Kodi theranostics ndi chiyani?
Theranostics ndi mawu ophatikiza njira zochizira ndi zowunikira (kugwiritsa ntchito radionuclide imodzi kufanizira zotupa ndi radionuclide yachiwiri kuchiza zotupa popereka cheza chopha khansa). Kwenikweni, zimatanthawuza kuloza molekyu imodzi yolandirira pama cell a khansa okhala ndi ma radionuclides awiri osiyanasiyana (kuyerekeza ndi chithandizo). Izi ndikukwaniritsa njira yolondola komanso yokhazikika yamankhwala.
Gawo la diagnostics la Theranostics
Maselo a chotupa ali ndi chipolopolo, chotchedwa nembanemba; pali mapuloteni ena monga somatostatin receptor (SSTR2) pa nembanemba ya cell chotupa yomwe imatha kukhala chandamale cha mankhwala a khansa.
Ga-68 DOTATOC ndi mankhwala owunikira ma radioactive omwe amalimbana ndi SSTR2. Ga-68 DOTATOC imabayidwa mumtsempha wa wodwala ndipo imayendayenda m'magazi kupita ku ziwalo zonse ndi minofu ya thupi. Ngati wodwalayo ali ndi chotupa cha neuroendocrine ndi SSTR2 pa nembanemba ya cell chotupa, Ga-68 DOTATOC imangirira ku SSTR2 ndipo chotupacho chidzawunikira pa PET scan.
Gawo lochizira la Theranostics
Khansara ya neuroendocrine ikapezeka pogwiritsa ntchito scan ya Ga68-DOTATOC PET, Ga-68 imatha kusinthidwa ndi radionuclide ina, monga lutetium-177 (Lu-177) kapena yttrium-90 (Y-90), yomwe imatha kupha ndikupha ma cell chotupa. omwe ali ndi SSTR2 pa nembanemba yawo.
Therapeutic Y-90-DOTATOC ndi Lu-177-DOTATATE onse amatha kubayidwa m'mitsempha ya wodwala ndikupita ku gawo lililonse la thupi lomwe lili ndi mapuloteni a SSTR2. Mankhwala ochiritsirawa amamangiriza ku mapuloteni a SSTR2 monga kiyi mu loko, kulola kuti mankhwalawa alowe m'maselo a chotupa ndikupha mwa kuwononga DNA ya selo. Maselo athanzi ozungulira chotupa omwe alibe mapuloteni a SSTR2 pa nembanemba yawo samakhudzidwa ndi mankhwalawa.
Njira yotereyi imalola akatswiri a oncologist kuti azitha kufanizira kwathunthu minofu ya khansa yomwe imatha kuchiritsidwa, kusankha odwala kuti agwiritsidwe ntchito pachipatala, kuwona komwe othandizira adzaperekedwe, ndikuwunika kuthekera kwa wothandizira kuti achepetse zotupa pakapita nthawi. Theranostics imapatsa akatswiri a oncologists zida zatsopano komanso zogwira mtima kwambiri zopangira njira zochiritsira zolondola ndikulosera zaubwino wamankhwala enaake potengera momwe wodwalayo alili mamolekyulu ndi ma genomic.
THERANOSICS: KUONA ZIMENE TIMACHITA—KUCHITA ZIMENE TIKUONA
Ichi chimatchedwanso chithandizo cha radionuclide chomwe chimayang'ana kwambiri cholinga cha maselo a khansa omwe amagwira ntchito. Chifukwa chake, kuchuluka kwa ma radiation kumatha kulunjika pa chotupacho popanda kukhudza maselo ambiri athanzi.
Kodi ma theranostics amasiyana bwanji ndi ma radiotherapy achikhalidwe?
