Theranostics yog dab tsi?
Theranostics yog lub ntsiab lus rau kev sib xyaw ntawm kev kho mob thiab kev kuaj mob (siv ib qho radionuclide rau cov duab qog thiab thib ob radionuclide los kho cov qog los ntawm kev xa cov hluav taws xob tua hluav taws xob). Yeej, nws txhais tau hais tias lub hom phiaj ib leeg receptor molecule ntawm cov qog nqaij hlav cancer nrog ob qhov sib txawv ntawm radionuclides (kev ntsuam xyuas thiab kev kho). Qhov no yog kom ua tiav qhov tseeb thiab tus kheej txoj kev kho mob.
Diagnostic theem ntawm Theranostics
Cov qog hlwb muaj lub plhaub, hu ua daim nyias nyias; muaj qee cov proteins xws li somatostatin receptor (SSTR2) ntawm cov qog cell membrane uas tuaj yeem ua lub hom phiaj rau cov tshuaj mob qog noj ntshav.
Ga-68 DOTATOC yog cov tshuaj siv hluav taws xob kuaj mob uas tsom rau SSTR2. Ga-68 DOTATOC yog txhaj rau hauv tus neeg mob cov hlab ntsha thiab taug kev thoob plaws hauv cov hlab ntsha mus rau tag nrho cov kabmob thiab cov ntaub so ntswg ntawm lub cev. Yog tias tus neeg mob muaj cov qog neuroendocrine nrog SSTR2 ntawm cov qog cell membranes, Ga-68 DOTATOC yuav khi rau SSTR2 thiab cov qog yuav teeb rau ntawm PET scan.
Therapeutic theem ntawm Theranostics
Thaum kuaj mob qog noj ntshav neuroendocrine tau kuaj pom siv Ga68-DOTATOC PET scan, Ga-68 tuaj yeem hloov nrog lwm cov radionuclide, xws li lutetium-177 (Lu-177) lossis yttrium-90 (Y-90), uas tuaj yeem tsom thiab tua cov qog hlwb. uas muaj SSTR2 ntawm lawv daim nyias nyias.
Kev kho mob Y-90-DOTATOC thiab Lu-177-DOTATATE tuaj yeem raug txhaj rau hauv tus neeg mob cov leeg thiab mus rau txhua qhov ntawm lub cev uas muaj SSTR2 proteins. Cov tshuaj kho mob no khi rau SSTR2 cov protein zoo li tus yuam sij hauv lub xauv, tso cai rau cov tshuaj nkag mus rau hauv cov qog hlwb thiab tua nws los ntawm kev puas tsuaj rau lub cell DNA. Cov hlwb noj qab haus huv nyob ib puag ncig cov qog uas tsis muaj SSTR2 cov proteins ntawm lawv daim nyias nyias tsis cuam tshuam los ntawm cov tshuaj.
Cov tswv yim zoo li no tso cai rau cov kws kho mob tuaj yeem pom cov duab kho mob qog noj ntshav ntau dua, xaiv cov neeg mob rau kev siv tshuaj kho mob, saib kom meej qhov chaw kho mob yuav raug xa mus, thiab saib xyuas lub peev xwm ntawm tus neeg kho mob kom txo cov qog nyob rau lub sijhawm. Theranostics muab cov kws kho mob oncologist nrog cov cuab yeej tshiab thiab muaj txiaj ntsig zoo los tsim cov tswv yim kho mob thiab kwv yees cov txiaj ntsig ntawm kev kho mob tshwj xeeb raws li cov neeg mob tshwj xeeb molecular thiab genomic profile.
THERANOSTICS: Pom qhov peb kho - kho qhov peb pom
Qhov no kuj yog hu ua tsom rua kev kho radionuclide raws li nws yog tsom rau lub hom phiaj molecular ntawm kev ua haujlwm qog noj ntshav. Yog li ntawd, kev siv hluav taws xob ntau dua tuaj yeem raug tsom ntawm cov qog tsis cuam tshuam rau ntau lub cev noj qab haus huv.
Yuav ua li cas theranostics txawv ntawm ib txwm siv hluav taws xob kho mob?
Kev kho hluav taws xob tuaj yeem ua tau zoo heev hauv kev kho mob qog noj ntshav, lossis txo cov tsos mob ntawm cov neeg mob uas tsis tuaj yeem kho mob qog noj ntshav siab. Kwv yees li ib nrab ntawm tag nrho cov neeg mob qog noj ntshav yuav tau txais kev kho hluav taws xob ntawm qee qhov ntawm lawv cov kev kho mob, uas siv sab nraud lossis sab hauv xa tawm x-rays, protons lossis lwm yam khoom siv hluav taws xob siab rau lub hom phiaj thiab rhuav tshem cov qog nqaij hlav cancer. Txawm hais tias kev txhim kho thev naus laus zis tau txo qis kev noj qab haus huv cov ntaub so ntswg tsis zoo, cov tshuaj siv hluav taws xob ib txwm tseem ua rau muaj kev phiv uas tuaj yeem nyuaj rau qee cov neeg mob zam. Tsis tas li ntawd, ib txwm siv hluav taws xob kho mob tsis tuaj yeem tsom mus rau ntau dua ib qhov chaw ntawm cov kab mob, txwv nws cov txiaj ntsig rau cov neeg mob qog noj ntshav metastatic. Txawm li cas los xij, ib txwm siv xov tooj cua tseem yog ib qho ntawm oncology cov cuab yeej kho mob muaj zog tshaj plaws.
