Streptomycin - Ngā Whakamahinga, Te Inenga, Ngā Pānga Taha me Ētahi Atu

Kupu Whakataki: He aha te Streptomycin?

He paturopi te Streptomycin nō te momo rongoā aminoglycoside. I kitea tuatahitia i te tau 1943, ā, e whakamahia ana hei rongoā i ngā mate kitakita maha, inā koa ko ērā i puta mai i te Mycobacterium tuberculosis, te kitakita e kawe ana i te mate kohi (TB). Mā te aukati i te hanganga pūmua kitakita, ka whai hua ki te maha o ngā kitakita karamu-kino me ētahi kitakita karamu-pai.

Ngā Whakamahinga o te Streptomycin

Kua whakaaetia te Streptomycin mō ētahi whakamahinga hauora, tae atu ki:

• Kohi (TB): He maha ngā wā ka whakamahia ngātahitia me ētahi atu rongoā ārai-TB hei rongoā i ngā mate TB hohe.
• Nga mate huakita: He whai hua ki ngā mate urutā i puta mai i te Yersinia pestis (mate urutā) me te Francisella tularensis (tularemia).
• Endocarditis: I ētahi wā ka whakamahia hei rongoā whakakotahi mō te endocarditis huakita.
• Te pūkerōsisa: Ka whakamahia ngātahi me ētahi atu paturopi hei rongoā i te brucellosis, he mate e puta mai ana i te huakita Brucella.

Kia pehea te E mahi te reira?

Ka mahi te Streptomycin mā te here ki te ribosome huakita, he mea nui mō te hanga pūmua. Mā te whakararuraru i te mahi a te ribosome, ka ārai i te huakita ki te whakaputa pūmua e tika ana mō tō rātou tipu me te whakaputa uri. Ko tēnei mahi ka arahi ki te matenga o te huakita, ka āwhina ki te whakakore i te mate mai i te tinana.

Te Inenga me te Whakahaerenga

Ka rerekē te horopeta o te Streptomycin i runga i te mate e rongoatia ana me te tau me te taumaha o te tūroro.

Ngā pakeke:

Ko te horopeta noa mō te mate kohi he 15 mg/kg (tae atu ki te 1 karamu te mōrahi) ka tukuna ki roto i te uaua kotahi i te rā, ka wehea rānei kia rua ngā horopeta (hei tauira, 25-30 mg/kg 2-3 ngā wā i te wiki).

Tamariki:

Mō ngā tamariki, ko te horopeta he 20-40 mg/kg/rā (kaua e neke atu i te 1-2 karamu i runga i te tau), ka wehea te horopeta ia rā, ka hoatu mā te werohanga.

Ka tukuna te Streptomycin mā te werohanga ā-roto, ā, ka rerekē pea te auau i runga i te mahere maimoatanga motuhake. He mea nui kia whai i ngā tohutohu a te kaiwhakarato hauora mō te horopeta me te whakahaerenga.

Ngā Pānga Taha o te Streptomycin

Ko ngā pānga taha noa o te Streptomycin ko:

• Te wero me te ruaki
• Tuhinga o mua
• Rash
• Fever
• Mamae i te wāhi werohanga

Ka taea e nga paanga kino te whakauru:

• Te paitini ā-tinana: (ngaronga o te whakarongo)
• Nephrotoxicity: (mate whatukuhu)
• Tauhohenga mate pāwera: (te pupuhi, te uaua ki te manawa)
• Te aukati i te pūnaha io: (ngoikoretanga o te uaua)

Me whakaatu wawe nga turoro i nga tohu kino, rereke ranei ki ta raatau ratonga hauora.

Ngä Whakauru Iwi

Ka taea e te Streptomycin te taunekeneke me ētahi rongoā, ka nui ake pea te mōrearea o ngā pānga taha, ka whakaiti rānei i te whai huatanga. Ko ngā taunekeneke matua o ngā rongoā ko:

• Ētahi atu Aminoglycosides: Te pikinga ake o te mōrearea o te paitini ki ngā hua o te pūnaha toto.
• Diuretics: Pērā i te furosemide, ka taea te whakanui ake i te mōrearea o te paitini o te tinana.
• Ko nga Neuromuscular Blockers: Ka piki ake pea te mōrearea o te aukati i te pūnaha io-uaua.

Me whakamohio atu ki to kaiwhakarato hauora mo nga rongoa katoa, taapiri, me nga hua otaota ka tangohia e koe hei karo i nga taunekeneke pea.

