Dr. Ravichand Siddachari

Research

Research Experience • Research fellow in Tata memorial Hospital : • Photodynamic Therapy Project (International multicentric trial) Duration- 2 nd September2002- 31st August 2003. Institution- Tata Memorial hospital Nature of work included patient selection, arranging for investigations, carrying out the procedure of photodynamic therapy, assessing response and its complications under GCP guidelines. • Trained in designing, organizing and conduction of trials as per GCP guidelines. Helped in designing the following trials :- • Assisted in designing a randomized controlled trial in Head and Neck oncology: Elective versus therapeutic neck dissection in early cancer of oral tongue. The trial is ongoing at Tata Memorial hospital • Assisted in designing a randomized controlled trial in plastic and reconstructive services: Role of anticoagulants in Head and Neck microvascular reconstruction. A randomized controlled study to evaluate its use for prophylaxis of thrombosis. • Assisted in designing a a randomized controlled trial: A comparison between D1 and D2 lymphadenectomy in Gastric cancer.

• Assisted in designing phase II study of Laparoscopic Anterior Resection and Abdomino-perineal resection for canacer of rectum, rectosigmoid and anal canal lesions

Research fellow, HPB and Liver transplantation unit St.Vincent’s University Hospital, Dublin, Ireland From 11.07.2011 to 09.11.2012 10 Research Project: Gene Expression in liver tissue; effect of tissue ischaemia time with relevance to the development of biomarkers in colorectal liver metastases. Nature of work: Apart from clinical work including organ procurement (On call rota 1in 3) and liver.

transplantation and other liver surgical procedures I was involved in research project in Trinity College, Dublin. This project involved in taking liver tissue samples in patients undergoing liver resection for colorectal liver metastases. The specimens are collected at different time points to analyze alterations in the expression of genes. RNA and protein are extracted and analyzed. The thesis was submitted to University College Dublin, Ireland in Jan 2013 and awarded MCh. Also involved in other research projects which were carried out in our lab : 1. “ Soluble CD1d: a novel receptor of iNKT cells and possible immunotherapeutic agent” 2. “Hepatic iNKT cell populations in perfusates obtained during liver transplantation” 3. “ CD141+ ( BDCA-3) Dendrtic cells ( DC) are depleted in Hepatitis C virus ( HCV) – infected liver”.

Publications 1. Laryngeal amyloidosis. Journal of Otolaryngology. 2005 Feb; 34(1):60-3. 2. Management of renal cell carcinoma with solitary metastasis World J Surg Oncol. 2005 Jul; 20;3:48. 3. Laparoscopic surgery for malignancy- a review article- Bombay Hospital Journal, 2005 Oct; 47:359-361 4. D2 Lymphadenectomy for Gastric cancer in Tata Memorial Hosital: Indian data can now be incorporated in future international trials. Accepted for publication in “Digestive Surgery” ( 2006) 5. Gastro-entero-pancreatic Neuroendocrine Tumors: A chapter in Handbook on Evidence Based Medicine of Endocrine Tumors, Published by Tata Memorial Hospital, Feb 2006. 6. Ectopic Thyroid Cancer. Ann Thorac Cardiovasc Surg. 2007 Apr;13(2):122-4. 7. Post-operative deep vein thrombosis in patients with colorectal cancer: Indian J Gastroenterol 2008 Mar-Apr; 27: 71-73 8. Elective neck dissection for the management of the N0 neck in early cancer of the oral tongue: need for a randomized controlled trial. Head Neck. 2009 May;31(5):618-24 9. CD141+ myeloid dendritic cells are enriched in healthy human liver. Kelly A, Fahey R, Fletcher JM, Keogh C, Carroll AG, Siddachari R, Geoghegan J, Hegarty JE, Ryan EJ, O’Farrelly C.J Hepatol. 2013 Aug 19. doi:pii: S0168- 8278(13)00592-8. 10.1016/j.jhep.2013.08.007. [Epub ahead of print] 10. Neoadjuvant chemoradiotherapy followed by liver transplantation for unresectable cholangiocarcinoma: a single-centre national experience. Duignan S, Maguire D, Ravichand CS, Geoghegan J, Hoti E, Fennelly D, Armstrong J, Rock K, Mohan H, Traynor O.HPB (Oxford). 2013 Apr 18. doi: 10.1111/hpb.12082.

Top 5   Registrar in Liver Transplantation and HPB/GI surgery

at St. Vincent’s University Hospital, which is a National Centre for Liver

Transplantation and Hepatobiliary-pancreatic diseases for 2 years from

July 2009 to July 2011 and as Research Fellow for one year till July 2012.3

• Passed intercollegiate specialty exam in General Surgery with subspecialty in

HPB/ Upper GI and awarded Fellowship of Intercollegiate Board of UK and

Ireland