Verified By July 17, 2023
GIST stands for Gastrointestinal Stromal Tumor, which is a rare type of cancer that occurs in the gastrointestinal (GI) tract, primarily in the stomach or small intestine. It belongs to a group of tumors known as soft tissue sarcomas, which develop in the connective tissues of the body.
GISTs arise from specialized cells called interstitial cells of Cajal (ICC), which are responsible for regulating the contractions of the GI tract. These tumors can be benign (non-cancerous) or malignant (cancerous), with the majority being malignant. GISTs can vary in size and aggressiveness, and their behavior is determined by several factors, including the size, location, and mutation status of the tumor.
One of the key features of GISTs is the presence of mutations in a specific gene called KIT or PDGFRA. These mutations activate certain signaling pathways, leading to uncontrolled growth and division of the tumor cells. Testing for these mutations has become an essential part of diagnosing GISTs and determining the most appropriate treatment strategy.
The symptoms of GISTs can vary depending on the location and size of the tumor. Some common symptoms include:
In recent years, significant advancements have been made in the understanding and treatment of GISTs. Research has led to improved diagnostic techniques, a better understanding of the molecular basis of the disease, and the development of new targeted therapies. These advancements have significantly improved the prognosis and outcomes for individuals with GISTs, offering hope for better management and increased survival rates.
Apollo Hospitals, Navi Mumbai, offers advanced oncology services for the assessment, management & prevention of complex as well as rare cancers. From world renowned cancer surgeons, state-of-the-art infrastructure to the most advanced 4th generation Da Vinci Xi robotic system for a comfortable recovery after surgery and Radionuclide therapy for thyroid cancers, Apollo Hospitals, Navi Mumbai, has the best cancer centre in Mumbai.
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November 19, 2019