Ngā Hua o te Streptomycin

He maha ngā painga haumanu o te Streptomycin:

• Te Whai Huatanga ki ngā Taumaha Ātete: Ka whai hua pea ki ētahi momo huakita e ātete ana ki ētahi atu paturopi.
• Whakakotahitanga: He maha ngā wā ka whakamahia ngātahitia me ētahi atu paturopi, hei whakarei ake i te whai huatanga o te maimoatanga mō ngā mate pēnei i te mate kohi.
• Mahi Tere: Ka taea e te Streptomycin te whakaiti tere i te nui o ngā huakita, ā, ka tere ake te ora o ētahi mate.

Ngā ārai mō te whakamahi i te Streptomycin

Me karo ētahi tāngata i te whakamahi i te Streptomycin, tae atu ki:

• Wahine Hapu: Kāwai Hapūtanga D a te FDA; karohia i te wā katoa o te hapūtanga, ko te mōrearea nui rawa atu i ngā toru marama tuarua/tuatoru (te kino o te io angaanga tuawaru).
• Ko nga taangata kei te mate pukupuku: Te pikinga ake o te mōrearea o te paitini ki ngā hua o te pūnaha toto.
• Te hunga he hītori o te ototoxicity: Tērā pea ka kino haere te ngaronga o te whakarongo, te taurite rānei o mua me te Streptomycin.

Whakatupato me nga Whakatupato

I mua i te tīmatanga o te Streptomycin, me whai whakamātautau taiwhanga ngā tūroro, tae atu ki ngā whakamātautau mahi whatukuhu, hei aroturuki i ngā pānga taha pea. He mea nui kia whakamōhiotia ngā kaiwhakarato hauora mō ngā mate hauora, ngā mate pāwera, ngā rongoā rānei e tangohia ana.

FAQs

• He aha te whakamahinga o te Streptomycin? Ko te streptomycin te mea matua e whakamahia ana hei rongoā i te mate kohi me ētahi mate kitakita pēnei i te mate urutā me te brucellosis.
• Me pēhea te hoatutanga o te Streptomycin? Ka hoatu mā te werohanga ā-roto, kotahi te wā i te rā.
• He aha nga paanga taha noa? Ko ngā pānga taha noa ko te whakapairuaki, te ruaki, me te ponana.
• Ka taea e te Streptomycin te whakararu i te whakarongo? Ae, ka pā he paitini ki te roro, ka ngaro ai te rongo i ētahi tūroro.
• He haumaru te whakamahi i te Streptomycin i te wā e hapu ana? Kao, ka aukatihia i te wa e hapu ana na te kino pea ki te kopu.
• He pēhea te mahi a te Streptomycin? Ka aukati i te hanganga pūmua huakita mā te herea ki te ribosome, ka mate ai te huakita.
• Me aha ahau ki te ngaro ahau i te horopeta? Whakapā atu ki tō kaiwhakarato hauora; kaua e tāruatia te horopeta.
• Ka taea e au te inu waipiro i te wā e tango ana i te Streptomycin? Kāore he taunekeneke tika engari me karo i te waipiro hei ārai i te matewai ka nui ake te paitini ki ngā pūtau o te tinana.
• Kia pēhea te roa e hiahiatia ana e au te tango i te Streptomycin? Ka rerekē te roa o te maimoatanga i runga i te mate e rongoatia ana; whai i ngā tohutohu a tō kaiwhakarato hauora.
• He here kai kei runga i te Streptomycin? Kāore he here kai motuhake, engari me pupuri tonu i te kai taurite. Āta karohia te kai nui-konutai mēnā kei te ngoikore te whatukuhu.

Nga Ingoa Tohu

Kei te wātea te Streptomycin hei Werohanga Streptomycin Sulfate (whānui; kāore he waitohu matua i te nuinga o ngā mākete).

Opaniraa

He mea nui tonu te Streptomycin hei rongoā paturopi mō ngā mate kitakita motuhake, inā koa ko te mate kohi. Nā tōna kaha ki te mahi whai hua ki ngā momo mate ātete me tōna tūranga i roto i te rongoā whakakotahi, he mea nui tēnei i roto i te rongoā hou. Heoi, he mea nui kia whakamahia tēnei rongoā i raro i te arataki a te tohunga hauora hei whakaiti i ngā mōrearea me te whakarite kia whai hua te maimoatanga.