Iiseli ze-T ziyinxalenye yamajoni omzimba asetyenziswa ngumzimba ukulwa umhlaza kunye nezinye izifo. Iiseli ze-T ezitshintshwe ngokwemfuza zaziwa njenge-chimeric antigen receptor T (CAR T) iiseli. Ukusebenzisa isakhono seeseli T ezitshintshiweyo zokufumana nokuphelisa iiseli zomhlaza, unyango lweeseli zeCAR T luphucula imiqobo yendalo yomzimba ngokuchasene nesigulo.
Njengomnikelo wegazi, igazi liqokelelwa kwizigulana ukuze kwahlulwe ii-T seli. Ezi seli ze-T ziguqulwa ke kwibhubhoratri phantsi kweliso leengcali ukuvakalisa i-Chimeric Antigen Receptor. Phambi kokulawulwa kweeseli zeCar T, izigulana kufuneka zenze ichemotherapy ukulungiselela imizimba yazo kunyango lweeseli zeCar T. Nje ukuba zifakelwe, iiseli zeCar T kulindeleke ukuba zibone kwaye zinciphise iiseli zomhlaza ezixhathisayo ngokuvula amajoni omzimba.
Ukusukela ngo-2017, i-FDA ivume unyango lweeseli zeCar T ezintandathu zokunyanga umhlaza wegazi njengeLymphomas, iintlobo ezithile zeLeukemia kwaye kutshanje, i-myeloma emininzi. Izigulana ezifanelekileyo kwi-Car T cell therapy kufuneka zihlangabezane neendlela ze-FDA kwaye zibe nempilo entle ngokubanzi ukusingatha ixesha lokulinda kunye neziphumo ebezingalindelekanga.
