Menene theranostics?
Theranostics shine kalmar hadewar hanyoyin warkewa da bincike (amfani da radionuclide ɗaya don hoton ciwace-ciwacen daji da radionuclide na biyu don magance ciwace-ciwace ta hanyar isar da radiation mai kashe kansa). Ainihin, yana nufin ƙaddamar da kwayar cutar mai karɓa guda ɗaya akan ƙwayoyin cutar kansa tare da radionuclides daban-daban guda biyu (hoto da magani). Wannan don cimma daidaitaccen dabarun jiyya na keɓaɓɓen.
Lokacin bincike na Theranostics
Kwayoyin Tumor suna da harsashi, wanda ake kira membrane; akwai wasu sunadaran irin su somatostatin receptor (SSTR2) akan membrane cell tumor wanda zai iya zama manufa ga magungunan ciwon daji.
Ga-68 DOTATOC magani ne na rediyoaktif wanda ke nufin SSTR2. Ana allurar Ga-68 DOTATOC a cikin jijiyar majiyyaci kuma yana tafiya cikin jini zuwa dukkan gabobin jiki da kyallen jikin mutum. Idan mai haƙuri yana da ƙwayar neuroendocrine tare da SSTR2 akan ƙwayar ƙwayar ƙwayar ƙwayar cuta, Ga-68 DOTATOC zai ɗaure zuwa SSTR2 kuma ƙwayar za ta haskaka a kan PET scan.
Therapeutic lokaci na Theranostics
Da zarar an gano ciwon daji na neuroendocrine ta amfani da Ga68-DOTATOC PET scan, ana iya maye gurbin Ga-68 tare da wani radionuclide, irin su lutium-177 (Lu-177) ko yttrium-90 (Y-90), wanda zai iya yin hari da kashe ƙwayoyin tumor. wanda ke da SSTR2 akan membranes.
Therapeutic Y-90-DOTATOC da Lu-177-DOTATATE za a iya allura su a cikin jijiyar majiyyaci da tafiya zuwa kowane sashe na jikin da ke da sunadaran SSTR2. Wadannan magungunan warkewa suna ɗaure su da sunadaran SSTR2 kamar maɓalli a cikin kulle, ƙyale miyagun ƙwayoyi ya shiga cikin ƙwayoyin tumo kuma ya kashe ta ta hanyar lalata DNA ɗin tantanin halitta. Kwayoyin lafiya da ke kewaye da ƙari waɗanda ba su da sunadaran SSTR2 a jikin jikinsu ba sa shafar maganin.
Irin wannan dabarar tana ba masana ilimin cututtukan daji damar yin hoton kyallen da za a iya magance su gaba ɗaya, zaɓi marasa lafiya don aikace-aikacen warkewa, duba daidai inda za a ba da magungunan warkewa, da kuma lura da ikon wakili na warkewa don rage ciwace-ciwacen daji na tsawon lokaci. Theranostics suna ba da masana ilimin oncologists tare da labari da kayan aiki masu tasiri sosai don ƙirƙirar ingantattun dabarun jiyya da hasashen fa'idodin wani jiyya bisa ga majiyyata na musamman na kwayoyin halitta da bayanan kwayoyin halitta.
MAGANIN ARZIKI: GANIN ABINDA MUKE MAGANI—MAGANIN ABINDA MUKA GANI
Wannan kuma ake kira niyya radionuclide far kamar yadda aka yi niyya a kan manufa ta musamman na kwayoyin cutar daji masu aiki. Sabili da haka, ana iya yin niyya mafi girma na radiation a cikin ƙwayar cuta ba tare da rinjayar yawancin ƙwayoyin lafiya na al'ada ba.
Yaya hanyoyin kwantar da hankali ya bambanta da na gargajiya na rediyo?
Magungunan radiation na iya yin tasiri sosai wajen magance ciwon daji, ko rage alamun cututtuka a cikin marasa lafiya masu ciwon daji na mataki na gaba wanda ba za a iya magance su ba. Kimanin rabin duk masu fama da ciwon daji za su sami maganin radiation a wani lokaci a cikin jiyyarsu, wanda ke amfani da hasken rana na waje ko na ciki, protons ko wasu barbashi masu ƙarfi don kaiwa hari da lalata ƙwayoyin cutar kansa. Duk da yake ingantattun hanyoyin fasaha sun rage lalacewar nama mai lafiya, maganin rediyo na gargajiya har yanzu yana haifar da sakamako masu illa waɗanda zasu iya zama da wahala ga wasu marasa lafiya suyi haƙuri. Bugu da ƙari, maganin rediyo na gargajiya ba zai iya kai hari fiye da wuri ɗaya na cututtuka ba, yana iyakance amfanin sa ga marasa lafiya da ciwon daji. Koyaya, maganin rediyo na gargajiya ya kasance ɗaya daga cikin kayan aikin jiyya mafi ƙarfi na oncology.
