IFiziksi yezoNyango

Isebe libonelela ngeenkonzo ezikumgangatho ophakamileyo, eziqinisekisiweyo ezikumgangatho ophezulu ukuze kuphunyezwe iinjongo eziziinkalo ezininzi zokufumana uxilongo oluchanekileyo kunye nonyango olukhuselekileyo, oluchanekileyo nolusebenzayo lwesigulana kusetyenziswa ukusasazeka kwemitha.

Isebe licwangciselwe ukubonelela ngenkonzo eyodwa, elungiselelwe iimfuno zesigulana ngasinye, ngokusebenzisa ubungqina obusekelwe kwindlela yenzululwazi, imigaqo emiselweyo, imfundo kunye nophando olutsha. Isebe lijonge ukuthotyelwa kwemigaqo yokusetyenziswa kwezonyango kwi-ionizing radiation kuwo wonke amasebe esibhedlele.

Ukunikezelwa konyango lwezonyango kubandakanya: i-chemotherapy, unyango lwe-hormone, unyango olujoliswe kuyo, unyango lwe-biological kunye ne-immunotherapy. Isetyenziswa ikakhulu kwezi meko zilandelayo:

• Iqabane ngaxeshanye kwiradiotherapy ukwandisa ukusebenza kwemitha.
• Unyango lweNeoadjuvant: Inikwe phambi konyango oluqinisekileyo olunokuba yi-chemo-radiotherapy okanye utyando. Oku kunikezelwa ukwenza imihlaza engasebenziyo
  esebenzayo ngokunciphisa ubungakanani kwezinye izigulana.
• Unyango lweAdjuvant: Oku kunikezelwa emva kotyando ukunciphisa umngcipheko wokuphinda.
• Unyango lwePalliative: Ukulawula umhlaza ophezulu (umhlaza oye wanwenwela ngaphaya kwendawo ovela kuyo) okanye umhlaza wasekuhlaleni onganyangekiyo kutyando okanye kunyango lweradiyo.

Ukwahluka kwesebe

Iqela lokuqala kuMzantsi-mpuma-Asia ukuya kwikliniki yonyango ye-proton yonyango ye-pencil yomgangatho wobugcisa. Iqela liphumeze ngempumelelo iindlela zonyango zeproton zamva nje kwiindawo ezahlukeneyo zeklinikhi kubandakanya awona matyala acela umngeni.

Amandla esebe axhomekeke kwinkonzo edibeneyo enikezelwa liqela leengcali zonyango ezikhethekileyo kwiindawo ezithile kunye nenjongo yokugqibela yokubonelela ngononophelo olungcono kwisigulane.

Iprofayile yePhysics yezoNyango

Iingcali zonyango ngabasebenzi bezempilo abanemfundo kunye noqeqesho olukhethekileyo kwiikhonsepthi kunye nobuchule bokusebenzisa i-physics kumayeza. Zonke iingcali zefiziksi zonyango kwiqela ziye zatyebisa amava kunyango oluchanekileyo oluphezulu kunye neendlela ezininzi zokucinga, ukulinganiswa, ukulinganisa kunye nokuqinisekiswa komgangatho we-radiotherapy yamva nje yobugcisa kunye nezixhobo zokuxilonga usebenzisa i-radiation detectors ephezulu, i-phantom kunye nezixhobo.

Amalungu eqela afumene uqeqesho olukhethekileyo kunyango lweproton beam kumaziko adumileyo kwihlabathi liphela.