Ma radiation amatha kukhala othandiza kwambiri pochiza khansa, kapena kuchepetsa zizindikiro kwa odwala omwe ali ndi khansa yapamwamba yosachiritsika. Pafupifupi theka la odwala onse omwe ali ndi khansa adzalandira chithandizo chamankhwala cha radiation panthawi inayake pamankhwala awo, omwe amagwiritsa ntchito ma x-ray, ma protoni kapena tinthu tambiri tambiri tomwe timayang'ana ndikuwononga ma cell a khansa. Ngakhale njira zamakono zamakono zachepetsa kuwonongeka kwa minofu yathanzi, ma radiotherapy achikhalidwe amachititsabe mavuto omwe angakhale ovuta kwa odwala ena kulekerera. Kuphatikiza apo, chithandizo chamankhwala chachikhalidwe sichingathe kulunjika malo opitilira matenda, ndikuchepetsa zothandiza kwa odwala omwe ali ndi khansa ya metastatic. Komabe, radiotherapy yachikhalidwe imakhalabe imodzi mwazida zamphamvu kwambiri za oncology.
Njira yatsopanoyi yochizira chotupa - yomwe imayang'aniridwa ndi radionuclide therapy - ikukonzanso kagwiritsidwe ntchito ka ma radiation olondola a oncology ndikupereka kalasi yatsopano yochizira khansa. Cholinga cha chitukuko cha chithandizo cha radionuclide ndikuphatikiza ma isotopi a alpha-, beta- kapena gamma-particle emitting isotopes - kapena radionuclides - ndi ma peptides, ma antibodies, kapena mamolekyu ang'onoang'ono, kuti apange chithandizo chapadera chamitundu ina ya zotupa. Kukaperekedwa kwa wodwalayo kudzera m'mitsempha, njira zochiritsira za radionuclide zimapangidwira kuti ziyende molunjika kupita ku chotupacho kukapereka ma radiation achire molondola kwambiri. Kulondola uku kumapangidwira kuyang'ana kwambiri kuperekedwa kwa ma radiation ku minofu yotupa ndikuchepetsa kukhudzana ndi ma radiation ku minofu yabwinobwino.
Ndi khansa yamtundu wanji yomwe ingachiritsidwe ndi theranostics?
Theranostics ikhoza kukhala yothandiza pochiza zotupa za metastatic, zosagwira ntchito pamlingo wapamwamba wa matenda kuphatikiza khansa ya prostate, zotupa za neuroendocrine za ziwalo zosiyanasiyana monga m'mimba, kapamba, matumbo ang'onoang'ono & akulu ndi mapapo. Pomaliza, kuchotsedwa kwa chithokomiro chotsalira pambuyo pa opaleshoni ndikuchiza khansa ya chithokomiro cha metastatic kulinso mugamut of theranostics.
Makhansa omwe ali pamwambawa ali ndi umboni wokwanira womwe ulipo kuti pali phindu lenileni logwiritsa ntchito chithandizo cha radionuclide. Komabe, makhansa ena ambiri amathanso kukhala ndi phindu akawonetsa mitundu ina ya zolandilira monga fibroblast activation protein (FAP) ndi chemokine receptors (CXCR4), imatha kuyang'aniridwa ndi theranostics.
Ma Radionuclide Theranostics athu a Molecular komanso omwe amayang'ana akuphatikizapo:
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- PRRT : Lutetium -177 DOTA Therapy
Actinium - 225 DOTA Therapy
Yttrium-90 DOTA Therapy for Neuro endocrine zotupa - PRLT : Lutetium -177 PSMA Therapy for Prostate Cancer
- TARE: Yttrium- 90 SIR sphere therapy ya khansa ya chiwindi / metastases ya chiwindi
- FAPI : Fibroblast activation Protein inhibitor Therapy
Lutetium-177 FAPI Therapy ndi
Actinium -225 FAPI Therapy ya mitundu pafupifupi 28 ya khansa yapamwamba
- PRRT : Lutetium -177 DOTA Therapy
- NKHANI : Odziwika bwino I - 131 Radio Iodine Therapy for thyroid cancersSamarium - 153 Pain Palliation Therapy for bone metastases.I-131 MIBG mankhwala a pheochromocytoma
Zimangoganiziridwa pazochitika zapadera zachipatala pazifukwa zachifundo kuyambira pano.
Tsitsani Leaflet
Kupambana Khansa ndi Apollo Proton Cancer Center
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