Wannan sabon tsarin kula da ƙari - maganin radionuclide da aka yi niyya - yana sake yin amfani da jiyya na radiation a daidaitaccen ilimin oncology da kuma sadar da sabon nau'in maganin cutar kansa. Manufar ci gaban maganin radionuclide da aka yi niyya shine haɗa alpha-, beta- ko gamma-barbashi masu fitar da isotopes - ko radionuclides - tare da peptides, ƙwayoyin rigakafi, ko ƙananan ƙwayoyin cuta, don haɓaka hanyoyin kwantar da hankali tare da ƙayyadaddun takamaiman ga wasu nau'ikan ciwace-ciwace. Ana isar da shi ga majiyyaci ta cikin jijiya, an tsara magungunan radionuclide da aka yi niyya don tafiya kai tsaye zuwa ƙari don isar da radiation warkewa tare da madaidaicin gaske. Wannan madaidaicin an yi niyya ne don mayar da hankali kan isar da radiation zuwa ƙwayar ƙwayar cuta yayin da ake rage tasirin radiation zuwa nama na yau da kullun.
Wane irin ciwon daji ne za a iya bi da shi tare da magungunan warkewa?
Theranostics na iya zama mai tasiri a cikin magance metastatic, ciwace-ciwacen ciwace-ciwacen ciwace-ciwacen ci gaba a cikin ci gaba na cututtukan da suka haɗa da kansar prostate, ciwace-ciwacen neuroendocrine na gabobin daban-daban kamar ciki, pancreas, ƙanana & manyan hanji da huhu. Ƙarshe amma ba ƙarami ba, zubar da ragowar thyroid ɗin bayan tiyata da kuma maganin ciwon daji na thyroid na metastatic shima yana cikin gamut na theranostics.
Ciwon daji na sama suna da isassun shaidu da ake samu a halin yanzu cewa akwai takamaiman fa'ida cikin amfani da maganin radionuclide. Duk da haka, da yawa sauran ciwon daji na iya samun fa'ida lokacin da suka bayyana wasu nau'ikan masu karɓan manufa kamar furotin kunnawa fibroblast (FAP) da masu karɓa na chemokine (CXCR4), ana iya yin niyya tare da hanyoyin kwantar da hankali.
Kwayoyin Halittanmu da Niyya Theranostics na Radionuclide sun haɗa da:
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- PRRT : Lutetium -177 DOTA Therapy
Actinium - 225 DOTA Therapy
Yttrium-90 DOTA Therapy don Neuro endocrine ciwace-ciwacen daji - PRLT : Lutetium-177 PSMA Therapy don Prostate cancers
- TARE : Yttrium-90 SIR Sphere therapy for Hanta Cancers / Hanta metastases
- FAPI: Fibroblast activation Protein inhibitor Therapy
Lutetium-177 FAPI Therapy da
Actinium-225 FAPI Therapy don kusan nau'ikan ciwon daji guda 28
- PRRT : Lutetium -177 DOTA Therapy
- KUMA : Sanannen I – 131 Rediyo Iodine Therapy for thyroid cancersSamarium – 153 Pain Palliation Therapy for kashi metastases.I-131 MIBG far for pheochromocytoma
An yi la'akari da shi kawai akan yanayi na musamman na asibiti akan dalilai na tausayi kamar yanzu.
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Nasara akan Ciwon daji tare da Apollo Proton Cancer Center
Ci gaba a cikin Ciwon daji! Nauyin ciwon daji na girma a duniya yana ba da labari mai ban tsoro. Don magance wannan barazanar da ke tasowa, Cibiyar Ciwon daji ta Apollo Proton tana ba da cikakkiyar kuma cikakkiyar bayani. Kamar yadda kula da ciwon daji ya zama ɗaya daga cikin buƙatun kiwon lafiya mafi girma a duk faɗin duniya, mun yi imanin yana da mahimmanci don sake fayyace manufarmu, don sake dawo da himmarmu kan mai da hankali guda ɗaya - don yaƙi da cutar kansa, don shawo kan cutar kansa! hasken bege ga miliyoyin, yana ba su ƙarfin gwiwa don tsayawa da kallon cutar kansa.
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