Lynch Syndrome, also known as Hereditary Nonpolyposis Colorectal Cancer (HNCC)
1. Most common hereditary cause of colon cancer and is believed to account for 3-5% of all colorectal cancers.
2. It increases the risk of colorectal cancer. Individuals with lynch syndrome have a 25% risk 0f colon cancer by age 50.
3. That risk increases with age. By age 70, individuals with lynch syndrome have an up to 82% risk of colorectal cancer.
4. It also increases the risk for many other types of cancer. Lynch syndrome increases the risk of; Endometrial cancer by up to 71%, gastric cancer by up to 13% and ovarian cancer by up to 12%. There is up to 90% lifetime risk of developing some type of cancer.
5. It can lead to multiple cancer diagnosis. Individuals with lynch syndrome who have been diagnosed with one cancer have a significantly increased risk of developing a second cancer within 15 years.
6. It is caused by gene mutations: Lynch syndrome is caused by mutations in genes involved in the repair of DNA replication errors.
7. These mutations run in families. Red flags in family history may indicate an increased risk of lynch syndrome. 1st or second degree relative with colorectal or endometrial cancer before age 50. 2 or more relatives with a lynch syndrome cancer, one before age 50. 3 or more relatives with a lynch syndrome cancer at any age.
8. Asking about persona; medical history is also important. These red flags in an individual’s personal medical history may help identify those who would benefit from generic testing.
9. Genetic testing can be used to access risk. Genetic testing for gene mutations associated with lynch syndrome helps to identify individuals who may be at risk for colorectal and other cancers.
10. Medical management may help reduce cancer risk or detect cancer earlier. Preventive measures may significantly reduce the risk of cancer.