te manawa kino e kiia nei ko te torsades de pointes - inā koa me tana metabolite N-acetylprocainamide i roto i ngā raruraru tākihi. Me rapu awhina hauora tonu koe mō te mamae o te uma, te poto o te manawa, te hemo, te whanoke nui rānei.

Ngä Whakauru Iwi

Ka taea e te Procainamide te taunekeneke me ētahi atu rongoā, ka whakapiki ake i ngā mōrearea pānga taha, ka whakaiti rānei i te whai huatanga. Ko ngā taunekeneke matua ko:

• Ētahi atu rongoā antiarrhythmic: Ka kino ake pea ngā pānga tāpiringa i ngā arrhythmias.
• Ngā rongoā e whakaroa ana i te QT: (hei tauira, ētahi rongoā ārai pouri pēnei i te citalopram, ngā paturopi pēnei i te ciprofloxacin, ngā rongoā ārai hinengaro): Ka whakanui ake i te mōrearea o te torsades de pointes.
• Ngā aukati huna whatukuhu: (hei tauira, cimetidine, trimethoprim): Whakanuia ngā taumata o te Procainamide.

Kia mōhio: Kāore te Procainamide e whakapūngaohia e ngā whākōkī CYP450 engari mā te acetylation; ka puta tōna matū hohe NAPA mā tēnei ara, me te rerekētanga o ngā "acetylators tere/pōturi." Me whakamōhio atu ki tō tākuta mō ngā rongoā katoa, ngā tāpiringa, me ngā otaota.

Nga painga o te Procainamide

He maha ngā painga haumanu o te Procainamide:

• He whai hua mō ngā Arrhythmias Motuhake: He tino whai hua tēnei mō ngā arrhythmia ventricular, ā, he kōwhiringa pono ina kore e angitu ētahi atu maimoatanga.
• Te Hunga Tere o te Mahi: Ina tukuna mā roto i te uaua, ka taea e te Procainamide te whakatau tere i te manawataki o te ngakau i roto i ngā āhuatanga ohorere.
• Hītori Roa o te Whakamahi: Kua roa a Procainamide e whakamahia ana i roto i ngā tau maha, ā, kua roa nei e mōhiotia ana te haumaru me te whai huatanga.

Ngā ārai mō te whakamahi i te Procainamide

Me karo ētahi tāngata i te whakamahi i te Procainamide, tae atu ki:

• Ngā tūroro e aukati katoa ana i te ngākau mēnā kāore he pacemaker ā rātou, nā te mea kei te tūpono te asystole.
• Ngā wāhine hapū, nā te mea ka pā kino ki te tamaiti i roto i te kōpū (Kāwai C).
• Ko te hunga e pāngia ana e te myasthenia gravis, te systemic lupus erythematosus, te hunga rānei e pāngia ana e te mate pāwera ki te rongoā.

Kia tūpato ki te hunga e roa ana te wā QT, te aukati AV tuarua/tuatoru o te tohu, te mate ate/whākihi kino rānei, te kore taurite o ngā electrolytes rānei, nā te mea ka piki ake te tūponotanga o te arrhythmia.

Whakatupato me nga Whakatupato

I mua i te tīmatanga o te Procainamide, me whai whakamātautau taiwhanga motuhake ngā tūroro hei aroturuki i te mahi o te ngākau me ngā taumata toto. He mea nui ngā wā tirotiro auau hei whakarite kei te whai hua te rongoā, ā, hei whakarerekē i ngā horopeta ina hiahiatia. Me tūpato hoki ngā tūroro ki te whai wāhi atu ki ngā mahi e hiahia ana kia mataara, nā te mea ka taea e te Procainamide te whakapouri i a rātou anō.

FAQs

• He aha te whakamahinga o te Procainamide? E whakamahia ana te Procainamide hei rongoā i ngā pāorooro o te ngakau, inā koa te ventricular tachycardia me te atrial fibrillation.
• Me pēhea te hoatutanga o te Procainamide? Ka taea te tango ā-waha hei papa, ka taea rānei te hoatu hei werohanga i te hōhipera.
• He aha nga paanga taha noa? Ko nga paanga kino noa ko te nausea, te mangere, me te ngenge.
• Ka taea te tango i te Procainamide me ētahi atu rongoā? Ka taea e ētahi rongoā te taunekeneke me te Procainamide, nō reira he mea nui kia whakamōhio koe ki tō tākuta mō ngā rongoā katoa e tangohia ana e koe.
• He haumaru te Procainamide i te wā e hapu ana? Me karohia te Procainamide e ngā wāhine hapu mēnā kāore i tohua e te tākuta, nā te mea ka tūpono he mōrearea ki te tamaiti kei roto i te pēpi.
• He pēhea te mahi a te Procainamide? Mā te aukati i ngā awa konutai i roto i te ngākau ka mahi, ka āwhina ki te whakatau i te manawataki o te ngākau.
• Me aha ahau ki te ngaro ahau i te horopeta? Mena ka ngaro koe i tetahi horopeta, tangohia i te wa e mahara ana koe. Mena kua tata ki te horopeta e whai ake nei, pekehia te horopeta kua ngaro ka haere tonu ki to waarangi.
• Ka pā mai pea ngā pānga kino kino i te Procainamide? Āe, ka puta pea ngā pānga kino, tae atu ki ngā aukati ngākau me ngā mate toto. Rapua he awhina hauora mēnā ka pāngia koe e ngā tohu kino.
• Kia pēhea te roa e mahi ai te Procainamide? Ka rerekē pea te tīmatanga o te mahi; ka tere pea ngā pānga o te werohanga ā-uaua, ka roa ake pea te wā mō te wā e horomia ana.
• Me aroturuki tonu i te wā e tango ana koe i te Procainamide? Ae, he mea nui te aroturukitanga auau o te mahi o te ngākau me ngā taumata o te toto kia mau ai te haumaru me te whai huatanga.

Nga Ingoa Tohu

Kei te wātea te Procainamide i raro i ētahi ingoa waitohu, tae atu ki:

• Pronestyl
• Procanbid

Opaniraa

He rongoā nui te Procainamide mō te whakahaere i ngā momo arrhythmias, e tuku ana i ngā kōwhiringa maimoatanga whai hua mō ngā tūroro he ngakau pāhekeheke te āhua. He mea nui te mārama ki ōna whakamahinga, ngā pānga taha, me ngā taunekeneke mō te maimoatanga haumaru me te whai hua. Me kōrero tonu ki tētahi kaiwhakarato hauora i mua i te tīmatanga, i te whakamutu rānei i tētahi rongoā.