Txoj hauv kev tshiab no rau kev kho mob qog - tsom rau kev kho mob radionuclide - yog rov tsim kho kev siv hluav taws xob kho mob hauv qhov tseeb oncology thiab xa cov chav kawm tshiab ntawm kev kho mob qog noj ntshav. Lub hom phiaj ntawm kev txhim kho radionuclide txoj kev txhim kho yog txhawm rau ua ke alpha-, beta- lossis gamma-particle emitting isotopes - lossis radionuclides - nrog peptides, tshuaj tiv thaiv kab mob, lossis cov molecules me, los tsim kho kev kho mob nrog rau qee hom qog nqaij hlav. Xa mus rau tus neeg mob intravenously, tsom radionuclide kev kho mob yog tsim los mus ncaj qha mus rau lub qog kom xa cov tshuaj kho mob nrog high precision. Qhov no precision yog npaj los tsom xa cov hluav taws xob mus rau cov qog nqaij hlav thaum txo qis hluav taws xob raug rau cov ntaub so ntswg.
Hom mob qog noj ntshav twg tuaj yeem kho nrog theranostics?
Theranostics tuaj yeem ua tau zoo hauv kev kho mob metastatic, cov qog ua tsis tau zoo nyob rau theem siab ntawm cov kab mob nrog rau cov qog nqaij hlav prostate, cov qog nqaij hlav neuroendocrine ntawm ntau yam kabmob xws li plab, pancreas, me & cov hnyuv loj thiab lub ntsws. Qhov kawg tab sis tsis yog qhov tsawg tshaj plaws, tom qab kev ua haujlwm ablation ntawm cov thyroid seem seem thiab kev kho mob ntawm cov qog nqaij hlav qog noj ntshav kuj tseem nyob hauv gamut ntawm theranostics.
Cov qog nqaij hlav saum toj no muaj pov thawj txaus muaj tam sim no tias muaj txiaj ntsig zoo hauv kev siv radionuclide kho. Txawm li cas los xij, ntau lwm cov qog nqaij hlav kuj tseem yuav muaj txiaj ntsig thaum lawv nthuav qhia qee hom hom phiaj receptors xws li fibroblast activation protein (FAP) thiab chemokine receptors (CXCR4), tuaj yeem raug tsom nrog kev kho mob.
Peb Molecular thiab tsom Radionuclide Theranostics suav nrog:
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- PRRT: Lutetium -177 DOTA Kev Kho Mob
Actinium - 225 DOTA Kev Kho Mob
Yttrium-90 DOTA Therapy rau Neuro endocrine hlav - PRLT: Lutetium -177 PSMA Kev Kho Mob rau Prostate cancer
- TARE: Yttrium- 90 SIR sphere therapy for Liver cancers / Liver metastases
- FAPI: Fibroblast activation Protein inhibitor Therapy
Lutetium-177 FAPI Kev Kho Mob thiab
Actinium -225 FAPI Kev Kho Mob rau txog 28 hom mob qog noj ntshav
- PRRT: Lutetium -177 DOTA Kev Kho Mob
- TSEEM CEEB: Paub zoo kuv – 131 Xov tooj cua Iodine Therapy rau thyroid cancersSamarium – 153 Pain Palliation Therapy rau pob txha metastases.I-131 MIBG kev kho mob rau pheochromocytoma
Tsuas yog nyob rau ntawm qhov tshwj xeeb kev kho mob scenarios ntawm lub siab hlub tshua txog tam sim no.
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Yeej dhau Cancer nrog Apollo Proton Cancer Center
Qhov kev vam meej hauv Kev Kho Mob Cancer! Lub ntiaj teb loj hlob mob qog noj ntshav qhia ib zaj dab neeg tsis zoo. Txhawm rau tiv thaiv qhov kev hem thawj loj zuj zus no, Apollo Proton Cancer Center muab cov kev daws teeb meem ua tiav thiab ua tiav. Raws li kev saib xyuas mob qog noj ntshav tau dhau los ua ib qho tseem ceeb tshaj plaws hauv kev kho mob thoob plaws ntiaj teb, peb ntseeg tias nws yog ib qho tseem ceeb uas yuav tsum tau hloov kho peb lub hom phiaj, rov pib dua peb txoj kev mob siab rau ib leeg-lub siab tsom ntsoov - txhawm rau tiv thaiv mob qog noj ntshav, kom kov yeej mob qog noj ntshav! ray ntawm kev cia siab rau lab, infusing lawv nrog lub siab tawv sawv thiab ntsia mob qog noj ntshav.
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