Pediatric Liver Transplant (LT) is now an established procedure for End Stage Liver Disease (ESLD), with biliary atresia being the commonest indication. Intensive pre-transplant evaluation, nutritional buildup and immunization are the fundamental pre-requisites of a successful LT. With improvement in surgical micro-anastomotic techniques and superior immunosuppressive regimens, the success rate of pediatric LT is in excess of 90%.
Pediatric Liver Transplant FAQs
- Who is a candidate for a liver transplant?Children who suffer from end-stage liver disease due to various causes may be considered for liver transplantation. The most common indication in children is biliary atresia.
- How is it decided that my child needs a liver transplant?Eligibility is determined by a comprehensive medical evaluation by the transplant team.
- What does a pre transplant evaluation process consists of?This consists of checking all the body systems with regards to optimal function and presence of unexpected disease. Your child’s immunization records will be reviewed. Following transplantation, some vaccines cannot be given and others may not be as effective.
- A detailed nutritional assessment will also be performed. Several tests will be performed:
- Laboratory blood and urine tests.
- Electrocardiogram (ECG) and a chest X-ray.
- CT scan of the liver and blood vessels
- Who can be the donor for transplantation?There are two sources: deceased and living donors.
- Deceased donors are individuals whose organs have been made available after brain death. As this option is scarce in India, living related liver transplantation is the only feasible option in our country.
- For living related transplants, a related donor (usually parent) with a compatible blood type donates a portion of their liver to the child. Fortunately, the liver of the donor is able to grow back to its full size in 8-12 weeks. Living liver donors should be healthy, with a near normal body mass index (not obese) adults who have the ability to understand the procedure.
The donor should have no medical, emotional, or psychological impairments that could potentially increase the risk of the surgery.
- What does a pre-transplant evaluation process consist of?This consists of checking all the body systems with regards to optimal function and presence of unexpected disease. Your child’s immunization records will be reviewed. Following transplantation, some vaccines cannot be given and others may not be as effective. A detailed nutritional assessment will also be performed. Several tests will be performed:
- Laboratory blood and urine tests
- Electrocardiogram (ECG) and a Chest X-ray, Echocardiography
- Ultrasound of the liver and blood vessels
- CT angiography abdomen
- HLA testing for establishing a relationship between the donor and recipient.
- What are the pros and cons of living donor transplantation?The advantage of living related donor transplant is that the procedure can be scheduled electively that works best for the donor and recipient. There is a very small risk of complications to the donor. Out of the 170 pediatric living related liver transplants performed in our programme at Delhi there have been no significant complications in the donor population.
- What is the average hospital stay for a donor?Most donors are hospitalized for 7-10 days after the surgery. The incision staples are usually removed about 7-10 days postoperatively.
- How does donation affect the donor’s ability to work?The recovery time for this type of surgery varies, but most donors are advised that they will require up to 3 months before complete recovery of normal health and activity.
- How long will the operation take?A typical liver transplant can last from 8-12 hours. The surgery for the donor lasts approximately 5-6 hours.
- What are the risks of transplant surgery?There are risks with transplant surgery just as with any major surgery. Some immediate complications can include bleeding and blood clotting problems, respiratory problems and malfunction of the donor liver. Long term complications include rejection (when the child’s immune system does not accept the new liver) and infection. Fortunately, most of these complications are treatable.
- What is the postoperative period like for the child who undergoes liver transplantation?After your child’s surgery, he/she will be taken to transplant ICU where he/she will stay for a week. After your child is transferred out of ICU to the paediatric floor, the length of stay will depend on how quickly he/she recovers. Average length of hospital stay is about 3 weeks.
- What medications will my child take at home after transplant?Your child will take 2 major types of medications in addition to multivitamins and health supplements to prevent rejection. If your child misses a dose, you need to contact our team immediately.
- Once my child leaves the hospital, what happens?Initially your child has to come to the transplant clinic twice a week for laboratory work up and physical examination or as frequently advised by our team. As recovery progresses, these visits become less frequent.
- Who will look after my child long term?Your child will be looked after by the primary paediatrician who will be supported by our team.
- What restrictions will my child have during her recovery?For the first six weeks after surgery, your child should avoid strenuous exercises.
- What lifestyle changes are associated with liver transplants?Most patients can return to a normal or near-normal lifestyle six months after a successful liver transplant. Recipients should avoid exposure to people with infections. Maintaining a balanced diet, and staying on prescribed medications are vital to stay healthy. Children can attend school and participate in sports and other age-appropriate activities and can have a normal married life in the future with no fertility issues.
- What is the survival rate for children with liver transplants?Our centre performed the first successful paediatric liver transplant in India in 1998. Our survival rate is about 90%. Survival rates vary from centre to centre around the world. Our results are comparable to the most well established centres from across the world.
- Pediatric Liver Transplant Team – Liver Transplant By
• Dr. Prof. Darius Mirza
• Dr. Chirag DesaiPediatric Intensivist
• Dr. Pushkar SrivastavaPediatric Nephrologist
• Dr. Sheetal AgarwalPediatric Liver Transplant Physician
• Dr. Pathik Parikh - Anaesthetist
• Dr. Bhavesh Patel
• Dr. Kunal Soni
• Dr. Ankit Chauhan
• Dr. Maulik Shah