• UGqr Dayananda Sharma Shamurailatpam, I-PhD, iDipRP, i-MCPI – (iNtloko, iSebe lezoNyango lwezoNyango)
• UGqr MP Noufal, I-PhD, iDipRP, i-MCPI, i-MS – (iGqirha eliPhezulu lezoNyango)
• UMnu. Kartikeswar Patro, M.Sc., DipRP – (uGqirha oPhezulu wezoNyango)
• UGqr. K. Ganapathy, PhD – (uGqirha oPhezulu wezoNyango)
• UGqr. A. Manikandan, I-PhD, iDipRP – (iGqirha eliPhezulu lezoNyango)
• UGqr. T. Rajesh, I-PhD, i-MCPI – (uGqirha wezoNyango oPhezulu)
• UMnu Mayur Sawant, M.Sc., DipRP – (uGqirha wezoNyango)
• UMnu Suryakant Kaushik, M.Sc., DipRP – (uGqirha wezoNyango oMncinci)

Itekhnoloji yonyango lweProton kwi-APCC

Iteknoloji yonyango yefoton kwi-APCC

Iinkonzo zeklinikhi

Isebe libonelela ngeenkonzo zefiziksi zonyango eziqinisekisiweyo ezisemgangathweni ukusukela ekugunyazisweni kokuqala ukuya kwiinkonzo zemihla ngemihla zeklinikhi kunye nohlalutyo olubalulekileyo kwiingcali ezahlukeneyo zesibhedlele ikakhulu kwiRadiation Oncology, Diagnostic radiology kunye neNuclear Medicine.

Ukuqalisa: Iimpawu zokusebenza kwazo naziphi na izixhobo ezitsha ezivelisa imitha, isoftware enxulumeneyo kunye nezixhobo ezincedisayo zilinganiswa kwaye zivavanywe ngononophelo ngokulandela imigangatho eyahlukeneyo yesizwe neyehlabathi kunye neenkqubo. Ukuqalisa ngempumelelo kuqinisekisa imvume evela kwiqumrhu elilawulayo lesizwe kunye nokusetyenziswa ngokukhuselekileyo kwezixhobo zonyango lwezigulane. Kwi-APCC, inkqubo yePROTEUS-PLUS kunye neRadiXact-X9 HT kunye neRayStation enxulumene nayo (RaySearch Lab, eSweden) kunye nePrecision (Accuray, e-USA) iTPS zinikwe umsebenzi wokunyanga izigulane kusetyenziswa i-radiotherapy echanekileyo kakhulu esebenzisa i-photon kunye ne-proton. Iqela lethu liqhubeka nokuphuhlisa iindlela ezintsha zonyango kunye nokusetyenziswa kweklinikhi emva kokuqinisekiswa okubanzi. Ngaphandle koko, iqela likwanikezele izixhobo ezahlukeneyo zokubonisa imifanekiso ezivelisa imitha kubandakanya i-Aquilion-LB Wide bore CT (eToshiba, eJapan) kunye neBiograph Vision Digital PET-CT (eSiemens, eJamani).

Ukulinganisa: Iingcali zefiziksi zonyango zilinganisa kwaye zilinganise ukuhanjiswa kwedosi yemitha ngezixhobo ezahlukeneyo ezivelisa imitha emva kokwenziwa kwemisebenzi yamazwe ngamazwe kwaye ziqinisekise ukuba iyalandeleka ukuya kumgangatho ophambili.

Uqinisekiso lomgangatho: Ukuqinisekisa ukuhanjiswa kwedosi yemitha emiselweyo ngokukhuselekileyo nangokuchanekileyo kwisigulana, isebe lenza uvavanyo lomgangatho oluphindaphindeneyo lwezixhobo zokuhambisa unyango (i-PROTEUS-PLUS kunye ne-RadiXact-X9 HT) kunye nezinto ezinxulumene nazo rhoqo ngeentsuku zemihla ngemihla, zeveki, zenyanga kunye nezonyaka. Isebe likwaqinisekisa ukusebenza kakuhle kwezixhobo zokuthatha imifanekiso ezifakwe kumatshini we-proton/photon therapy (ukuqinisekisa indawo yesigulana ngaphambi konyango) kunye nezinye izixhobo zokuxilonga.

Ukucwangciswa konyango: Izigulana ezibhalisele naluphi na uhlobo lonyango lwemitha kufuneka zenze amalungiselelo anzulu ngaphambi konyango emva kwe-SOP yesebe. Iqala ngokulungiselela izixhobo zokuthintela ukunyakaza ezenzelwe wena, kulandele ukucaciswa kwethumba kunye namalungu abalulekileyo kusetyenziswa iiseti zemifanekiso ye-volumetric ye-multi-modality (CT, MRI, PET). Unyango olucetywayo lulinganiswa kwi-TPS kusetyenziswa imodeli yesigulana kunye nomatshini. Ukusasazwa kwedosi ngaphakathi kwesigulana kubalwa kusetyenziswa ii-algorithms ze-Monte-Carlo/convolution superposition ezintsonkothileyo nezichanekileyo. Isicwangciso sonyango esiveliswa ngaloo ndlela sivavanywa liqela le-Radiation oncologist kunye ne-Medical Physicist ukuqinisekisa ukufezekiswa kwenjongo yeklinikhi echazwe kwangaphambili.

Ukucwangciswa koNyango lweProton: Uphuhliso lwetekhnoloji lwePROTEUS-PLUS lusenza sikwazi ukucwangcisa nokunyanga isigulane sethu ngendlela ephucukileyo ye-Intensity Modulated Proton Therapy (IMPT). Ukucwangciswa konyango lwe-IMPT kwenziwa kwi-RayStation TPS. Kubandakanya ukulungiswa okuntsonkothileyo kokuphinda-phinda kwamandla eproton amaninzi kunye namabala amaninzi eproton, izikhundla zawo, isithuba kunye nobunzima ukuze kufezekiswe idosi ehambelana kakhulu nethumba kunye nokugcina izicubu eziqhelekileyo ezikufutshane. Sisebenzisa i-SFO, i-MFO, i-Hybrid kunye ne-Robust optimization ngokuxhomekeke kubunzima kunye neemfuno zetyala leklinikhi. Ukulungiswa okuqinileyo kwe-4D, i-Layer kunye ne-volumetric re-painting IMPT kusetyenziswa kwi-tumor eguquguqukayo. I-Adaptive IMPT yenziwa rhoqo kwiindawo zonyango ezibonisayo.

Ucwangciso loNyango lwe-Photon/High Energy X-ray: Izicwangciso zonyango lwe-photon radiation therapy zenziwa kwi-Precision TPS kusetyenziswa i-helical intensity modulated radiotherapy (IMRT) yazo zonke iindawo zonyango. I-SBRT, i-frameless SRS, i-SRT kunye ne-adaptive radiotherapy nazo zenziwa rhoqo kwiimeko ezibonisiweyo. Ngaphandle kokunyanga iindawo ezininzi ezinzima zonyango, sikwaqalise i-Total marrow irradiation (TMI)/Total marrow kunye ne-lymphoid irradiation (TMLI) okokuqala eIndiya.

Research

Isebe le-Medical Physics kwi-APCC lizibandakanya ngokukhutheleyo kunye nemisebenzi yophando oluyilayo enxulumene nokucinga ngeendlela ezininzi kunye nonyango oluchanekileyo oluphezulu lweradiyo kusetyenziswa zombini iproton kunye ne-photon beam.

Umdla wethu wangoku wophando ubandakanya, uphuhliso lwesoftware yangaphakathi, uphando lobuchule obutsha bonyango, ubukrelekrele bokwenziwa kunye nokufunda koomatshini, i-in-vivo kunye ne-in-vitro cell-line yokufunda, ukujongana nemibuzo engaphendulwanga, idatha enkulu evela kumatshini wefayile yelog njl.njl.

Isebe lineeprojekthi ezininzi eziqhubekayo ze-intramural kunye neprojekthi yentsebenziswano namaziko ahloniphekileyo e-Indiya nakwamanye amazwe. Isebe likwabandakanyeka kulingo lwezonyango kunye neeprojekthi zophando eziphonononga ukuhanjiswa kwemitha ye-ionizing kunye ne-non-ionizing kwizigulane ngeenjongo zokuxilonga kunye nonyango.

Isiphumo sophando lwethu oluqhubekayo luyafumaneka kwiCandelo loPapasho lwakutsha nje